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Species | Susan PrescottSummaryAffiliation: University of Western Australia Country: Australia Publications
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Publications
Presymptomatic differences in Toll-like receptor function in infants who have allergySusan L Prescott
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 122:391-9, 399.e1-5. 2008..Microbial exposure might play a key role in allergy development, but little is known about the role of Toll-like receptors (TLRs)...
Immune dysregulation in allergic respiratory disease: the role of T regulatory cellsSusan L Prescott
Department of Paediatrics, University of Western Australia, Perth, Western Australia, P O Box D184, Princess Margaret Hospital, Perth, WA 6001, Australia
Pulm Pharmacol Ther 18:217-28. 2005..Understanding these influences and their mechanism of action could lead to strategies to prevent disease...- Maternal allergen exposure as a risk factor for childhood asthmaSusan L Prescott
UWA School of Pediatrics and Child Health, Princess Margaret Hospital, Perth, WA, Australia
Curr Allergy Asthma Rep 6:75-80. 2006..This underscores the importance of further defining the events in this early period, to determine causal pathways and better strategies for prevention... - Clinical effects of probiotics are associated with increased interferon-gamma responses in very young children with atopic dermatitisS L Prescott
School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia
Clin Exp Allergy 35:1557-64. 2005..The purpose of this study was to determine the underlying immunological effects that are associated with these apparent clinical benefits... - The Australasian Society of Clinical Immunology and Allergy position statement: Summary of allergy prevention in childrenSusan L Prescott
School of Paediatrics and Child Health Research, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth, WA 6001
Med J Aust 182:464-7. 2005..Immunotherapy may be considered as a treatment option for children with allergic rhinitis, and may prevent the subsequent development of asthma... - Supplementation with vitamins C, E, beta-carotene and selenium has no effect on anti-oxidant status and immune responses in allergic adults: a randomized controlled trialJ A Dunstan
School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia
Clin Exp Allergy 37:180-7. 2007..The aim of this study in adults was to determine the effects of dietary anti-oxidants on allergen-specific immune responses in sensitized individuals... 
Effects of probiotics on atopic dermatitis: a randomised controlled trialS Weston
School of Paediatrics and Child Health Research, University of Western Australia, Perth, Australia
Arch Dis Child 90:892-7. 2005..The aim of the study was to investigate the effects of probiotics on moderate or severe atopic dermatitis (AD) in young children...- Maternal reactivity to fetal alloantigens is related to newborn immune responses and subsequent allergic diseaseS L Prescott
School of Paediatrics and Child Health Research, University of Western Australia, Perth, WA, Australia
Clin Exp Allergy 35:417-25. 2005..Women prone to allergic immune responses to allergens may also have altered immune responses to other antigens including fetal antigens... - Cytosine-phosphate-guanine motifs fail to promote T-helper type 1-polarized responses in human neonatal mononuclear cellsS L Prescott
School of Paediatrics and Child Health Research, University of Western Australia, Perth, WA 6001, Australia
Clin Exp Allergy 35:358-66. 2005..However, little is known about their effects on immature immune responses in this period... - Prenatal fatty acid status and immune development: the pathways and the evidenceSusan L Prescott
School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, GPO Box D184, Perth, 6840, WA, Australia
Lipids 42:801-10. 2007.... - Developmental immunology and vaccines: cellular immune development and future vaccine strategiesSusan Prescott
School of Pediatrics and Child Health, University of Western Australia, Perth, Western Australia
Expert Rev Vaccines 3:339-42. 2004..It describes how the development of future vaccine strategies relies on a detailed understanding of immune ontogeny and the potential consequences of intervention on developing cellular immune responses... - The development of respiratory inflammation in childrenSusan L Prescott
School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital, Perth
Paediatr Respir Rev 7:89-96. 2006..These observations highlight the need to identify affected or at-risk children early and to develop interventions that can abort or prevent ongoing airway inflammation and remodelling... - Early origins of allergic disease: a review of processes and influences during early immune developmentSusan L Prescott
Department of Paediatrics, University of Western Australia, Perth, Western Australia, Australia
Curr Opin Allergy Clin Immunol 3:125-32. 2003..This review examines new developments in the area of foetal and early postnatal immune maturation. It secondly addresses early predisposing influences and protective factors that may have a future role in allergy prevention... - Neonatal interleukin-12 capacity is associated with variations in allergen-specific immune responses in the neonatal and postnatal periodsS L Prescott
