J K Olynyk

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi Iron overload impairs pro-inflammatory cytokine responses by Kupffer cells
    J K Olynyk
    Department of Medicine, The University of Western Australia, Nedlands Australia
    J Gastroenterol Hepatol 16:438-44. 2001
  2. ncbi Gadolinium chloride suppresses hepatic oval cell proliferation in rats with biliary obstruction
    J K Olynyk
    University Department of Medicine, Fremantle Hospital, Western Australia
    Am J Pathol 152:347-52. 1998
  3. ncbi Colorectal cancer screening by general practitioners: comparison with national guidelines
    J K Olynyk
    University Department of Medicine, Fremantle Hospital, WA
    Med J Aust 168:331-4. 1998
  4. ncbi Isolation and primary culture of rat Kupffer cells
    J K Olynyk
    University Department of Medicine, Fremantle Hospital, Western Australia, Australia
    J Gastroenterol Hepatol 13:842-5. 1998
  5. ncbi A population-based study of the clinical expression of the hemochromatosis gene
    J K Olynyk
    Department of Medicine, University of Western Australia, Fremantle, Australia
    N Engl J Med 341:718-24. 1999
  6. ncbi Hepatitis C and iron
    J K Olynyk
    Department of Medicine, Fremantle Hospital, University of Western Australia, Australia
    Keio J Med 48:124-31. 1999
  7. ncbi Evolution of untreated hereditary hemochromatosis in the Busselton population: a 17-year study
    John K Olynyk
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, Fremantle, Western Australia
    Mayo Clin Proc 79:309-13. 2004
  8. ncbi Fecal occult blood and flexible sigmoidoscopy screening for colorectal cancer: modeling the impact on colonoscopy requirements and cancer detection rates
    J K Olynyk
    Departments of Medicine, University of Western Australia, Australia
    J Gastroenterol Hepatol 16:389-92. 2001
  9. ncbi Screening for hemochromatosis: patients with liver disease, families, and populations
    Sumedha P Galhenage
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, PO Box 480, Fremantle, Western Australia 6959
    Curr Gastroenterol Rep 6:44-51. 2004
  10. ncbi The C282Y polymorphism of the hereditary hemochromatosis gene is associated with increased sex hormone-binding globulin and normal testosterone levels in men
    B B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    J Endocrinol Invest 33:544-8. 2010

Collaborators

Detail Information

Publications71

  1. ncbi Iron overload impairs pro-inflammatory cytokine responses by Kupffer cells
    J K Olynyk
    Department of Medicine, The University of Western Australia, Nedlands Australia
    J Gastroenterol Hepatol 16:438-44. 2001
    ..The aim of the present study was to determine the effect of chronic iron overload on Kupffer cell cytokine production...
  2. ncbi Gadolinium chloride suppresses hepatic oval cell proliferation in rats with biliary obstruction
    J K Olynyk
    University Department of Medicine, Fremantle Hospital, Western Australia
    Am J Pathol 152:347-52. 1998
    ..Alternatively, gadolinium may directly affect oval cell proliferation after BDL...
  3. ncbi Colorectal cancer screening by general practitioners: comparison with national guidelines
    J K Olynyk
    University Department of Medicine, Fremantle Hospital, WA
    Med J Aust 168:331-4. 1998
    ....
  4. ncbi Isolation and primary culture of rat Kupffer cells
    J K Olynyk
    University Department of Medicine, Fremantle Hospital, Western Australia, Australia
    J Gastroenterol Hepatol 13:842-5. 1998
    ..Kupffer cells were adherent in culture after 2 h. This method for Kupffer cell isolation resulted in a yield of 80-120 x 10(6) Kupffer cells per liver...
  5. ncbi A population-based study of the clinical expression of the hemochromatosis gene
    J K Olynyk
    Department of Medicine, University of Western Australia, Fremantle, Australia
    N Engl J Med 341:718-24. 1999
    ..We recommended liver biopsy for subjects with serum ferritin levels of 300 ng per milliliter or higher. The subjects were followed for up to four years...
