Brian G G Oliver

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. doi request reprint Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages
    B G G Oliver
    Discipline of Pharmacology, The University of Sydney, Sydney, NSW 2006, Australia
    Thorax 63:519-25. 2008
  2. pmc Increased proinflammatory responses from asthmatic human airway smooth muscle cells in response to rhinovirus infection
    Brian G G Oliver
    Department of Pharmacology, University of Sydney, NSW, 2006, Australia
    Respir Res 7:71. 2006
  3. doi request reprint β2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers
    Kyoko Niimi
    Cell Biology Group, Woolcock Institute of Medical Research, School of Medical Sciences, The Univ of Sydney, Sydney, NSW, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L334-42. 2012
  4. doi request reprint TGF-β enhances deposition of perlecan from COPD airway smooth muscle
    Yukikazu Ichimaru
    Cell Biology Group, Woolcock Institute of Medical Research, NSW, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L325-33. 2012
  5. doi request reprint Matrix proteins from smoke-exposed fibroblasts are pro-proliferative
    David I Krimmer
    Woolcock Institute of Medical Research Cell Biology, Sydney, New South Wales, Australia
    Am J Respir Cell Mol Biol 46:34-9. 2012
  6. doi request reprint Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function
    Lyn M Moir
    Woolcock Institute of Medical Research, Sydney, Australia
    J Pharmacol Exp Ther 337:557-66. 2011
  7. pmc Is low dose inhaled corticosteroid therapy as effective for inflammation and remodeling in asthma? A randomized, parallel group study
    Melissa Baraket
    Woolcock Institute of Medical Research, Sydney, NSW, Australia
    Respir Res 13:11. 2012
  8. doi request reprint Tissue and matrix influences on airway smooth muscle function
    Janette K Burgess
    Discipline of Pharmacology, Bosch Institute, University of Sydney, Sydney, Australia
    Pulm Pharmacol Ther 22:379-87. 2009
  9. pmc Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma
    Hisako Matsumoto
    Discipline of Pharmacology, University of Sydney, NSW 2006, Australia
    Thorax 62:848-54. 2007
  10. pmc The expression and activity of cathepsins D, H and K in asthmatic airways
    Alen Faiz
    Cell Biology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    PLoS ONE 8:e57245. 2013