Department of Paediatrics, Division of Clinical Sciences and Division of Cell Biology, School of Paediatrics and Child Health Research, University of Western Australia, and Princess Margaret Hospital, Perth, Australia
Clin Exp Allergy 33:566-72. 2003.... - Allergy: the price we pay for cleaner living?Susan L Prescott
Department of Paediatrics, University of Western Australia, Perth, Western Australia, Australia
Ann Allergy Asthma Immunol 90:64-70. 2003..This article reviews the current evidence for this relationship in the context of improved public health and living conditions... - An update of immunotherapy for specific allergiesSusan L Prescott
Department of Paediatrics, University of Western Australia, Princess Margaret Hospital, PO Box D184, Perth, Western Australia 6001
Curr Drug Targets Inflamm Allergy 1:65-75. 2002..Ideally these methods will eventually be replaced by strategies targeting the prevention of allergic responses (immunoprophylaxis)... - New concepts of cytokines in asthma: is the Th2/Th1 paradigm out the window?S L Prescott
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia
J Paediatr Child Health 39:575-9. 2003..It also highlights emerging concepts that the excessive and inappropriate immune responses seen in allergic disease may be related to dysfunction of various interleukin-10 producing regulatory cell populations... - N-3 polyunsaturated fatty acids and allergic diseaseSusan L Prescott
School of Paediatrics and Child Health, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth, WA 6001, Australia
Curr Opin Clin Nutr Metab Care 7:123-9. 2004..This review examines the evidence for a potential role of changing dietary intake of omega-3 polyunsaturated fatty acids in the development, treatment and prevention of allergic diseases... - Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trialJanet A Dunstan
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 112:1178-84. 2003..More detailed follow-up studies are required in larger cohorts to establish the robustness of these findings and to ascertain their significance in relation to longer-term modification of allergic disease in children... - The relationship between persistent organic pollutants in maternal and neonatal tissues and immune responses to allergens: A novel exploratory studyPaul S Noakes
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia 6001, Australia
Chemosphere 63:1304-11. 2006..However, the relationship between Th1 immune function and OC contamination is consistent with other reports and is worth investigating as a relevant factor in populations where OC contamination is greater... - Maternal mood scores in mid-pregnancy are related to aspects of neonatal immune functionEugen Mattes
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Subiaco, P O Box 855, West Perth, WA 6872, Australia
Brain Behav Immun 23:380-8. 2009..Although there are recognised associations between psychological and immune function, the effects of maternal depressive symptoms on fetal immune development have not been investigated... - Association of maternal smoking with increased infant oxidative stress at 3 months of agePaul S Noakes
School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, Perth, WA 6840, Australia
Thorax 62:714-7. 2007..The aim of this study was to examine the effects of maternal smoking on markers of infant oxidative stress... - Modulation of in vivo and in vitro cytokine production over the course of pregnancy in allergic and non-allergic mothersLiza Anne Breckler
School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia
Pediatr Allergy Immunol 21:14-21. 2010..This may be a factor that contributes to the increased risk of atopy in infants born to allergic mothers... - A novel role for interleukin-1 receptor signaling in the developmental regulation of immune responses to endotoxinDavid Martino
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia
Pediatr Allergy Immunol 23:567-72. 2012..The data suggest that IL-1R1 expression in the neonatal period provides an additional level of Myd88-dependent signaling during this period of heighted susceptibility to infection... - Strategies to prevent or reduce allergic diseaseSusan Prescott
School of Paediatrics and Child Health Research, University of Western Australia, Perth, WA 6840, Australia
Ann Nutr Metab 59:28-42. 2011..Despite the current uncertainties, prevention remains the best long-term strategy to reduce the growing burden of allergic disease... - n -- 3 fatty acid supplementation during pregnancy in women with allergic disease: effects on blood pressure, and maternal and fetal lipidsAnne E Barden
School of Medicine and Pharmacology, Royal Perth Hospital Unit, GPO Box X2213, Perth, WA 6847, Australia
Clin Sci (Lond) 111:289-94. 2006..The effects of fish oil on lipids and blood pressure in non-pregnant individuals appear to be lost when it is administered during pregnancy... - Effects of early cigarette smoke exposure on early immune development and respiratory diseaseSusan L Prescott
School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, GPO Box D184, Perth, Western Australia 6840, Australia
Paediatr Respir Rev 9:3-9; quiz 10. 2008.... - Antimicrobial and anti-inflammatory activity of five Taxandria fragrans oils in vitroKatherine A Hammer
