Affiliation: University of Sydney
- Group I and II metabotropic glutamate receptors alter brain cortical metabolic and glutamate/glutamine cycle activity: a 13C NMR spectroscopy and metabolomic studyCaroline Rae
School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales, Australia
J Neurochem 92:405-16. 2005..All ligand effects were separated from control and from each other using two principal components. The ramifications of these findings are discussed...
- Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentationCaroline Rae
Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales, Australia
J Neurochem 85:503-14. 2003..The resultant implications for metabolic compartmentation and regulation of metabolism by transport processes are discussed...
- Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malariaCaroline Rae
Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, Sydney NSW 2006, Australia
FASEB J 18:499-510. 2004..This was accompanied by mild up-regulation of expression of metabolic enzymes. These changes are consistent with benign hypermetabolism whose cause remains a subject of speculation...
- Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trialCaroline Rae
Discipline of Biochemistry, School of Molecular and Microbial Biosciences G08, The University of Sydney, Sydney, NSW 2006, Australia
Proc Biol Sci 270:2147-50. 2003..These findings underline a dynamic and significant role of brain energy capacity in influencing brain performance...
- Enlarged temporal lobes in Turner syndrome: an X-chromosome effect?Caroline Rae
Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, Sydney, NSW 2006, Australia
Cereb Cortex 14:156-64. 2004..These temporal lobe abnormalities are discussed with reference to genes which are absent in Turner syndrome and to hormonal differences between Turner syndrome subjects and 46,XX controls...
- A metabolomic approach to ionotropic glutamate receptor subtype function: a nuclear magnetic resonance in vitro investigationCaroline Rae
School of Molecular and Microbial Biosciences, The University of Sydney, Sydney, New South Wales, Australia
J Cereb Blood Flow Metab 26:1005-17. 2006..D-Ser was highly stimulatory of net flux into the Krebs cycle. These data show that the metabolic response to iGluR perturbation in vitro is a sensitive discriminator of function...
- Understanding your inhibitions: effects of GABA and GABAA receptor modulation on brain cortical metabolismFatima A Nasrallah
Prince of Wales Medical Research Institute, and Brain Sciences UNSW, Randwick, New South Wales, Australia
J Neurochem 108:57-71. 2009..These results highlight the utility of a different but robust approach to study of the GABAergic system using metabolic systems analysis...
- Now I know my ABC. A systems neurochemistry and functional metabolomic approach to understanding the GABAergic systemCaroline Rae
Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia
J Neurochem 109:109-16. 2009....
- Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1'S,2'R)-2-(carboxycyclopropyl)glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopyCharbel El Hajj Moussa
Department of Anatomy and Histology, The University of Sydney, Australia
Neurochem Res 27:27-35. 2002..At 50 microM, intracellular L-CCG III could reach > 10 mM and metabolism might be affected directly...
- Brain metabolic markers reflect susceptibility status in cytokine gene knockout mice with murine cerebral malariaSapan B Parekh
Discipline of Pathology, Institute for Biomedical Research, The University of Sydney, Sydney, NSW 2006, Australia
Int J Parasitol 36:1409-18. 2006..Thus these metabolic changes are firmly linked both to the immune system response to malaria and to the occurrence of pathogenic changes in experimental CM...
- The effects of large neutral amino acid supplements in PKU: an MRS and neuropsychological studySuzanne Schindeler
Western Sydney Genetics Program, The Children s Hospital at Westmead, Sydney, Australia
Mol Genet Metab 91:48-54. 2007....
- For want of a nail. ramifications of a single gene deletion, dystrophin, in the brain of the mouseTrent Wallis
Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, NSW, 2006, Australia
Front Biosci 9:74-84. 2004..We relate these findings to known functional deficits and discuss the possible mechanisms behind the altered gene expression...
- Inhibitors of glutamate transport modulate distinct patterns in brain metabolismCharbel E H Moussa
Anatomy and Histology, Institute for Biomedical Research, School of Medical Science, Sydney, Australia
J Neurosci Res 85:342-50. 2007..This indicates that different inhibition mechanisms or different colocalisation of the separate transporter subtypes with glutamate receptors can produce significantly different metabolic and functional outcomes for the brain...
- Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apneaDelwyn J Bartlett
Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia
Sleep Med 5:593-6. 2004..As the hippocampus is particularly susceptible to hypoxia, we hypothesized that it may show biochemical abnormalities, and they may relate to apnea severity...
- Understanding your inhibitions: modulation of brain cortical metabolism by GABA(B) receptorsFatima A Nasrallah
Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia
J Cereb Blood Flow Metab 27:1510-20. 2007..This is consistent with GABAergic activity being context dependent, and this conclusion should be taken into account when evaluating functional imaging data involving modulation of neuronal inhibition...
- Rottlerin inhibits (Na+, K+)-ATPase activity in brain tissue and alters D-aspartate dependent redistribution of glutamate transporter GLAST in cultured astrocytesKhoa T D Nguyen
School of Medical Sciences and Bosch Institute for Biomedical Research, The University of Sydney, Sydney, NSW 2006, Australia
Neurochem Res 34:1767-74. 2009....
- Effects of glutamate transport substrates and glutamate receptor ligands on the activity of Na-/K(+)-ATPase in brain tissue in vitroEllas K Nanitsos
School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, New South Wales, Australia
Clin Exp Pharmacol Physiol 31:762-9. 2004....
- Cerebellar morphology in developmental dyslexiaCaroline Rae
Department of Biochemistry, The University of Sydney, NSW, Australia
Neuropsychologia 40:1285-92. 2002....
- Brain bioenergetics and cognitive abilityCaroline Rae
Russell Cairns Unit, Radcliffe Infirmary, The University of Oxford, Oxford, UK
Dev Neurosci 25:324-31. 2003..We assessed how these observations may be interpreted in the context of a metabolic vs. histological debate...
- Abnormalities in brain biochemistry associated with lack of dystrophin: studies of the mdx mouseCaroline Rae
Department of Biochemistry, The University of Sydney, Sydney, NSW 2006, Australia
Neuromuscul Disord 12:121-9. 2002..Using brain cortical slices we found no difference in the response of dystrophic tissue to hypoosmotic shock, but increased, substrate-dependent oxygen consumption rates at low oxygen partial pressures...
- Immunopathogenesis of cerebral malariaNicholas H Hunt
Molecular Immunopathology Unit, Institute for Biomedical Research, University of Sydney, Sydney, NSW, Australia
Int J Parasitol 36:569-82. 2006....
- Corpus callosum morphology and its relationship to cognitive function in neurofibromatosis type 1Natalie Pride
Department of Psychology, Macquarie University, Sydney, Australia
J Child Neurol 25:834-41. 2010....
- Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: a pattern-recognition 1H NMR studyVictoria G Dunne
Department of Neurosurgery, Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia
NMR Biomed 18:24-33. 2005..Thus, the approach allowed the prediction of outcome as well as confirming the presence of aSAH...
- Alanine metabolism, transport, and cycling in the brainStefan Broer
School of Biochemistry and Molecular Biology, Australian National University, Acton, Canberra ACT, Australia
J Neurochem 102:1758-70. 2007..Our results show that system L isoform LAT2 is critical for alanine uptake into astrocytes. However, alanine does not provide any significant carbon for energy or neurotransmitter metabolism under the conditions studied...
- Modulation of brain metabolism by very low concentrations of the commonly used drug delivery vehicle dimethyl sulfoxide (DMSO)Fatima A Nasrallah
Prince of Wales Medical Research Institute, Randwick, Australia
J Neurosci Res 86:208-14. 2008..Therefore, care should be taken when evaluating the actions of drugs administered in combination with DMSO...
- Memory training alters hippocampal neurochemistry in healthy elderlyMichael J Valenzuela
Neuropsychiatric Institute, The Prince of Wales Hospital, Euroa Centre, Randwick, NSW 2031, Australia
Neuroreport 14:1333-7. 2003..Biochemical changes related to cellular energy and cell-membrane turnover were found to increase after structured memory exercises and were limited to the medial temporal lobe...
- An investigation of neuronal integrity in severe paediatric traumatic brain injuryLouise Parry
Rehabilitation Department, The Children s Hosptial at Westmead, Australia
Child Neuropsychol 10:248-61. 2004..Findings indicate a role of proton MRS as a measure of neuronal integrity following severe paediatric TBI and suggest a potential association of MRS with specific neuropsychological impairments...