Genomes and Genes
A S Prakash
Affiliation: University of Queensland
- Pyrrolizidine alkaloids in human dietA S Prakash
National Research Centre for Environmental Toxicology, 39, Kessels Road, Coopers Plains, QLD 4108, Australia
Mutat Res 443:53-67. 1999..Based on the extensive reports on the outcome of human exposure available in the literature, we conclude that while humans face the risk of veno-occlusive disease and childhood cirrhosis PAs are not carcinogenic to humans...
- Kinetics of DNA alkylation, depurination and hydrolysis of anti diol epoxide of benzo(a)pyrene and the effect of cadmium on DNA alkylationA S Prakash
National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Australia
Chem Biol Interact 125:133-50. 2000..Based on these and our earlier findings, we propose a mechanism for the synergistic effect of cadmium in chemically induced carcinogenesis...
- Mechanism of bracken fern carcinogenesis: evidence for H-ras activation via initial adenine alkylation by ptaquilosideA S Prakash
National Research Centre for Environmental Toxicology NRCET, Coopers Plains, Australia
Nat Toxins 4:221-7. 1996..These results suggest that initial alkylation of adenine by PT in codon 61 followed by depurination and error in DNA synthesis lead to activation of H-ras proto-oncogene...
- Stability and DNA alkylation rates of the simplest functional analogues of CC-1065, para-hydroxy and para-amino phenethyl bromidesR L Shalders
National Research Centre for Environmental Toxicology, Coopers Plains, QLD, Australia
Chem Biol Interact 117:83-94. 1999..A possible mechanism of action of these drugs is presented based on these findings...