Research Topics
| J Jane PillowSummaryAffiliation: University of Western Australia Country: Australia Publications
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Detail Information
Publications
Innovation in surfactant therapy II: surfactant administration by aerosolizationJ Jane Pillow
Centre for Neonatal Research and Education, University of Western Australia, Perth, WA, Australia
Neonatology 101:337-44. 2012..Further work is also required to determine the optimum delivery route (mask, intranasal prong, nasopharyngeal or laryngeal), dosing amount and redosing interval...- Oxygen, temperature and humidity of inspired gases and their influences on airway and lung tissue in near-term lambsJ Jane Pillow
School of Women s and Infants Health, The University of Western Australia, Subiaco, Perth 6008, Australia
Intensive Care Med 35:2157-63. 2009..We hypothesized that oxygen content and humidity of inspired air would influence markers of pulmonary inflammation in ventilated lambs... - Variable ventilation improves ventilation and lung compliance in preterm lambsJ Jane Pillow
School of Women s and Infants Health, M550, University of Western Australia, 374 Bagot Rd, Subiaco, Perth, WA 6008, Australia
Intensive Care Med 37:1352-9. 2011..We assessed the physiological consequences of variable ventilation in the immature lung... - Bubble continuous positive airway pressure enhances lung volume and gas exchange in preterm lambsJ Jane Pillow
School of Women s and Infants Health, The University of Western Australia, Perth, Australia
Am J Respir Crit Care Med 176:63-9. 2007..The technique used to provide continuous positive airway pressure (CPAP) to the newborn may influence lung function and breathing efficiency... - Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambsGraeme R Polglase
School of Women s and Infants Health, The University of Western Australia, Perth, Western Australia, 6009, Australia
Pediatr Res 64:517-22. 2008..Ventilation resulted in localization of IL-6 to the small airways. Initial ventilation of preterm lambs with PEEP and/or VT of 8 mL/kg did not prevent an inflammatory injury to the lung... - Ventilation-mediated injury after preterm delivery of Ureaplasma parvum colonized fetal lambsGraeme R Polglase
School of Women s and Infants Health, The University of Western Australia, Subiaco, Western Australia 6009, Australia
Pediatr Res 67:630-5. 2010..Antenatal colonization with UP did not change lung function or modulate the lung injury and inflammation caused by high VT ventilation... - Cardiopulmonary haemodynamics in lambs during induced capillary leakage immediately after preterm birthGraeme R Polglase
Women s and Infants Health, University of Western Australia, Crawley, WA, Australia
Clin Exp Pharmacol Physiol 38:222-8. 2011..Capillary leakage might contribute to postnatal cardiopulmonary failure in preterm infants... - Pulmonary vascular and alveolar development in preterm lambs chronically colonized with Ureaplasma parvumGraeme R Polglase
The University of Western Australia, Perth, Australia
Am J Physiol Lung Cell Mol Physiol 299:L232-41. 2010..We conclude that chronic exposure to U. parvum does not cause sustained effects on air space or vascular development in premature lambs... - Cardiovascular and pulmonary consequences of airway recruitment in preterm lambsGraeme R Polglase
School of Women s and Infants Health, The University of Western Australia, M094, 35 Stirling Highway, Crawley, 6009, Western Australia, Australia
J Appl Physiol 106:1347-55. 2009..These changes are likely due to the concomitant increase in downstream pulmonary vascular resistance and increased cardiovascular constraint induced by PEEP... - Lung and systemic inflammation in preterm lambs on continuous positive airway pressure or conventional ventilationGraeme R Polglase
School of Women s and Infants Health, The University of Western Australia, Perth, Western Australia 6009, Australia
Pediatr Res 65:67-71. 2009..Blood neutrophils decreased similarly after LPS in CPAP and CMV groups. Cytokine markers of lung injury or the systemic response to intratracheal LPS were not decreased by CPAP relative to CMV, in preterm lambs.. - Variability in preterm lamb lung mechanics after intra-amniotic endotoxin is associated with changes in surfactant pool size and morphometryJ Jane Pillow
Centre for Child Health Research, The University of Western Australia, Perth, Australia
