J M Quinn
Affiliation: University of Melbourne
- A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitroJ M Quinn
The University of Melbourne, Department of Medicine and St Vincent s Institute of Medical Research, Fitzroy, Australia
Endocrinology 139:4424-7. 1998..We propose that this methodology can be employed to investigate the direct effects of cytokines and other factors on human osteoclast differentiation...
- The generation of highly enriched osteoclast-lineage cell populationsJ M W Quinn
St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
Bone 30:164-70. 2002..These can be employed to generate osteoclast populations of high purity and in large numbers when stimulated by TGFbeta, which greatly augments the osteoclastogenic effects of RANKL...
- A novel osteoblast-derived C-type lectin that inhibits osteoclast formationH Zhou
Department of Medicine, University of Melbourne, St Vincent s Hospital, and St Vincent s Institute of Medical Research, Fitzroy, Victoria 3065, Australia
J Biol Chem 276:14916-23. 2001..The overlapping tissue distribution of OCIL mRNA and protein with that of RANKL strongly suggests an interaction between these molecules in the skeleton and in extraskeletal tissues...
- Transforming growth factor beta affects osteoclast differentiation via direct and indirect actionsJ M Quinn
Department of Medicine, St. Vincent's Institute of Medical Research and The University of Melbourne, Fitzroy, Victoria, Australia
J Bone Miner Res 16:1787-94. 2001..Such actions may be critical to the control of physiological and pathophysiological osteolysis...
- Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissuesV Kartsogiannis
Department of Medicine, The University of Melbourne and St Vincent s Institute of Medical Research, St Vincent s Hospital, Fitzroy, Victoria, Australia
Bone 25:525-34. 1999..RANKL was also developmentally regulated, as evidenced by its expression in the intestine, liver, and lung at E15 and newborn mouse but not in the adult...
- Myeloma cells can directly contribute to the pool of RANKL in bone bypassing the classic stromal and osteoblast pathway of osteoclast stimulationF P L Lai
Alfred Pathology Service, Alfred Hospital, Melbourne, Victoria, Australia
Br J Haematol 126:192-201. 2004..Finally, we provide evidence that the differentiation observed is at least in part the result of myeloma cell expression of RANKL. We therefore conclude that myeloma cells can directly contribute to the pool of RANKL in bone...