Research Topics
Species | C PantelisSummaryAffiliation: University of Melbourne Country: Australia Publications
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Publications
Spatial working memory deficits in schizophrenia: relationship with tardive dyskinesia and negative symptomsC Pantelis
Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, University of Melbourne, Sunshine Hospital, St Albans, Victoria 3021, Australia
Am J Psychiatry 158:1276-85. 2001..This study examined the interrelationship between negative symptoms, orofacial tardive dyskinesia, and specific neurocognitive processes, particularly those involved in memory and executive function, in patients with schizophrenia...- Neuroimaging and emerging psychotic disorders: the Melbourne ultra-high risk studiesC Pantelis
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Sunshine Hospital, 176 Furlong Road, St Albans, Victoria 3021, Australia
Int Rev Psychiatry 19:371-81. 2007..Further, active changes during transition to illness may present the potential to intervene and ameliorate these changes with potential benefit clinically... - Relationship of behavioural and symptomatic syndromes in schizophrenia to spatial working memory and attentional set-shifting abilityC Pantelis
Melbourne Neuropsychiatry Centre, The University of Melbourne, Parkville and Sunshine Hospital, St Albans, Victoria, Australia
Psychol Med 34:693-703. 2004..Few studies have assessed their relationship with neuropsychological deficits. We hypothesized that these syndromes may represent behavioural manifestations of frontal-subcortical impairments, previously described in schizophrenia... 
Attentional set-shifting ability in first-episode and established schizophrenia: Relationship to working memoryChristos Pantelis
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Sunshine Hospital, St Albans, Victoria 3021, Australia
Schizophr Res 112:104-13. 2009..Longitudinal studies assessing these cognitive functions from illness onset or in prepsychotic individuals are required...- Early and late neurodevelopmental disturbances in schizophrenia and their functional consequencesChristos Pantelis
Cognitive Neuropsychiatry Research and Academic Unit, Sunshine Hospital, 176 Furlong Road, St Albans, 3021, Victoria, Australia
Aust N Z J Psychiatry 37:399-406. 2003..In this paper we review the timing of structural changes in schizophrenia and argue that schizophrenia is a neuro-developmental disorder with limited progressive brain changes occurring during the evolution and early phase of psychosis... - Managing patients with "treatment-resistant" schizophreniaChristos Pantelis
Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, University of Melbourne at Sunshine Hospital, St Albans, Vic
Med J Aust 178:S62-6. 2003..Although pharmacological treatment is a necessary first step in managing incompletely recovered patients, adjunctive psychosocial interventions are needed to optimise treatment success... - Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparisonChristos Pantelis
Cognitive Neuropsychiatry Research and Academic Unit, and Melbourne Neuropsychiatry Centre, Mental Health Programme, Department of Psychiatry, University of Melbourne and Sunshine Hospital, Victoria, Melbourne, Australia
Lancet 361:281-8. 2003..We investigated this issue with MRI to study people with prodromal symptoms who are at ultra high-risk for the development of psychosis... - Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophreniaChristos Pantelis
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Sunshine Hospital, Victoria
Schizophr Bull 31:672-96. 2005.... - The cognitive neuropsychiatric approach to investigating the neurobiology of schizophrenia and other disordersChristos Pantelis
Cognitive Neuropsychiatry Research and Academic Unit, Sunshine Hospital, 176 Furlong Road, St Albans, VIC 3021, Australia
J Psychosom Res 53:655-64. 2002..Further, an assessment of the brain-behaviour relationships through this emerging discipline provides testable models for further study, using a range of techniques including functional and other imaging techniques... - Characterizing anterior cingulate activation in chronic schizophrenia: a group and single-subject fMRI studyB J Harrison
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia
Acta Psychiatr Scand 116:271-9. 2007..In this study, we sought to further evaluate the notion of dAC hypofunction in chronic schizophrenia patients using a cognitive task specifically designed to activate this region, enabling both group and single-subject level analyses... - Spatial working memory ability is a marker of risk-for-psychosisS J Wood
Cognitive Neuropsychiatry Research and Academic Unit, PACE Clinic, Department of Psychiatry, University of Melbourne, Sunshine Hospital, St Albans, Vic, Australia
Psychol Med 33:1239-47. 2003..02). CONCLUSIONS: Spatial working memory abilities are impaired in those at high-risk for psychosis. The relationship between working memory and negative symptoms may be useful as a predictive tool... - Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individualsStephen J Wood
Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Australia
Schizophr Bull 29:831-43. 2003..This finding did not discriminate between those UHR individuals who later became psychotic and those who did not... - A longitudinal study of hippocampal volume in first episode psychosis and chronic schizophreniaS J Wood
The Cognitive Neuropsychiatry Research and Academic Unit, The University of Melbourne and Sunshine Hospital, Melbourne, Australia
Schizophr Res 52:37-46. 2001..Alternatively, the period before the onset of frank psychotic symptoms may be the point of greatest risk for progressive change... - Progressive gray matter reduction of the superior temporal gyrus during transition to psychosisTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
Arch Gen Psychiatry 66:366-76. 2009..It is unknown whether these progressive processes predate the onset of psychosis... - Neurocognitive predictors of functional outcome two to 13 years after identification as ultra-high risk for psychosisA Lin
Orygen Youth Health Research Centre and Centre for Youth Mental Health, University of Melbourne, Australia
Schizophr Res 132:1-7. 2011..This longitudinal study aimed to investigate neurocognitive predictors of poor functional outcome in a group identified as ultra-high risk (UHR) for psychosis between two and 13 years prior... - Stability of olfactory identification deficits in neuroleptic-naive patients with first-episode psychosisW J Brewer
Cognitive Neuropsychiatry Research, University of Melbourne, Parkville, Melbourne, Australia
Am J Psychiatry 158:107-15. 2001..Olfactory identification deficits and their relationship to negative symptoms in patients with schizophrenia were examined in patients with recent-onset psychosis, the majority of whom were neuroleptic naive... - Anterior cingulate activation during Stroop task performance: a PET to MRI coregistration study of individual patients with schizophreniaMurat Yucel
Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, Howard Florey Institute, University of Melbourne, Victoria, Australia
Am J Psychiatry 159:251-4. 2002.... - Meta-analysis of volumetric abnormalities in cortico-striatal-pallidal-thalamic circuits in major depressive disorderE Bora
Department of Psychiatry, The University of Melbourne and Melbourne Health, Vic, Australia
Psychol Med 42:671-81. 2012..However, the robustness of these findings across studies is unclear, as is the extent to which they are influenced by demographic, clinical and pharmacological factors... - Visuospatial memory and learning in first-episode schizophreniform psychosis and established schizophrenia: a functional correlate of hippocampal pathology?S J Wood
Cognitive Neuropsychiatry Research and Academic Unit, University of Melbourne, Sunshine Hospital, St Albans, Victoria, Australia
Psychol Med 32:429-38. 2002..Given the reported findings of reduced hippocampal volume in schizophrenia, we used a theoretically sensitive test of the right medial temporal lobe to determine the nature of the visuospatial memory deficit in the disorder... - Selective bilateral hippocampal volume loss in chronic schizophreniaD Velakoulis
Applied Schizophrenia Division, Mental Health Research Institute of Victoria, Melbourne, Australia
Biol Psychiatry 50:531-9. 2001..Group discrimination on the basis of hippocampal volume and shape measures was moderately good. A full three-dimensional analysis of hippocampal shape, based on large samples, would be a useful extension of the study... - Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individualsDennis Velakoulis
Melbourne Neuropsychiatry Centre and Department of Psychiatry, University of Melbourne, Australia
