Research Topics
| D V PowSummaryAffiliation: University of Queensland Country: Australia Publications
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Detail Information
Publications
Localization of taurine transporters, taurine, and (3)H taurine accumulation in the rat retina, pituitary, and brainDavid V Pow
Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
Glia 37:153-68. 2002..The heterogeneous distribution of taurine and its transporters in the brain does not reconcile well with the possibility that taurine acts solely as a ubiquitous osmolyte in nervous tissues...- Loss of glial glutamate transporters and induction of neuronal expression of GLT-1B in the hypoxic neonatal pig brainDavid V Pow
Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane 4072, Australia
Brain Res Dev Brain Res 153:1-11. 2004.... - Nuclear kinesis, neurite sprouting and abnormal axonal projections of cone photoreceptors in the aged and AMD-afflicted human retinaDavid V Pow
School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Exp Eye Res 84:850-7. 2007.... - Visualising the activity of the cystine-glutamate antiporter in glial cells using antibodies to aminoadipic acid, a selectively transported substrateD V Pow
Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia
Glia 34:27-38. 2001..Because cystine uptake is associated with glutamate release, it is suggested that this antiporter might contribute to release of glutamate from glial cells under some pathophysiological conditions... - Developmental expression of excitatory amino acid transporter 5: a photoreceptor and bipolar cell glutamate transporter in rat retinaD V Pow
Department of Anatomical Sciences, University of Queensland, Brisbane, Australia
Neurosci Lett 280:21-4. 2000..The positions and morphology of these terminals suggests that they are the terminals of both rod and cone rod bipolar cells. We conclude that in rat retina, EAAT5 is a photoreceptor and bipolar cell glutamate transporter... - Amino acids and their transporters in the retinaD V Pow
Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane 4072, Australia
Neurochem Int 38:463-84. 2001.... - Are neuronal transporters relevant in retinal glutamate homeostasis?D V Pow
Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
Neurochem Int 37:191-8. 2000.... - Antisense knockdown of GLAST, a glial glutamate transporter, compromises retinal functionN L Barnett
Vision, Touch, and Hearing Research Centre, The University of Queensland, Brisbane, Australia
Invest Ophthalmol Vis Sci 41:585-91. 2000..To elucidate the role of the glial glutamate transporter GLAST, in the regulation of retinal function... - Expression of glycine and the glycine transporter glyt-1 in the developing rat retinaD V Pow
Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia
Vis Neurosci 17:1-9. 2000..This temporal pattern of labelling strongly indicates that bipolar cells label for glycine when gap junctions become functional between glycine/glyt-1 immunoreactive amacrine cells and cone bipolar cells... - Expression of the exon 9-skipping form of EAAT2 in astrocytes of ratsL T Macnab
School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Neuroscience 150:705-11. 2007..Conversely, the limited expression in gray matter suggests it is unlikely to be important for modulating synaptic levels of glutamate... - Differential perturbation of neuronal and glial glutamate transport systems in retinal ischaemiaN L Barnett
Vision, Touch and Hearing Research Centre, School of Biomedical Sciences, The University of Queensland, 4072, Brisbane, Australia
Neurochem Int 39:291-9. 2001..Manipulation of GLAST function could alleviate the degeneration and blindness that result from ischaemic retinal disease... - Expression of glycine and the glycine transporter Glyt-1 in the developing rat retinaD V Pow
Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia
Vis Neurosci 17:1R-9R. 2000..This temporal pattern of labelling strongly indicates that bipolar cells label for glycine when gap junctions become functional between glycine/glyt-1 immunoreactive amacrine cells and cone bipolar cells... - Glyt-1 expression in cultured human Müller cells and intact retinaeP Reye
Department of Physiology and Pharmacology, University of Queensland, Brisbane, Queensland, Australia
Glia 34:311-5. 2001..These data suggest that Glyt-1 expression in cultured Müller cells is an epiphenomenon associated with culturing in vitro, rather than a normal physiological or even pathophysiological phenomenon in vivo... - The dendritic architecture of the cholinergic plexus in the rabbit retina: selective labeling by glycine accumulation in the presence of sarcosineD I Vaney
Vision, Touch and Hearing Research Centre, Department of Physiology and Pharmacology, The University of Queensland, Brisbane, Queensland, Australia
J Comp Neurol 421:1-13. 2000..It is not known how the dendritic co-fasciculation develops, but the cholinergic dendritic plexus may provide the initial scaffold, because the dendrites of the On-Off DS cells commonly run along the outside of the cholinergic fascicles... - Inhibition of Müller cell glutamine synthetase rapidly impairs the retinal response to lightN L Barnett
Vision, Touch and Hearing Research Centre, The University of Queensland, Brisbane, Australia
Glia 30:64-73. 2000.... - GLAST1b, the exon-9 skipping form of the glutamate-aspartate transporter EAAT1 is a sensitive marker of neuronal dysfunction in the hypoxic brainS M Sullivan