  6. ncbi Hepatitis C and iron
    J K Olynyk
    Department of Medicine, Fremantle Hospital, University of Western Australia, Australia
    Keio J Med 48:124-31. 1999
    ....
  7. ncbi Evolution of untreated hereditary hemochromatosis in the Busselton population: a 17-year study
    John K Olynyk
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, Fremantle, Western Australia
    Mayo Clin Proc 79:309-13. 2004
    ..To describe the evolution of biochemical and clinical features during a 17-year period in untreated subjects homozygous for the C282Y mutation in the hemochromatosis gene...
  8. ncbi Fecal occult blood and flexible sigmoidoscopy screening for colorectal cancer: modeling the impact on colonoscopy requirements and cancer detection rates
    J K Olynyk
    Departments of Medicine, University of Western Australia, Australia
    J Gastroenterol Hepatol 16:389-92. 2001
    ..AiM: The aim of this study was to estimate the colonoscopy requirements and the likely impact of fecal occult blood and flexible sigmoidoscopy screening on the detection of colorectal cancer by using previously published data...
  9. ncbi Screening for hemochromatosis: patients with liver disease, families, and populations
    Sumedha P Galhenage
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, PO Box 480, Fremantle, Western Australia 6959
    Curr Gastroenterol Rep 6:44-51. 2004
    ..Opportunistic screening during routine health assessments may also be recommended. However, large-scale screening of the average-risk population is not recommended on the basis of current evidence...
  10. ncbi The C282Y polymorphism of the hereditary hemochromatosis gene is associated with increased sex hormone-binding globulin and normal testosterone levels in men
    B B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    J Endocrinol Invest 33:544-8. 2010
    ..However, it is unclear whether men who are heterozygotes for C282Y or H63D exhibit subtle abnormalities of sex hormone status...
  11. ncbi Flexible sigmoidoscopy screening for colorectal cancer in average-risk subjects: a community-based pilot project
    J K Olynyk
    University Department of Medicine, Fremantle Hospital, WA
    Med J Aust 165:74-6. 1996
    ..To test a pilot screening program for colorectal cancer...
  12. ncbi The new iron age
    D Trinder
    Department of Medicine, University of Western Australia, Fremantle Hospital, Fremantle 6160, Western Australia, Australia
    Int J Mol Med 6:607-12. 2000
    ..Variations in the form of iron deposits in different types of iron overload disease e.g. HH or beta-thalessemia, the site of iron deposition and the clinical treatment used will be discussed...
  13. ncbi High prevalence of coeliac disease in a population-based study from Western Australia: a case for screening?
    C J Hovell
    Fremantle Hospital, WA
    Med J Aust 175:247-50. 2001
    ..To determine the prevalence of coeliac disease in an Australian rural community...
  14. ncbi Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3
    S F Drake
    School of Medicine and Pharmacology, Fremantle Hospital, University of Western Australia, PO Box 480, Fremantle, 6959, WA, Australia
    Am J Physiol Gastrointest Liver Physiol 292:G323-8. 2007
    ..These findings support a model in which TfR2 is a sensor of Fe status and regulates duodenal Fe absorption and liver Fe uptake...
  15. ncbi Molecular pathogenesis of iron overload
    D Trinder
    Department of Medicine and Western Australian Institute for Medical Research, University of Western Australia, Freemantle, Australia
    Gut 51:290-5. 2002
    ..Recently, a number of new genes involved in iron metabolism have been identified which is allowing the molecular mechanisms of iron absorption to be elucidated...
  16. ncbi Serum testosterone levels correlate with haemoglobin in middle-aged and older men
    B B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Intern Med J 39:532-8. 2009
    ..The relation between testosterone and haemoglobin (Hb) in younger and middle-aged men is less well defined. The aim of the study was to examine the association between testosterone and Hb levels in men spanning middle to older ages...
