Lyle J Palmer

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Shaking the tree: mapping complex disease genes with linkage disequilibrium
    Lyle J Palmer
    Western Australian Institute for Medical Research and University of Western Australia Centre for Medical Research, University of Western Australia
    Lancet 366:1223-34. 2005
  2. ncbi request reprint Whole genome scan for obstructive sleep apnea and obesity in African-American families
    Lyle J Palmer
    Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 169:1314-21. 2004
  3. pmc The effect of missing data on linkage disequilibrium mapping and haplotype association analysis in the GAW14 simulated datasets
    Pamela A McCaskie
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Ground Floor, B Block, Hospital Avenue, Nedlands, Australia
    BMC Genet 6:S151. 2005
  4. pmc Genome-wide linkage and association mapping of disease genes with the GAW14 simulated datasets
    Kim W Carter
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Hospital Avenue, Nedlands, Western Australia
    BMC Genet 6:S41. 2005
  5. pmc JLIN: a java based linkage disequilibrium plotter
    Kim W Carter
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Nedlands, 6009, Western Australia
    BMC Bioinformatics 7:60. 2006
  6. ncbi request reprint The Western Australian Twin Register: a population-based register of adult and child multiples
    Jessica D Y Lee
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, Perth, Western Australia, Australia
    Twin Res Hum Genet 9:712-7. 2006
  7. ncbi request reprint Cholesteryl ester transfer protein gene haplotypes, plasma high-density lipoprotein levels and the risk of coronary heart disease
    Pamela A McCaskie
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Nedlands, WA, 6009, Australia
    Hum Genet 121:401-11. 2007
  8. ncbi request reprint UK Biobank: bank on it
    Lyle J Palmer
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, WA 6008, Australia
    Lancet 369:1980-2. 2007
  9. pmc Sex differences in the association of regional fat distribution with the severity of obstructive sleep apnea
    Laila Simpson
    Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Perth, Australia
    Sleep 33:467-74. 2010
  10. doi request reprint Association of Interleukin-1 gene polymorphisms with central obesity and metabolic syndrome in a coronary heart disease population
    Kim W Carter
    Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, WA, Australia
    Hum Genet 124:199-206. 2008

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Shaking the tree: mapping complex disease genes with linkage disequilibrium
    Lyle J Palmer
    Western Australian Institute for Medical Research and University of Western Australia Centre for Medical Research, University of Western Australia
    Lancet 366:1223-34. 2005
    ....
  2. ncbi request reprint Whole genome scan for obstructive sleep apnea and obesity in African-American families
    Lyle J Palmer
    Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 169:1314-21. 2004
    ..Our results suggest that there are both shared and unshared genetic factors underlying susceptibility to OSA and obesity, and that the genetic determinants of obesity in this population may be modulated by apnea severity...
  3. pmc The effect of missing data on linkage disequilibrium mapping and haplotype association analysis in the GAW14 simulated datasets
    Pamela A McCaskie
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Ground Floor, B Block, Hospital Avenue, Nedlands, Australia
    BMC Genet 6:S151. 2005
    ..It was concluded that ignoring individuals with missing data substantially affects the number of regions of LD detected which, in turn, could affect tagging SNPs chosen to generate haplotypes...
  4. pmc Genome-wide linkage and association mapping of disease genes with the GAW14 simulated datasets
    Kim W Carter
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Hospital Avenue, Nedlands, Western Australia
    BMC Genet 6:S41. 2005
    ..Using generalized linear mixed models, we modelled the effect of the three predefined phenotypic categories on disease status and concluded that the phenotypes defining the "anxiety-related" category best predicted the outcome...
  5. pmc JLIN: a java based linkage disequilibrium plotter
    Kim W Carter
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Nedlands, 6009, Western Australia
    BMC Bioinformatics 7:60. 2006
    ..Visualisation techniques are becoming essential to analyse the ever-growing volume of data and results available with any given analysis...
  6. ncbi request reprint The Western Australian Twin Register: a population-based register of adult and child multiples
    Jessica D Y Lee
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, Perth, Western Australia, Australia
    Twin Res Hum Genet 9:712-7. 2006
    ..These resources are in the process of being enabled for national and international access...
