Michael P Pender

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. pmc Decreased CD8+ T cell response to Epstein-Barr virus infected B cells in multiple sclerosis is not due to decreased HLA class I expression on B cells or monocytes
    Michael P Pender
    The University of Queensland, School of Medicine, Health Sciences Building, Royal Brisbane and Women s Hospital, Queensland 4029, Australia
    BMC Neurol 11:95. 2011
  2. pmc The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosis
    Michael P Pender
    School of Medicine, The University of Queensland, Queensland, Australia
    Neuroscientist 17:351-67. 2011
  3. doi An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population
    Attila L Szvetko
    Genomics Research Centre, Griffith Institute for Health and Medical Research, School of Medical Science, Griffith University, Gold Coast Campus, PMB50 GCMC Qld 9726, Queensland, Australia
    Brain Res 1255:148-52. 2009
  4. ncbi Correlation of blood T cell and antibody reactivity to myelin proteins with HLA type and lesion localization in multiple sclerosis
    Judith M Greer
    Neuroimmunology Research Unit, School of Medicine, University of Queensland, Royal Brisbane and Women s Hospital, Herston, Brisbane, Queensland, Australia
    J Immunol 180:6402-10. 2008
  5. doi CTLA-4 single-nucleotide polymorphisms in a Caucasian population with schizophrenia
    Amanda L Jones
    The University of Queensland, UQ Centre for Clinical Research, Brisbane, QLD 4029, Australia
    Brain Behav Immun 23:347-50. 2009
  6. ncbi Immunology of multiple sclerosis
    Michael P Pender
    Neuroimmunology Research Centre, Clinical Sciences Building, Royal Brisbane and Womens Hospital, Herston, Queensland 4029, Australia
    Curr Allergy Asthma Rep 7:285-92. 2007
  7. doi Myelin proteolipid protein: an effective autoantigen and target of autoimmunity in multiple sclerosis
    Judith M Greer
    School of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia
    J Autoimmun 31:281-7. 2008
  8. doi Preventing and curing multiple sclerosis by controlling Epstein-Barr virus infection
    Michael P Pender
    School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    Autoimmun Rev 8:563-8. 2009
  9. ncbi Increased circulating T cell reactivity to GM1 ganglioside in patients with Guillain-Barré syndrome
    Peter A Csurhes
    Department of Medicine, The University of Queensland, Brisbane, Australia
    J Clin Neurosci 12:409-15. 2005
  10. ncbi Chemokines and chemokine receptors: potential therapeutic targets in multiple sclerosis
    Diane M Muller
    Neuroimmunology Research Centre, The University of Queensland, C Floor, Clinical Sciences Building, Royal Brisbane Hospital, Herston, Australia 4029
    Curr Drug Targets Inflamm Allergy 3:279-90. 2004

