D V Pow

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi request reprint Localization of taurine transporters, taurine, and (3)H taurine accumulation in the rat retina, pituitary, and brain
    David V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    Glia 37:153-68. 2002
  2. ncbi request reprint Loss of glial glutamate transporters and induction of neuronal expression of GLT-1B in the hypoxic neonatal pig brain
    David V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane 4072, Australia
    Brain Res Dev Brain Res 153:1-11. 2004
  3. ncbi request reprint Nuclear kinesis, neurite sprouting and abnormal axonal projections of cone photoreceptors in the aged and AMD-afflicted human retina
    David V Pow
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Exp Eye Res 84:850-7. 2007
  4. ncbi request reprint Visualising the activity of the cystine-glutamate antiporter in glial cells using antibodies to aminoadipic acid, a selectively transported substrate
    D V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia
    Glia 34:27-38. 2001
  5. ncbi request reprint Developmental expression of excitatory amino acid transporter 5: a photoreceptor and bipolar cell glutamate transporter in rat retina
    D V Pow
    Department of Anatomical Sciences, University of Queensland, Brisbane, Australia
    Neurosci Lett 280:21-4. 2000
  6. ncbi request reprint Amino acids and their transporters in the retina
    D V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane 4072, Australia
    Neurochem Int 38:463-84. 2001
  7. ncbi request reprint Are neuronal transporters relevant in retinal glutamate homeostasis?
    D V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    Neurochem Int 37:191-8. 2000
  8. ncbi request reprint Antisense knockdown of GLAST, a glial glutamate transporter, compromises retinal function
    N L Barnett
    Vision, Touch, and Hearing Research Centre, The University of Queensland, Brisbane, Australia
    Invest Ophthalmol Vis Sci 41:585-91. 2000
  9. ncbi request reprint Expression of glycine and the glycine transporter glyt-1 in the developing rat retina
    D V Pow
    Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia
    Vis Neurosci 17:1-9. 2000
  10. ncbi request reprint Expression of the exon 9-skipping form of EAAT2 in astrocytes of rats
    L T Macnab
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Neuroscience 150:705-11. 2007

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Localization of taurine transporters, taurine, and (3)H taurine accumulation in the rat retina, pituitary, and brain
    David V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    Glia 37:153-68. 2002
    ..The heterogeneous distribution of taurine and its transporters in the brain does not reconcile well with the possibility that taurine acts solely as a ubiquitous osmolyte in nervous tissues...
  2. ncbi request reprint Loss of glial glutamate transporters and induction of neuronal expression of GLT-1B in the hypoxic neonatal pig brain
    David V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane 4072, Australia
    Brain Res Dev Brain Res 153:1-11. 2004
    ....
  3. ncbi request reprint Nuclear kinesis, neurite sprouting and abnormal axonal projections of cone photoreceptors in the aged and AMD-afflicted human retina
    David V Pow
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Exp Eye Res 84:850-7. 2007
    ....
  4. ncbi request reprint Visualising the activity of the cystine-glutamate antiporter in glial cells using antibodies to aminoadipic acid, a selectively transported substrate
    D V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia
    Glia 34:27-38. 2001
    ..Because cystine uptake is associated with glutamate release, it is suggested that this antiporter might contribute to release of glutamate from glial cells under some pathophysiological conditions...
  5. ncbi request reprint Developmental expression of excitatory amino acid transporter 5: a photoreceptor and bipolar cell glutamate transporter in rat retina
    D V Pow
    Department of Anatomical Sciences, University of Queensland, Brisbane, Australia
    Neurosci Lett 280:21-4. 2000
    ..The positions and morphology of these terminals suggests that they are the terminals of both rod and cone rod bipolar cells. We conclude that in rat retina, EAAT5 is a photoreceptor and bipolar cell glutamate transporter...
  6. ncbi request reprint Amino acids and their transporters in the retina
    D V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane 4072, Australia
    Neurochem Int 38:463-84. 2001
    ....
  7. ncbi request reprint Are neuronal transporters relevant in retinal glutamate homeostasis?
    D V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    Neurochem Int 37:191-8. 2000
    ....
  8. ncbi request reprint Antisense knockdown of GLAST, a glial glutamate transporter, compromises retinal function
    N L Barnett
    Vision, Touch, and Hearing Research Centre, The University of Queensland, Brisbane, Australia
    Invest Ophthalmol Vis Sci 41:585-91. 2000
    ..To elucidate the role of the glial glutamate transporter GLAST, in the regulation of retinal function...
