Susan L Prescott

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. doi Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases
    Susan L Prescott
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 131:23-30. 2013
  2. doi Cord blood 25-hydroxyvitamin d3 and allergic disease during infancy
    Anderson P Jones
    MBBS, School of Pediatrics and Child Health Research, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth WA 6001, Australia
    Pediatrics 130:e1128-35. 2012
  3. doi Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial
    N D'Vaz
    School of Paediatrics and Child Health Research SPACH, Princess Margaret Hospital, University of Western Australia, PO Box D184, Perth, Western Australia, 6001 Australia
    Pediatrics 130:674-82. 2012
  4. pmc Associations between maternal antioxidant intakes in pregnancy and infant allergic outcomes
    Christina E West
    School of Paediatrics and Child Health Research, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth WA 6001, Australia
    Nutrients 4:1747-58. 2012
  5. doi Allergic disease in the first year of life is associated with differences in subsequent neurodevelopment and behaviour
    Suzanne J Meldrum
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    Early Hum Dev 88:567-73. 2012
  6. doi Presymptomatic differences in Toll-like receptor function in infants who have allergy
    Susan L Prescott
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 122:391-9, 399.e1-5. 2008
  7. ncbi n -- 3 fatty acid supplementation during pregnancy in women with allergic disease: effects on blood pressure, and maternal and fetal lipids
    Anne E Barden
    School of Medicine and Pharmacology, Royal Perth Hospital Unit, GPO Box X2213, Perth, WA 6847, Australia
    Clin Sci (Lond) 111:289-94. 2006
  8. doi Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions
    Joanne G Lisciandro
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 130:1167-1174.e10. 2012
  9. doi Maternal mood scores in mid-pregnancy are related to aspects of neonatal immune function
    Eugen Mattes
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Subiaco, P O Box 855, West Perth, WA 6872, Australia
    Brain Behav Immun 23:380-8. 2009
  10. doi Modulation of in vivo and in vitro cytokine production over the course of pregnancy in allergic and non-allergic mothers
    Liza Anne Breckler
    School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia
    Pediatr Allergy Immunol 21:14-21. 2010

Collaborators

Detail Information

Publications52

  1. doi Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases
    Susan L Prescott
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 131:23-30. 2013
    ..In this context allergic disease provides a very important early target to assess the effectiveness of environmental strategies to reduce immune dysregulation...
  2. doi Cord blood 25-hydroxyvitamin d3 and allergic disease during infancy
    Anderson P Jones
    MBBS, School of Pediatrics and Child Health Research, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth WA 6001, Australia
    Pediatrics 130:e1128-35. 2012
    ..The aim of this study was to investigate the association between vitamin D exposure in utero and allergic outcomes in the first year of life...
  3. doi Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial
    N D'Vaz
    School of Paediatrics and Child Health Research SPACH, Princess Margaret Hospital, University of Western Australia, PO Box D184, Perth, Western Australia, 6001 Australia
    Pediatrics 130:674-82. 2012
    ..The objective of this study was to assess the effect of fish oil n-3 PUFA supplementation from birth to 6 months of age on infant allergic disease...
  4. pmc Associations between maternal antioxidant intakes in pregnancy and infant allergic outcomes
    Christina E West
    School of Paediatrics and Child Health Research, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth WA 6001, Australia
    Nutrients 4:1747-58. 2012
    ..In summary, this study suggests that maternal diet of fresh foods rich in vitamin C is associated with reduced risk of infant wheeze, and that copper intake is associated with reduced risk of several allergic outcomes...
  5. doi Allergic disease in the first year of life is associated with differences in subsequent neurodevelopment and behaviour
    Suzanne J Meldrum
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    Early Hum Dev 88:567-73. 2012
    ..Recent trials suggest a link between neuropsychological function, atopy and allergic disease particularly in early childhood; however the nature of this association remains unclear...