Arch Gen Psychiatry 63:139-49. 2006..These studies have been limited by small samples and the absence of patients early in the course of illness... - Dysfunction of dorsolateral prefrontal cortex in antipsychotic-naïve schizophreniform psychosisBen J Harrison
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Australia
Psychiatry Res 148:23-31. 2006.... - Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disordersTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Schizophr Res 105:236-44. 2008..These findings suggest that the CSP is not a neurodevelopmental marker of psychosis and cast doubt over the notion that it plays a major role in the neurobiology of psychosis... - A disturbed sense of self in the psychosis prodrome: linking phenomenology and neurobiologyB Nelson
Orygen Youth Health Research Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
Neurosci Biobehav Rev 33:807-17. 2009..Further empirical work examining the relationship between neurobiological and phenomenological variables may be of value in identifying risk markers for psychosis onset... - Evidence for progression of brain structural abnormalities in schizophrenia: beyond the neurodevelopmental modelD Velakoulis
Cognitive Neuropsychiatry Research and Academic Unit, University of Melbourne and Sunshine Hospital, St Albans, Victoria, Australia
Aust N Z J Psychiatry 34:S113-26. 2000.... - Comparison of set-shifting ability in patients with chronic schizophrenia and frontal lobe damageC Pantelis
Department of Psychiatry, The University of Melbourne, Parkville, Australia
Schizophr Res 37:251-70. 1999..The relevance of these findings to understanding the nature of prefrontal cortical deficits in chronic schizophrenia is discussed. The implication of these findings to the rehabilitation of these patients is considered... - Major psychoses with mixed psychotic and mood symptoms: are mixed psychoses associated with different neurobiological markers?E Bora
Department of Psychiatry, Melbourne Neuropsychiatry Centre, and Melbourne Health, ORYGEN Research Centre, The University of Melbourne, Melbourne, Vic, Australia
Acta Psychiatr Scand 118:172-87. 2008..As controversies mainly arise in mixed psychoses that occupy the intermediate zone between schizophrenia and BD, investigating neurobiological markers of mixed psychoses may be relevant to understanding the nature of psychotic disorders... - Neuropsychological deficits in obsessive-compulsive disorder: a comparison with unipolar depression, panic disorder, and normal controlsR Purcell
Department of Psychology, The University of Melbourne, Royal Melbourne Hospital, Australia
Arch Gen Psychiatry 55:415-23. 1998..We directly compared cognitive function in patients with OCD with that in matched patients with unipolar depression and panic disorder and healthy control subjects to establish the specific nature of neuropsychological deficits in OCD... - Ethyl-eicosapentaenoic acid in first-episode psychosis. A 1H-MRS studyGregor E Berger
Department of Psychiatry, ORYGEN Research Centre, University of Melbourne, Parkville, Australia
Neuropsychopharmacology 33:2467-73. 2008..Larger confirmatory studies of these postulated metabolic brain effects of E-EPA are warranted... - Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosisTsutomu Takahashi
Melbourne Neuropsychiatry Centre, c o National Neuroscience Facility, 161 Barry Street, Carlton South, Victoria 3053, Australia
Br J Psychiatry 196:206-11. 2010..Morphological abnormalities of the superior temporal gyrus have been consistently reported in schizophrenia, but the timing of their occurrence remains unclear... - Theory of mind impairment in schizophrenia: meta-analysisEmre Bora
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Vic, Australia
Schizophr Res 109:1-9. 2009..Our review also suggests that future research should consider the potential moderating influence of IQ deficits on ToM performance in "remitted" patients, as well as the potential effects of residual symptoms... - Functional connectivity during Stroop task performanceBen J Harrison
Brain Sciences Institute, Swinburne University of Technology, Melbourne, Australia
Neuroimage 24:181-91. 2005..These findings may also provide some additional insight into the nature of anterior cingulate- and prefrontal cortical contributions to implementing cognitive control in the brain... 
Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging studyD Sun
Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Parkville, Vic, Australia
Mol Psychiatry 14:976-86. 2009....- Meta-analytic review of neurocognition in bipolar II disorderE Bora
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton, Vic, Australia
Acta Psychiatr Scand 123:165-74. 2011..To examine this issue, we conducted a quantitative review of the cognitive profile of clinically stable patients with BD II in comparison with both patients with BD I and healthy controls... - Anterior cingulate activation in antipsychotic-naïve first-episode schizophreniaM Yucel
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Carlton South, VIC 3053, Australia
Acta Psychiatr Scand 115:155-8. 2007..Anterior cingulate (ACC) hypo-activity is commonly observed in chronically ill schizophrenia patients. However, it is unclear whether this is secondary to persistent illness and/or medication... - A combined spectroscopic and functional MRI investigation of the dorsal anterior cingulate region in opiate addictionM Yucel
ORYGEN Research Centre, Melbourne, Vic, Australia
Mol Psychiatry 12:611, 691-702. 2007.... - Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosisMark Walterfang
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia
Psychiatry Res 173:77-82. 2009..This suggests that schizoaffective disorder may represent two interacting illness processes or be mid-way along a continuum of these two broad categories of illness at first psychosis... - Corpus callosum shape alterations in individuals prior to the onset of psychosisMark Walterfang
Melbourne Neuropsychiatry Centre and Department of Psychiatry, University of Melbourne, North Western Mental Health Program, Sunshine Hospital, Melbourne, Australia
Schizophr Res 103:1-10. 2008..These changes may reflect primary pathology of orbitofrontal and medial frontal cortex, or deficits in anterior interhemispheric myelination... - Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosisTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Schizophr Res 111:94-102. 2009..Whether these longitudinal changes are features of the disorder or related to treatment with antipsychotic medication remains to be determined... - Impairments of response conflict monitoring and resolution in schizophreniaM Yucel
Cognitive Neuropsychiatry Research and Academic Unit, Mental Health Research Institute of Victoria, Parkville, Australia
Psychol Med 32:1251-60. 2002..However, this hypothesis is based on performance on paradigms that require overt or covert shifts of spatial attention... - In vivo evidence for early neurodevelopmental anomaly of the anterior cingulate cortex in bipolar disorderA Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Vic, Australia
Acta Psychiatr Scand 116:467-72. 2007..We investigated the evidence for early neurodevelopmental anomalies in the ACC and adjacent paracingulate cortex (PaC) of BD patients by studying cortical folding patterns of the region... - Frontostriatal deficits in unipolar major depressionM A Rogers
Department of Psychology, Monash University, Clayton, Victoria, Australia
Brain Res Bull 47:297-310. 1998..It is concluded that, while there is evidence of frontostriatal deficit in major depression, the exact nature of such deficits is uncertain. Issues such as component vs. system dysfunction need to be addressed... - Individual differences in anterior cingulate/paracingulate morphology are related to executive functions in healthy malesAlexander Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Sunshine Hospital, 176 Furlong Road, St Albans, Victoria 3021, Australia
Cereb Cortex 14:424-31. 2004..It therefore appears that normal variations in brain morphology are associated with individual differences in cognitive abilities... - Morphology of the corpus callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illnessMark Walterfang
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne North Western Mental Health Program, Sunshine Hospital, Royal Melbourne Hospital, Melbourne corrected
Br J Psychiatry 192:429-34. 2008..The shape of the corpus callosum may differ in schizophrenia, although no study has compared first-episode with established illness... - Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophreniaTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Schizophr Res 108:49-56. 2009.... - Volumetric MRI study of the insular cortex in individuals with current and past major depressionTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria 3053, Australia
J Affect Disord 121:231-8. 2010..Nevertheless, it remains largely unknown whether MDD patients exhibit morphologic changes of the insular cortex, and whether such changes reflect state or trait markers of the disorder... - Abnormal executive function in attention deficit hyperactivity disorder: the effect of stimulant medication and age on spatial working memoryR Barnett