  17. ncbi Outcomes for women in a flexible sigmoidoscopy-based colorectal cancer screening programme
    C H Viiala
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    Intern Med J 38:90-4. 2008
    ..Our aim was to review the outcomes for female participants in a community-based CRC screening project using FS...
  18. ncbi Hereditary hemochromatosis is characterized by a clinically definable arthropathy that correlates with iron load
    G J Carroll
    University of Notre Dame Australia, Fremantle Campus, and Fremantle Hospital, Fremantle, Western Australia, Australia
    Arthritis Rheum 63:286-94. 2011
    ..To determine the frequency and character of arthropathy in hereditary hemochromatosis (HH) and to investigate the relationship between this arthropathy, nodal interphalangeal osteoarthritis, and iron load...
  19. ncbi Upregulation of lymphotoxin beta expression in liver progenitor (oval) cells in chronic hepatitis C
    K N Lowes
    Biochemistry and Molecular Biology, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley 6009, Australia
    Gut 52:1327-32. 2003
    ..LT-beta expression is significantly increased when fibrosis or cirrhosis is present, suggesting a role for LT-beta in the pathogenesis of chronic hepatitis C and a possible role in oval cell mediated liver regeneration...
  20. ncbi Serum ferritin and cardiovascular disease: a 17-year follow-up study in Busselton, Western Australia
    M W Knuiman
    School of Population Health, The University of Western Australia, Crawley, Western Australia, Australia
    Am J Epidemiol 158:144-9. 2003
    ..96 (95% confidence interval: 0.60, 1.53) for CHD and 1.43 (95% confidence interval: 0.78, 2.64) for stroke. Little or no evidence was found that ferritin level was a risk factor for cardiovascular disease...
  21. ncbi Outcomes after 10 years of a community-based flexible sigmoidoscopy screening program for colorectal carcinoma
    Charlie H Viiala
    Endoscopy Unit, Department of Gastroenterology, Fremantle Hospital, Fremantle, and School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
    Med J Aust 187:274-7. 2007
    ..To evaluate the outcomes 10 years after a flexible sigmoidoscopy colorectal cancer (CRC) screening program in asymptomatic average-risk individuals...
  22. ncbi Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet
    Janina E E Tirnitz-Parker
    School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Australia
    Int J Biochem Cell Biol 39:2226-39. 2007
    ..These novel murine oval cell lines, together with a reliable method for isolation and culture of primary oval cells, will provide a useful tool for investigating the contribution of oval cells to liver regeneration...
  23. ncbi Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice
    Belinda Knight
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Alma Rd, Fremantle, WA 6101, Australia
    J Hepatol 46:134-41. 2007
    ..Interferon-gamma is known to regulate Th1 cell activities during immune challenge. Therefore, we hypothesised that progenitor cell-mediated regeneration is associated with a Th1 immune response...
  24. ncbi Evaluation of the "Cellscreen" system for proliferation studies on liver progenitor cells
    Cornelia S Viebahn
    School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, 35 Stirling Highway, M310, Crawley, WA 6009, Australia
    Eur J Cell Biol 85:1265-74. 2006
    ..Hence, this technique proves superior to the common proliferation assays opening up new dimensions of proliferation studies in cell biology...
  25. ncbi C-kit inhibition by imatinib mesylate attenuates progenitor cell expansion and inhibits liver tumor formation in mice
    Belinda Knight
    School of Medicine and Pharmacology, Centre for Medical Research, University of Western Australia, Fremantle, Western Australia, Australia
    Gastroenterology 135:969-79, 979.e1. 2008
    ..Therefore, we hypothesized that the c-kit inhibitor imatinib mesylate (IM) would suppress LPC growth and, therefore, may exert antitumorigenic effects in the liver...
  26. ncbi Body mass index is a stronger predictor of alanine aminotransaminase levels than alcohol consumption
    Leon A Adams
    School of Medicine and Pharmacology, Fremantle Hospital Campus, The University of Western Australia, Fremantle, Australia
    J Gastroenterol Hepatol 23:1089-93. 2008
    ..The relative effects of obesity compared to alcohol on liver injury are uncertain. We examined their effects on alanine aminotransferase (ALT) and gamma glutamyltransferase (GGT) levels in a population-based cohort...