  6. doi Presymptomatic differences in Toll-like receptor function in infants who have allergy
    Susan L Prescott
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 122:391-9, 399.e1-5. 2008
    ..Microbial exposure might play a key role in allergy development, but little is known about the role of Toll-like receptors (TLRs)...
  7. ncbi n -- 3 fatty acid supplementation during pregnancy in women with allergic disease: effects on blood pressure, and maternal and fetal lipids
    Anne E Barden
    School of Medicine and Pharmacology, Royal Perth Hospital Unit, GPO Box X2213, Perth, WA 6847, Australia
    Clin Sci (Lond) 111:289-94. 2006
    ..The effects of fish oil on lipids and blood pressure in non-pregnant individuals appear to be lost when it is administered during pregnancy...
  8. doi Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions
    Joanne G Lisciandro
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 130:1167-1174.e10. 2012
    ..There is increasing evidence that the process of immune deviation already begins in utero, but the underlying immunologic mechanisms are not clear...
  9. doi Maternal mood scores in mid-pregnancy are related to aspects of neonatal immune function
    Eugen Mattes
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Subiaco, P O Box 855, West Perth, WA 6872, Australia
    Brain Behav Immun 23:380-8. 2009
    ..Although there are recognised associations between psychological and immune function, the effects of maternal depressive symptoms on fetal immune development have not been investigated...
  10. doi Modulation of in vivo and in vitro cytokine production over the course of pregnancy in allergic and non-allergic mothers
    Liza Anne Breckler
    School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia
    Pediatr Allergy Immunol 21:14-21. 2010
    ..This may be a factor that contributes to the increased risk of atopy in infants born to allergic mothers...
  11. pmc Ontogeny of Toll-like and NOD-like receptor-mediated innate immune responses in Papua New Guinean infants
    Joanne G Lisciandro
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    PLoS ONE 7:e36793. 2012
    ....
  12. ncbi Maternal fish oil supplementation in pregnancy modifies neonatal leukotriene production by cord-blood-derived neutrophils
    Susan L Prescott
    School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital, Perth, WA 6001, Australia
    Clin Sci (Lond) 113:409-16. 2007
    ..It also provides evidence of another pathway through which long-chain PUFAs status can influence early immune development...
  13. pmc Association of maternal smoking with increased infant oxidative stress at 3 months of age
    Paul S Noakes
    School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, Perth, WA 6840, Australia
    Thorax 62:714-7. 2007
    ..The aim of this study was to examine the effects of maternal smoking on markers of infant oxidative stress...
  14. doi Effects of high-dose fish oil supplementation during early infancy on neurodevelopment and language: a randomised controlled trial
    Suzanne J Meldrum
    School of Paediatrics and Child Health, University of Western Australia, M561, 35 Stirling Highway, Crawley, 6009 WA, Australia
    Br J Nutr 108:1443-54. 2012
    ..However, some indication of benefits to early communicative development was observed...
  15. doi Changes in thymic regulatory T-cell maturation from birth to puberty: differences in atopic children
    Meri K Tulic
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 129:199-206.e1-4. 2012
    ..Characterization of regulatory immune pathways is a research priority for both the pathogenesis of allergic disease and potential therapeutic strategies...
  16. doi Differences in innate immune function between allergic and nonallergic children: new insights into immune ontogeny
    Meri K Tulic
    Childhood Allergy and Immunology Research, School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 127:470-478.e1. 2011
    ..Microbial products are of central interest in the modulation of allergic propensity...
  17. ncbi FOXP3 mRNA expression at 6 months of age is higher in infants who develop atopic dermatitis, but is not affected by giving probiotics from birth
    Angie L Taylor
    School of Paediatrics and Child Health Research, University of Western Australia, Perth, WA, Australia
    Pediatr Allergy Immunol 18:10-9. 2007
    ..Probiotic supplementation and gut colonization did not appear to substantially modify these regulatory pathways, or the risk of developing atopic dermatitis...