Discipline of Microbiology and Immunology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, WA, Australia
Microbiol Immunol 52:522-30. 2008..In conclusion, T. fragrans oil showed both antimicrobial and anti-inflammatory activity in vitro, however, the clinical relevance of this remains to be determined... - HLA-DR expression on neonatal monocytes is associated with allergen-specific immune responsesJohn W Upham
Division of Cell Biology, Telethon Institute for Child Health Research, PO Box 855, West Perth, WA 6872, Australia
J Allergy Clin Immunol 114:1202-8. 2004..The specific mechanisms regulating priming of T-cell immunity to common allergens during early childhood remain to be elucidated, though increasing evidence indicates that antigen-presenting cell function is impaired in childhood... - Algorithmic models to predict allergic disease using multiple neonatal markersMegan Hodder
School of Pediatrics and Child Health Research, University of Western Australia Perth Western Australia P O Box D184, Princess Margaret Hospital, Perth WA 6001, Australia
Indian Pediatr 46:291-2. 2009.... - Fish oil supplementation in pregnancy lowers F2-isoprostanes in neonates at high risk of atopyAnne E Barden
School of Medicine and Pharmacology, Royal Perth Hospital Unit, PO Box X2213, Perth, WA, 6847, Australia
Free Radic Res 38:233-9. 2004..Clinical follow-up of these infants will help to determine if there are sustained effects on postnatal oxidative stress and expression of allergic disease... - Neonatal innate cytokine responses to BCG controlling T-cell development vary between populationsAnita H J van den Biggelaar
Telethon Institute for Child Health Research, Center for Child Health Research, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 124:544-50, 550.e1-2. 2009..The protective effect of Mycobacterium bovis BCG vaccination against infection and atopy varies between populations... - Asthma and pregnancy: emerging evidence of epigenetic interactions in uteroSusan L Prescott
University of Western Australia, Perth, Western Australia
Curr Opin Allergy Clin Immunol 9:417-26. 2009.... - Role of dietary immunomodulatory factors in the development of immune toleranceSusan L Prescott
School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital, Perth, WA, Australia
Nestle Nutr Workshop Ser Pediatr Program 64:185-94; discussion 194-200, 251-7. 2009..This review explores the potential effects of early dietary and nutritional factors in tolerogenic immune processes that are normally initiated during initial food allergen encounter... - Allergic disease: understanding how in utero events set the sceneSusan L Prescott
School of Paediatrics and Child Health Research, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth, WA 6001, Australia
Proc Nutr Soc 69:366-72. 2010..All these observations underscore the need for ongoing research to understand the pathogenesis and rising incidence of disease in the hope of better strategies to reverse this... - The importance of early complementary feeding in the development of oral tolerance: concerns and controversiesSusan L Prescott
School of Paediatrics and Child Health Research, University of Western Australia, Perth, WA, Australia
Pediatr Allergy Immunol 19:375-80. 2008..It will also examine the growing case for introducing complementary foods from around 4 months of age and maintaining breastfeeding during this early feeding period, for at least 6 months if possible... - Silent mysteries: epigenetic paradigms could hold the key to conquering the epidemic of allergy and immune diseaseD J Martino
School of Pediatrics and Child Health Research, University of Western Australia, Perth, Western Australia, Australia
Allergy 65:7-15. 2010..Identifying genes that are differentially silenced or activated in relation to subsequent disease will not only assist in identifying causal pathways, but may also help identify the contributing environmental factors... - Development of interleukin-12-producing capacity throughout childhoodJohn W Upham
Telethon Institute for Child Health Research and Centre for Child Health Research, Perth, Australia
Infect Immun 70:6583-8. 2002.... - Probiotics for the prevention or treatment of allergic diseasesSusan L Prescott
School of Paediatrics and Child Health Research, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth WA 6001, Australia
J Allergy Clin Immunol 120:255-62. 2007..As more studies are completed, these factors are likely to make robust meta-analyses problematic to perform... - Protein kinase Czeta: a novel protective neonatal T-cell marker that can be upregulated by allergy prevention strategiesSusan L Prescott
School of Pediatrics and Child Health, University of Western Australia, Perth, WA, Australia
J Allergy Clin Immunol 120:200-6. 2007..Variations in neonatal T-cell function have been associated with allergic disease... - Maternal fish oil supplementation in pregnancy modifies neonatal leukotriene production by cord-blood-derived neutrophilsSusan L Prescott
School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital, Perth, WA 6001, Australia
Clin Sci (Lond) 113:409-16. 2007..It also provides evidence of another pathway through which long-chain PUFAs status can influence early immune development... - Perinatal HIV transmission and pregnancy outcomes in indigenous women in Western AustraliaMarisa T Gilles
