John E Pimanda

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint The von Willebrand factor-reducing activity of thrombospondin-1 is located in the calcium-binding/C-terminal sequence and requires a free thiol at position 974
    John E Pimanda
    Centre for Thrombosis and Vascular Research and Cytokine Research Unit, School of Medical Sciences, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Blood 100:2832-8. 2002
  2. ncbi request reprint Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13
    John E Pimanda
    Centre for Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia
    Blood 103:627-9. 2004
  3. ncbi request reprint Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice
    John E Pimanda
    Centre for Vascular Research, University of New South Wales and the Department of Haematology, The Prince of Wales Hospital, Sydney, New South Wales 2052, Australia
    J Biol Chem 279:21439-48. 2004
  4. ncbi request reprint Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer
    John E Pimanda
    Department of Hematology, Cambridge Institute of Medical Research, University of Cambridge, Cambridge CB2 2XY, UK
    Blood 107:4737-45. 2006
  5. pmc The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity
    John E Pimanda
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, United Kingdom
    Proc Natl Acad Sci U S A 104:840-5. 2007
  6. pmc Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code
    John E Pimanda
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    Blood 112:4512-22. 2008
  7. pmc Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development
    John E Pimanda
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 104:17692-7. 2007
  8. doi request reprint Gene regulatory networks governing haematopoietic stem cell development and identity
    John E Pimanda
    Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
    Int J Dev Biol 54:1201-11. 2010
  9. ncbi request reprint A perspective on the measurement of ADAMTS13 in thrombotic thrombocytopaenic purpura
    John E Pimanda
    The University of New South Wales and The Department of Haematology, The Prince of Wales Hospital, Sydney, Australia
    Eur J Haematol 70:257-62. 2003
  10. doi request reprint Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver
    Josette Renee Landry
    Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Cambridge, United Kingdom
    Blood 111:3005-14. 2008