  27. ncbi Differential findings for CD14-positive hepatic monocytes/macrophages in primary biliary cirrhosis, chronic hepatitis C and nonalcoholic steatohepatitis
    Katherine L Leicester
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Liver Int 26:559-65. 2006
    ..In hepatitis C, an increased number of CD14-positive cells are associated with high inflammatory activity...
  28. ncbi Population-based study of the relationship between mutations in the hemochromatosis (HFE) gene and arthritis
    Colin A Sherrington
    Department of Gastroenterology, Fremantle Hospital, Fremantle, Western Australia, Australia
    J Gastroenterol Hepatol 21:595-8. 2006
    ..The aim of the present study was to determine whether mutations in the HFE gene are associated with an increased prevalence of arthritis...
  29. ncbi Antiproliferative effects of interferon alpha on hepatic progenitor cells in vitro and in vivo
    Rebecca Lim
    School of Medicine and Pharmacology, University of Western Australia, Nedlands, Western Australia
    Hepatology 43:1074-83. 2006
    ..05). In conclusion, interferon alpha-based treatment reduced the number of hepatic progenitor cells in chronic liver injury by modulating apoptosis, proliferation, and differentiation. Supplementay material for this article can..
  30. ncbi Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor
    Richard A Davies
    University of Western Australia Centre for Medical Research, Western Australian Institute for Medical Research, Crawley, 6009, Western Australia
    Carcinogenesis 27:1607-16. 2006
    ..These results suggest that the SC-236 induced reduction of M2PK-positive oval cell numbers may be due to COX-2 dependent inhibition of Akt phosphorylation and induction of apoptosis...
  31. ncbi Clinical expression of hemochromatosis gene (HFE) variants
    Oyekoya T Ayonrinde
    Hepatology 46:960-2. 2007
  32. ncbi Hereditary hemochromatosis in the post-HFE era
    John K Olynyk
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    Hepatology 48:991-1001. 2008
    ....
  33. ncbi Noncitrus fruits as novel dietary environmental modifiers of iron stores in people with or without HFE gene mutations
    Elizabeth A Milward
    School of Biomedical Sciences and Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW, Australia
    Mayo Clin Proc 83:543-9. 2008
    ..To investigate whether citrus fruit, noncitrus fruit, and other dietary factors act as environmental modifiers of iron status in the absence or presence of hemochromatotic HFE gene mutations...
  34. ncbi Prevalence, characteristics, and prognostic significance of HFE gene mutations in type 2 diabetes: the Fremantle Diabetes Study
    Timothy M E Davis
    School of Medicine and Pharmacology, Fremantle Hospital, University of Western Australia, Fremantle, Australia
    Diabetes Care 31:1795-801. 2008
    ..To examine the relationship between iron status, hereditary hemochromatosis (HFE) gene mutations, and clinical features and outcomes of type 2 diabetes in a well-characterized representative sample of community-based patients...
  35. ncbi The role of Hfe in transferrin-bound iron uptake by hepatocytes
    Anita C G Chua
    School of Medicine and Pharmacology, The University of Western Australia, Fremantle Hospital, Western Australia, Australia
    Hepatology 47:1737-44. 2008
    ..Diferric transferrin up-regulated hepatocyte Tfr2 protein expression but not iron uptake, suggesting that Tfr2 may have a limited role in the Tfr1-independent pathway...
  36. ncbi Iron-overload-related disease in HFE hereditary hemochromatosis
    Katrina J Allen
    Murdoch Children s Research Institute, University of Melbourne, Melbourne, Australia
    N Engl J Med 358:221-30. 2008
    ..Diseases related to iron overload develop in some C282Y homozygotes, but the extent of the risk is controversial...