  18. doi Evidence for age-related and individual-specific changes in DNA methylation profile of mononuclear cells during early immune development in humans
    David J Martino
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    Epigenetics 6:1085-94. 2011
    ..Further studies are now needed to examine evolving epigenetic variations in specific cell populations in relation to environmental exposures, immune phenotype and subsequent disease susceptibility...
  19. ncbi Protein kinase Czeta: a novel protective neonatal T-cell marker that can be upregulated by allergy prevention strategies
    Susan L Prescott
    School of Pediatrics and Child Health, University of Western Australia, Perth, WA, Australia
    J Allergy Clin Immunol 120:200-6. 2007
    ..Variations in neonatal T-cell function have been associated with allergic disease...
  20. doi Role of dietary immunomodulatory factors in the development of immune tolerance
    Susan L Prescott
    School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital, Perth, WA, Australia
    Nestle Nutr Workshop Ser Pediatr Program 64:185-94; discussion 194-200, 251-7. 2009
    ..This review explores the potential effects of early dietary and nutritional factors in tolerogenic immune processes that are normally initiated during initial food allergen encounter...
  21. doi Does early feeding promote development of oral tolerance?
    Debra J Palmer
    School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital, Perth, Australia
    Curr Allergy Asthma Rep 12:321-31. 2012
    ..Until the results of these studies are available it is difficult to provide definitive recommendations regarding the role of early feeding in the induction of oral tolerance and prevention of food allergy...
  22. doi Effects of early cigarette smoke exposure on early immune development and respiratory disease
    Susan L Prescott
    School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, GPO Box D184, Perth, Western Australia 6840, Australia
    Paediatr Respir Rev 9:3-9; quiz 10. 2008
    ....
  23. ncbi Prenatal fatty acid status and immune development: the pathways and the evidence
    Susan L Prescott
    School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, GPO Box D184, Perth, 6840, WA, Australia
    Lipids 42:801-10. 2007
    ....
  24. doi Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns
    Joanne G Lisciandro
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    Pediatr Allergy Immunol 23:173-80. 2012
    ..This potentially occurs by altering early development of immuno-regulatory pathways including T regulatory cells (T(reg)). There is now increasing evidence that such conditioning begins in utero...
  25. pmc Genetic variations in IL28B and allergic disease in children
    Silvana Gaudieri
    School of Anatomy and Human Biology, University of Western Australia, Nedlands, Australia
    PLoS ONE 7:e30607. 2012
    ..In the context of rising rates of disease, these immunologic differences already present at birth imply very early interaction between genetic predisposition and prenatal environmental influences...
  26. doi Early regular egg exposure in infants with eczema: A randomized controlled trial
    Debra J Palmer
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia Women s and Children s Health Research Institute, Adelaide, Australia Electronic address
    J Allergy Clin Immunol 132:387-392.e1. 2013
    ..Observational studies suggest that early regular ingestion of allergenic foods might reduce the risk of food allergy...
  27. ncbi The development of respiratory inflammation in children
    Susan L Prescott
    School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital, Perth
    Paediatr Respir Rev 7:89-96. 2006
    ..These observations highlight the need to identify affected or at-risk children early and to develop interventions that can abort or prevent ongoing airway inflammation and remodelling...
  28. doi The importance of early complementary feeding in the development of oral tolerance: concerns and controversies
    Susan L Prescott
    School of Paediatrics and Child Health Research, University of Western Australia, Perth, WA, Australia
    Pediatr Allergy Immunol 19:375-80. 2008
    ..It will also examine the growing case for introducing complementary foods from around 4 months of age and maintaining breastfeeding during this early feeding period, for at least 6 months if possible...
  29. pmc Progress in understanding postnatal immune dysregulation in allergic disease
    Susan L Prescott
    School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia
    World Allergy Organ J 3:162-6. 2010
    ..To further understand the pathogenesis of these altered patterns of immune response, future research needs to encompass the complexity of gene-environmental interactions, which confer individual susceptibility to environmental exposures...
  30. ncbi Does fish oil supplementation in pregnancy reduce the risk of allergic disease in infants?