Collaborators

Detail Information

Publications17

  1. doi request reprint Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages
    B G G Oliver
    Discipline of Pharmacology, The University of Sydney, Sydney, NSW 2006, Australia
    Thorax 63:519-25. 2008
    ..Exacerbations of these diseases are also frequently associated with bacterial and atypical bacterial infection. Alveolar macrophages are the major immune cells in the airways and are important in defence against bacterial infections...
  2. pmc Increased proinflammatory responses from asthmatic human airway smooth muscle cells in response to rhinovirus infection
    Brian G G Oliver
    Department of Pharmacology, University of Sydney, NSW, 2006, Australia
    Respir Res 7:71. 2006
    ..We hypothesised that rhinovirus induction of inflammatory cytokine release from airway smooth muscle is augmented and differentially regulated in asthmatic compared to normal HASM cells...
  3. doi request reprint β2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers
    Kyoko Niimi
    Cell Biology Group, Woolcock Institute of Medical Research, School of Medical Sciences, The Univ of Sydney, Sydney, NSW, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L334-42. 2012
    ..This leads us to speculate that continual therapy with β2AR agonists is unlikely to cause PDE4-mediated tachyphylaxis...
  4. doi request reprint TGF-β enhances deposition of perlecan from COPD airway smooth muscle
    Yukikazu Ichimaru
    Cell Biology Group, Woolcock Institute of Medical Research, NSW, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L325-33. 2012
    ..Seeding on perlecan domains did not increase proliferation of any ASMC type. TGF-β(1)-induced perlecan deposition may enhance attachment of migrating ASMC in vivo and thus may be a mechanism for ASMC layer hypertrophy in COPD...
  5. doi request reprint Matrix proteins from smoke-exposed fibroblasts are pro-proliferative
    David I Krimmer
    Woolcock Institute of Medical Research Cell Biology, Sydney, New South Wales, Australia
    Am J Respir Cell Mol Biol 46:34-9. 2012
    ..ECM produced from COPD fibroblasts after CSE exposure has proproliferative effects. Thus, the ECM in patients with COPD may create an environment that promotes airway remodeling...
  6. doi request reprint Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function
    Lyn M Moir
    Woolcock Institute of Medical Research, Sydney, Australia
    J Pharmacol Exp Ther 337:557-66. 2011
    ..In addition, PIK75 decreased cell survival in TGFβ-stimulated asthmatic, but not nonasthmatic, ASM cells. In conclusion, specific PI3K isoforms may play a role in pathophysiological events relevant to airway wall remodeling...
  7. pmc Is low dose inhaled corticosteroid therapy as effective for inflammation and remodeling in asthma? A randomized, parallel group study
    Melissa Baraket
    Woolcock Institute of Medical Research, Sydney, NSW, Australia
    Respir Res 13:11. 2012
    ..Although symptom/lung function response to low and high dose ICS medication is comparable, it is uncertain whether low dose ICSs are as effective as high dose in the treatment of inflammation and remodeling...
  8. doi request reprint Tissue and matrix influences on airway smooth muscle function
    Janette K Burgess
    Discipline of Pharmacology, Bosch Institute, University of Sydney, Sydney, Australia
    Pulm Pharmacol Ther 22:379-87. 2009
    ..This review summarises our current understanding of the influence of the ECM on ASM function...
  9. pmc Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma
    Hisako Matsumoto
    Discipline of Pharmacology, University of Sydney, NSW 2006, Australia
    Thorax 62:848-54. 2007
    ..The purpose of this study was to establish a method to measure contraction of ASM cells by embedding them into a collagen gel, and to compare the contraction between subjects with and without asthma...
  10. pmc The expression and activity of cathepsins D, H and K in asthmatic airways
    Alen Faiz
    Cell Biology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    PLoS ONE 8:e57245. 2013
    ..This indicates that while CTSD possesses the potential to directly regulate tumstatin, and thus angiogenesis through this mechanism however, it is not likely to be involved in the dysregulation of tumstatin found in asthmatic airways...
  11. pmc Characterising the mechanism of airway smooth muscle β2 adrenoceptor desensitization by rhinovirus infected bronchial epithelial cells
    David Van Ly
    Woolcock Institute of Medical Research, Sydney, Australia
    PLoS ONE 8:e56058. 2013
    ..It was deduced that the mechanism by which β2 adrenoceptor desensitization occurs was by pattern recognition receptor activation of COX-2 induced prostaglandins...
  12. doi request reprint Molecular mechanisms of combination therapy with inhaled corticosteroids and long-acting beta-agonists
    Judith L Black
    School of Medical Sciences Pharmacology and Woolcock Institute of Medical Research, Sydney Medical School, The University of Sydney, NSW, Australia
    Chest 136:1095-100. 2009
    ..Delineation of the exact mechanisms underlying these effects will ensure rational, direct therapy...
  13. ncbi request reprint In vitro studies of lymphangioleiomyomatosis
    J L Black
    Dept of Pharmacology, University of Sydney, NSW 2006, and Transplant Unit, St Vincents Hospital, Sydney, Australia
    Eur Respir J 26:569-76. 2005
    ..In conclusion, lymphangioleiomyomatosis cells exhibit abnormal properties in vitro that may contribute to pathophysiology and symptomatology in patients with lymphangioleiomyomatosis...
  14. pmc Differential regulation of extracellular matrix and soluble fibulin-1 levels by TGF-β₁ in airway smooth muscle cells
    Ling Chen
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Shapingba, Chongqing, China
    PLoS ONE 8:e65544. 2013
    ..Therefore the increased deposition of FBLN-1 by ASM cells into the ECM following treatment with TGF-β1 is likely due to incorporation of soluble FBLN-1 rather than de-novo synthesis...
  15. doi request reprint Th1 cytokine-induced syndecan-4 shedding by airway smooth muscle cells is dependent on mitogen-activated protein kinases
    Xiahui Tan
    Univ of Sydney, Sydney, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L700-10. 2012
    ..ASMC syndecan-4 production during Th1 inflammatory conditions may regulate chemokine activity and mast cell recruitment to the ASM in asthma...
  16. ncbi request reprint A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro
    Janette K Burgess
    Department of Pharmacology, University of Sydney, NSW, Australia
    J Allergy Clin Immunol 118:649-57. 2006
    ..Airway smooth muscle (ASM) cells may contribute to airway remodeling through the release of growth factors, cytokines, and extracellular matrix (ECM) proteins. The effect of current asthma therapies on this release is not known...
  17. doi request reprint CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle
    D I Krimmer
    Discipline of Pharmacology, The University of Sydney, Sydney, NSW 2006, Australia
    Allergy 64:1074-82. 2009
    ..The aim of this study was to examine the effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on ASM CD40 and OX40L expression...