  37. ncbi Clinical perspectives on hereditary hemochromatosis
    Oyekoya T Ayonrinde
    School of Medicine and Pharmacology, University of Western Australia, Western Australia, Australia
    Crit Rev Clin Lab Sci 45:451-84. 2008
    ..This review traverses the road from HFE genotype to phenotype with a focus on clinical penetrance, modifier factors for disease expression, and current thoughts and controversies on HH diagnosis and screening...
  38. ncbi HCV, iron, and oxidative stress: the new choreography of hepcidin
    Debbie Trinder
    Gastroenterology 134:348-51. 2008
  39. ncbi Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron
    Ross M Graham
    School of Medicine and Pharmacology, The University of Western Australia, Fremantle Hospital, P O Box 480, Fremantle, WA 6959, Australia
    J Hepatol 48:327-34. 2008
    ..Also present in these disorders are increased levels of plasma non-transferrin-bound iron. This study sought to clarify the role of transferrin receptor 2 in the uptake of transferrin-bound and non-transferrin-bound iron...
  40. ncbi The regulation of cellular iron metabolism
    Anita C G Chua
    School of Medicine and Pharmacology, University of Western Australia, Fremantle, Western Australia, Australia
    Crit Rev Clin Lab Sci 44:413-59. 2007
    ..Current knowledge on their roles in maintaining iron homeostasis and how their dysregulation leads to the pathogenesis of HH are discussed...
  41. ncbi Interferon-gamma exacerbates liver damage, the hepatic progenitor cell response and fibrosis in a mouse model of chronic liver injury
    Belinda Knight
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, PO Box 480, Fremantle 6959, WA, Australia
    J Hepatol 47:826-33. 2007
    ..However to date, no studies have directly tested the ability of IFNgamma to mediate the HPC response in an in vivo model...
  42. ncbi Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse
    Anita C G Chua
    School of Medicine and Pharmacology, Fremantle Hospital, The University of Western Australia, Fremantle, WA 6160, Australia
    J Hepatol 44:176-82. 2006
    ..The correlation between iron release and ferroportin expression suggests that iron export in hepatocytes is mediated by ferroportin...
  43. ncbi Lymphotoxin-beta production following bile duct ligation: possible role for Kupffer cells
    Clair M Lee
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
    J Gastroenterol Hepatol 20:1762-8. 2005
    ..The aim of this study was to determine in an animal model of bile duct ligation liver injury whether LT-beta expression is induced and whether Kupffer cells are an intrahepatic source of LT-beta...
  44. ncbi A population-based study of the biochemical and clinical expression of the H63D hemochromatosis mutation
    Peter A Gochee
    Queensland Institute of Medical Research and the University of Queensland, Brisbane, Western Australia
    Gastroenterology 122:646-51. 2002
    ..We accessed a well-defined population in Busselton, Australia, and determined the frequency of the H63D mutation and its influence on total body iron stores...
  45. ncbi Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis
    Anita C G Chua
    School of Medicine and Pharmacology, The University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle 6959, WA, Australia
    Blood 104:1519-25. 2004
    ..Inhibition of uptake by divalent metals and up-regulation of DMT1 expression suggested that NTBI uptake was mediated by DMT1...
  46. ncbi Screening for HFE and iron overload
    John Ombiga
    Department of Gastroenterology, Fremantle Hospital, Fremantle, Western Australia, Australia
    Semin Liver Dis 25:402-10. 2005
    ..Potential ethical, legal, and psychosocial issues arising through application of genetic screening programs also must be resolved prior to implementation of general population screening programs...
  47. ncbi Screening sigmoidoscopy for colorectal cancer: further pieces in the jigsaw
    Charlie H Viiala
    Med J Aust 180:493-4. 2004
  48. ncbi Differential effects of gadolinium chloride on Kupffer cells in vivo and in vitro
    Clair M Lee
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, P.O. Box 480, Fremantle 6959, WA, Australia
    Int J Biochem Cell Biol 36:481-8. 2004
    ..In vitro, GdCl has a dose dependent effect on phagocytosis but only effects viability and TNFalpha production at high concentrations. ED2 expression of cultured Kupffer cells is not affected by GdCl...