  9. ncbi request reprint Expression of glycine and the glycine transporter glyt-1 in the developing rat retina
    D V Pow
    Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia
    Vis Neurosci 17:1-9. 2000
    ..This temporal pattern of labelling strongly indicates that bipolar cells label for glycine when gap junctions become functional between glycine/glyt-1 immunoreactive amacrine cells and cone bipolar cells...
  10. ncbi request reprint Expression of the exon 9-skipping form of EAAT2 in astrocytes of rats
    L T Macnab
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Neuroscience 150:705-11. 2007
    ..Conversely, the limited expression in gray matter suggests it is unlikely to be important for modulating synaptic levels of glutamate...
  11. ncbi request reprint Differential perturbation of neuronal and glial glutamate transport systems in retinal ischaemia
    N L Barnett
    Vision, Touch and Hearing Research Centre, School of Biomedical Sciences, The University of Queensland, 4072, Brisbane, Australia
    Neurochem Int 39:291-9. 2001
    ..Manipulation of GLAST function could alleviate the degeneration and blindness that result from ischaemic retinal disease...
  12. ncbi request reprint Expression of glycine and the glycine transporter Glyt-1 in the developing rat retina
    D V Pow
    Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia
    Vis Neurosci 17:1R-9R. 2000
    ..This temporal pattern of labelling strongly indicates that bipolar cells label for glycine when gap junctions become functional between glycine/glyt-1 immunoreactive amacrine cells and cone bipolar cells...
  13. ncbi request reprint Glyt-1 expression in cultured human Müller cells and intact retinae
    P Reye
    Department of Physiology and Pharmacology, University of Queensland, Brisbane, Queensland, Australia
    Glia 34:311-5. 2001
    ..These data suggest that Glyt-1 expression in cultured Müller cells is an epiphenomenon associated with culturing in vitro, rather than a normal physiological or even pathophysiological phenomenon in vivo...
  14. ncbi request reprint The dendritic architecture of the cholinergic plexus in the rabbit retina: selective labeling by glycine accumulation in the presence of sarcosine
    D I Vaney
    Vision, Touch and Hearing Research Centre, Department of Physiology and Pharmacology, The University of Queensland, Brisbane, Queensland, Australia
    J Comp Neurol 421:1-13. 2000
    ..It is not known how the dendritic co-fasciculation develops, but the cholinergic dendritic plexus may provide the initial scaffold, because the dendrites of the On-Off DS cells commonly run along the outside of the cholinergic fascicles...
  15. ncbi request reprint Inhibition of Müller cell glutamine synthetase rapidly impairs the retinal response to light
    N L Barnett
    Vision, Touch and Hearing Research Centre, The University of Queensland, Brisbane, Australia
    Glia 30:64-73. 2000
    ....
  16. ncbi request reprint GLAST1b, the exon-9 skipping form of the glutamate-aspartate transporter EAAT1 is a sensitive marker of neuronal dysfunction in the hypoxic brain
    S M Sullivan
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Neuroscience 149:434-45. 2007
    ..We propose that GLAST1b represents a novel and sensitive marker for the detection of neurons at risk of dying in response to hypoxic and other excitotoxic insults and may have wider applicability in experimental and clinical contexts...
  17. pmc Excitatory amino acid transporter 5 is widely expressed in peripheral tissues
    A Lee
    UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia, Queensland, Australia
    Eur J Histochem 57:e11. 2013
    ..We conclude that EAAT5 is a widely distributed protein. Whether it functions in all locations as a glutamate transporter, or mainly as a glutamate-gated chloride conductance, remains to be determined...
  18. ncbi request reprint Expression of pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1R) in the ewe hypothalamus: distribution and colocalization with tyrosine hydroxylase-immunoreactive neurones
    S T Anderson
    School of Biomedical Sciences, The University of Queensland, Queensland, Australia
    J Neuroendocrinol 17:298-305. 2005
    ..These observations, together with previous in vivo studies, suggest that PACAP could act directly on TIDA neurones via PAC1R to increase dopamine release and consequently inhibit prolactin secretion in the sheep...
  19. ncbi request reprint Glial glutamate transporter expression patterns in brains from multiple mammalian species
    Susan M Williams
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    Glia 49:520-41. 2005
    ..Collectively our data suggest that assumptions as to the roles of glutamate transporters in any species may need to be tested empirically...
  20. ncbi request reprint Hypoxic preconditioning in neonatal rat brain involves regulation of excitatory amino acid transporter 2 and estrogen receptor alpha
    Helena Cimarosti
    Howard Florey Institute, University of Melbourne, Victoria 3010, Australia Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurosci Lett 385:52-7. 2005
    ..The endogenous molecular mechanisms modulated by hypoxia preconditioning may contribute to the development of hypoxia-induced ischemic tolerance, and may provide novel therapeutic targets for the treatment of cerebral ischemia...
