Caroline Rae

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi Group I and II metabotropic glutamate receptors alter brain cortical metabolic and glutamate/glutamine cycle activity: a 13C NMR spectroscopy and metabolomic study
    Caroline Rae
    School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales, Australia
    J Neurochem 92:405-16. 2005
  2. ncbi Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation
    Caroline Rae
    Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales, Australia
    J Neurochem 85:503-14. 2003
  3. ncbi Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria
    Caroline Rae
    Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, Sydney NSW 2006, Australia
    FASEB J 18:499-510. 2004
  4. pmc Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial
    Caroline Rae
    Discipline of Biochemistry, School of Molecular and Microbial Biosciences G08, The University of Sydney, Sydney, NSW 2006, Australia
    Proc Biol Sci 270:2147-50. 2003
  5. ncbi Enlarged temporal lobes in Turner syndrome: an X-chromosome effect?
    Caroline Rae
    Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, Sydney, NSW 2006, Australia
    Cereb Cortex 14:156-64. 2004
  6. ncbi A metabolomic approach to ionotropic glutamate receptor subtype function: a nuclear magnetic resonance in vitro investigation
    Caroline Rae
    School of Molecular and Microbial Biosciences, The University of Sydney, Sydney, New South Wales, Australia
    J Cereb Blood Flow Metab 26:1005-17. 2006
  7. doi Understanding your inhibitions: effects of GABA and GABAA receptor modulation on brain cortical metabolism
    Fatima A Nasrallah
    Prince of Wales Medical Research Institute, and Brain Sciences UNSW, Randwick, New South Wales, Australia
    J Neurochem 108:57-71. 2009
  8. doi Now I know my ABC. A systems neurochemistry and functional metabolomic approach to understanding the GABAergic system
    Caroline Rae
    Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia
    J Neurochem 109:109-16. 2009
  9. ncbi Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1'S,2'R)-2-(carboxycyclopropyl)glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy
    Charbel El Hajj Moussa
    Department of Anatomy and Histology, The University of Sydney, Australia
    Neurochem Res 27:27-35. 2002
  10. ncbi Brain metabolic markers reflect susceptibility status in cytokine gene knockout mice with murine cerebral malaria
    Sapan B Parekh
    Discipline of Pathology, Institute for Biomedical Research, The University of Sydney, Sydney, NSW 2006, Australia
    Int J Parasitol 36:1409-18. 2006