  49. ncbi Cost-effectiveness of colorectal cancer screening: comparison of community-based flexible sigmoidoscopy with fecal occult blood testing and colonoscopy
    John K Olynyk
    The Lewin Group, a Division of Quintiles Australia, Sydney, New South Wales, Australia
    J Gastroenterol Hepatol 19:38-47. 2004
    ..CONCLUSIONS: Flexible sigmoidoscopy and colonoscopy are cost-effective strategies for reducing the disease burden of colorectal cancer...
  50. ncbi Oval cell-mediated liver regeneration: Role of cytokines and growth factors
    Kym N Lowes
    Western Australian Institute for Medical Research, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley, Australia
    J Gastroenterol Hepatol 18:4-12. 2003
    ..This review outlines recent developments in the field of oval cell research and focuses on cytokines and growth factors that have been implicated in regulating oval cell proliferation and differentiation...
  51. ncbi Effects of body iron stores and haemochromatosis genotypes on coronary heart disease outcomes in the Busselton health study
    Christopher J Fox
    Department of Gastroenterology, Fremantle Hospital, Fremantle, Western Australia, Australia
    J Cardiovasc Risk 9:287-93. 2002
    ..The aims of this study were to determine in a stable community population whether increased iron stores or haemochromatosis gene mutations were risk factors for coronary heart disease...
  52. ncbi Flexible sigmoidoscopy screening for colorectal neoplasia in average-risk people: evaluation of a five-year rescreening interval
    Cameron F E Platell
    Department of Surgery, University of Western Australia at Fremantle Hospital
    Med J Aust 176:371-3. 2002
    ..To determine the prevalence of colorectal neoplasia detected by rescreening people with average risk five years after initial screening by flexible sigmoidoscopy...
  53. ncbi Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse
    Debbie Trinder
    Department of Medicine, University of Western Australia and Western Australian Institute for Medical Research, Perth 6009, Western Australia, Australia
    Proc Natl Acad Sci U S A 99:5622-6. 2002
    ..These data support the hypothesis that HFE regulates duodenal uptake of transferrin-bound iron from plasma, and that this mechanism of sensing body iron status, as reflected in plasma iron levels, is impaired in HH...
  54. ncbi Liver biopsy in the 21st century: where and why?
    Adrian Griffiths
    Med J Aust 176:52-3. 2002
  55. ncbi Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance
    Timothy G St Pierre
    School of Physics, University of Western Australia, Perth, Australia
    Blood 105:855-61. 2005
    ..Measurements of proton transverse relaxivity of aqueous MnCl2 phantoms on 13 different magnetic resonance imaging units using the method yielded a coefficient of variation of 2.1%...
  56. ncbi CD14-positive hepatic monocytes/macrophages increase in hereditary hemochromatosis
    Katherine L Leicester
    School of Medicine and Pharmacology, University of Western Australia, Australia
    Liver Int 24:446-51. 2004
    ..In control human liver, Kupffer cells had a very low expression of CD14. These findings suggest that CD14-positive monocytes/macrophages may contribute to the process of hepatic fibrogenesis in HH...
  57. ncbi Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury
    Belinda Knight
    School of Biomedical and Chemical Sciences, University of Western Australia, Nedlands, Western Australia, Australia
    Immunol Cell Biol 83:364-74. 2005
    ..In summary, our results document a close correlation between inflammation, cytokine production and the expansion of oval cells in the liver during experimental chronic injury...
  58. ncbi Jekyll and Hyde: evolving perspectives on the function and potential of the adult liver progenitor (oval) cell
    Belinda Knight
    School of Medicine and Pharmacology, University of Western Australia
    Bioessays 27:1192-202. 2005
    ..In the context of liver disease, LPCs may indeed be the cell of the future and understandably "our favourite cell"...
  59. ncbi Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta
    Belinda Knight
    School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, Australia
    Carcinogenesis 26:1782-92. 2005
    ..In summary, PPARgamma agonists reduce oval cell proliferation and fibrosis during chronic liver injury and may be useful in the prevention of hepatocellular carcinoma...
