Herman W Raadsma

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint Host responses during experimental infection with Fasciola gigantica or Fasciola hepatica in Merino sheep I. Comparative immunological and plasma biochemical changes during early infection
    H W Raadsma
    Reprogen, Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, University of Sydney, Camden, NSW 2570, Australia
    Vet Parasitol 143:275-86. 2007
  2. pmc Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight
    Herman W Raadsma
    ReproGen Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden, NSW 2570, Australia
    Genet Sel Evol 41:34. 2009
  3. ncbi request reprint Predicting genetic merit for mastitis and fertility in dairy cattle using genome wide selection and high density SNP screens
    H W Raadsma
    Co operative Research Centre for Innovative Dairy Products CRC IDP ReproGen, Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, The University of Sydney, Camden, Australia
    Dev Biol (Basel) 132:219-23. 2008
  4. doi request reprint Host responses during experimental infection with Fasciola gigantica and Fasciola hepatica in Merino sheep II. Development of a predictive index for Fasciola gigantica worm burden
    H W Raadsma
    Reprogen Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science University of Sydney, Camden, NSW 2570, Australia
    Vet Parasitol 154:250-61. 2008
  5. pmc Mapping quantitative trait loci (QTL) in sheep. II. Meta-assembly and identification of novel QTL for milk production traits in sheep
    Herman W Raadsma
    ReproGen Animal Bioscience Group, Faculty of Veterinary Science, University of Sydney, Camden NSW 2570, Australia
    Genet Sel Evol 41:45. 2009
  6. pmc Mapping Quantitative Trait Loci (QTL) in sheep. III. QTL for carcass composition traits derived from CT scans and aligned with a meta-assembly for sheep and cattle carcass QTL
    Colin R Cavanagh
    ReproGen Animal Bioscience Group, Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden NSW 2570, Australia
    Genet Sel Evol 42:36. 2010
  7. pmc Assignment of chromosomal locations for unassigned SNPs/scaffolds based on pair-wise linkage disequilibrium estimates
    Mehar S Khatkar
    Reprogen Animal Bioscience, Faculty of Veterinary Science, University of Sydney, Camden NSW 2570, Australia
    BMC Bioinformatics 11:171. 2010
  8. ncbi request reprint A missense mutation (c.184C>T) in ovine CLN6 causes neuronal ceroid lipofuscinosis in Merino sheep whereas affected South Hampshire sheep have reduced levels of CLN6 mRNA
    Imke Tammen
    Centre for Advanced Technologies in Animal Genetics and Reproduction REPROGEN, Faculty of Veterinary Science, The University of Sydney, PMB3, Camden, NSW, Australia
    Biochim Biophys Acta 1762:898-905. 2006
  9. pmc Linkage disequilibrium on chromosome 6 in Australian Holstein-Friesian cattle
    Mehar S Khatkar
    Centre for Advanced Technologies in Animal Genetics and Reproduction, Reprogen, and Co operative Research Centre for Innovative Dairy Products, Faculty of Veterinary Science, University of Sydney PMB 3, Camden NSW 2570, Australia
    Genet Sel Evol 38:463-77. 2006
  10. pmc Mapping quantitative trait loci (QTL) in sheep. IV. Analysis of lactation persistency and extended lactation traits in sheep
    Elisabeth Jonas
    ReproGen Animal Bioscience Group, Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden, NSW 2570, Australia
    Genet Sel Evol 43:22. 2011

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Host responses during experimental infection with Fasciola gigantica or Fasciola hepatica in Merino sheep I. Comparative immunological and plasma biochemical changes during early infection
    H W Raadsma
    Reprogen, Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, University of Sydney, Camden, NSW 2570, Australia
    Vet Parasitol 143:275-86. 2007
    ..hepatica appears to be more pathogenic than F. gigantica because of its rapid increase in size and the speed of its progression through the migratory phases of its life cycle...
  2. pmc Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight
    Herman W Raadsma
    ReproGen Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden, NSW 2570, Australia
    Genet Sel Evol 41:34. 2009
    ..Fifty-four putative QTL were identified on nine chromosomes. Significant QTL with sex-specific effects (i.e. QTL x sex interaction) in the range of 0.4 to 0.7 SD were found on ovine chromosomes 1, 3, 6, 11, 21, 23, 24 and 26...