Collaborators

Detail Information

Publications27

  1. ncbi Group I and II metabotropic glutamate receptors alter brain cortical metabolic and glutamate/glutamine cycle activity: a 13C NMR spectroscopy and metabolomic study
    Caroline Rae
    School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales, Australia
    J Neurochem 92:405-16. 2005
    ..All ligand effects were separated from control and from each other using two principal components. The ramifications of these findings are discussed...
  2. ncbi Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation
    Caroline Rae
    Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales, Australia
    J Neurochem 85:503-14. 2003
    ..The resultant implications for metabolic compartmentation and regulation of metabolism by transport processes are discussed...
  3. ncbi Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria
    Caroline Rae
    Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, Sydney NSW 2006, Australia
    FASEB J 18:499-510. 2004
    ..This was accompanied by mild up-regulation of expression of metabolic enzymes. These changes are consistent with benign hypermetabolism whose cause remains a subject of speculation...
  4. pmc Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial
    Caroline Rae
    Discipline of Biochemistry, School of Molecular and Microbial Biosciences G08, The University of Sydney, Sydney, NSW 2006, Australia
    Proc Biol Sci 270:2147-50. 2003
    ..These findings underline a dynamic and significant role of brain energy capacity in influencing brain performance...
  5. ncbi Enlarged temporal lobes in Turner syndrome: an X-chromosome effect?
    Caroline Rae
    Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, Sydney, NSW 2006, Australia
    Cereb Cortex 14:156-64. 2004
    ..These temporal lobe abnormalities are discussed with reference to genes which are absent in Turner syndrome and to hormonal differences between Turner syndrome subjects and 46,XX controls...
  6. ncbi A metabolomic approach to ionotropic glutamate receptor subtype function: a nuclear magnetic resonance in vitro investigation
    Caroline Rae
    School of Molecular and Microbial Biosciences, The University of Sydney, Sydney, New South Wales, Australia
    J Cereb Blood Flow Metab 26:1005-17. 2006
    ..D-Ser was highly stimulatory of net flux into the Krebs cycle. These data show that the metabolic response to iGluR perturbation in vitro is a sensitive discriminator of function...
  7. doi Understanding your inhibitions: effects of GABA and GABAA receptor modulation on brain cortical metabolism
    Fatima A Nasrallah
    Prince of Wales Medical Research Institute, and Brain Sciences UNSW, Randwick, New South Wales, Australia
    J Neurochem 108:57-71. 2009
    ..These results highlight the utility of a different but robust approach to study of the GABAergic system using metabolic systems analysis...
  8. doi Now I know my ABC. A systems neurochemistry and functional metabolomic approach to understanding the GABAergic system
    Caroline Rae
    Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia
    J Neurochem 109:109-16. 2009
    ....
  9. ncbi Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1'S,2'R)-2-(carboxycyclopropyl)glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy
    Charbel El Hajj Moussa
    Department of Anatomy and Histology, The University of Sydney, Australia
    Neurochem Res 27:27-35. 2002
    ..At 50 microM, intracellular L-CCG III could reach > 10 mM and metabolism might be affected directly...
  10. ncbi Brain metabolic markers reflect susceptibility status in cytokine gene knockout mice with murine cerebral malaria
    Sapan B Parekh
    Discipline of Pathology, Institute for Biomedical Research, The University of Sydney, Sydney, NSW 2006, Australia
    Int J Parasitol 36:1409-18. 2006
    ..Thus these metabolic changes are firmly linked both to the immune system response to malaria and to the occurrence of pathogenic changes in experimental CM...
  11. ncbi The effects of large neutral amino acid supplements in PKU: an MRS and neuropsychological study
    Suzanne Schindeler
    Western Sydney Genetics Program, The Children s Hospital at Westmead, Sydney, Australia
    Mol Genet Metab 91:48-54. 2007
    ....
  12. ncbi For want of a nail. ramifications of a single gene deletion, dystrophin, in the brain of the mouse
    Trent Wallis
    Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, NSW, 2006, Australia
    Front Biosci 9:74-84. 2004
    ..We relate these findings to known functional deficits and discuss the possible mechanisms behind the altered gene expression...
  13. ncbi Inhibitors of glutamate transport modulate distinct patterns in brain metabolism
    Charbel E H Moussa
    Anatomy and Histology, Institute for Biomedical Research, School of Medical Science, Sydney, Australia
    J Neurosci Res 85:342-50. 2007
