Michael P Pender

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi request reprint Immunology of multiple sclerosis
    Michael P Pender
    Neuroimmunology Research Centre, Clinical Sciences Building, Royal Brisbane and Womens Hospital, Herston, Queensland 4029, Australia
    Curr Allergy Asthma Rep 7:285-92. 2007
  2. ncbi request reprint Treating autoimmune demyelination by augmenting lymphocyte apoptosis in the central nervous system
    Michael P Pender
    Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Australia
    J Neuroimmunol 191:26-38. 2007
  3. ncbi request reprint Dysarthria and dysphagia due to the opercular syndrome in multiple sclerosis
    M P Pender
    Department of Neurology, Royal Brisbane and Women s Hospital, Herston, Queensland 4029, Australia
    Mult Scler 13:817-9. 2007
  4. pmc Decreased T cell reactivity to Epstein-Barr virus infected lymphoblastoid cell lines in multiple sclerosis
    M P Pender
    University of Queensland, School of Medicine, Royal Brisbane and Women s Hospital, Queensland, Australia
    J Neurol Neurosurg Psychiatry 80:498-505. 2009
  5. doi request reprint Preventing and curing multiple sclerosis by controlling Epstein-Barr virus infection
    Michael P Pender
    School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    Autoimmun Rev 8:563-8. 2009
  6. ncbi request reprint The pathogenesis of primary progressive multiple sclerosis: antibody-mediated attack and no repair?
    Michael P Pender
    School of Medicine, Neuroimmunology Research Centre, The University of Queensland, Australia
    J Clin Neurosci 11:689-92. 2004
  7. doi request reprint An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population
    Attila L Szvetko
    Genomics Research Centre, Griffith Institute for Health and Medical Research, School of Medical Science, Griffith University, Gold Coast Campus, PMB50 GCMC Qld 9726, Queensland, Australia
    Brain Res 1255:148-52. 2009
  8. doi request reprint CTLA-4 single-nucleotide polymorphisms in a Caucasian population with schizophrenia
    Amanda L Jones
    The University of Queensland, UQ Centre for Clinical Research, Brisbane, QLD 4029, Australia
    Brain Behav Immun 23:347-50. 2009
  9. ncbi request reprint Correlation of blood T cell and antibody reactivity to myelin proteins with HLA type and lesion localization in multiple sclerosis
    Judith M Greer
    Neuroimmunology Research Unit, School of Medicine, University of Queensland, Royal Brisbane and Women s Hospital, Herston, Brisbane, Queensland, Australia
    J Immunol 180:6402-10. 2008
  10. ncbi request reprint Effect of gender on T-cell proliferative responses to myelin proteolipid protein antigens in patients with multiple sclerosis and controls
    Judith M Greer
    Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Australia
    J Autoimmun 22:345-52. 2004

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Immunology of multiple sclerosis
    Michael P Pender
    Neuroimmunology Research Centre, Clinical Sciences Building, Royal Brisbane and Womens Hospital, Herston, Queensland 4029, Australia
    Curr Allergy Asthma Rep 7:285-92. 2007
    ....
  2. ncbi request reprint Treating autoimmune demyelination by augmenting lymphocyte apoptosis in the central nervous system
    Michael P Pender
    Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Australia
    J Neuroimmunol 191:26-38. 2007
    ..In the case of T cells, apoptosis can be augmented by enhancing activation-induced T-cell apoptosis through the CD95 (Fas) pathway and by inhibiting costimulation-induced anti-apoptotic pathways mediated through BCL-2 and BCL-X L...
  3. ncbi request reprint Dysarthria and dysphagia due to the opercular syndrome in multiple sclerosis
    M P Pender
    Department of Neurology, Royal Brisbane and Women s Hospital, Herston, Queensland 4029, Australia
    Mult Scler 13:817-9. 2007
    ..This was caused by a recent inflammatory demyelinating lesion in the right perisylvian juxtacortical region, superimposed on a pre-existing left perisylvian lesion, which had previously caused temporary isolated right tongue weakness...
  4. pmc Decreased T cell reactivity to Epstein-Barr virus infected lymphoblastoid cell lines in multiple sclerosis
    M P Pender
    University of Queensland, School of Medicine, Royal Brisbane and Women s Hospital, Queensland, Australia
    J Neurol Neurosurg Psychiatry 80:498-505. 2009
    ..To investigate T cell and antibody immunity to Epstein-Barr virus (EBV) in multiple sclerosis (MS)...
  5. doi request reprint Preventing and curing multiple sclerosis by controlling Epstein-Barr virus infection
    Michael P Pender
    School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    Autoimmun Rev 8:563-8. 2009
    ..Thus it is proposed that vaccination against EBV will prevent MS, and that effective antiviral drugs will inhibit disease progression in people with MS and potentially be curative...