Maroondah Hospital Child and Adolescent Mental Health Service, Victoria, Australia
Psychol Med 31:1107-15. 2001..These deficits were not present in the current sample of children who were receiving psychostimulant medication... - Attention deficit hyperactivity disorder: anxiety phenomena in children treated with psychostimulant medication for 6 months or moreA L Vance
Maroondah Child and Adolescent Psychiatry Service, Victoria, Australia
Aust N Z J Psychiatry 33:399-406. 1999..We propose that anxiety will be increased in children with ADHD who are treated with psychostimulant medication in the intermediate- to long-term who are identified by clinicians as poor responders... - Mapping grey matter reductions in schizophrenia: an anatomical likelihood estimation analysis of voxel-based morphometry studiesA Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia
Schizophr Res 108:104-13. 2009.... - Incidental radiological findings on brain magnetic resonance imaging in first-episode psychosis and chronic schizophreniaD I Lubman
Cognitive Neuropsychiatry Research and Academic Unit, The University of Melbourne and Sunshine Hospital, Melbourne, Australia
Acta Psychiatr Scand 106:331-6. 2002..To investigate whether patients with first-episode psychosis or chronic schizophrenia have an increased incidence of magnetic resonance imaging (MRI) brain abnormalities compared with control subjects... - An MRI study of the superior temporal subregions in first-episode patients with various psychotic disordersTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Schizophr Res 113:158-66. 2009..Our findings indicate that morphologic abnormalities of the STG gray matter are specific to schizophrenia among various psychotic disorders, implicating its role in the underlying pathophysiology of schizophrenia... - Cognitive impairment in affective psychoses: a meta-analysisEmre Bora
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Alan Gilbert Building NNF Level 3, Carlton 3053, Australia
Schizophr Bull 36:112-25. 2010..In general, the pattern of cognitive impairments in AP was similar to reported findings in euthymic patients with BD, but relatively more pronounced... - Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disordersTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Prog Neuropsychopharmacol Biol Psychiatry 32:1708-14. 2008.... - Gray matter reduction of the superior temporal gyrus in patients with established bipolar I disorderTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
J Affect Disord 123:276-82. 2010..Functional abnormalities of the superior temporal gyrus (STG) have been implicated in the pathophysiology of bipolar disorder, but magnetic resonance imaging (MRI) studies of this region have yielded inconsistent findings... - Decreased cortical muscarinic receptors define a subgroup of subjects with schizophreniaE Scarr
Centre for Neuroscience, The University of Melbourne, Parkville, Vic, Australia
Mol Psychiatry 14:1017-23. 2009.... - Reduced volume of parietal and frontal association areas in patients with schizophrenia characterized by passivity delusionsP Maruff
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Sunshine Hospital, St Albans, Melbourne, Australia
Psychol Med 35:783-9. 2005..CONCLUSIONS: These data provide direct evidence for the involvement of the parietal lobe in the pathophysiology of passivity delusions in schizophrenia... - Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relativesEmre Bora
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Vic, Australia
J Affect Disord 113:1-20. 2009..Our aim was to delineate neuropsychological deficits related to genetic susceptibility, illness process and iatrogenic factors in bipolar disorder (BD)... - Dopamine modulates neural networks involved in effort-based decision-makingSeyed M Assadi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
Neurosci Biobehav Rev 33:383-93. 2009..This is apparently achieved by modulating other neurotransmission systems and by transmitting different signals via D1 vs. D2 receptor subtypes and phasic vs. tonic firing... - Olfactory impairments in child attention-deficit/hyperactivity disorderFelicity R Karsz
University of Melbourne, Victoria, Australia
J Clin Psychiatry 69:1462-8. 2008.... - A manual and automated MRI study of anterior cingulate and orbito-frontal cortices, and caudate nucleus in obsessive-compulsive disorder: comparison with healthy controls and patients with schizophreniaJem Riffkin
Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Victoria, Australia
Psychiatry Res 138:99-113. 2005..The findings suggest that in contrast to findings in SCZ, there are very few (if any) gross structural anomalies in OCD... - Anterior cingulate volume in adolescents with first-presentation borderline personality disorderSarah Whittle
ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Psychiatry Res 172:155-60. 2009..Longitudinal studies are needed to examine the nature of this abnormality over the course of the disorder... - Early processing deficits in object working memory in first-episode schizophreniform psychosis and established schizophreniaBirgit Mathes
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Sunshine Hospital, Melbourne, Australia
Psychol Med 35:1053-62. 2005..CONCLUSIONS: Our results suggest a deficit in patients with psychotic illness in the initial processes necessary to actively maintain information, such as the ability to form an internal representation of complex objects... - Cognitive impairment in schizophrenia and affective psychoses: implications for DSM-V criteria and beyondEmre Bora
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Alan Gilbert Building NNF Level 3, Carlton 3053, Australia
Schizophr Bull 36:36-42. 2010..Given the state of current evidence, these possibilities appear to represent the most parsimonious approaches to the inclusion of cognitive deficits in the diagnostic criteria of schizophrenia and, potentially, of mood disorders... - Pituitary volume and early treatment response in drug-naïve first-episode psychosis patientsB Garner
Orygen Youth Health Research Centre, University of Melbourne, Australia
Schizophr Res 113:65-71. 2009..This study examined whether pituitary volume at the onset of psychosis may be a potential predictor of early treatment response in first-episode psychosis (FEP) patients... - Theory of mind impairment: a distinct trait-marker for schizophrenia spectrum disorders and bipolar disorder?E Bora
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Victoria, Australia
Acta Psychiatr Scand 120:253-64. 2009..The aim of this study was to critically review the literature in order to determine if Theory of Mind (ToM) impairment can be considered a trait-marker for schizophrenia spectrum disorders and bipolar disorder (BD)... - Bimanual coordination in chronic schizophreniaM A Bellgrove
Department of Psychology, Monash University, Clayton, Victoria, Australia
Brain Cogn 45:325-41. 2001..A disturbance in the ability to switch attention during the out-of-phase task may also be involved... - The three-syndrome model of schizophrenia: meta-analysis of an artefactG W Stuart
Mental Health Research Institute of Victoria, Parkville, Australia
Schizophr Res 39:233-42. 1999..It is concluded that the three-syndrome model of schizophrenia is largely an artefact of inadequate measurement at the symptom level... - Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individualsAlex Fornito
Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne, Carlton South, Victoria, Australia
Biol Psychiatry 64:758-65. 2008..In this study, we characterized prepsychotic ACC abnormalities in a sample of individuals at ultra-high-risk (UHR) for psychosis... - White-matter abnormalities in adolescents with long-term inhalant and cannabis use: a diffusion magnetic resonance imaging studyMurat Yucel
Orygen Youth Health Research Centre, 35 Poplar Rd, Parkville, Victoria 3052, Australia
J Psychiatry Neurosci 35:409-12. 2010.... - Regional brain abnormalities associated with long-term heavy cannabis useMurat Yucel
MAPS, ORYGEN Research Centre, 35 Poplar Rd, Melbourne, Victoria, Australia
Arch Gen Psychiatry 65:694-701. 2008..Cannabis is the most widely used illicit drug in the developed world. Despite this, there is a paucity of research examining its long-term effect on the human brain... - Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophreniaLuca Cocchi
Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Australia
Schizophr Res 115:163-72. 2009.... - Whole-brain anatomical networks: does the choice of nodes matter?Andrew Zalesky
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Neuroimage 50:970-83. 2010..9 vs. sigma(4000)=53.6+/-2.2). These findings indicate that any comparison of network parameters across studies must be made with reference to the spatial scale of the nodal parcellation... - Hoarding behaviors in children with learning disabilitiesRenee Testa
Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Australia
J Child Neurol 26:574-9. 2011..It is unclear whether underlying cognitive features may play a major role in the development of hoarding behaviors in children with learning disabilities... - From neuroprogression to neuroprotection: implications for clinical careMichael Berk
Department of Clinical and Biomedical Sciences Barwon Health, University of Melbourne, Melbourne, Vic
Med J Aust 193:S36-40. 2010..These developments need to be combined with service initiatives to maximise the opportunities for early diagnosis and intervention... - Neuroprotective effects of ethyl-eicosapentaenoic acid in first episode psychosis: a longitudinal T2 relaxometry pilot studyStephen J Wood
Melbourne Neuropsychiatry Centre, University of Melbourne, Australia