    Janet A Dunstan
    School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia
    Curr Opin Allergy Clin Immunol 5:215-21. 2005
    ..This review will examine recent evidence for the use of fish oil during this early period as a primary prevention strategy for allergic disease...
  31. ncbi The relationship between persistent organic pollutants in maternal and neonatal tissues and immune responses to allergens: A novel exploratory study
    Paul S Noakes
    School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia 6001, Australia
    Chemosphere 63:1304-11. 2006
    ....
  32. ncbi The effects of maternal smoking on early mucosal immunity and sensitization at 12 months of age
    Paul Noakes
    School of Paediatrics and Child Health Research, University of Western Australia, Perth, Australia
    Pediatr Allergy Immunol 18:118-27. 2007
    ..The increased mucosal inflammation in these children was not associated with effects on early allergy propensity...
  33. doi Asthma and pregnancy: emerging evidence of epigenetic interactions in utero
    Susan L Prescott
    University of Western Australia, Perth, Western Australia
    Curr Opin Allergy Clin Immunol 9:417-26. 2009
    ....
  34. pmc Thymic indoleamine 2,3-dioxygenase-positive eosinophils in young children: potential role in maturation of the naive immune system
    Meri K Tulic
    Centre for Child Health Research, University of Western Australia, Perth, Australia
    Am J Pathol 175:2043-52. 2009
    ..57, P = 0.02) and toll-like receptor 4 expression (r = -0.74, P = 0.002). Taken together, these results suggest that functional thymic IDO+ eosinophils during human infant life may have an immunomodulatory role in Th2 immune responses...
  35. doi Silent mysteries: epigenetic paradigms could hold the key to conquering the epidemic of allergy and immune disease
    D J Martino
    School of Pediatrics and Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Allergy 65:7-15. 2010
    ..Identifying genes that are differentially silenced or activated in relation to subsequent disease will not only assist in identifying causal pathways, but may also help identify the contributing environmental factors...
  36. doi Allergic disease: understanding how in utero events set the scene
    Susan L Prescott
    School of Paediatrics and Child Health Research, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth, WA 6001, Australia
    Proc Nutr Soc 69:366-72. 2010
    ..All these observations underscore the need for ongoing research to understand the pathogenesis and rising incidence of disease in the hope of better strategies to reverse this...
  37. doi Neonatal innate cytokine responses to BCG controlling T-cell development vary between populations
    Anita H J van den Biggelaar
    Telethon Institute for Child Health Research, Center for Child Health Research, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 124:544-50, 550.e1-2. 2009
    ..The protective effect of Mycobacterium bovis BCG vaccination against infection and atopy varies between populations...
  38. doi Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function
    Miranda Smith
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 121:1460-6, 1466.e1-7. 2008
    ..The role of regulatory T (Treg) cells in allergic predisposition is not known...
  39. doi Role of diet in the development of immune tolerance in the context of allergic disease
    Christina E West
    School of Paediatrics and Child Health Research, University of Western Australia, and Princess Margareth Hospital, Perth, Western Australia, Australia
    Curr Opin Pediatr 22:635-41. 2010
    ..Diet is arguably one of the most significant environmental exposures during early development. Here, we explore the effects of key perinatal dietary exposures on immune development and susceptibility to allergic disease...
  40. ncbi Skin prick testing predicts peanut challenge outcome in previously allergic or sensitized children with low serum peanut-specific IgE antibody concentration
    Richard C Nolan
    Department of Immunology, Princess Margaret Hospital for Children, Perth, WA, Australia
    Pediatr Allergy Immunol 18:224-30. 2007
    ..In this cohort, not challenging children with a SPT wheal of >or=7 mm would have avoided 15 of 18 positive challenges and denied a challenge to one out of 27 tolerant children...
  41. ncbi Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial
    Angie L Taylor
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 119:184-91. 2007
    ..Despite preliminary evidence, the role of probiotics in allergy prevention is unclear...
  42. pmc Vitamin D and allergic disease: sunlight at the end of the tunnel?