  3. ncbi request reprint Predicting genetic merit for mastitis and fertility in dairy cattle using genome wide selection and high density SNP screens
    H W Raadsma
    Co operative Research Centre for Innovative Dairy Products CRC IDP ReproGen, Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, The University of Sydney, Camden, Australia
    Dev Biol (Basel) 132:219-23. 2008
    ..PLS was computationally more efficient than GAR...
  4. doi request reprint Host responses during experimental infection with Fasciola gigantica and Fasciola hepatica in Merino sheep II. Development of a predictive index for Fasciola gigantica worm burden
    H W Raadsma
    Reprogen Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science University of Sydney, Camden, NSW 2570, Australia
    Vet Parasitol 154:250-61. 2008
    ..The utility of a predictive index under both field and experimental inoculation conditions is discussed...
  5. pmc Mapping quantitative trait loci (QTL) in sheep. II. Meta-assembly and identification of novel QTL for milk production traits in sheep
    Herman W Raadsma
    ReproGen Animal Bioscience Group, Faculty of Veterinary Science, University of Sydney, Camden NSW 2570, Australia
    Genet Sel Evol 41:45. 2009
    ....
  6. pmc Mapping Quantitative Trait Loci (QTL) in sheep. III. QTL for carcass composition traits derived from CT scans and aligned with a meta-assembly for sheep and cattle carcass QTL
    Colin R Cavanagh
    ReproGen Animal Bioscience Group, Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden NSW 2570, Australia
    Genet Sel Evol 42:36. 2010
    ..The assembly demonstrated QTL with effects on carcass composition in homologous regions on OAR1, 2, 6 and 21...
  7. pmc Assignment of chromosomal locations for unassigned SNPs/scaffolds based on pair-wise linkage disequilibrium estimates
    Mehar S Khatkar
    Reprogen Animal Bioscience, Faculty of Veterinary Science, University of Sydney, Camden NSW 2570, Australia
    BMC Bioinformatics 11:171. 2010
    ..It also provides an alternative means for verification of genetic maps. We exemplified LODE in cattle...
  8. ncbi request reprint A missense mutation (c.184C>T) in ovine CLN6 causes neuronal ceroid lipofuscinosis in Merino sheep whereas affected South Hampshire sheep have reduced levels of CLN6 mRNA
    Imke Tammen
    Centre for Advanced Technologies in Animal Genetics and Reproduction REPROGEN, Faculty of Veterinary Science, The University of Sydney, PMB3, Camden, NSW, Australia
    Biochim Biophys Acta 1762:898-905. 2006
    ..184C>T mutation but show reduced expression of CLN6 mRNA in a range of tissues as determined by real-time PCR. Lack of linkage precludes CLN6 as a candidate for NCL in Borderdale sheep...
  9. pmc Linkage disequilibrium on chromosome 6 in Australian Holstein-Friesian cattle
    Mehar S Khatkar
    Centre for Advanced Technologies in Animal Genetics and Reproduction, Reprogen, and Co operative Research Centre for Innovative Dairy Products, Faculty of Veterinary Science, University of Sydney PMB 3, Camden NSW 2570, Australia
    Genet Sel Evol 38:463-77. 2006
    ..Overall, the results indicate a high level of LD on chromosome 6 in Australian dairy cattle...
  10. pmc Mapping quantitative trait loci (QTL) in sheep. IV. Analysis of lactation persistency and extended lactation traits in sheep
    Elisabeth Jonas
    ReproGen Animal Bioscience Group, Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden, NSW 2570, Australia
    Genet Sel Evol 43:22. 2011
    ..An extended lactation is defined by a longer period of milkability. This study is the first investigation to examine the presence of quantitative trait loci (QTL) for extended lactation and lactation persistency in sheep...
  11. pmc A primary assembly of a bovine haplotype block map based on a 15,036-single-nucleotide polymorphism panel genotyped in holstein-friesian cattle
    Mehar S Khatkar
    Centre for Advanced Technologies in Animal Genetics and Reproduction REPROGEN, University of Sydney, Camden NSW 2570, Australia
    Genetics 176:763-72. 2007
    ..Overall, the results suggest that as many as 75,000-100,000 tag SNPs would be needed to track all important haplotype blocks in the bovine genome. This would require approximately 250,000 SNPs in the discovery phase...