  7. ncbi request reprint Cholesteryl ester transfer protein gene haplotypes, plasma high-density lipoprotein levels and the risk of coronary heart disease
    Pamela A McCaskie
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Nedlands, WA, 6009, Australia
    Hum Genet 121:401-11. 2007
    ..These results suggest that raising HDL-C via CETP inhibition may not alter risk of CHD. Randomized control trials are needed to determine whether CETP inhibition will in reality reduce risk of CHD by raising HDL-C...
  8. ncbi request reprint UK Biobank: bank on it
    Lyle J Palmer
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, WA 6008, Australia
    Lancet 369:1980-2. 2007
  9. pmc Sex differences in the association of regional fat distribution with the severity of obstructive sleep apnea
    Laila Simpson
    Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Perth, Australia
    Sleep 33:467-74. 2010
    ....
  10. doi request reprint Association of Interleukin-1 gene polymorphisms with central obesity and metabolic syndrome in a coronary heart disease population
    Kim W Carter
    Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, WA, Australia
    Hum Genet 124:199-206. 2008
    ....
  11. pmc SimHap GUI: an intuitive graphical user interface for genetic association analysis
    Kim W Carter
    Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, Australia
    BMC Bioinformatics 9:557. 2008
    ....
  12. doi request reprint 15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness
    Pamela A McCaskie
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Perth, WA, Australia
    Hum Genet 123:445-53. 2008
    ..This study is novel as it is the first to examine the association between 15-lipoxygenase polymorphisms and atherosclerotic indicators. These findings suggest a possible role of ALOX15 polymorphisms in focal plaque formation...
  13. ncbi request reprint Single-nucleotide polymorphisms in the interleukin-10 gene: differences in frequencies, linkage disequilibrium patterns, and haplotypes in three United States ethnic groups
    Ross Lazarus
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Genomics 80:223-8. 2002
    ..No SNP caused amino acid changes. Differences in pairwise linkage-disequilibrium (LD) patterns and in SNP and haplotype frequency distributions among the three populations may be of potential importance for disease association studies...
  14. ncbi request reprint Role of prostanoid DP receptor variants in susceptibility to asthma
    Tsuyoshi Oguma
    Combined Program in Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 351:1752-63. 2004
    ..A study of a mouse model suggests that the receptor is required for the expression of the asthma phenotype. Our associations of asthma with functional genetic variants of PTGDR link these observations...
  15. ncbi request reprint The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:1649-56. 2004
    ..We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers...
  16. ncbi request reprint Covariance components models for longitudinal family data
    Paul R Burton
    Biostatistics and Genetic Epidemiology, Department of Health Sciences, Institute of Genetics, University of Leicester, UK
    Int J Epidemiol 34:1063-77; discussion 1077-9. 2005
    ..We demonstrate the efficacy of our methods using a range of simulated data analyses, and illustrate its practical application to longitudinal blood pressure data measured in families from the Framingham Heart Study...
  17. ncbi request reprint Relationship between obstructive sleep apnea and diurnal leptin rhythms
    Sanjay R Patel
    Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Sleep 27:235-9. 2004
    ..Several studies have reported an association between obstructive sleep apnea and leptin, a hormone that influences satiety and body weight. We evaluated the relationship of leptin levels and the overnight change in levels with sleep apnea...
  18. doi request reprint Association of PARL rs3732581 genetic variant with insulin levels, metabolic syndrome and coronary artery disease
    Brenda L Powell
    Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Perth, Australia
    Hum Genet 124:263-70. 2008
    ..There were significant effects of the variant on mean IMT and risk of CAD. A role for PARL in metabolic conditions cannot be excluded and more comprehensive genetic studies are warranted...
  19. ncbi request reprint Stromelysin-1 (MMP-3) gene 5A/6A promoter polymorphism is associated with blood pressure in a community population
    John P Beilby
    Clinical Biochemistry, Western Australian Centre for Pathology and Medical Research PathCentre and School of Surgery and Pathology, University of Western Australia, Perth, Western Australia
    J Hypertens 23:537-42. 2005
    ..Stromelysin-1 gene expression is partly regulated by a common polymorphism in the promoter region of either five or six consecutive adenosine bases (5A/6A)...
  20. doi request reprint The apolipoprotein AII rs5082 variant is associated with reduced risk of coronary artery disease in an Australian male population
    Jing Xiao
    Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Australia
    Atherosclerosis 199:333-9. 2008
    ..We conclude that the APOAII rs5082 polymorphism appears to be cardioprotective in this representative Caucasian Australian population...