  60. ncbi Hepatic expression of the tumor necrosis factor family member lymphotoxin-beta is regulated by interleukin (IL)-6 and IL-1beta: transcriptional control mechanisms in oval cells and hepatoma cell lines
    Lily S Subrata
    Biochemistry and Molecular Biology, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley, Western Australia, Australia
    Liver Int 25:633-46. 2005
    ..In hepatic oval cells observed following chronic liver injury, LT-beta levels are upregulated, suggesting a link between LT-beta and liver regeneration...
  61. ncbi Iron overload
    Chiang W Siah
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, P.O. Box 480, Fremantle 6959, Western Australia
    Clin Chim Acta 358:24-36. 2005
    ..Advances in the understanding of the natural history of iron overload disorders and new methods for clinical detection and management of hereditary hemochromatosis are also reviewed...
  62. ncbi Oncostatin M induces an acute phase response but does not modulate the growth or maturation-status of liver progenitor (oval) cells in culture
    Vance B Matthews
    UWA Centre for Medical Research, Western Australian Institute for Medical Research, University of Western Australia, Crawley 6009, Australia
    Exp Cell Res 306:252-63. 2005
    ..However, decreased albumin production, accompanied by increased expression of haptoglobin and fibrinogen, suggests that OSM induced an acute phase reaction in cultured oval cells...
  63. ncbi Duration of hepatic iron exposure increases the risk of significant fibrosis in hereditary hemochromatosis: a new role for magnetic resonance imaging
    John K Olynyk
    School of Medicine and Pharmacology, University of Western Australia, Nedlands, Western Australia
    Am J Gastroenterol 100:837-41. 2005
    ..The product of HIC and age is highly sensitive and specific for diagnosis of high-grade fibrosis and can be obtained using MRI...
  64. ncbi Effects of HFE gene mutations and alcohol on iron status, liver biochemistry and morbidity
    John K Olynyk
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    J Gastroenterol Hepatol 20:1435-41. 2005
    ....
  65. ncbi Kupffer cell cytokines interleukin-1beta and interleukin-10 combine to inhibit phosphoenolpyruvate carboxykinase and gluconeogenesis in cultured hepatocytes
    Stephanie T Yerkovich
    Biochemistry and Molecular Biology, University of Western Australia, Nedlands, 35 Stirling Highway, Crawley 6009, WA, Australia
    Int J Biochem Cell Biol 36:1462-72. 2004
    ....
  66. ncbi Iron and the response to treatment of hepatitis C
    Adrian Griffiths
    Am J Gastroenterol 97:788-90. 2002
  67. ncbi Aldehydic products of lipid peroxidation do not directly activate rat hepatic stellate cells
    John K Olynyk
    Department of Medicine, University of Western Australia, Western Australian Institute of Medical Research, Perth, Australia
    J Gastroenterol Hepatol 17:785-90. 2002
    ..CONCLUSIONS: Aldehydic products of lipid peroxidation do not directly activate HSC in early culture and alternative pathways may be responsible for HSC activation during oxidative stress...
  68. ncbi Hereditary haemochromatosis: to screen or not to screen?
    John K Olynyk
    J Hepatol 43:9-10. 2005
  69. ncbi Iron overload in blacks: ironing out the issues
    Paul J Fortun
    Am J Gastroenterol 98:1456-8. 2003
  70. ncbi Waiting times for colonoscopy and colorectal cancer diagnosis
    Charlie H Viiala
    Endoscopy Unit, Fremantle Hospital, Fremantle, WA
    Med J Aust 186:282-5. 2007
    ..To evaluate whether prolonged waiting times for colonoscopy in public hospitals could result in delayed diagnosis of colorectal carcinoma...
  71. ncbi Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers
    Tania A Roskams
    Department of Pathology, University Hospitals, University of Leuven, Leuven, Belgium
    Hepatology 39:1739-45. 2004
    ....