Collaborators

Detail Information

Publications24

  1. pmc Decreased CD8+ T cell response to Epstein-Barr virus infected B cells in multiple sclerosis is not due to decreased HLA class I expression on B cells or monocytes
    Michael P Pender
    The University of Queensland, School of Medicine, Health Sciences Building, Royal Brisbane and Women s Hospital, Queensland 4029, Australia
    BMC Neurol 11:95. 2011
    ....
  2. pmc The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosis
    Michael P Pender
    School of Medicine, The University of Queensland, Queensland, Australia
    Neuroscientist 17:351-67. 2011
    ..The hypothesis makes predictions that can be tested, including the prevention and successful treatment of MS by controlling EBV infection...
  3. doi An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population
    Attila L Szvetko
    Genomics Research Centre, Griffith Institute for Health and Medical Research, School of Medical Science, Griffith University, Gold Coast Campus, PMB50 GCMC Qld 9726, Queensland, Australia
    Brain Res 1255:148-52. 2009
    ....
  4. ncbi Correlation of blood T cell and antibody reactivity to myelin proteins with HLA type and lesion localization in multiple sclerosis
    Judith M Greer
    Neuroimmunology Research Unit, School of Medicine, University of Queensland, Royal Brisbane and Women s Hospital, Herston, Brisbane, Queensland, Australia
    J Immunol 180:6402-10. 2008
    ..These findings show that circulating T cells and Abs reactive against specific myelin Ags can correlate with lesion distribution in MS and suggest that they are of pathogenic relevance...
  5. doi CTLA-4 single-nucleotide polymorphisms in a Caucasian population with schizophrenia
    Amanda L Jones
    The University of Queensland, UQ Centre for Clinical Research, Brisbane, QLD 4029, Australia
    Brain Behav Immun 23:347-50. 2009
    ..These results suggest a role for the 3' UTR SNP and/or variants in high linkage disequilibrium with this SNP in the pathogenesis of schizophrenia...
  6. ncbi Immunology of multiple sclerosis
    Michael P Pender
    Neuroimmunology Research Centre, Clinical Sciences Building, Royal Brisbane and Womens Hospital, Herston, Queensland 4029, Australia
    Curr Allergy Asthma Rep 7:285-92. 2007
    ....
  7. doi Myelin proteolipid protein: an effective autoantigen and target of autoimmunity in multiple sclerosis
    Judith M Greer
    School of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia
    J Autoimmun 31:281-7. 2008
    ....
  8. doi Preventing and curing multiple sclerosis by controlling Epstein-Barr virus infection
    Michael P Pender
    School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    Autoimmun Rev 8:563-8. 2009
    ..Thus it is proposed that vaccination against EBV will prevent MS, and that effective antiviral drugs will inhibit disease progression in people with MS and potentially be curative...
  9. ncbi Increased circulating T cell reactivity to GM1 ganglioside in patients with Guillain-Barré syndrome
    Peter A Csurhes
    Department of Medicine, The University of Queensland, Brisbane, Australia
    J Clin Neurosci 12:409-15. 2005
    ..We suggest that T cell reactivity to gangliosides might play a contributory role in the pathogenesis of GBS and perhaps CIDP...
  10. ncbi Chemokines and chemokine receptors: potential therapeutic targets in multiple sclerosis
    Diane M Muller
    Neuroimmunology Research Centre, The University of Queensland, C Floor, Clinical Sciences Building, Royal Brisbane Hospital, Herston, Australia 4029
    Curr Drug Targets Inflamm Allergy 3:279-90. 2004
    ....
  11. ncbi Infection of autoreactive B lymphocytes with EBV, causing chronic autoimmune diseases
    Michael P Pender
    Department of Medicine, The University of Queensland, Clinical Sciences Building, Royal Brisbane Hospital, 4029, Herston, Queensland, Australia
    Trends Immunol 24:584-8. 2003
    ..The autoreactive T cells proliferate and produce cytokines, which recruit other inflammatory cells, with resultant target organ damage and chronic autoimmune disease...
  12. doi CD8+ T cells far predominate over CD4+ T cells in healthy immune response to Epstein-Barr virus infected lymphoblastoid cell lines
    Michael P Pender
    The University of Queensland, School of Medicine and Department of Neurology, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Blood 120:5085-7. 2012
  13. pmc Interleukin-6 gene promoter-572 C allele may play a role in rate of disease progression in multiple sclerosis
    Jun Yan
    The University of Queensland, Centre for Clinical Research, Royal Brisbane and Women s Hospital, 4029 Brisbane, Australia
    Int J Mol Sci 13:13667-79. 2012
    ..Interestingly, however, the -572 C allele showed a significant correlation with the MS severity score, suggesting a possible role in disease progression...
  14. ncbi Treating autoimmune demyelination by augmenting lymphocyte apoptosis in the central nervous system
    Michael P Pender
    Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Australia
    J Neuroimmunol 191:26-38. 2007
    ..In the case of T cells, apoptosis can be augmented by enhancing activation-induced T-cell apoptosis through the CD95 (Fas) pathway and by inhibiting costimulation-induced anti-apoptotic pathways mediated through BCL-2 and BCL-X L...
  15. ncbi Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis?
    Amanda L Jones
    Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Brisbane, Australia
    Immunol Cell Biol 83:9-17. 2005
    ..Recent findings regarding specific autoimmune responses directed against neurotransmitter receptors in the brain in patients with schizophrenia will also be reviewed...
  16. ncbi Restricted diffusion on MR imaging of an acute cerebral lesion
    Jeyaraj D Pandian
    Department of Neurology, Royal Briabane and Women s Hospital, Herston Road, Brisbane, Queensland, Australia
    J Clin Neurosci 15:456, 487. 2008
  17. ncbi Increased circulating T cell reactivity to GM3 and GQ1b gangliosides in primary progressive multiple sclerosis
    Michael P Pender
    Department of Medicine, The University of Queensland, Queensland, Australia
    J Clin Neurosci 10:63-6. 2003
    ..These findings suggest that ganglioside-specific T cells may contribute to the axonal damage in primary progressive MS...
  18. doi Adherence to MRI protocol consensus guidelines in multiple sclerosis: an Australian multi-centre study
    Michael Curley
    Department of Medical Imaging, Royal Brisbane and Women s Hospital, Australia
    J Med Imaging Radiat Oncol 56:594-8. 2012
    ....
  19. ncbi The pathogenesis of primary progressive multiple sclerosis: antibody-mediated attack and no repair?
    Michael P Pender
    School of Medicine, Neuroimmunology Research Centre, The University of Queensland, Australia
    J Clin Neurosci 11:689-92. 2004
    ..Inhibition of autoantibody production by inducing B-cell apoptosis with rituximab is a potential new therapy for primary progressive MS...
  20. ncbi Multiple sclerosis with idiopathic dilated cardiomyopathy: a case report
    Annabelle N Sellbach
    Department of Neurology, Royal Brisbane and Women s Hospital, Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Herston, Australia
    Eur Neurol 53:214-5. 2005
  21. ncbi Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population
    Lotti Tajouri
    Genomics Research Centre, School of Health Science, Griffith University Gold Coast, Southport, Queensland, Australia
    J Neurogenet 19:25-38. 2005
    ..Our results support a role for the VDR gene increasing the risk of developing multiple sclerosis, particularly the progressive clinical subtypes of MS...
  22. ncbi Lower motor neuron weakness after diving-related decompression
    Robert D Henderson
    Department of Neurology, Royal Brisbane and Women s Hospital, School of Medicine, University of Queensland, Australia
    Neurology 66:451-2. 2006
  23. ncbi Effect of gender on T-cell proliferative responses to myelin proteolipid protein antigens in patients with multiple sclerosis and controls
    Judith M Greer
    Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Australia
    J Autoimmun 22:345-52. 2004
    ..We suggest that this may be relevant to the higher prevalence of MS in women...
  24. ncbi Blood-brain barrier disruption and lesion localisation in experimental autoimmune encephalomyelitis with predominant cerebellar and brainstem involvement
    Diane M Muller
    Neuroimmunology Research Centre, The University of Queensland, Clinical Sciences Building, Royal Brisbane and Women s Hospital, Herston, Brisbane Q4029, Australia
    J Neuroimmunol 160:162-9. 2005
    ..Irrespective of the clinical type, the BBB was disrupted in the cerebellum and brainstem. Pertussis toxin had no effect on lesion distribution. Thus, lesion distribution is not influenced solely by BBB permeability...