  12. ncbi request reprint Bulldog dwarfism in Dexter cattle is caused by mutations in ACAN
    Julie A L Cavanagh
    Reprogen, The University of Sydney, PMB3, Camden, New South Wales 2570, Australia
    Mamm Genome 18:808-14. 2007
    ..The heterozygous and homozygous-affected Dexter cattle could prove invaluable as a model for human disorders caused by mutations in ACAN...
  13. pmc Extent of genome-wide linkage disequilibrium in Australian Holstein-Friesian cattle based on a high-density SNP panel
    Mehar S Khatkar
    Centre for Advanced Technologies in Animal Genetics and Reproduction REPROGEN, University of Sydney, Camden, NSW 2570, Australia
    BMC Genomics 9:187. 2008
    ..Finally, relatively little information is available on comparative LD structures including other mammalian species such as human and mouse, and we compare LD structure in cattle with public-domain data from both human and mouse...
  14. pmc Strategies and utility of imputed SNP genotypes for genomic analysis in dairy cattle
    Mehar S Khatkar
    Reprogen Animal Bioscience, Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden, NSW 2570, Australia
    BMC Genomics 13:538. 2012
    ..For the accuracy of genomic selection, a comparison of direct genetic values (DGV) was made by dividing the data into training and validation sets under a range of imputation scenarios...
  15. pmc A first-generation metric linkage disequilibrium map of bovine chromosome 6
    Mehar S Khatkar
    Centre for Advanced Technologies in Animal Genetics and Reproduction REPROGEN, University of Sydney and CRC for Innovative Dairy Products, Camden NSW 2570, Australia
    Genetics 174:79-85. 2006
    ..The mean swept radius (the distance over which LD is likely to be useful for mapping) is 13.3 Mb, confirming extensive LD in Holstein-Friesian dairy cattle, which makes such populations ideal for whole-genome association studies...
  16. pmc Heritability and phenotypic variation of canine hip dysplasia radiographic traits in a cohort of Australian German shepherd dogs
    Bethany J Wilson
    Faculty of Veterinary Science, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 7:e39620. 2012
    ....
  17. doi request reprint Comparative transcriptome analyses reveal conserved and distinct mechanisms in ovine and bovine lactation
    Mini Singh
    Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden NSW 2570, Australia
    Funct Integr Genomics 13:115-31. 2013
    ..The conserved processes across the two species suggest the use of the ovine as a suitable model for lactation studies, considering the challenges and expense of conducting lactation physiology and genomics studies within the cow...
  18. pmc Quantitative trait loci mapping in dairy cattle: review and meta-analysis
    Mehar S Khatkar
    Centre for Advanced Technologies in Animal Genetics and Reproduction (ReproGen, and Co-operative Research Centre for Innovative Dairy Products, Faculty of Veterinary Science, University of Sydney, PMB 3, Camden NSW 2570, Australia
    Genet Sel Evol 36:163-90. 2004
    ..6 percent of the genetic variance of milk yield, respectively. The first of these regions (near marker BM143) affects five separate milk production traits (protein yield, protein percent, fat yield, fat percent, as well as milk yield)...
  19. doi request reprint A functional genomics approach to evaluate candidate genes located in a QTL interval for milk production traits on BTA6
    P A Sheehy
    REPROGEN and Cooperative Research Centre for Innovative Dairy Products, Faculty of Veterinary Science, University of Sydney, Camden, NSW 2570, Australia
    Anim Genet 40:492-8. 2009
    ..While these findings do not exclude other positional candidates from influencing lactation, they support the hypothesis that the gene product of SPP1 is a significant lactational regulatory molecule...
  20. ncbi request reprint Physical and linkage mapping of the bovine zinc transporter 4 (ZNT4) gene to chromosome 10
    I Tammen
    Centre for Advanced Technologies in Animal Genetics and Reproduction, Department of Veterinary Clinical Sciences, University of Sydney, Camden, Australia
    Anim Genet 30:474-5. 1999
  21. ncbi request reprint Neuronal ceroid lipofuscinosis in Australian Merino sheep: a new animal model
    I Tammen
    Centre for Advanced Technologies in Animal Genetics and Reproduction REPROGEN, University of Sydney, 425 Werombi Road, Camden NSW 2570, Australia
    Eur J Paediatr Neurol 5:37-41. 2001
    ..NCL in Merino and South Hampshire sheep are therefore potential animal models for the human late infantile variant CLN6...
