A S Prakash

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi Pyrrolizidine alkaloids in human diet
    A S Prakash
    National Research Centre for Environmental Toxicology, 39, Kessels Road, Coopers Plains, QLD 4108, Australia
    Mutat Res 443:53-67. 1999
  2. ncbi Kinetics of DNA alkylation, depurination and hydrolysis of anti diol epoxide of benzo(a)pyrene and the effect of cadmium on DNA alkylation
    A S Prakash
    National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Australia
    Chem Biol Interact 125:133-50. 2000
  3. ncbi Mechanism of bracken fern carcinogenesis: evidence for H-ras activation via initial adenine alkylation by ptaquiloside
    A S Prakash
    National Research Centre for Environmental Toxicology NRCET, Coopers Plains, Australia
    Nat Toxins 4:221-7. 1996
  4. ncbi Stability and DNA alkylation rates of the simplest functional analogues of CC-1065, para-hydroxy and para-amino phenethyl bromides
    R L Shalders
    National Research Centre for Environmental Toxicology, Coopers Plains, QLD, Australia
    Chem Biol Interact 117:83-94. 1999

Collaborators

Detail Information

Publications4

  1. ncbi Pyrrolizidine alkaloids in human diet
    A S Prakash
    National Research Centre for Environmental Toxicology, 39, Kessels Road, Coopers Plains, QLD 4108, Australia
    Mutat Res 443:53-67. 1999
    ..Based on the extensive reports on the outcome of human exposure available in the literature, we conclude that while humans face the risk of veno-occlusive disease and childhood cirrhosis PAs are not carcinogenic to humans...
  2. ncbi Kinetics of DNA alkylation, depurination and hydrolysis of anti diol epoxide of benzo(a)pyrene and the effect of cadmium on DNA alkylation
    A S Prakash
    National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Australia
    Chem Biol Interact 125:133-50. 2000
    ..Based on these and our earlier findings, we propose a mechanism for the synergistic effect of cadmium in chemically induced carcinogenesis...
  3. ncbi Mechanism of bracken fern carcinogenesis: evidence for H-ras activation via initial adenine alkylation by ptaquiloside
    A S Prakash
    National Research Centre for Environmental Toxicology NRCET, Coopers Plains, Australia
    Nat Toxins 4:221-7. 1996
    ..These results suggest that initial alkylation of adenine by PT in codon 61 followed by depurination and error in DNA synthesis lead to activation of H-ras proto-oncogene...
  4. ncbi Stability and DNA alkylation rates of the simplest functional analogues of CC-1065, para-hydroxy and para-amino phenethyl bromides
    R L Shalders
    National Research Centre for Environmental Toxicology, Coopers Plains, QLD, Australia
    Chem Biol Interact 117:83-94. 1999
    ..A possible mechanism of action of these drugs is presented based on these findings...