Am J Physiol Lung Cell Mol Physiol 287:L992-8. 2004..Despite the complex cascade of events initiated by antenatal endotoxin exposure, variability in lung tissue mechanics is associated primarily with changes in alveolar Sat PC pool and lung morphology... - Fetal responses to lipopolysaccharide-induced chorioamnionitis alter immune and airway responses in 7-week-old sheepAndrea J X Lee
School of Women s and Infant s Health, The University of Western Australia, Perth, Australia
Am J Obstet Gynecol 204:364.e17-24. 2011..We hypothesized that fetal innate immune responses to lipopolysaccharide-induced chorioamnionitis would alter postnatal systemic immune and airway responsiveness... - Intrauterine inflammation causes pulmonary hypertension and cardiovascular sequelae in preterm lambsGraeme R Polglase
School of Women s and Infants Health, The University of Western Australia, Crawley, Western Australia, Australia
J Appl Physiol 108:1757-65. 2010.... - Lung volume and ventilation inhomogeneity in preterm infants at 15-18 months corrected ageSven M Schulzke
School of Women s and Infant s Health, University of Western Australia, Perth, Australia
J Pediatr 156:542-9.e2. 2010.... - High positive end-expiratory pressure during high-frequency jet ventilation improves oxygenation and ventilation in preterm lambsGabrielle C Musk
School of Women s and Infants Health, University of Western Australia, Perth, Western Australia 6009, Australia
Pediatr Res 69:319-24. 2011..Inflammatory markers were lower in the PEEPadj group. Adjusted PEEP during HFJV improves oxygenation and lung compliance and reduces ventilator requirements despite reducing pulmonary perfusion... - Differential effect of recruitment maneuvres on pulmonary blood flow and oxygenation during HFOV in preterm lambsGraeme R Polglase
School of Women s and Infants Health, M094 The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, 6009, Australia
J Appl Physiol 105:603-10. 2008..Thus the choice of volume recruitment maneuvre influences the magnitude of change in OI and PBF that occurs during HFOV. Despite significantly improving OI, the ramp recruitment approach causes sustained changes in PBF... - Feasibility and short-term effects of biphasic positive airway pressure versus assist-control ventilation in preterm lambsSven M Schulzke
School of Women s and Infant s Health, University of Western Australia, Crawley, Western Australia 6009, Australia
Pediatr Res 66:665-70. 2009..In unsedated preterm lambs, BiLevel ventilation provides gas exchange equivalent to A-C ventilation and potentially results in reduced lung injury... - Bubble CPAP: is the noise important? An in vitro studyJ Jane Pillow
Centre for Child Health Research, The University of Western Australia, Perth, 6008 Western Australia, Australia
Pediatr Res 57:826-30. 2005..Lung mechanics and applied flow influence the magnitude of the noise superimposed on the transmitted pressure waveform and may influence lung volume recruitment in bubble CPAP... - Monitoring of lung volume recruitment and derecruitment using oscillatory mechanics during high-frequency oscillatory ventilation in the preterm lambJ Jane Pillow
Clinical Sciences Division, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Australia
Pediatr Crit Care Med 5:172-80. 2004..Minimization of Z(ti) is crucial to damping of P(tr) and may limit potential barotrauma to proximal alveolar units during establishment of HFOV... - High-frequency oscillatory ventilation: mechanisms of gas exchange and lung mechanicsJ Jane Pillow
Institute for Child Health Research, and the School of Women's and Infants' Health, University of Western Australia, Subiaco, Perth, Australia
Crit Care Med 33:S135-41. 2005..Monitoring of lung volume, respiratory mechanics, and ventilation homogeneity may facilitate individual optimization of HFOV ventilatory settings in the future... - Partitioning of airway and parenchymal mechanics in unsedated newborn infantsJ Jane Pillow
Portex Unit, Respiratory Physiology, Institue of Child Health, and Neonatal Unit, University College London Hospital, UK
Pediatr Res 58:1210-5. 2005..Measurements of lung function are feasible in the unsedated newborn infant using low-frequency forced oscillations and confirm the important contribution of tissue resistance to lung mechanics in the developing lung... - Lung function tests in neonates and infants with chronic lung disease: global and regional ventilation inhomogeneityJ Jane Pillow
Telethon Institute for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