Psychiatry Res 182:180-2. 2010..There was an increase in T(2) in the placebo group but not in the E-EPA group, suggesting a neuroprotective effect of E-EPA treatment. In addition, the smaller the increase in T(2), the greater the improvement in negative symptoms... - Progressive brain structural changes mapped as psychosis develops in 'at risk' individualsDaqiang Sun
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
Schizophr Res 108:85-92. 2009..We hypothesized that progressive volume loss occurs in prefrontal regions during the transition to psychosis... - Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigationStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
Neurobiol Dis 33:354-7. 2009..This study provides further evidence of significant perturbations in brain GSH in first episode psychosis, and supports a broader involvement of GSH in the pathophysiology of schizophrenia... - Voxelwise meta-analysis of gray matter abnormalities in bipolar disorderEmre Bora
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia
Biol Psychiatry 67:1097-105. 2010..We conducted a meta-analysis of gray matter abnormalities in bipolar disorder (BD) using voxel-based morphometry studies to help clarify the structural abnormalities underpinning this condition... - Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorderAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, School of Behavioural Science, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053, Australia
Br J Psychiatry 194:426-33. 2009.... - Altered corticostriatal functional connectivity in obsessive-compulsive disorderBen J Harrison
Institut d Alta Tecnologia Parc de Recerca Biomèdica de Barcelona, Centro Radiológico Computerizado Corporació Sanitària, Barcelona, Spain
Arch Gen Psychiatry 66:1189-200. 2009..quot; Although neuroimaging studies of patients have supported this network model of OCD, very few have applied measurements that are sensitive to brain connectivity features... - Anterior cingulate glutamate-glutamine levels predict symptom severity in women with obsessive-compulsive disorderMurat Yucel
Melbourne Neuropsychiatry Centre, National Neuroscience Facility, Carlton South, Australia
Aust N Z J Psychiatry 42:467-77. 2008..The purpose of the present study was to investigate how ACC biochemistry in OCD varies as a function of gender, hemisphere, subregion, and symptomatology... - Surface-based morphometry of the anterior cingulate cortex in first episode schizophreniaAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
Hum Brain Mapp 29:478-89. 2008.... - Non-reduction in hippocampal volume is associated with higher risk of psychosisLisa J Phillips
PACE Clinic, Department of Psychiatry, University of Melbourne, 35 Poplar Road, Victoria 3052, Parkville, Australia
Schizophr Res 58:145-58. 2002..Alternatively, selection factors associated with the UHR cohort may have created a bias in the results. Replication of these results is required in other high-risk cohorts... - Clinical staging: a heuristic model for psychiatry and youth mental healthPatrick D McGorry
University of Melbourne, Melbourne, Vic, Australia
Med J Aust 187:S40-2. 2007..Young people with emerging mental and substance use disorders could be the main beneficiaries... - Increased duration of illness is associated with reduced volume in right medial temporal/anterior cingulate grey matter in patients with chronic schizophreniaDennis Velakoulis
Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, University of Melbourne and Sunshine Hospital, St Albans, Australia
Schizophr Res 57:43-9. 2002..The inverse correlation between right frontal, temporal and cerebellar volumes and the time since the onset of schizophrenia could reflect progressive tissue loss following the first episode of the disorder... - Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorderAlex Fornito
Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia
Psychiatry Res 162:123-32. 2008..These findings suggest that bipolar disorder is associated with more pronounced changes in the PaC, and that reliance on volumetric measures alone may obscure more subtle differences... - Increased prefrontal cerebral blood flow in first-episode schizophrenia following treatment: longitudinal positron emission tomography studyWarrick J Brewer
ORYGEN Research Centre, Locked Bag 10, Parkville, VIC 3052, Australia and Early Psychosis Prevention and Intervention Centre, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
Aust N Z J Psychiatry 41:129-35. 2007..The objective of the current study was to investigate executive-control related neural activity from first onset of the illness through to symptom stabilization... - Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosisWarrick J Brewer
ORYGEN Research Centre, Melbourne, Australia
Am J Psychiatry 162:71-8. 2005..While cognitive deficits are frequently reported in psychotic disorders, it is unclear whether these impairments predate the onset of illness and to what extent they are predictive of later transition to psychosis... - Abnormal white matter microstructure in schizophrenia: a voxelwise analysis of axial and radial diffusivityMarc L Seal