  6. ncbi request reprint The pathogenesis of primary progressive multiple sclerosis: antibody-mediated attack and no repair?
    Michael P Pender
    School of Medicine, Neuroimmunology Research Centre, The University of Queensland, Australia
    J Clin Neurosci 11:689-92. 2004
    ..Inhibition of autoantibody production by inducing B-cell apoptosis with rituximab is a potential new therapy for primary progressive MS...
  7. doi request reprint An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population
    Attila L Szvetko
    Genomics Research Centre, Griffith Institute for Health and Medical Research, School of Medical Science, Griffith University, Gold Coast Campus, PMB50 GCMC Qld 9726, Queensland, Australia
    Brain Res 1255:148-52. 2009
    ....
  8. doi request reprint CTLA-4 single-nucleotide polymorphisms in a Caucasian population with schizophrenia
    Amanda L Jones
    The University of Queensland, UQ Centre for Clinical Research, Brisbane, QLD 4029, Australia
    Brain Behav Immun 23:347-50. 2009
    ..These results suggest a role for the 3' UTR SNP and/or variants in high linkage disequilibrium with this SNP in the pathogenesis of schizophrenia...
  9. ncbi request reprint Correlation of blood T cell and antibody reactivity to myelin proteins with HLA type and lesion localization in multiple sclerosis
    Judith M Greer
    Neuroimmunology Research Unit, School of Medicine, University of Queensland, Royal Brisbane and Women s Hospital, Herston, Brisbane, Queensland, Australia
    J Immunol 180:6402-10. 2008
    ..These findings show that circulating T cells and Abs reactive against specific myelin Ags can correlate with lesion distribution in MS and suggest that they are of pathogenic relevance...
  10. ncbi request reprint Effect of gender on T-cell proliferative responses to myelin proteolipid protein antigens in patients with multiple sclerosis and controls
    Judith M Greer
    Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Australia
    J Autoimmun 22:345-52. 2004
    ..We suggest that this may be relevant to the higher prevalence of MS in women...
  11. ncbi request reprint Infection of autoreactive B lymphocytes with EBV, causing chronic autoimmune diseases
    Michael P Pender
    Department of Medicine, The University of Queensland, Clinical Sciences Building, Royal Brisbane Hospital, 4029, Herston, Queensland, Australia
    Trends Immunol 24:584-8. 2003
    ..The autoreactive T cells proliferate and produce cytokines, which recruit other inflammatory cells, with resultant target organ damage and chronic autoimmune disease...
  12. doi request reprint Myelin proteolipid protein: an effective autoantigen and target of autoimmunity in multiple sclerosis
    Judith M Greer
    School of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia
    J Autoimmun 31:281-7. 2008
    ....
  13. ncbi request reprint Increased circulating T cell reactivity to GM1 ganglioside in patients with Guillain-Barré syndrome
    Peter A Csurhes
    Department of Medicine, The University of Queensland, Brisbane, Australia
    J Clin Neurosci 12:409-15. 2005
    ..We suggest that T cell reactivity to gangliosides might play a contributory role in the pathogenesis of GBS and perhaps CIDP...
  14. ncbi request reprint Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis?
    Amanda L Jones
    Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Brisbane, Australia
    Immunol Cell Biol 83:9-17. 2005
    ..Recent findings regarding specific autoimmune responses directed against neurotransmitter receptors in the brain in patients with schizophrenia will also be reviewed...
  15. pmc Decreased CD8+ T cell response to Epstein-Barr virus infected B cells in multiple sclerosis is not due to decreased HLA class I expression on B cells or monocytes
    Michael P Pender
    The University of Queensland, School of Medicine, Health Sciences Building, Royal Brisbane and Women s Hospital, Queensland 4029, Australia
    BMC Neurol 11:95. 2011
    ....
  16. ncbi request reprint Increased circulating T cell reactivity to GM3 and GQ1b gangliosides in primary progressive multiple sclerosis
    Michael P Pender
    Department of Medicine, The University of Queensland, Queensland, Australia
    J Clin Neurosci 10:63-6. 2003
    ..These findings suggest that ganglioside-specific T cells may contribute to the axonal damage in primary progressive MS...
  17. doi request reprint CD8+ T cells far predominate over CD4+ T cells in healthy immune response to Epstein-Barr virus infected lymphoblastoid cell lines
    Michael P Pender
    The University of Queensland, School of Medicine and Department of Neurology, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Blood 120:5085-7. 2012
  18. pmc Interleukin-6 gene promoter-572 C allele may play a role in rate of disease progression in multiple sclerosis
    Jun Yan
    The University of Queensland, Centre for Clinical Research, Royal Brisbane and Women s Hospital, 4029 Brisbane, Australia
    Int J Mol Sci 13:13667-79. 2012
    ..Interestingly, however, the -572 C allele showed a significant correlation with the MS severity score, suggesting a possible role in disease progression...