Pediatr Pulmonol 41:105-21. 2006..For both techniques, there is an urgent need to establish guidelines regarding data collection, analysis, and interpretation in infants both with and without CLDI... - Impact of conventional breath inspiratory time during high-frequency jet ventilation in preterm lambsGabrielle C Musk
School of Women s and Infants Health, The University of Western Australia, Crawley, WA, Australia
Neonatology 101:267-73. 2012..Conventional mechanical ventilator (CMV) breaths during high-frequency jet ventilation (HFJV) are advocated to recruit and stabilize alveoli... - Ontogeny of proteolytic signaling and antioxidant capacity in fetal and neonatal diaphragmYong Song
Centre for Neonatal Research and Education, The University of Western Australia, Crawley 6009, Western Australia, Australia
Anat Rec (Hoboken) 295:864-71. 2012..002). The proteolytic signaling and antioxidant capacity patterns reflect the adaptive process to metabolic change and muscle maturity with development... - Variable ventilation enhances ventilation without exacerbating injury in preterm lambs with respiratory distress syndromeClare A Berry
Centre for Neonatal Research and Education, School of Women s and Infants Health, University of Western Australia, Perth, Australia
Pediatr Res 72:384-92. 2012..Conclusions:VV improves ventilation efficiency and in vivo lung compliance in the ovine preterm lung without increasing lung inflammation or lung injury... - Lung-function tests in neonates and infants with chronic lung disease: tidal breathing and respiratory controlDavid N Baldwin
Centre for Child Health Research and Telethon Institute for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
Pediatr Pulmonol 41:391-419. 2006..Clinical observations are supported by formal comparison of tidal breathing parameters and control of breathing indices in the research setting... - The management of evolving bronchopulmonary dysplasiaSven M Schulzke
School of Women s and Infants Health, The University of Western Australia, Perth, Australia
Paediatr Respir Rev 11:143-8. 2010..Several ongoing randomised trials are evaluating optimal oxygen saturation targets in preterm infants. The most beneficial respiratory support strategy to minimise lung injury remains unclear and requires further investigation... - Lung function tests in neonates and infants with chronic lung disease: lung and chest-wall mechanicsMonika Gappa
Department of Pediatric Pulmonology and Neonatology, Medizinische Hochschule Hannover, Hannover, Germany
Pediatr Pulmonol 41:291-317. 2006..New methods such as the low-frequency forced oscillation technique, which differentiate the tissue and airway components of respiratory mechanics, are likely to require further development before they can be of clinical significance... - Lung function tests in neonates and infants with chronic lung disease of infancy: functional residual capacityGeorg Hulskamp
Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Institute of Child Health and Great Ormond Street Hospital for Children National Health Service NHS Trust, London, UK
Pediatr Pulmonol 41:1-22. 2006..Although lung volume measurements in extremely preterm infants were described in a research environment, resolution of several issues is required before such investigations can be translated into routine clinical monitoring... - Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheepNoah H Hillman
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Am J Respir Crit Care Med 176:575-81. 2007..Premature infants are exposed to potentially injurious ventilation in the delivery room. Assessments of lung injury are confounded by effects of subsequent ventilatory support... - Progressive decline in plethysmographic lung volumes in infants: physiology or technology?Georg Hulskamp
Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
Am J Respir Crit Care Med 168:1003-9. 2003..These findings emphasize the need to establish reference data for lung function tests in infants that are appropriate for the equipment and protocols in current use... - An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool childrenNicole Beydon
Am J Respir Crit Care Med 175:1304-45. 2007 - Dependence of intrapulmonary pressure amplitudes on respiratory mechanics during high-frequency oscillatory ventilation in preterm lambsJ Jane Pillow
Clinical Sciences Division, Centre for Child Health Research, Subiaco, West Perth, Western Australia
Pediatr Res 52:538-44. 2002....