Research Topics
Species | Michael P PenderSummaryAffiliation: University of Queensland Country: Australia Publications
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Detail Information
Publications
Decreased CD8+ T cell response to Epstein-Barr virus infected B cells in multiple sclerosis is not due to decreased HLA class I expression on B cells or monocytesMichael P Pender
The University of Queensland, School of Medicine, Health Sciences Building, Royal Brisbane and Women s Hospital, Queensland 4029, Australia
BMC Neurol 11:95. 2011....
The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosisMichael P Pender
School of Medicine, The University of Queensland, Queensland, Australia
Neuroscientist 17:351-67. 2011..The hypothesis makes predictions that can be tested, including the prevention and successful treatment of MS by controlling EBV infection...- An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian populationAttila L Szvetko
Genomics Research Centre, Griffith Institute for Health and Medical Research, School of Medical Science, Griffith University, Gold Coast Campus, PMB50 GCMC Qld 9726, Queensland, Australia
Brain Res 1255:148-52. 2009.... 
Correlation of blood T cell and antibody reactivity to myelin proteins with HLA type and lesion localization in multiple sclerosisJudith M Greer
Neuroimmunology Research Unit, School of Medicine, University of Queensland, Royal Brisbane and Women s Hospital, Herston, Brisbane, Queensland, Australia
J Immunol 180:6402-10. 2008..These findings show that circulating T cells and Abs reactive against specific myelin Ags can correlate with lesion distribution in MS and suggest that they are of pathogenic relevance...- CTLA-4 single-nucleotide polymorphisms in a Caucasian population with schizophreniaAmanda L Jones
The University of Queensland, UQ Centre for Clinical Research, Brisbane, QLD 4029, Australia
Brain Behav Immun 23:347-50. 2009..These results suggest a role for the 3' UTR SNP and/or variants in high linkage disequilibrium with this SNP in the pathogenesis of schizophrenia... - Immunology of multiple sclerosisMichael P Pender
Neuroimmunology Research Centre, Clinical Sciences Building, Royal Brisbane and Womens Hospital, Herston, Queensland 4029, Australia
Curr Allergy Asthma Rep 7:285-92. 2007.... - Myelin proteolipid protein: an effective autoantigen and target of autoimmunity in multiple sclerosisJudith M Greer
School of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia
J Autoimmun 31:281-7. 2008.... - Preventing and curing multiple sclerosis by controlling Epstein-Barr virus infectionMichael P Pender
School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
Autoimmun Rev 8:563-8. 2009..Thus it is proposed that vaccination against EBV will prevent MS, and that effective antiviral drugs will inhibit disease progression in people with MS and potentially be curative... - Increased circulating T cell reactivity to GM1 ganglioside in patients with Guillain-Barré syndromePeter A Csurhes
Department of Medicine, The University of Queensland, Brisbane, Australia
J Clin Neurosci 12:409-15. 2005..We suggest that T cell reactivity to gangliosides might play a contributory role in the pathogenesis of GBS and perhaps CIDP... - Chemokines and chemokine receptors: potential therapeutic targets in multiple sclerosisDiane M Muller
Neuroimmunology Research Centre, The University of Queensland, C Floor, Clinical Sciences Building, Royal Brisbane Hospital, Herston, Australia 4029
Curr Drug Targets Inflamm Allergy 3:279-90. 2004.... - Infection of autoreactive B lymphocytes with EBV, causing chronic autoimmune diseasesMichael P Pender
Department of Medicine, The University of Queensland, Clinical Sciences Building, Royal Brisbane Hospital, 4029, Herston, Queensland, Australia
Trends Immunol 24:584-8. 2003..The autoreactive T cells proliferate and produce cytokines, which recruit other inflammatory cells, with resultant target organ damage and chronic autoimmune disease... - CD8+ T cells far predominate over CD4+ T cells in healthy immune response to Epstein-Barr virus infected lymphoblastoid cell linesMichael P Pender