  19. pmc The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosis
    Michael P Pender
    School of Medicine, The University of Queensland, Queensland, Australia
    Neuroscientist 17:351-67. 2011
    ..The hypothesis makes predictions that can be tested, including the prevention and successful treatment of MS by controlling EBV infection...
  20. ncbi request reprint T-cell apoptosis in human glioblastoma multiforme: implications for immunotherapy
    David G Walker
    Department of Neurosurgery, Royal Brisbane and Women s Hospital, c Post Office RBH, Herston, Q4029 Australia
    J Neuroimmunol 175:59-68. 2006
    ..Our results have implications for the design of immunotherapies for GBM...
  21. ncbi request reprint Chemokines and chemokine receptors: potential therapeutic targets in multiple sclerosis
    Diane M Muller
    Neuroimmunology Research Centre, The University of Queensland, C Floor, Clinical Sciences Building, Royal Brisbane Hospital, Herston, Australia 4029
    Curr Drug Targets Inflamm Allergy 3:279-90. 2004
    ....
  22. ncbi request reprint Blood-brain barrier disruption and lesion localisation in experimental autoimmune encephalomyelitis with predominant cerebellar and brainstem involvement
    Diane M Muller
    Neuroimmunology Research Centre, The University of Queensland, Clinical Sciences Building, Royal Brisbane and Women s Hospital, Herston, Brisbane Q4029, Australia
    J Neuroimmunol 160:162-9. 2005
    ..Irrespective of the clinical type, the BBB was disrupted in the cerebellum and brainstem. Pertussis toxin had no effect on lesion distribution. Thus, lesion distribution is not influenced solely by BBB permeability...
  23. ncbi request reprint Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population
    Lotti Tajouri
    Genomics Research Centre, School of Health Science, Griffith University Gold Coast, Southport, Queensland, Australia
    J Neurogenet 19:25-38. 2005
    ..Our results support a role for the VDR gene increasing the risk of developing multiple sclerosis, particularly the progressive clinical subtypes of MS...
  24. ncbi request reprint Restricted diffusion on MR imaging of an acute cerebral lesion
    Jeyaraj D Pandian
    Department of Neurology, Royal Briabane and Women s Hospital, Herston Road, Brisbane, Queensland, Australia
    J Clin Neurosci 15:456, 487. 2008
  25. ncbi request reprint Multiple sclerosis with idiopathic dilated cardiomyopathy: a case report
    Annabelle N Sellbach
    Department of Neurology, Royal Brisbane and Women s Hospital, Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Herston, Australia
    Eur Neurol 53:214-5. 2005
  26. ncbi request reprint Lower motor neuron weakness after diving-related decompression
    Robert D Henderson
    Department of Neurology, Royal Brisbane and Women s Hospital, School of Medicine, University of Queensland, Australia
    Neurology 66:451-2. 2006
  27. ncbi request reprint Investigation of an inducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population
    Lotti Tajouri
    Genomics Research Centre, School of Health Science, Griffith University Gold Coast, Southport, QLD 4215, Australia
    Brain Res Bull 64:9-13. 2004
    ..4, P(genotype) = 0.15; chi(2) = 3.4, P(allele) = 0.082) and for each subtype of MS (P > 0.05). This suggests that there is no direct association of this iNOS gene variant with MS susceptibility...
  28. ncbi request reprint Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis
    Lotti Tajouri
    Genomics Research Centre, School of Medical Science, Griffith University Gold Coast, Southport, QLD 4215, Australia
    Brain Res Bull 69:327-31. 2006
    ..15 and P=0.32, respectively). Hence, results from the present study do not support a major role for either functional gene mutation in MS susceptibility...
  29. ncbi request reprint Oligodendrocyte apoptosis before immune attack in multiple sclerosis?
    Michael P Pender
    Ann Neurol 57:158; author reply 158-9. 2005
  30. ncbi request reprint CSF testing for multiple sclerosis
    Michael P Pender
    Lancet Neurol 4:522-3. 2005
  31. ncbi request reprint Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population
    Lotti Tajouri
    Genomics Research Centre, School of Health Science, Griffith University Gold Coast, Southport, Queensland, 4215 Australia
    J Neurol Sci 218:25-8. 2004
    ..05). Statistical analysis indicated that there is no association of this nNOS variant and MS and hence the gene does not appear to play a genetically significant role in disease susceptibility...
  32. ncbi request reprint Allelic variation investigation of the estrogen receptor within an Australian multiple sclerosis population
    Lotti Tajouri
    Genomics Research Centre, School of Health Science, Griffith University Gold Coast, Southport, Queensland 4215, Australia
    J Neurol Sci 252:9-12. 2007
    ..50) and Btg1 (P = 0.45) marker. Our results do not support a role for these two ESR1 markers in multiple sclerosis susceptibility, however other markers within ESR1 should not be excluded for potential involvement in the disorder...