Research Topics
Species | P E NormanSummaryAffiliation: University of Western Australia Country: Australia Publications
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Detail Information
Publications
Infrarenal aortic diameter predicts all-cause mortalityPaul Norman
School of Surgery and Pathology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia
Arterioscler Thromb Vasc Biol 24:1278-82. 2004..To assess the relationship between infrarenal aortic diameter and subsequent all-cause mortality in men aged 65 years or older...- Long-term relative survival following surgery for abdominal aortic aneurysm: a reviewP E Norman
University Department of Surgery, Fremantle Hospital, PO Box 480, Western Australia, 6959 Fremantle, Australia
Cardiovasc Surg 9:219-24. 2001..This is in marked contrast to the situation for patients with malignant disease. With the current interest in population screening and endoluminal stenting for AAA, an understanding of long-term survival is increasingly important... - Peripheral arterial disease: prognostic significance and prevention of atherothrombotic complicationsPaul E Norman
School of Surgery and Pathology, Fremantle Hospital, PO Box 480, Fremantle, WA 6959, Australia
Med J Aust 181:150-4. 2004..Patients with PAD require medical management to prevent future coronary and cerebral vascular events. There are currently insufficient data to recommend routine population screening for asymptomatic PAD using the ABPI... - C-reactive protein levels and the expansion of screen-detected abdominal aortic aneurysms in menPaul Norman
School of Surgery and Pathology, The University of Western Australia, Fremantle Hospital, Fremantle, Western Australia
Circulation 110:862-6. 2004..CRP levels have also been found to be elevated in patients with abdominal aortic aneurysms (AAAs). The aim of this study was to assess the relation between CRP levels and rates of expansion of small AAAs... - Long-term relative survival in elderly patients after carotid endarterectomy: a population-based studyPaul E Norman
School of Surgery and Pathology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle, Western Australia 6959
Stroke 34:e95-8. 2003..The aim of the present study was to assess relative survival in those patients >or=80 years of age undergoing carotid endarterectomy... 
Population based randomised controlled trial on impact of screening on mortality from abdominal aortic aneurysmPaul E Norman
School of Surgery and Pathology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle, WA 6959, Australia
BMJ 329:1259. 2004..To assess whether screening for abdominal aortic aneurysms in men reduces mortality...- Peripheral arterial disease and risk of cardiac death in type 2 diabetes: the Fremantle Diabetes StudyPaul E Norman
School of Surgery and Pathology, Fremantle Hospital, P O Box 480, Fremantle, Western Australia 6959, Australia
Diabetes Care 29:575-80. 2006..The purpose of this study was to examine the natural history of peripheral arterial disease (PAD) complicating type 2 diabetes, in particular the influence of PAD on the risk of cardiac death and the adequacy of PAD risk factor management... - Maternal and postnatal vitamin D ingestion influences rat aortic structure, function and elastin contentPaul Norman
University Department of Surgery, Fremantle Hospital, P O Box 480, Western Australia 6959, Fremantle, Australia
Cardiovasc Res 55:369-74. 2002..Here we have investigated, in rats, the hypothesis that increased exposure to vitamin D during gestation and in the postnatal period alters aortic elastin content and aortic function... - Long term relative survival after surgery for abdominal aortic aneurysm in western Australia: population based studyP E Norman
University Department of Surgery, Fremantle Hospital, PO Box 480, Fremantle, Western Australia 6959, Australia
BMJ 317:852-6. 1998..To determine the long term relative survival of all patients who had surgery for abdominal aortic aneurysm in Western Australia during 1985-94... - The influence of gender on outcome following peripheral vascular surgery: a reviewP E Norman
University Department of Surgery, Fremantle Hospital, Western Australia, Australia
Cardiovasc Surg 8:111-5. 2000..The causes may include delayed diagnosis and referral, increased co-morbidity and possibly the effect of smaller arteries in women... 