School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Neuroscience 149:434-45. 2007..We propose that GLAST1b represents a novel and sensitive marker for the detection of neurons at risk of dying in response to hypoxic and other excitotoxic insults and may have wider applicability in experimental and clinical contexts... - Expression of pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1R) in the ewe hypothalamus: distribution and colocalization with tyrosine hydroxylase-immunoreactive neuronesS T Anderson
School of Biomedical Sciences, The University of Queensland, Queensland, Australia
J Neuroendocrinol 17:298-305. 2005..These observations, together with previous in vivo studies, suggest that PACAP could act directly on TIDA neurones via PAC1R to increase dopamine release and consequently inhibit prolactin secretion in the sheep... - Glial glutamate transporter expression patterns in brains from multiple mammalian speciesSusan M Williams
Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
Glia 49:520-41. 2005..Collectively our data suggest that assumptions as to the roles of glutamate transporters in any species may need to be tested empirically... - Hypoxic preconditioning in neonatal rat brain involves regulation of excitatory amino acid transporter 2 and estrogen receptor alphaHelena Cimarosti
Howard Florey Institute, University of Melbourne, Victoria 3010, , Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
Neurosci Lett 385:52-7. 2005..The endogenous molecular mechanisms modulated by hypoxia preconditioning may contribute to the development of hypoxia-induced ischemic tolerance, and may provide novel therapeutic targets for the treatment of cerebral ischemia... - Immunocytochemical analysis of D-serine distribution in the mammalian brain reveals novel anatomical compartmentalizations in glia and neuronsSusan M Williams
Department of Anatomy, School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
Glia 53:401-11. 2006.... - Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: Evidence for delayed up-regulation and redistribution of GLT-1Chew L Lau
Brain Injury and Repair Program, Howard Florey Institute, Vic. 3010, Australia
Neurochem Int 48:604-10. 2006..These findings suggest an association of cytoskeletal changes in glia with EAAT activity, with the predominant adaptation involving up-regulation and redistribution of GLT-1... 
MAP2 provides reliable early assessment of neural injury in the newborn piglet model of birth asphyxiaBarbara E Lingwood
Perinatal Research Centre, University of Queensland, Royal Brisbane and Women s Hospital, Herston, QLD 4029, Australia
J Neurosci Methods 171:140-6. 2008..Results indicate that MAP2 immunoreactivity 6h after hypoxia/ischaemia is a reliable marker of neural injury in the neonatal piglet...- Expression of the exon 3 skipping form of GLAST, GLAST1a, in brain and retinaLauren T Macnab
School of Biomedical Sciences, University of Newcastle, New South Wales, Australia
Neuroreport 17:1867-70. 2006.... - AMD-like lesions in the rat retina: a latent consequence of perinatal hemorrhageDavid V Pow
Department of Anatomy, University of Newcastle, NSW, Australia
Invest Ophthalmol Vis Sci 49:2790-8. 2008..This study was conducted to examine the potential long-term sequelae of hemorrhaging in the eyes of rats that exhibited transient spontaneous microhemorrhages a few days after birth... - Early loss of the glutamate transporter splice-variant GLT-1v in rat cerebral cortex following lateral fluid-percussion injuryJae Hyuk Yi
Department of Medicine, Hopital Saint Luc, University of Montreal, Montreal, Quebec, Canada
Glia 49:121-33. 2005.... - A new GLT1 splice variant: cloning and immunolocalization of GLT1c in the mammalian retina and brainThomas Rauen
Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Street 2, D 48149 Munster, Germany
Neurochem Int 45:1095-106. 2004..Similarly, cone photoreceptors express two glutamate transporters. We suggest that differential usage of these transporters by rod and cone photoreceptors may influence the kinetics of glutamate transmission by these neurons... - Distribution of two splice variants of the glutamate transporter GLT-1 in the developing rat retinaPeter Reye
Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
J Comp Neurol 447:323-30. 2002.... - Identification of cholinoceptive glycinergic neurons in the mammalian retinaNina A Dmitrieva
Vision Science Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 4390, USA
J Comp Neurol 456:167-75. 2003..Thus, our findings indicate that ACh in the mammalian retina may modulate glycinergic circuits via extrasynaptic beta2alpha3 nAChRs... - Neuronal migration and glial remodeling in degenerating retinas of aged rats and in nonneovascular AMDRobert Sullivan
Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
Invest Ophthalmol Vis Sci 44:856-65. 2003..To demonstrate structural and immunocytochemical changes associated with light-induced degeneration in albino rat retinas and human AMD retinas... - Decrease in glial glutamate transporter variants and excitatory amino acid receptor down-regulation in a murine model of ALS-PDCJason M B Wilson
Programme in Neuroscience, University of British Columbia, Vancouver, British Columbia
Neuromolecular Med 3:105-18. 2003..Deciphering the series of events leading to neurodegeneration in cycad-fed animals may provide clues leading to therapeutic approaches to halt the early stages of disease progression... - Distribution of two splice variants of the glutamate transporter GLT-1 in rat brain and pituitaryPeter Reye