Collaborators

Detail Information

Publications26

  1. ncbi request reprint The von Willebrand factor-reducing activity of thrombospondin-1 is located in the calcium-binding/C-terminal sequence and requires a free thiol at position 974
    John E Pimanda
    Centre for Thrombosis and Vascular Research and Cytokine Research Unit, School of Medical Sciences, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Blood 100:2832-8. 2002
    ..Alkylation of Cys974 in the C-terminal TSP-1 construct, which is a serine in TSP-2, ablated VWF reductase activity. These results imply that the reductase function of TSP-1 centers around Cys974 in the C-terminal sequence...
  2. ncbi request reprint Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13
    John E Pimanda
    Centre for Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia
    Blood 103:627-9. 2004
    ..The VWF-cleaving proteinase activity of the truncated enzyme was comparable to that of the wild-type enzyme but its secretion from transfected COS-7 cells was about 14% of the wild type...
  3. ncbi request reprint Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice
    John E Pimanda
    Centre for Vascular Research, University of New South Wales and the Department of Haematology, The Prince of Wales Hospital, Sydney, New South Wales 2052, Australia
    J Biol Chem 279:21439-48. 2004
    ..These findings indicate that TSP-1 influences plasma and platelet VWF multimeric size differently and may be more relevant for control of the VWF released from platelets...
  4. ncbi request reprint Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer
    John E Pimanda
    Department of Hematology, Cambridge Institute of Medical Research, University of Cambridge, Cambridge CB2 2XY, UK
    Blood 107:4737-45. 2006
    ..This study therefore establishes the transcriptional framework within which endoglin functions during angiogenesis...
  5. pmc The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity
    John E Pimanda
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, United Kingdom
    Proc Natl Acad Sci U S A 104:840-5. 2007
    ..Taken together, our results integrate three key determinants of HSC development; the Scl transcriptional network, Runx1 activity, and the Bmp4/Smad signaling pathway...
  6. pmc Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code
    John E Pimanda
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    Blood 112:4512-22. 2008
    ..This modular assembly of regulators gives blood and endothelial cells the regulatory freedom to independently fine-tune gene expression and emphasizes the role of regulatory divergence in driving functional divergence...
  7. pmc Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development
    John E Pimanda
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 104:17692-7. 2007
    ....
  8. doi request reprint Gene regulatory networks governing haematopoietic stem cell development and identity
    John E Pimanda
    Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
    Int J Dev Biol 54:1201-11. 2010
    ..In this review we cover the fundamentals of network architecture, methods used to reconstruct networks, current knowledge of haematopoietic and related transcriptional networks, current challenges and future outlook...
  9. ncbi request reprint A perspective on the measurement of ADAMTS13 in thrombotic thrombocytopaenic purpura
    John E Pimanda
    The University of New South Wales and The Department of Haematology, The Prince of Wales Hospital, Sydney, Australia
    Eur J Haematol 70:257-62. 2003
    ..In this review, we evaluate the value of measuring this enzyme in the management of TTP...
  10. doi request reprint Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver
    Josette Renee Landry
    Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Cambridge, United Kingdom
    Blood 111:3005-14. 2008
    ..Together, our data provide a key component of the transcriptional network of early hematopoiesis by identifying downstream targets of Scl that can explain key aspects of the early Scl(-/-) phenotype...
  11. doi request reprint Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes
    Dominik Beck
    Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
    Blood 122:e12-22. 2013
    ..Taken together, these data reveal the power of integrating multifactor sequencing of chromatin immunoprecipitates with coding and noncoding gene expression to identify regulatory circuits controlling cell identity. ..
  12. doi request reprint Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia
    Eva Diffner
    Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
    Blood 121:2289-300. 2013
    ....
  13. pmc A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis
    Kathy Knezevic
    Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia
    Mol Cell Biol 31:2817-26. 2011
    ..Taken together, we describe a scenario in which a key hematopoietic transcription factor controls its own expression levels by transcriptionally controlling its controller...
  14. doi request reprint Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators
    Nicola K Wilson
    University of Cambridge Department of Haematology, Cambridge Institute for Medical Research, Hills Road, Cambridge, CB2 0XY, UK
    Cell Stem Cell 7:532-44. 2010
    ..Taken together, this study demonstrates the power of genome-wide analysis in generating novel functional insights into the transcriptional control of stem and progenitor cells...
  15. ncbi request reprint The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype
    Wan Y I Chan
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, United Kingdom
    Blood 109:1908-16. 2007
    ..Furthermore, coregulation of Scl and Lyl1 later during development may explain the mild phenotype of Scl-/- adult HSCs...
  16. pmc Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 stem cell enhancer are active in bone cells
    John E Pimanda
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, United Kingdom
    Mol Cell Biol 26:2615-25. 2006
    ....
  17. doi request reprint Cell signalling pathways that mediate haematopoietic stem cell specification
    Jonathon Marks-Bluth
    Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia
    Int J Biochem Cell Biol 44:2175-84. 2012
    ..In conclusion we will discuss how this knowledge has led to the generation of blood cells in the laboratory and consider the implications of that advancement...
  18. doi request reprint ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer
    Julie A I Thoms
    Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
    Blood 117:7079-89. 2011
    ..Taken together, these data illustrate that ERG promotes T-ALL and that failure to extinguish activity of stem cell enhancers associated with regulatory transcription factors such as ERG can contribute to the development of leukemia...
  19. doi request reprint BloodChIP: a database of comparative genome-wide transcription factor binding profiles in human blood cells
    Diego Chacon
    Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia
    Nucleic Acids Res 42:D172-7. 2014
    ..All queries can be exported into external sites to construct TF-gene and protein-protein networks and to evaluate the association of genes with cellular processes and tissue expression. ..
  20. pmc Reassembly of nucleosomes at the MLH1 promoter initiates resilencing following decitabine exposure
    Luke B Hesson
    Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    PLoS Genet 9:e1003636. 2013
    ....
  21. doi request reprint Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription
    Bo Wang
    Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
    Arterioscler Thromb Vasc Biol 30:536-45. 2010
    ..EGR-1 autoregulation, and histone modification in the EGR-1 promoter, represent key mechanisms in EGR-1 control, but have not been explored...
  22. ncbi request reprint Novel and emerging therapies in cardiology and haematology
    John E Pimanda
    Centre for Vascular Research, The University of New South Wales, and Department of Haematology, The Prince of Wales Hospital, Sydney, Australia
    Curr Drug Targets Cardiovasc Haematol Disord 3:101-23. 2003
    ..Here we review current advances in pharmacological treatments in cardiology and haematology, grouped primarily by disease process, focusing on novel and emerging therapies likely to be of importance in the future...
  23. doi request reprint Signal analysis for genome-wide maps of histone modifications measured by ChIP-seq
    Dominik Beck
    Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia
    Bioinformatics 28:1062-9. 2012
    ....
  24. doi request reprint Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition
    Petra S Bachmann
    Children s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia
    Blood 116:3013-22. 2010
    ..These findings provide a novel therapeutic strategy to reverse glucocorticoid resistance and improve outcome for high-risk pediatric ALL...
  25. ncbi request reprint The proto-oncogene ERG in megakaryoblastic leukemias
    Liat Rainis
    Department of Pediatric Hematology Oncology, Safra Children s Hospital and Hematology Institute, Sheba Cancer Research Center, Sheba Medical Center, Tel Hashomer, Israel
    Cancer Res 65:7596-602. 2005
    ....
  26. ncbi request reprint A common origin of the 4143insA ADAMTS13 mutation
    Reinhard Schneppenheim
    University Medical Center Hamburg Eppendorf, Department of Pediatric Hematology and Oncology, Martinistrasse 52, D 20246 Hamburg, Germany
    Thromb Haemost 96:3-6. 2006
    ..We conclude that 4143insA has a common genetic background and is frequent among patients with hereditary ADAMTS13 deficiency in Northern and Central European countries...