  21. ncbi request reprint Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids
    Linda Schaeffer
    GSF National Research Center for Environment and Health, Institute of Epidemiology, 85764 Neuherberg, Germany
    Hum Mol Genet 15:1745-56. 2006
    ..0 x 10(-13)). Carriers of the rare alleles of several SNPs and their respective haplotypes had a lower prevalence of allergic rhinitis and atopic eczema. No association was found for total and specific IgE levels...
  22. ncbi request reprint Association between osteopontin and human abdominal aortic aneurysm
    Jonathan Golledge
    The Vascular Biology Unit, School of Medicine, James Cook University, Townsville, Queensland, 4811 Australia
    Arterioscler Thromb Vasc Biol 27:655-60. 2007
    ..The relationship between serum concentration of OPN and variants of the OPN gene with human abdominal aortic aneurysm (AAA) was investigated...
  23. doi request reprint Celestial3D: a novel method for 3D visualization of familial data
    Angeline M Loh
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research and UWA Centre for Medical Research, The University of Western Australia, Perth, Australia
    Bioinformatics 24:1210-1. 2008
    ..We have made freely available a software tool--'Celestial3D'--that implements these novel techniques. AVAILABILITY: Freely available to non-commercial users...
  24. doi request reprint Respiratory infections and lung function in an Australian Aboriginal community
    A W Bill Musk
    Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
    Respirology 13:257-62. 2008
    ..To investigate the association between serological evidence of past infections with common respiratory pathogens and lung function in members of an isolated community of Aborigines from tropical coastal north-western Australia...
  25. ncbi request reprint Replicating genotype-phenotype associations
    Stephen J Chanock
    Division of Cancer Epidemiology and Genetics, Bethesda, Maryland 20892 4605, USA
    Nature 447:655-60. 2007
  26. doi request reprint Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease
    Steven Wiltshire
    Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, Australia
    Hum Genet 123:307-13. 2008
    ..In conclusion, we found no robust evidence for the associations between K198N and hypertension, systolic blood pressure or HDL levels seen in previous studies...
  27. ncbi request reprint Meta-analysis of genome-wide linkage studies in BMI and obesity
    Catherine L Saunders
    King s College London, Guy s, King s and St Thomas School of Medicine, London, United Kingdom
    Obesity (Silver Spring) 15:2263-75. 2007
    ..The objective was to provide an overall assessment of genetic linkage data of BMI and BMI-defined obesity using a nonparametric genome scan meta-analysis...
  28. pmc Fine mapping versus replication in whole-genome association studies
    Geraldine M Clarke
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    Am J Hum Genet 81:995-1005. 2007
    ..Our results provide a basis for the design and interpretation of GWA replication studies and point to the importance of a clear distinction between fine mapping and replication after GWA...
  29. doi request reprint Comprehensive analysis of tagging sequence variants in DTNBP1 shows no association with schizophrenia or with its composite neurocognitive endophenotypes
    Kirsten Peters
    Laboratory for Molecular Genetics, Western Australian Institute for Medical Research, University of Western Australia, Nedlands, Western Australia, Australia
    Am J Med Genet B Neuropsychiatr Genet 147:1159-66. 2008
    ..The framework and results of this study should facilitate further attempts at re-analysis of DTNBP1, in terms of standardized approaches to both phenotype definition and analysis of genetic variation...
  30. ncbi request reprint Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma
    John S Witte
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106 4945, USA
    Eur J Hum Genet 10:82-5. 2002
    ..16 (95% CI=1.04-9.66; P=0.04). LTalpha-NcoI*1 was weakly associated with asthma, and analysis of both genes suggests that only the TNFalpha-308*2 allele increases risk of asthma...
  31. ncbi request reprint Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease
    Ross Lazarus
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Immunol Rev 190:9-25. 2002
    ..These and other factors must be taken into account in the design and analysis of disease association studies...
  32. pmc A whole-genome scan for obstructive sleep apnea and obesity
    Lyle J Palmer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 72:340-50. 2003
    ....
  33. ncbi request reprint Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies
    Ross Lazarus
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Genomics 81:85-91. 2003
    ..This study suggests that there is substantial diversity in human TLR9, possibly associated with asthma in Europeans but not African Americans. No association was detected with three other diseases potentially related to innate immunity...
