Affiliation: University of Queensland
Spann K, Loh Z, Lynch J, Ullah A, Zhang V, Baturcam E, et al
. IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice. Am J Pathol. 2014;184:1795-806 pubmed publisher
..In the absence of a robust type I IFN-?/? response, targeting the IPS-1 signaling pathway may limit the overexuberant inflammatory response that occurs as a consequence of viral persistence. ..
Foo S, Zhang V, Lalwani A, Lynch J, Zhuang A, Lam C, et al
. Regulatory T cells prevent inducible BALT formation by dampening neutrophilic inflammation. J Immunol. 2015;194:4567-76 pubmed publisher
Ullah M, Revez J, Loh Z, Simpson J, Zhang V, Bain L, et al
. Allergen-induced IL-6 trans-signaling activates Î³Î´ T cells to promote type 2 and type 17 airway inflammation. J Allergy Clin Immunol. 2015;136:1065-73 pubmed publisher
..Experimental asthma associated with both high IL-6 and high sIL-6R levels in the airways is attenuated by treatment with IL-6R inhibitors. ..
Lee J, Lee J, Phipps S, Noakes P, Woodruff T. Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1 G93A mouse model of amyotrophic lateral sclerosis. J Neuroinflammation. 2015;12:90 pubmed publisher
..These results suggest that enhanced glial TLR4 signalling during disease progression contributes to end-stage ALS pathology in hSOD1(G93A) mice. ..
Lynch J, Werder R, Simpson J, Loh Z, Zhang V, Haque A, et al
. Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening antiviral immunity. J Allergy Clin Immunol. 2016;138:1326-1337 pubmed publisher
Simpson J, Lynch J, Loh Z, Zhang V, Werder R, Spann K, et al
. The Absence of Interferon-β Promotor Stimulator-1 (IPS-1) Predisposes to Bronchiolitis and Asthma-like Pathology in Response to Pneumoviral Infection in Mice. Sci Rep. 2017;7:2353 pubmed publisher
..Our findings suggest that TLR7 and RLR signalling work collaboratively to optimally control the host response to pneumovirus infection thereby protecting against viral bronchiolitis and subsequent asthma. ..
Werder R, Zhang V, Lynch J, Snape N, Upham J, Spann K, et al
. Chronic IL-33 expression predisposes to virus-induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity. J Allergy Clin Immunol. 2018;141:1607-1619.e9 pubmed publisher
..The latter phenotype was replicated in rhinovirus-infected human AECs, suggesting that anti-IL-33 therapy has the additional benefit of enhancing host defense. ..