Matrix metalloproteinase-2 gene variants and abdominal aortic aneurysmL Smallwood
School of Surgery, University of Western Australia, Fremantle Hospital, Fremantle, WA 6959, Australia
Eur J Vasc Endovasc Surg 38:169-71. 2009..To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA)...- The Quality of Surgical Care Project: benchmark standards of open resection for abdominal aortic aneurysm in Western AustraliaJ B Semmens
Centre for Health Services Research, Department of Public Health, University of Western Australia, Nedlands, Australia
Aust N Z J Surg 68:404-10. 1998..The purpose of this study is to establish benchmark standards in WA for operative mortality, 5-year survival and length of stay in all patients who were surgically treated for aneurysm of the abdominal aorta (AAA) in WA... - Falling incidence of amputations for peripheral occlusive arterial disease in Western Australia between 1980 and 1992E Mattes
Department of Surgery, University of Western Australia, Australia
Eur J Vasc Endovasc Surg 13:14-22. 1997..To assess temporal trends in the incidence of surgical procedures for peripheral occlusive arterial disease (POAD) and associated changes in outcome as measured by the rate of major lower limb amputations for POAD... - Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysmL Smallwood
Schools of Surgery, University of Western Australia, Fremantle, Western Australia
Br J Surg 95:1239-44. 2008..Increased matrix metalloproteinase (MMP) 9 activity has been implicated in the formation of abdominal aortic aneurysm (AAA). The aim was to explore the association between potentially functional variants of the MMP-9 gene and AAA... - Abdominal aortic aneurysm: the prognosis in women is worse than in menP E Norman
School of Surgery and Pathology, University of Western Australia, Fremantle, Western Australia
Circulation 115:2865-9. 2007 - Does the Mediterranean paradox extend to abdominal aortic aneurysm?K Jamrozik
Department of Public Health, The University of Western Australia, Nedlands, Western Australia
Int J Epidemiol 30:1071-5. 2001..We sought to test, in men undergoing ultrasound screening for abdominal aortic aneurysms (AAA) in Western Australia, clinical impressions that the prevalence of AAA is high in Dutch migrants and low in migrants from Mediterranean countries... - Population-based study of carotid endarterectomy in Western AustraliaC L Laurvick
Centre for Health Services Research, School of Population Health, Western Australia, Australia
Br J Surg 91:168-73. 2004..The aim of this study was to determine whether carotid endarterectomy rates have continued to rise despite the reducing trend in most manifestations of atherosclerotic cardiovascular disease... - Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. The Health In Men StudyB B Yeap
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Osteoporos Int 23:599-606. 2012..Differences in osteocalcin levels might influence glucose metabolism and thereby cardiovascular risk, or reflect changes in bone turnover thus representing a marker for poorer health outcomes... - Negative association between infra-renal aortic diameter and glycaemia: the Health in Men StudyM T Q Le
School of Surgery and Pathology, The University of Western Australia, Nedlands, Western Australia, Australia
Eur J Vasc Endovasc Surg 33:599-604. 2007..The aim of this study was to assess whether there is a similar relationship between both diabetes and glucose level, and infra-renal aortic diameter throughout its range... - Prevalence of abdominal aortic aneurysms in men with diabetesE Mattes
Department of Surgery, University of Western Australia, Fremantle Hospital, WA
Med J Aust 166:630-3. 1997..To assess the prevalence of abdominal aortic aneurysm (AAA) in men with diabetes aged 60 years and over... - Screening for abdominal aortic aneurysm: lessons from a population-based studyK Jamrozik
Department of Public Health, University of Western Australia, Nedlands
Med J Aust 173:345-50. 2000..To test the acceptability of screening and to identify modifiable risk factors for abdominal aortic aneurysm (AAA) in men... - The potential for a selective screening strategy for abdominal aortic aneurysmC A Spencer
Department of Public Health, University of Western Australia, Nedlands
J Med Screen 7:209-11. 2000..To investigate the feasibility of selective screening for abdominal aortic aneurysm (AAA) based on identification of a target group of manageable size defined by risk factors for AAA... - The association between C-reactive protein concentration and depression in later life is due to poor physical health: results from the Health in Men Study (HIMS)Osvaldo P Almeida
WA Centre for Health and Ageing, University of Western Australia, Australia
Psychol Med 37:1775-86. 2007..This study aimed to investigate the association between high CRP concentration and depression while taking physical health into account... - Successful mental health aging: results from a longitudinal study of older Australian menOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Royal Perth Hospital, Perth, WA 6009, Australia
Am J Geriatr Psychiatry 14:27-35. 2006..The authors investigated the associations of medical and lifestyle factors with the mental health of men in their 80s... - Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemiaLeon Flicker