  34. ncbi request reprint DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma
    Rebecca M Baron
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 166:927-32. 2002
    ..This study suggests that epithelium-specific ETS-2 and ETS-3 genes are unlikely to contain polymorphic loci that have a major impact on asthma susceptibility in our population...
  35. ncbi request reprint Population stratification and spurious allelic association
    Lon R Cardon
    Wellcome Trust Centre for Human Genetics, University of Oxford, OX3 7BN, Oxford, UK
    Lancet 361:598-604. 2003
    ..We discuss past evidence for population stratification on genotype-phenotype association studies, review methods to detect and account for it, and present suggestions for future study design and analysis...
  36. ncbi request reprint Apolipoprotein E gene polymorphisms are associated with carotid plaque formation but not with intima-media wall thickening: results from the Perth Carotid Ultrasound Disease Assessment Study (CUDAS)
    John P Beilby
    PathCentre, Western Australian Centre for Pathology and Medical Research, Clinical Biochemistry, Nedlands, Western Australia, Australia
    Stroke 34:869-74. 2003
    ....
  37. ncbi request reprint Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 166:1449-56. 2002
    ..Based on these results, we found no evidence that genetic variation in TLR4 contributes to asthma susceptibility...
  38. ncbi request reprint Pharmacogenetics of asthma
    Lyle J Palmer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 165:861-6. 2002
  39. pmc Lack of reproducibility of linkage results in serially measured blood pressure data
    Sanjay R Patel
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusettes, USA
    BMC Genet 4:S37. 2003
    ....
  40. ncbi request reprint Association of an allelic variant of interleukin-6 with subclinical carotid atherosclerosis in an Australian community population
    Caroline M L Chapman
    Clinical Biochemistry, Western Australian Centre for Pathology and Medical Research, Western Australia, Perth, Australia
    Eur Heart J 24:1494-9. 2003
    ..We examined the association of a common functional variant in the IL-6 gene with carotid intimal-medial wall thickness (IMT) and the presence of plaques in a randomly selected, cross-sectional Australian population...
  41. ncbi request reprint Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes
    Edwin K Silverman
    Channing Laboratory, Division of Pulmonary and Critical Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 11:623-32. 2002
    ..In smokers only, the maximum two point LOD score for mild airflow obstruction was 3.14. These observations provide suggestive evidence that there is a locus on chromosome 12p which contributes to susceptibility to early-onset COPD...
  42. pmc Genome-wide linkage analysis of longitudinal phenotypes using sigma2A random effects (SSARs) fitted by Gibbs sampling
    Lyle J Palmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    BMC Genet 4:S12. 2003
    ..We have now demonstrated in this paper the use of SSARs in the context of longitudinal family data...
  43. ncbi request reprint Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma
    Eric S Silverman
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 169:214-9. 2004
    ..We conclude that the T allele of C-509T is associated with the diagnosis of asthma and may enhance TGF-beta1 gene transcription...
  44. pmc Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease
    Edwin K Silverman
    Channing Laboratory and Division of Pulmonary and Critical Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 70:1229-39. 2002
    ..The significant linkage of FEV(1)/FVC to chromosome 2q could reflect one or more genes influencing the development of airflow obstruction or dysanapsis...
  45. ncbi request reprint C-reactive protein and its role in metabolic syndrome: mendelian randomisation study
    Nicholas J Timpson
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR, UK
    Lancet 366:1954-9. 2005
    ..Our aim was to generate estimates of the association between plasma CRP and metabolic syndrome phenotypes that were free from confounding and reverse causation, to assess the causal role of this protein...
  46. doi request reprint Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus
    Patricia H Gallego
    Department of Pediatric Endocrinology and Diabetes, Princess Margaret Hospital, Perth, WA, Australia
    J Diabetes Complications 22:191-8. 2008
    ....
  47. pmc Response to Epstein et al
    Paul R Burton
    Am J Hum Genet 71:441-2. 2002
  48. ncbi request reprint The New Epidemiology: putting the pieces together in complex disease aetiology
    Lyle J Palmer
    Int J Epidemiol 33:925-8. 2004
  49. ncbi request reprint Parametric linkage analysis
    Lyle J Palmer
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 195:13-35. 2002
  50. ncbi request reprint Infants with flow limitation at 4 weeks: outcome at 6 and 11 years
    Stephen W Turner
    University Department of Paediatrics, Princess Margaret Hospital for Children, Perth, Western Australia, Australia
    Am J Respir Crit Care Med 165:1294-8. 2002
    ..We suggest that the physiologic abnormality that causes flow limitation in early infancy may identify an at-risk group, different from asthma, who have reduced lung function and increased airway responsiveness in later life...