  22. ncbi request reprint Genome-wide genetic diversity of Holstein Friesian cattle reveals new insights into Australian and global population variability, including impact of selection
    K R Zenger
    Co operative Research Centre for Innovative Dairy Products, Centre for Advanced Technologies in Animal Genetics and Reproduction REPROGEN, University of Sydney, Camden, NSW, Australia
    Anim Genet 38:7-14. 2007
    ..These results indicate that inbreeding, genetic drift and selection has had little effect at reducing genetic diversity and differentiating the Australian Holstein Friesian population at a genome-wide level...
  23. ncbi request reprint Characterization of the bovine aggrecan gene: genomic structure and physical and linkage mapping
    J A L Cavanagh
    Centre for Advanced Technologies in Animal Genetics and Reproduction REPROGEN, Faculty of Veterinary Science, The University of Sydney, Camden NSW 2570, Australia
    Anim Genet 36:452-4. 2005
  24. ncbi request reprint Neuronal ceroid lipofuscinosis in Devon cattle is caused by a single base duplication (c.662dupG) in the bovine CLN5 gene
    Peter J Houweling
    Centre for Advanced Technologies in Animal Genetics and Reproduction REPROGEN, Faculty of Veterinary Science, The University of Sydney, PMB3, Camden NSW, Australia
    Biochim Biophys Acta 1762:890-7. 2006
    ..As cattle are anatomically and physiologically similar to humans with a human-like central nervous system and easy to maintain and breed, they provide a valuable alternative model for CLN5 studies...
  25. pmc NetView: a high-definition network-visualization approach to detect fine-scale population structures from genome-wide patterns of variation
    Markus Neuditschko
    Reprogen Animal Bioscience, Faculty of Veterinary Science, University of Sydney, Camden, New South Wales, Australia
    PLoS ONE 7:e48375. 2012
    ..NetView can be used on any data from which a genetic relationship/distance between individuals can be calculated...
  26. pmc Multi-species comparative analysis of the equine ACE gene identifies a highly conserved potential transcription factor binding site in intron 16
    Natasha A Hamilton
    ReproGen Animal Bioscience Group, Faculty of Veterinary Science, University of Sydney, Camperdown, New South Wales, Australia
    PLoS ONE 8:e55434. 2013
    ..This advance will allow further analysis leading to a better understanding of the mechanisms underpinning the associations seen between the human Alu polymorphism and enzyme levels, cardiovascular disease states and elite athleticism...
  27. doi request reprint The influence of extracellular matrix and prolactin on global gene expression profiles of primary bovine mammary epithelial cells in vitro
    L G Riley
    Reprogen, University of Sydney, NSW, Australia
    Anim Genet 41:55-63. 2010
    ..This mammosphere model is a useful model system for functional genomics studies of certain aspects of dairy cattle lactation...
  28. ncbi request reprint Technical note: Whole-genome amplification of DNA extracted from cattle semen samples
    R J Hawken
    CSIRO Livestock Industries, Queensland Biosciences Precinct, St Lucia, 4067, Queensland, Australia
    J Dairy Sci 89:2217-21. 2006
    ..These results illustrate that WGA is a suitable method for the amplification and recovery of DNA from bull semen samples for routine genomic investigations...
  29. ncbi request reprint Effect of myostatin F94L on carcass yield in cattle
    G S Sellick
    Livestock Systems Alliance, University of Adelaide, Adelaide, South Australia 5351, Australia
    Anim Genet 38:440-6. 2007
    ..433A allele were partially recessive. This study provides strong evidence that a MSTN genotype can produce an intermediate, non-double muscling phenotype, which should be of significant value for beef cattle producers...
  30. ncbi request reprint Identification of two allelic forms of ovine CD4 exhibiting a Ser183/Pro183 polymorphism in the coding sequence of domain 3
    R Boscariol
    Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue, Que H9X3V9, Canada
    Vet Immunol Immunopathol 113:305-12. 2006
    ..This polymorphism changes the first codon position of amino acid 183 and results in a Pro/Ser substitution in the N-terminal region of domain 3 of the CD4 protein...