Melbourne Neuropsychiatry Centre, The University of Melbourne, Victoria, Australia
Schizophr Res 101:106-10. 2008..This finding suggests that the loss of white matter integrity in schizophrenia is the result of demyelination and/or changes to the axonal cytoskeleton rather than gross axonal damage... - Modulation of brain resting-state networks by sad mood inductionBen J Harrison
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia
PLoS ONE 3:e1794. 2008..While these 'resting-state networks' may be relatively enduring phenomena, other evidence suggest that dynamic changes in their functional connectivity may also emerge depending on the brain state of subjects during scanning... - Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorderAndrew M Chanen
ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Psychiatry Res 163:116-25. 2008..Hippocampal and amygdala volume reductions observed in adult BPD samples might develop during the course of the disorder, although longitudinal studies are needed to examine this... - Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosisBelinda Garner
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
Biol Psychiatry 58:417-23. 2005..032). CONCLUSIONS: The phase before the onset of psychosis is associated with a larger pituitary volume, suggesting activation of the HPA axis... - Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathologyAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
Schizophr Bull 35:973-93. 2009..We discuss the potential mechanisms that might facilitate integration of these findings and consider strategies for future research... - Implications of lipid biology for the pathogenesis of schizophreniaGregor E Berger
Early Psychosis Prevention and Intervention Centre, MH SKY EPPIC, Victoria
Aust N Z J Psychiatry 36:355-66. 2002..Both aspects are proposed as being important in the pathogenesis of schizophrenia. The purpose of this paper is to examine the implications of lipid biology, in particular the role of essential fatty acids (EFA), for schizophrenia... - Fractionation of verbal memory impairment in schizophrenia and schizophreniform psychosisStephen J Wood
Melbourne Neuropsychiatry Centre, c National Neuroscience Facility, Carlton, Melbourne, Victoria, Australia
Aust N Z J Psychiatry 41:732-9. 2007..The impact of antipsychotic medications is also unclear. The purpose of the present paper was to investigate verbal memory performance in established schizophrenia (SZ) and first-episode schizophreniform psychosis (FE)... - Brain changes during the onset of schizophrenia: implications for neurodevelopmental theoriesStephen J Wood
Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Vic
Med J Aust 190:S10-3. 2009..Although the cause of these changes is unclear, they challenge the conventional neurodevelopmental model of schizophrenia... - Frontotemporal dementia presenting as schizophrenia-like psychosis in young people: clinicopathological series and review of casesD Velakoulis
Neuropsychiatry Unit, Level 2 John Cade Building, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
Br J Psychiatry 194:298-305. 2009..Few studies have investigated the relationship between schizophrenia and frontotemporal dementia... - Treatment of psychogenic polydipsia: comparison of risperidone and olanzapine, and the effects of an adjunctive angiotensin-II receptor blocking drug (irbesartan)D Kruse
Austin and Repatriation Medical Centre, Department of Psychiatry and Psychology, Melbourne, Australia
Aust N Z J Psychiatry 35:65-8. 2001..The benefit derived with irbesartan implicates the involvement of brain angiotensin systems centrally in helping to regulate drinking behaviour... - Neurobiological findings in early phase schizophreniaD Copolov
The Mental Health Research Institute of Victoria, 155 Oak St, Parkville, Victoria, Australia
Brain Res Brain Res Rev 31:157-65. 2000..Although there is a growing literature on first episode psychosis, there is a striking dearth of information on the neurobiology of the prodrome... - Age of onset of schizophrenia: perspectives from structural neuroimaging studiesNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD, USA
Schizophr Bull 37:504-13. 2011..The importance of examining trajectories of development and the need for future combined approaches, using multimodal imaging together with molecular studies is discussed... - Efficacy and tolerability of ziprasidone versus risperidone in patients with acute exacerbation of schizophrenia or schizoaffective disorder: an 8-week, double-blind, multicenter trialDonald E N Addington
Department of Psychiatry, Foothills Medical Center, Calgary, Alberta, Canada
J Clin Psychiatry 65:1624-33. 2004..Thus, we compared ziprasidone and risperidone in patients with acute exacerbation of schizophrenia or schizoaffective disorder...