The University of Queensland, School of Medicine and Department of Neurology, Royal Brisbane and Women s Hospital, Brisbane, Australia
Blood 120:5085-7. 2012 - Interleukin-6 gene promoter-572 C allele may play a role in rate of disease progression in multiple sclerosisJun Yan
The University of Queensland, Centre for Clinical Research, Royal Brisbane and Women s Hospital, 4029 Brisbane, Australia
Int J Mol Sci 13:13667-79. 2012..Interestingly, however, the -572 C allele showed a significant correlation with the MS severity score, suggesting a possible role in disease progression... - Treating autoimmune demyelination by augmenting lymphocyte apoptosis in the central nervous systemMichael P Pender
Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Australia
J Neuroimmunol 191:26-38. 2007..In the case of T cells, apoptosis can be augmented by enhancing activation-induced T-cell apoptosis through the CD95 (Fas) pathway and by inhibiting costimulation-induced anti-apoptotic pathways mediated through BCL-2 and BCL-X L... - Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis?Amanda L Jones
Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Brisbane, Australia
Immunol Cell Biol 83:9-17. 2005..Recent findings regarding specific autoimmune responses directed against neurotransmitter receptors in the brain in patients with schizophrenia will also be reviewed... - Restricted diffusion on MR imaging of an acute cerebral lesionJeyaraj D Pandian
Department of Neurology, Royal Briabane and Women's Hospital, Herston Road, Brisbane, Queensland, Australia
J Clin Neurosci 15:456, 487. 2008 - Increased circulating T cell reactivity to GM3 and GQ1b gangliosides in primary progressive multiple sclerosisMichael P Pender
Department of Medicine, The University of Queensland, Queensland, Australia
J Clin Neurosci 10:63-6. 2003..These findings suggest that ganglioside-specific T cells may contribute to the axonal damage in primary progressive MS... - The pathogenesis of primary progressive multiple sclerosis: antibody-mediated attack and no repair?Michael P Pender
School of Medicine, Neuroimmunology Research Centre, The University of Queensland, Australia
J Clin Neurosci 11:689-92. 2004..Inhibition of autoantibody production by inducing B-cell apoptosis with rituximab is a potential new therapy for primary progressive MS... - Multiple sclerosis with idiopathic dilated cardiomyopathy: a case reportAnnabelle N Sellbach
Department of Neurology, Royal Brisbane and Women's Hospital, Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Herston, Australia
Eur Neurol 53:214-5. 2005 - Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian populationLotti Tajouri
Genomics Research Centre, School of Health Science, Griffith University Gold Coast, Southport, Queensland, Australia
J Neurogenet 19:25-38. 2005..Our results support a role for the VDR gene increasing the risk of developing multiple sclerosis, particularly the progressive clinical subtypes of MS... - Effect of gender on T-cell proliferative responses to myelin proteolipid protein antigens in patients with multiple sclerosis and controlsJudith M Greer
Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Australia
J Autoimmun 22:345-52. 2004..We suggest that this may be relevant to the higher prevalence of MS in women... - Lower motor neuron weakness after diving-related decompressionRobert D Henderson
Department of Neurology, Royal Brisbane and Women's Hospital, School of Medicine, University of Queensland, Australia
Neurology 66:451-2. 2006 - Blood-brain barrier disruption and lesion localisation in experimental autoimmune encephalomyelitis with predominant cerebellar and brainstem involvementDiane M Muller
Neuroimmunology Research Centre, The University of Queensland, Clinical Sciences Building, Royal Brisbane and Women's Hospital, Herston, Brisbane Q4029, Australia
J Neuroimmunol 160:162-9. 2005..Irrespective of the clinical type, the BBB was disrupted in the cerebellum and brainstem. Pertussis toxin had no effect on lesion distribution. Thus, lesion distribution is not influenced solely by BBB permeability...