    ..This indicates that different inhibition mechanisms or different colocalisation of the separate transporter subtypes with glutamate receptors can produce significantly different metabolic and functional outcomes for the brain...
  14. ncbi Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea
    Delwyn J Bartlett
    Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia
    Sleep Med 5:593-6. 2004
    ..As the hippocampus is particularly susceptible to hypoxia, we hypothesized that it may show biochemical abnormalities, and they may relate to apnea severity...
  15. ncbi Understanding your inhibitions: modulation of brain cortical metabolism by GABA(B) receptors
    Fatima A Nasrallah
    Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia
    J Cereb Blood Flow Metab 27:1510-20. 2007
    ..This is consistent with GABAergic activity being context dependent, and this conclusion should be taken into account when evaluating functional imaging data involving modulation of neuronal inhibition...
  16. doi Rottlerin inhibits (Na+, K+)-ATPase activity in brain tissue and alters D-aspartate dependent redistribution of glutamate transporter GLAST in cultured astrocytes
    Khoa T D Nguyen
    School of Medical Sciences and Bosch Institute for Biomedical Research, The University of Sydney, Sydney, NSW 2006, Australia
    Neurochem Res 34:1767-74. 2009
    ....
  17. ncbi Effects of glutamate transport substrates and glutamate receptor ligands on the activity of Na-/K(+)-ATPase in brain tissue in vitro
    Ellas K Nanitsos
    School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 31:762-9. 2004
    ....
  18. ncbi Cerebellar morphology in developmental dyslexia
    Caroline Rae
    Department of Biochemistry, The University of Sydney, NSW, Australia
    Neuropsychologia 40:1285-92. 2002
    ....
  19. ncbi Brain bioenergetics and cognitive ability
    Caroline Rae
    Russell Cairns Unit, Radcliffe Infirmary, The University of Oxford, Oxford, UK
    Dev Neurosci 25:324-31. 2003
    ..We assessed how these observations may be interpreted in the context of a metabolic vs. histological debate...
  20. ncbi Abnormalities in brain biochemistry associated with lack of dystrophin: studies of the mdx mouse
    Caroline Rae
    Department of Biochemistry, The University of Sydney, Sydney, NSW 2006, Australia
    Neuromuscul Disord 12:121-9. 2002
    ..Using brain cortical slices we found no difference in the response of dystrophic tissue to hypoosmotic shock, but increased, substrate-dependent oxygen consumption rates at low oxygen partial pressures...
  21. ncbi Immunopathogenesis of cerebral malaria
    Nicholas H Hunt
    Molecular Immunopathology Unit, Institute for Biomedical Research, University of Sydney, Sydney, NSW, Australia
    Int J Parasitol 36:569-82. 2006
    ....
  22. doi Corpus callosum morphology and its relationship to cognitive function in neurofibromatosis type 1
    Natalie Pride
    Department of Psychology, Macquarie University, Sydney, Australia
    J Child Neurol 25:834-41. 2010
    ....
  23. ncbi Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: a pattern-recognition 1H NMR study
    Victoria G Dunne
    Department of Neurosurgery, Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia
    NMR Biomed 18:24-33. 2005
    ..Thus, the approach allowed the prediction of outcome as well as confirming the presence of aSAH...
  24. ncbi Alanine metabolism, transport, and cycling in the brain
    Stefan Broer
    School of Biochemistry and Molecular Biology, Australian National University, Acton, Canberra ACT, Australia
    J Neurochem 102:1758-70. 2007
    ..Our results show that system L isoform LAT2 is critical for alanine uptake into astrocytes. However, alanine does not provide any significant carbon for energy or neurotransmitter metabolism under the conditions studied...
  25. ncbi Modulation of brain metabolism by very low concentrations of the commonly used drug delivery vehicle dimethyl sulfoxide (DMSO)
    Fatima A Nasrallah
    Prince of Wales Medical Research Institute, Randwick, Australia
    J Neurosci Res 86:208-14. 2008
    ..Therefore, care should be taken when evaluating the actions of drugs administered in combination with DMSO...
  26. ncbi Memory training alters hippocampal neurochemistry in healthy elderly
    Michael J Valenzuela
    Neuropsychiatric Institute, The Prince of Wales Hospital, Euroa Centre, Randwick, NSW 2031, Australia
    Neuroreport 14:1333-7. 2003
    ..Biochemical changes related to cellular energy and cell-membrane turnover were found to increase after structured memory exercises and were limited to the medial temporal lobe...
  27. ncbi An investigation of neuronal integrity in severe paediatric traumatic brain injury
    Louise Parry
    Rehabilitation Department, The Children s Hosptial at Westmead, Australia
    Child Neuropsychol 10:248-61. 2004
    ..Findings indicate a role of proton MRS as a measure of neuronal integrity following severe paediatric TBI and suggest a potential association of MRS with specific neuropsychological impairments...