Combined Universities Centre for Rural Health, Geraldton, WA, Australia
Aust N Z J Obstet Gynaecol 47:362-7. 2007..Implementation of obstetric and neonatal interventions has reduced mother to child transmission of HIV. Health outcomes for Aboriginal people are often worse than for non-Aboriginal people; was this the case for HIV infection in pregnancy?.. - Does fish oil supplementation in pregnancy reduce the risk of allergic disease in infants?Janet A Dunstan
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia
Curr Opin Allergy Clin Immunol 5:215-21. 2005..This review will examine recent evidence for the use of fish oil during this early period as a primary prevention strategy for allergic disease... - Epigenetics and prenatal influences on asthma and allergic airways diseaseDavid Martino
University of Western Australia, School of Paediatrics and Child Health Research, Princess Margaret Hospital for Children, GPO Box D 184, Perth, WA, 6840, Australia
Chest 139:640-7. 2011.... - Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trialAngie L Taylor
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 119:184-91. 2007..Despite preliminary evidence, the role of probiotics in allergy prevention is unclear... - The effects of maternal smoking on early mucosal immunity and sensitization at 12 months of agePaul Noakes
School of Paediatrics and Child Health Research, University of Western Australia, Perth, Australia
Pediatr Allergy Immunol 18:118-27. 2007..The increased mucosal inflammation in these children was not associated with effects on early allergy propensity... - Thymic indoleamine 2,3-dioxygenase-positive eosinophils in young children: potential role in maturation of the naive immune systemMeri K Tulic
Centre for Child Health Research, University of Western Australia, Perth, Australia
Am J Pathol 175:2043-52. 2009..57, P = 0.02) and toll-like receptor 4 expression (r = -0.74, P = 0.002). Taken together, these results suggest that functional thymic IDO+ eosinophils during human infant life may have an immunomodulatory role in Th2 immune responses... - FOXP3 mRNA expression at 6 months of age is higher in infants who develop atopic dermatitis, but is not affected by giving probiotics from birthAngie L Taylor
School of Paediatrics and Child Health Research, University of Western Australia, Perth, WA, Australia
Pediatr Allergy Immunol 18:10-9. 2007..Probiotic supplementation and gut colonization did not appear to substantially modify these regulatory pathways, or the risk of developing atopic dermatitis... - Avoidance or exposure to foods in prevention and treatment of food allergy?Susan L Prescott
School of Paediatrics and Child Health Research, University of Western Australia, Perth, Western Australia, Australia
Curr Opin Allergy Clin Immunol 10:258-66. 2010..To caution against premature proposals advocating change before epidemiological and clinical evidence warrants such a paradigm shift... - Skin prick testing predicts peanut challenge outcome in previously allergic or sensitized children with low serum peanut-specific IgE antibody concentrationRichard C Nolan
Department of Immunology, Princess Margaret Hospital for Children, Perth, WA, Australia
Pediatr Allergy Immunol 18:224-30. 2007..In this cohort, not challenging children with a SPT wheal of >or=7 mm would have avoided 15 of 18 positive challenges and denied a challenge to one out of 27 tolerant children... - Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell functionMiranda Smith
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 121:1460-6, 1466.e1-7. 2008..The role of regulatory T (Treg) cells in allergic predisposition is not known... - Postnatal development of monocyte cytokine responses to bacterial lipopolysaccharideStephanie T Yerkovich
Faculty of Medicine and Dentistry, Telethon Institute for Child Health Research, The University of Western Australia, Perth WA 6872, Western Australia
Pediatr Res 62:547-52. 2007.... - Fish oil supplementation in pregnancy modifies neonatal progenitors at birth in infants at risk of atopyJudah A Denburg
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Pediatr Res 57:276-81. 2005..Dietary n-3 PUFA supplementation during pregnancy in atopic mothers alters infant cord blood hemopoietic progenitor phenotype. This may have an impact on development of atopic disease... - The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: a randomized controlled trialJanet A Dunstan
School of Paediatrics and Child Health, The University of Western Australia, Crawley WA 6009
Pediatr Res 62:689-94. 2007..Thus, supplementation in pregnancy was associated with increased n-3 long-chain polyunsaturated fatty acids (LCPUFAs) in breast milk, particularly in early lactation, and this was positively associated with infant DHA status at 1 y... - Guidelines for the use of infant formulas to treat cows milk protein allergy: an Australian consensus panel opinionAndrew S Kemp
Department of Allergy and Immunology, Children s Hospital at Westmead, Sydney, NSW, Australia
Med J Aust 188:109-12. 2008..Amino acid formula is recommended as first choice in anaphylaxis and eosinophilic oesophagitis. If treatment with the initial formula is not successful, use of an alternative formula is recommended...