  21. ncbi request reprint Immunocytochemical analysis of D-serine distribution in the mammalian brain reveals novel anatomical compartmentalizations in glia and neurons
    Susan M Williams
    Department of Anatomy, School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Glia 53:401-11. 2006
    ....
  22. ncbi request reprint Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: Evidence for delayed up-regulation and redistribution of GLT-1
    Ross D O'Shea
    Brain Injury and Repair Program, Howard Florey Institute, VIC 3010, Australia
    Neurochem Int 48:604-10. 2006
    ..These findings suggest an association of cytoskeletal changes in glia with EAAT activity, with the predominant adaptation involving up-regulation and redistribution of GLT-1...
  23. ncbi request reprint Expression of the exon 3 skipping form of GLAST, GLAST1a, in brain and retina
    Lauren T Macnab
    School of Biomedical Sciences, University of Newcastle, New South Wales, Australia
    Neuroreport 17:1867-70. 2006
    ....
  24. doi request reprint AMD-like lesions in the rat retina: a latent consequence of perinatal hemorrhage
    David V Pow
    Department of Anatomy, University of Newcastle, NSW, Australia
    Invest Ophthalmol Vis Sci 49:2790-8. 2008
    ..This study was conducted to examine the potential long-term sequelae of hemorrhaging in the eyes of rats that exhibited transient spontaneous microhemorrhages a few days after birth...
  25. doi request reprint MAP2 provides reliable early assessment of neural injury in the newborn piglet model of birth asphyxia
    Barbara E Lingwood
    Perinatal Research Centre, University of Queensland, Royal Brisbane and Women s Hospital, Herston, QLD 4029, Australia
    J Neurosci Methods 171:140-6. 2008
    ..Results indicate that MAP2 immunoreactivity 6h after hypoxia/ischaemia is a reliable marker of neural injury in the neonatal piglet...
  26. ncbi request reprint Early loss of the glutamate transporter splice-variant GLT-1v in rat cerebral cortex following lateral fluid-percussion injury
    Jae Hyuk Yi
    Department of Medicine, Hopital Saint Luc, University of Montreal, Montreal, Quebec, Canada
    Glia 49:121-33. 2005
    ....
  27. ncbi request reprint Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease
    Heather L Scott
    Departments of Biochemistry and Physiology and Pharmacology, University of Queensland, Brisbane, Queensland, Australia, 4072
    J Neurosci 22:RC206. 2002
    ..This study implicates aberrant glutamate transporter expression as a mechanism involved in neurodegeneration in Alzheimer's disease...
  28. ncbi request reprint Distribution of two splice variants of the glutamate transporter GLT-1 in rat brain and pituitary
    Peter Reye
    School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia
    Glia 38:246-55. 2002
    ....
  29. ncbi request reprint Distribution of two splice variants of the glutamate transporter GLT-1 in the developing rat retina
    Peter Reye
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    J Comp Neurol 447:323-30. 2002
    ....
  30. ncbi request reprint Identification of cholinoceptive glycinergic neurons in the mammalian retina
    Nina A Dmitrieva
    Vision Science Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 4390, USA
    J Comp Neurol 456:167-75. 2003
    ..Thus, our findings indicate that ACh in the mammalian retina may modulate glycinergic circuits via extrasynaptic beta2alpha3 nAChRs...
  31. ncbi request reprint Neuronal migration and glial remodeling in degenerating retinas of aged rats and in nonneovascular AMD
    Robert Sullivan
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    Invest Ophthalmol Vis Sci 44:856-65. 2003
    ..To demonstrate structural and immunocytochemical changes associated with light-induced degeneration in albino rat retinas and human AMD retinas...
  32. ncbi request reprint Decrease in glial glutamate transporter variants and excitatory amino acid receptor down-regulation in a murine model of ALS-PDC
    Jason M B Wilson
    Programme in Neuroscience, University of British Columbia, Vancouver, British Columbia
    Neuromolecular Med 3:105-18. 2003
    ..Deciphering the series of events leading to neurodegeneration in cycad-fed animals may provide clues leading to therapeutic approaches to halt the early stages of disease progression...
  33. ncbi request reprint A new GLT1 splice variant: cloning and immunolocalization of GLT1c in the mammalian retina and brain
    Thomas Rauen
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Street 2, D 48149 Munster, Germany
    Neurochem Int 45:1095-106. 2004
    ..Similarly, cone photoreceptors express two glutamate transporters. We suggest that differential usage of these transporters by rod and cone photoreceptors may influence the kinetics of glutamate transmission by these neurons...