School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia
Glia 38:246-55. 2002.... - Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's diseaseHeather L Scott
Departments of Biochemistry and Physiology and Pharmacology, University of Queensland, Brisbane, Queensland, Australia, 4072
J Neurosci 22:RC206. 2002..This study implicates aberrant glutamate transporter expression as a mechanism involved in neurodegeneration in Alzheimer's disease... - Cloning, transport properties, and differential localization of two splice variants of GLT-1 in the rat CNS: implications for CNS glutamate homeostasisRobert Sullivan
School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, Brisbane 4072, Australia
Glia 45:155-69. 2004..Furthermore, GLT-1v may be crucial in ensuring that low levels of glutamate are maintained at extrasynaptic locations, especially in pathological conditions such as ischemia, motor neurone disease, and epilepsy... - Cytoskeletal anchoring of GLAST determines susceptibility to brain damage: an identified role for GFAPSusan M Sullivan
School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
J Biol Chem 282:29414-23. 2007..These data indicate that the cytoskeleton of the astrocyte plays an important role in protecting the brain against glutamate-mediated excitotoxicity... - Distribution of two splice variants of the glutamate transporter GLT1 in the retinas of humans, monkeys, rabbits, rats, cats, and chickensPeter Reye
Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane 4072, Queensland, Australia
J Comp Neurol 445:1-12. 2002..We conclude that the two variants of GLT1 are present in all species examined but are differentially distributed in a species-specific manner. Moreover, each cell type generally expresses only one splice variant of GLT1... - Dendritic and synaptic plasticity of neurons in the human age-related macular degeneration retinaRobert K P Sullivan
School of Biomedical Sciences, University of Newcastle, Newcastle, NSW, Australia
Invest Ophthalmol Vis Sci 48:2782-91. 2007..Remodeling events such as sprouting of neuronal processes and the reconnection of synapses are essential elements in repairing any damage to adult nervous tissues such as might occur in response to insults such as strokes or in AMD... - Central nervous system expression of the exon 9 skipping form of the glutamate transporter GLASTLauren T Macnab
School of Biomedical Sciences, University of Newcastle, and HMRI, NSW, Australia
Neuroreport 18:741-5. 2007..We suggest that alternate splicing of GLAST by subpopulations of neurons may indicate some dysfunction in these cells, and may be an indicator of inappropriate local excitation... - EAAT1 and D-serine expression are early features of human retinal developmentClaudia M Diaz
Discipline of Anatomy, School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Exp Eye Res 84:876-85. 2007..This study shows that key potential modifiers of NMDA receptor activity are present before synaptic vesicle proteins are evident and may thus play a role in shaping synaptogenesis in the developing human retina... - Light and electron microscopic analysis of aquaporin 1-like-immunoreactive amacrine cells in the rat retinaIn-Beom Kim
Department of Anatomy, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul 137-701, Korea
J Comp Neurol 452:178-91. 2002..In addition, synaptic output onto bipolar cells was rarely observed in sublamina b of the IPL. Thus, the AQP1 antibody labels a class of glycinergic amacrine cells with small to medium-sized dendritic fields in the rat retina... - Antibody production and immunocytochemical localization of amino acid transportersDavid V Pow
Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
Methods Mol Biol 227:213-44. 2003 - Thiamine deficiency results in downregulation of the GLAST glutamate transporter in cultured astrocytesAlan S Hazell
Department of Medicine, Hopital Saint Luc, University of Montreal, Montreal, Quebec, Canada
Glia 43:175-84. 2003..In addition, manipulation of group II mGluR activity may provide an important strategy in the treatment of this disorder... - Quantitative analysis of immunolabeling for serotonin and for glutamate transporters after administration of imipramine and citalopramSusan M Williams
Discipline of Anatomy, School of Biomedical Sciences, and Hunter Medical Research Institute (HMRI, University of Newcastle, Callaghan, NSW, 2308, Australia
Brain Res 1042:224-32. 2005.... - Differential expression of the GABA transporters GAT-1 and GAT-3 in brains of rats, cats, monkeys and humansDavid V Pow
Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, 4072, Australia
Cell Tissue Res 320:379-92. 2005..We suggest that differences in GAT distribution, especially the expression of GAT-3 by oligodendrocytes in humans, must be accommodated in extrapolating rodent models of GABA homeostasis to humans... - Evoked expression of the glutamate transporter GLT-1c in retinal ganglion cells in human glaucoma and in a rat modelRobert K P Sullivan
Department of Anatomy, School of Biomedical Sciences, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Invest Ophthalmol Vis Sci 47:3853-9. 2006..GLT-1c may be a useful indicator of the extent of stress of the retinal ganglion cells and thus a tool for examining outcomes of potential therapeutic and experimental interventions...