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Stroke 37:547-9. 2006..Previous studies, largely in younger individuals, have shown that B vitamins lowered tHcy by substantial amounts and that this effect is greater in people with higher tHcy and lower folate levels... - Improving maximum walking distance in early peripheral arterial disease: randomised controlled trialBess Fowler
University of Western Australia, Australia
Aust J Physiother 48:269-75. 2002..A combination of simple and safe interventions that are readily available in the community through physiotherapists and general practitioners has the potential to improve early peripheral arterial disease... - B-vitamins reduce plasma levels of beta amyloidLeon Flicker
School of Medicine and Pharmacology, University of Western Australia, Australia
Neurobiol Aging 29:303-5. 2008..E.) increase of A beta 40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of A beta 40 and have a role in the prevention of AD... - Association of cardiovascular risk factors and disease with depression in later lifeOsvaldo P Almeida
Unit of Geriatric Psychiatry, University of Western Australia and Royal Perth Hospital, Perth, WA, Australia
Am J Geriatr Psychiatry 15:506-13. 2007..The objective of this study is to determine the association between established cardiovascular risk factors and depression among older men... - Is there an association between chronic lung disease and abdominal aortic aneurysm expansion?Carole Spencer
School of Population Health, The University of Western Australia, Nedlands, Western Australia, Australia
ANZ J Surg 73:787-9. 2003..We sought such an association in a cohort of men with aneurysms detected in a population-based study of screening for aneurysms... - Homocysteine and depression in later lifeOsvaldo P Almeida
FRANZCP, Western Australian Centre for Health and Ageing, University of Western Australia, Mail Box M573, 35 Stirling Hwy, Crawley, WA 6009, Australia
Arch Gen Psychiatry 65:1286-94. 2008..Genetic association studies are not prone to the same sources of error and offer an opportunity to explore the consistency and external validity of this association... - Predictors, consequences and costs of diabetes-related lower extremity amputation complicating type 2 diabetes: the Fremantle Diabetes StudyW A Davis
School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle, WA 6959, Australia
Diabetologia 49:2634-41. 2006..The aims of this study were to assess the incidence, predictors, consequences, and inpatient cost of lower extremity amputation (LEA) in a community-based cohort of type 2 diabetic patients... - The anatomical distribution of iliac aneurysms: is there an embryological basis?P E Norman
University Department of Surgery, Fremantle Hospital, Fremantle, Western Australia
Eur J Vasc Endovasc Surg 25:82-4. 2003 - Vitamin D, shedding light on the development of disease in peripheral arteriesP E Norman
School of Surgery and Pathology, The University of Western Australia, Fremantle Hospital, Fremantle, Western Australia
Arterioscler Thromb Vasc Biol 25:39-46. 2005..This review explores the relationship between vitamin D and a range of physiological and pathological processes relevant to peripheral arteries... - Polymorphisms of the interleukin-6 gene promoter and abdominal aortic aneurysmL Smallwood
School of Surgery and Pathology, University of Western Australia
Eur J Vasc Endovasc Surg 35:31-6. 2008..Genetic association studies are one means of trying to clarify the role of specific mediators in the causal pathway. The aim of the present study was to examine the association between variants of the IL-6 gene and AAAs... - Carotid endarterectomy in octogenariansRaphael Varghese
School of Surgery and Pathology, The University of Western Australia, Fremantle Hospital, Fremantle, Western Australia
ANZ J Surg 74:215-7. 2004..The aim of the present study was to determine the trends and early outcome of carotid endarterectomy performed in octogenarians at a single institution... - Development of a rapid genotyping method for single nucleotide polymorphisms and its application in cancer studiesFabienne Grieu
Department of Radiation Oncology, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands 6009, Australia
Oncol Rep 11:501-4. 2004..The low start-up and running costs make this method particularly well suited for SNP genotyping studies that involve up to 1,000 DNA samples... - Lifestyle still predicts mortality in older men with established vascular diseaseCarole A Spencer
School of Population Health, The University of Western Australia, Nedlands, Australia
Prev Med 41:583-8. 2005..CONCLUSIONS: Our results highlight the importance of maintaining a healthy lifestyle through to old age, regardless of history of vascular disease... - Homocysteine and vitamin status in older people in PerthLeon A Flicker
Med J Aust 180:539-40. 2004 - Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: the Health in Men StudyS A Paul Chubb
PathWest, Department of Biochemistry, Fremantle Hospital, Western Australia, 6160 Australia
Eur J Endocrinol 158:785-92. 2008..As SHBG increases with age while testosterone declines, we examined the relative contributions of SHBG and testosterone to the risk of metabolic syndrome in older men... - Management of peripheral arterial disease in the elderly: focus on cilostazolTravis M Falconer
School of Surgery, University of Western Australia, Fremantle Hospital, Western Australia, Australia