  34. ncbi request reprint Cloning, transport properties, and differential localization of two splice variants of GLT-1 in the rat CNS: implications for CNS glutamate homeostasis
    Robert Sullivan
    School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, Brisbane 4072, Australia
    Glia 45:155-69. 2004
    ..Furthermore, GLT-1v may be crucial in ensuring that low levels of glutamate are maintained at extrasynaptic locations, especially in pathological conditions such as ischemia, motor neurone disease, and epilepsy...
  35. ncbi request reprint Antibody production and immunocytochemical localization of amino acid transporters
    David V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    Methods Mol Biol 227:213-44. 2003
  36. ncbi request reprint Distribution of two splice variants of the glutamate transporter GLT1 in the retinas of humans, monkeys, rabbits, rats, cats, and chickens
    Peter Reye
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane 4072, Queensland, Australia
    J Comp Neurol 445:1-12. 2002
    ..We conclude that the two variants of GLT1 are present in all species examined but are differentially distributed in a species-specific manner. Moreover, each cell type generally expresses only one splice variant of GLT1...
  37. ncbi request reprint Differential expression of the GABA transporters GAT-1 and GAT-3 in brains of rats, cats, monkeys and humans
    David V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, 4072, Australia
    Cell Tissue Res 320:379-92. 2005
    ..We suggest that differences in GAT distribution, especially the expression of GAT-3 by oligodendrocytes in humans, must be accommodated in extrapolating rodent models of GABA homeostasis to humans...
  38. ncbi request reprint Quantitative analysis of immunolabeling for serotonin and for glutamate transporters after administration of imipramine and citalopram
    Susan M Williams
    Discipline of Anatomy, School of Biomedical Sciences, and Hunter Medical Research Institute HMRI, University of Newcastle, Callaghan, NSW, 2308, Australia
    Brain Res 1042:224-32. 2005
    ....
  39. ncbi request reprint Light and electron microscopic analysis of aquaporin 1-like-immunoreactive amacrine cells in the rat retina
    In Beom Kim
    Department of Anatomy, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, Seoul 137 701, Korea
    J Comp Neurol 452:178-91. 2002
    ..In addition, synaptic output onto bipolar cells was rarely observed in sublamina b of the IPL. Thus, the AQP1 antibody labels a class of glycinergic amacrine cells with small to medium-sized dendritic fields in the rat retina...
  40. ncbi request reprint Dendritic and synaptic plasticity of neurons in the human age-related macular degeneration retina
    Robert K P Sullivan
    School of Biomedical Sciences, University of Newcastle, Newcastle, NSW, Australia
    Invest Ophthalmol Vis Sci 48:2782-91. 2007
    ..Remodeling events such as sprouting of neuronal processes and the reconnection of synapses are essential elements in repairing any damage to adult nervous tissues such as might occur in response to insults such as strokes or in AMD...
  41. ncbi request reprint Central nervous system expression of the exon 9 skipping form of the glutamate transporter GLAST
    Lauren T Macnab
    School of Biomedical Sciences, University of Newcastle, and HMRI, NSW, Australia
    Neuroreport 18:741-5. 2007
    ..We suggest that alternate splicing of GLAST by subpopulations of neurons may indicate some dysfunction in these cells, and may be an indicator of inappropriate local excitation...
  42. ncbi request reprint EAAT1 and D-serine expression are early features of human retinal development
    Claudia M Diaz
    Discipline of Anatomy, School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Exp Eye Res 84:876-85. 2007
    ..This study shows that key potential modifiers of NMDA receptor activity are present before synaptic vesicle proteins are evident and may thus play a role in shaping synaptogenesis in the developing human retina...
  43. ncbi request reprint Thiamine deficiency results in downregulation of the GLAST glutamate transporter in cultured astrocytes
    Alan S Hazell
    Department of Medicine, Hopital Saint Luc, University of Montreal, Montreal, Quebec, Canada
    Glia 43:175-84. 2003
    ..In addition, manipulation of group II mGluR activity may provide an important strategy in the treatment of this disorder...
  44. ncbi request reprint Evoked expression of the glutamate transporter GLT-1c in retinal ganglion cells in human glaucoma and in a rat model
    Robert K P Sullivan
    Department of Anatomy, School of Biomedical Sciences, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia
    Invest Ophthalmol Vis Sci 47:3853-9. 2006
    ..Glutamate transporters are key regulators of glutamate; therefore, the purpose of the study was to determine whether unusual excitation is associated with unusual expression of one or more transporters...
  45. ncbi request reprint Cytoskeletal anchoring of GLAST determines susceptibility to brain damage: an identified role for GFAP
    Susan M Sullivan
    School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Biol Chem 282:29414-23. 2007
    ..These data indicate that the cytoskeleton of the astrocyte plays an important role in protecting the brain against glutamate-mediated excitotoxicity...