Genomes and Genes
Affiliation: University of Queensland
- Heterozygosity for nuclear factor one x affects hippocampal-dependent behaviour in miceLachlan Harris
The School of Biomedical Sciences, The University of Queensland, Brisbane, Australia
PLoS ONE 8:e65478. 2013..These findings demonstrate that the level of Nfix expression during development and within the adult is essential for the function of the hippocampus during learning and memory...
- Electroporation of cDNA/Morpholinos to targeted areas of embryonic CNS in XenopusJulien Falk
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
BMC Dev Biol 7:107. 2007..Therefore, fine spatio-temporal control of over-expression or knock-down approaches is required to specifically address the role of a given gene in these processes...
- The transcription factor Nfix is essential for normal brain developmentChristine E Campbell
Dept of Biochemistry and New York State Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, 3435 Main St, Buffalo, NY 14214, USA
BMC Dev Biol 8:52. 2008..Recently the Nfix gene has been disrupted and these studies indicated that there were largely uncharacterized defects in brain and skeletal development in Nfix-deficient mice...
- Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient miceMichael Piper
Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia
Neural Dev 4:43. 2009..Therefore, we investigate here how Nfib functions to regulate non-cell-autonomous mechanisms of callosal formation...
- Nuclear factor one X regulates the development of multiple cellular populations in the postnatal cerebellumMichael Piper
School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
J Comp Neurol 519:3532-48. 2011....
- Specific glial populations regulate hippocampal morphogenesisGuy Barry
The University of Queensland, Queensland Brain Institute, and School of Biomedical Sciences, Brisbane, 4067, Australia
J Neurosci 28:12328-40. 2008..These data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis...
- NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1Michael Piper
Queensland Brain Institute, The University of Queensland, Brisbane, Australia
J Neurosci 30:9127-39. 2010....
- Multiple Slits regulate the development of midline glial populations and the corpus callosumDivya K Unni
The Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia
Dev Biol 365:36-49. 2012..Finally, our data also indicate that some of the roles of Slit proteins at the midline may be independent of Robo signalling, suggestive of additional receptors regulating Slit signalling during development...
- NFIB-mediated repression of the epigenetic factor Ezh2 regulates cortical developmentMichael Piper
Queensland Brain Institute, Institute for Molecular Bioscience, and the School of Biomedical Sciences, The University of Queensland, Brisbane, Australia 4069, QIMR Berghofer Medical Research Institute, Brisbane, Australia 4029, and Department of Biochemistry, Program in Genetics, Genomics and Bioinformatics, Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, New York 14203
J Neurosci 34:2921-30. 2014..Collectively, these results suggest that the downregulation of Ezh2 transcription by NFIB is an important component of the process of neural progenitor cell differentiation during cortical development. ..
- Emx and Nfi genes regulate cortical development and axon guidance in the telencephalonMichael Piper
The University of Queensland, Queensland Brain Institute and The School of Biomedical Sciences, Brisbane 4074, Australia
Novartis Found Symp 288:230-242; discussion 242-5, 276-81. 2007..We review the role of these genes in cortical cell migration, glial development and the formation of cortical axon projections, and examine the overlapping mutant phenotypes between the Emx and Nfi gene families...
- Neuropilin 1-Sema signaling regulates crossing of cingulate pioneering axons during development of the corpus callosumMichael Piper
Queensland Brain Institute, The University of Queensland, Queensland, Australia
Cereb Cortex 19:i11-21. 2009..These data highlight a central role for Npn1 in the development of projections from the cingulate cortex and further illustrate the importance of these pioneer axons in the formation of the CC...
- Nuclear factor one X regulates Bobby sox during development of the mouse forebrainChantelle Dixon
The School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia
Cell Mol Neurobiol 33:867-73. 2013..Moreover, we reveal that NFIX can repress Bbx promoter-driven expression. Collectively, these data suggest that Bbx is a downstream target of NFIX during development of the forebrain. ..
- CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surfaceLorine Wilkinson
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
J Biol Chem 278:34181-8. 2003..The presence of CRIM1 reduced the effective BMP4 concentration of the media, thereby acting as a BMP4 antagonist. Hence, CRIM1 modulates BMP activity by affecting its processing and delivery to the cell surface...
- Movement through Slits: cellular migration via the Slit familyMichael Piper
Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
Bioessays 25:32-8. 2003..This review focuses on the non-neuronal activities of Slit proteins, highlighting a common role for the Slit family in cellular migration...
- Nuclear factor I genes regulate neuronal migrationYee Hsieh Evelyn Heng
School of Biomedical Sciences, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia
Neurosignals 20:159-67. 2012....
- Nuclear factor one transcription factors in CNS developmentSharon Mason
Queensland Brain Institute, The University of Queensland, Building 79, St Lucia, 4072, Australia
Mol Neurobiol 39:10-23. 2009..Here, we discuss the importance and role of NFI in these processes in the context of several CNS systems including the neocortex, hippocampus, cerebellum, and spinal cord at both cellular and molecular levels...
- Exogenous Slit2 does not affect ureteric branching or nephron formation during kidney developmentMichael Piper
Institute for Molecular Bioscience, and Department of Biochemistry, University of Queensland, Brisbane, Australia
Int J Dev Biol 46:545-50. 2002..In situ analysis of the Slit receptors, Robo1 and Robo2, the vasculogenic markers VEGFA and Flk-1, and the stromal cell marker BF2 displayed no difference in comparison to controls...
- The neurodevelopmental hypothesis of schizophrenia: convergent clues from epidemiology and neuropathologyMichael Piper
School of Biomedical Science, University of Queensland, St Lucia, Queensland 4072, Australia
Psychiatr Clin North Am 35:571-84. 2012..Animal models involving early life exposures have been linked to changes in these same brain systems, providing convergent evidence for this long-standing hypothesis...