    Anderson P Jones
    School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia 6008, Australia
    Nutrients 4:13-28. 2012
    ..This review explores the findings of epidemiological, clinical and laboratory research, and the potential role of vitamin D in promoting the inappropriate immune responses which underpin the rise in a broad range of immune diseases...
  43. ncbi Maternal allergen exposure as a risk factor for childhood asthma
    Susan L Prescott
    UWA School of Pediatrics and Child Health, Princess Margaret Hospital, Perth, WA, Australia
    Curr Allergy Asthma Rep 6:75-80. 2006
    ..This underscores the importance of further defining the events in this early period, to determine causal pathways and better strategies for prevention...
  44. doi Randomized controlled trials investigating the role of allergen exposure in food allergy: where are we now?
    Jessica Metcalfe
    School of Paediatrics and Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Curr Opin Allergy Clin Immunol 13:296-305. 2013
    ..Here, we review the recent randomized controlled trials (RCTs) examining the controlled allergen exposure in both treatment and prevention of food allergy...
  45. ncbi Probiotics for the prevention or treatment of allergic diseases
    Susan L Prescott
    School of Paediatrics and Child Health Research, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth WA 6001, Australia
    J Allergy Clin Immunol 120:255-62. 2007
    ..As more studies are completed, these factors are likely to make robust meta-analyses problematic to perform...
  46. ncbi The Australasian Society of Clinical Immunology and Allergy position statement: Summary of allergy prevention in children
    Susan L Prescott
    School of Paediatrics and Child Health Research, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth, WA 6001
    Med J Aust 182:464-7. 2005
    ..Immunotherapy may be considered as a treatment option for children with allergic rhinitis, and may prevent the subsequent development of asthma...
  47. doi Avoidance or exposure to foods in prevention and treatment of food allergy?
    Susan L Prescott
    School of Paediatrics and Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Curr Opin Allergy Clin Immunol 10:258-66. 2010
    ..To caution against premature proposals advocating change before epidemiological and clinical evidence warrants such a paradigm shift...
  48. ncbi Immune dysregulation in allergic respiratory disease: the role of T regulatory cells
    Susan L Prescott
    Department of Paediatrics, University of Western Australia, Perth, Western Australia, P O Box D184, Princess Margaret Hospital, Perth, WA 6001, Australia
    Pulm Pharmacol Ther 18:217-28. 2005
    ..Understanding these influences and their mechanism of action could lead to strategies to prevent disease...
  49. ncbi Fish oil supplementation in pregnancy lowers F2-isoprostanes in neonates at high risk of atopy
    Anne E Barden
    School of Medicine and Pharmacology, Royal Perth Hospital Unit, PO Box X2213, Perth, WA, 6847, Australia
    Free Radic Res 38:233-9. 2004
    ..Clinical follow-up of these infants will help to determine if there are sustained effects on postnatal oxidative stress and expression of allergic disease...
  50. pmc Maternal smoking in pregnancy: do the effects on innate (toll-like receptor) function have implications for subsequent allergic disease?
    Susan L Prescott
    School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, Perth, Western Australia
    Allergy Asthma Clin Immunol 3:10-8. 2007
    ..Although "cleaner" environments have been implicated, here we explore the possibility that other common environmental exposures (such as maternal smoking) could also play a role...
  51. doi Achieving definitive results in long-chain polyunsaturated fatty acid supplementation trials of term infants: factors for consideration
    Suzanne J Meldrum
    School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia
    Nutr Rev 69:205-14. 2011
    ..The current literature indicates a docosahexaenoic acid dose of 0.32%, supplementation from birth to 12 months, and a total sample size of at least 286 (143 per group) should be included in the methodology of future trials...
  52. ncbi Algorithmic models to predict allergic disease using multiple neonatal markers
    Megan Hodder
    School of Pediatrics and Child Health Research, University of Western Australia Perth Western Australia P O Box D184, Princess Margaret Hospital, Perth WA 6001, Australia
    Indian Pediatr 46:291-2. 2009
    ....