  51. ncbi request reprint Ascaris lumbricoides infection is associated with increased risk of childhood asthma and atopy in rural China
    Lyle J Palmer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital
    Am J Respir Crit Care Med 165:1489-93. 2002
    ..These data suggest a complex relationship between ascariasis and susceptibility to childhood asthma among predisposed children that may involve an interaction with the immune response to inhaled aeroallergens...
  52. ncbi request reprint Endothelial nitric oxide synthase variants in cystic fibrosis lung disease
    Hartmut Grasemann
    Children s Hospital, University of Essen, Essen, Germany
    Am J Respir Crit Care Med 167:390-4. 2003
    ..aeruginosa...
  53. ncbi request reprint Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung
    Eric S Silverman
    Division of Pulmonary and Critical Care Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston 02115, USA
    Am J Respir Cell Mol Biol 27:697-704. 2002
    ..Overexpression of ESE-3 protein in 3T3 cells and human bronchial smooth muscle cells inhibits MMP-1 promoter activity, suggesting that ESE-3 may function as a transcriptional repressor...
  54. ncbi request reprint Do regular check ups and preventive drug use reduce asthma severity in school children?
    Lyle J Palmer
    Schools of Medicine, Pharmacology and Population Health, University of Western Australia
    Aust Fam Physician 33:573-6. 2004
    ..To investigate whether regular check ups and preventive drug use reduce asthma symptoms in school children...
  55. ncbi request reprint Decline in lung function in the Busselton Health Study: the effects of asthma and cigarette smoking
    Alan L James
    West Australian Sleep Disorders Research Institute, Queen Elizabeth II Medical Centre, Nedlands, Australia
    Am J Respir Crit Care Med 171:109-14. 2005
    ..Smoking and asthma had additive but not multiplicative effects on decline. Thus, asthma is associated with reduced lung function at the beginning of adult life as well as an increased rate of decline during adult life...
  56. ncbi request reprint The role of prostaglandin D receptor gene in asthma pathogenesis
    Craig M Lilly
    Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 33:224-6. 2005
  57. ncbi request reprint Genomic approaches to understanding obstructive sleep apnea
    Lyle J Palmer
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Physiol Neurobiol 135:187-205. 2003
    ..This chapter reviews the current state of knowledge of the genetics of OSA, with a focus on genomic approaches to understanding sleep disorders...
  58. ncbi request reprint Genetic epidemiology and public health: hope, hype, and future prospects
    George Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Lancet 366:1484-98. 2005
    ....
  59. ncbi request reprint The relationship between infant airway function, childhood airway responsiveness, and asthma
    Stephen W Turner
    School of Paediatrics and Child Health, University of Western Australia, and Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, Australia
    Am J Respir Crit Care Med 169:921-7. 2004
    ..Reduced airway function present in early infancy is associated with PW at 11 years of age, and this relationship is independent of the effect of increased AR and atopy in childhood...
  60. ncbi request reprint Association of a missense mutation in the NOS3 gene with exhaled nitric oxide levels
    Karin Storm van's Gravesande
    Division of Pulmonary and Critical Care Medicine, Tower 4B, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 168:228-31. 2003
    ....
  61. ncbi request reprint Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease
    Lyle J Palmer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Hum Mol Genet 12:1199-210. 2003
    ..This study has also identified several genomic regions that could contain loci regulating BDR in early-onset COPD families...
  62. ncbi request reprint Make it HuGE: human genome epidemiology reviews, population health, and the IJE
    George Davey Smith
    Int J Epidemiol 35:507-10. 2006
  63. ncbi request reprint Loosening the cuff: important new advances in modeling antihypertensive treatment effects in genetic studies of hypertension
    Lyle J Palmer
    Hypertension 41:197-8. 2003
  64. ncbi request reprint Smoking status and occupational exposure affects oxidative DNA injury in boilermakers exposed to metal fume and residual oil fly ash
    Sutapa Mukherjee
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 13:454-60. 2004
    ..In addition, boilermakers may have reduced ability to repair damaged DNA after ROFA and metal fume exposure. This finding has clinical relevance because these exposures may increase the cancer susceptibility of boilermakers...