Clin Interv Aging 3:17-23. 2008..In addition to risk factor management, treatment with cilostazol should be considered in patients with disabling IC... - Diabetes and aortic aneurysmJonathan Golledge
Am J Cardiol 101:1680-1. 2008 - Is screening for abdominal aortic aneurysm bad for your health and well-being?Carole A Spencer
School of Population Health, University of Western Australia, Nedlands, WA, Australia
ANZ J Surg 74:1069-75. 2004..The purpose of the present paper was to investigate whether screening for abdominal aortic aneurysm (AAA) causes health-related quality of life to change in men or their partners... - A simple lifestyle score predicts survival in healthy elderly menCarole A Spencer
School of Population Health, University of Western Australia, Clifton St, Nedlands, Western Australia 6907, Australia
Prev Med 40:712-7. 2005..CONCLUSIONS: Lifestyle remains an important predictor of mortality even in old age. Survival in older men without a history of cardiovascular disease can potentially be enhanced by promoting a healthy lifestyle... - In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men StudyBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
Eur J Endocrinol 156:585-94. 2007..We sought to determine the distribution and associations of reduced testosterone concentrations in older men... - Association between osteopontin and human abdominal aortic aneurysmJonathan Golledge
The Vascular Biology Unit, School of Medicine, James Cook University, Townsville, Queensland, 4811 Australia
Arterioscler Thromb Vasc Biol 27:655-60. 2007..The relationship between serum concentration of OPN and variants of the OPN gene with human abdominal aortic aneurysm (AAA) was investigated... - Medical treatment of peripheral arterial diseaseGraeme J Hankey
Department of Neurology, Royal Perth Hospital and School of Medicine and Pharmacology, University of Western Australia, Perth
JAMA 295:547-53. 2006.... - Indications for operative management of abdominal aortic aneurysmsFaraz Shakibaie
School of Surgery and Pathology, The University of Western Australia, Perth, Western Australia, Australia
ANZ J Surg 74:470-6. 2004..This review makes recommendations on the management of small abdominal aortic aneurysms according to the current available evidence... - Abdominal aortic aneurysm events in postmenopausal womenJanet T Powell
BMJ 337:a1894. 2008 - Abdominal aortic aneurysm repair in octogenariansPaul E Norman
ANZ J Surg 72:612. 2002 - Genome Wide Association Studies: identifying the genes that determine the risk of abdominal aortic aneurysmMatthew J Bown
Eur J Vasc Endovasc Surg 36:395-6. 2008 - Obesity, adipokines, and abdominal aortic aneurysm: Health in Men studyJonathan Golledge
Vascular Biology Unit, Department of Surgery, School of Medicine, James Cook University, Townsville, QLD, Australia 4811
Circulation 116:2275-9. 2007..Obesity is associated with occlusive artery disease but is not considered a risk factor for abdominal aortic aneurysm (AAA). We investigated the association between anthropometric measures of obesity, serum adipokines, and AAA... - Comparative roles of microvascular and nerve function in foot ulceration in type 2 diabetes: response to Krishnan et alDean T Williams
Diabetes Care 27:3026; author reply 3026-7. 2004 - Homocysteine and abdominal aortic aneurysmsPaul Moroz
School of Surgery and Pathology, University of Western Australia, Fremantle Hospital, Perth, Western Australia, Australia
ANZ J Surg 77:329-32. 2007..Further research is needed, given the potential benefit that simple vitamin supplementation may have for patients with AAA... - Reduced expansion rate of abdominal aortic aneurysms in patients with diabetes may be related to aberrant monocyte-matrix interactionsJonathan Golledge
Vascular Biology Unit, Department of Surgery, School of Medicine, James Cook University, Townsville, Qld 4811, Australia
Eur Heart J 29:665-72. 2008..The reason for this difference is unknown. We examined the role of diabetes and glycation on AAA expansion and extracellular matrix-monocyte interactions... - Relationship between two sequence variations in the gene for peroxisome proliferator-activated receptor-gamma and plasma homocysteine concentration. Health in men studyJonathan Golledge
The Vascular Biology Unit, Department of Surgery, School of Medicine, James Cook University, Townsville, QLD, 4811, Australia
Hum Genet 123:35-40. 2008..005). Our findings demonstrate a new genotypic association with plasma homocysteine. Replication will be required in other cohorts... - Matrix biology of abdominal aortic aneurysms in diabetes: mechanisms underlying the negative associationPaul E Norman
School of Surgery and Pathology, University of Western Australia, Fremantle, Western Australia
Connect Tissue Res 48:125-31. 2007..The aim of our present minireview is to compare the changes in matrix biology seen in diabetes and AAA and to explore molecular mechanisms that may explain the negative association and identify possible therapeutic implications... - Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohortsGregory T Jones
Department of Surgery, University of Otago, New Zealand
Arterioscler Thromb Vasc Biol 28:764-70. 2008..This study was undertaken, using the largest case series yet reported, to determine whether common genetic variants of the RAS are associated with either susceptibility or severity of AAA...