Brett Nixon

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. doi request reprint Composition and significance of detergent resistant membranes in mouse spermatozoa
    Brett Nixon
    Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    J Cell Physiol 218:122-34. 2009
  2. doi request reprint Molecular and functional characterization of the rabbit epididymal secretory protein 52, REP52
    Brett Nixon
    School of Environmental and Life Sciences, Discipline of Biological Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 78:910-20. 2008
  3. doi request reprint Elucidation of the signaling pathways that underpin capacitation-associated surface phosphotyrosine expression in mouse spermatozoa
    Brett Nixon
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, Australia
    J Cell Physiol 224:71-83. 2010
  4. doi request reprint Monotremes provide a key to understanding the evolutionary significance of epididymal sperm maturation
    Brett Nixon
    School of Environmental and Life Sciences, Discipline of Biological Sciences, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    J Androl 32:665-71. 2011
  5. doi request reprint Proteomic and functional analysis of human sperm detergent resistant membranes
    Brett Nixon
    Reproductive Science Group, University of Newcastle, Callaghan, New South Wales, Australia
    J Cell Physiol 226:2651-65. 2011
  6. doi request reprint The biological significance of detergent-resistant membranes in spermatozoa
    Brett Nixon
    Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, Australia
    J Reprod Immunol 83:8-13. 2009
  7. doi request reprint Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition
    Kate A Redgrove
    Reproductive Science Group, School of Environmental and Life Sciences, Discipline of Biological Sciences, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    Mol Hum Reprod 19:120-35. 2013
  8. doi request reprint Identification of the molecular chaperone, heat shock protein 1 (chaperonin 10), in the reproductive tract and in capacitating spermatozoa in the male mouse
    Andrew Walsh
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 78:983-93. 2008
  9. doi request reprint Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae
    Kate A Redgrove
    Reproductive Science Group, School of Environmental and Life Sciences, Discipline of Biological Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Dev Biol 356:460-74. 2011
  10. doi request reprint Investigation of the role of SRC in capacitation-associated tyrosine phosphorylation of human spermatozoa
    Lisa A Mitchell
    Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Mol Hum Reprod 14:235-43. 2008

Collaborators

Detail Information

Publications39

  1. doi request reprint Composition and significance of detergent resistant membranes in mouse spermatozoa
    Brett Nixon
    Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    J Cell Physiol 218:122-34. 2009
    ....
  2. doi request reprint Molecular and functional characterization of the rabbit epididymal secretory protein 52, REP52
    Brett Nixon
    School of Environmental and Life Sciences, Discipline of Biological Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 78:910-20. 2008
    ....
  3. doi request reprint Elucidation of the signaling pathways that underpin capacitation-associated surface phosphotyrosine expression in mouse spermatozoa
    Brett Nixon
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, Australia
    J Cell Physiol 224:71-83. 2010
    ..Collectively, these data highlight a previously unappreciated role of the ERK module in the modification of the sperm surface during capacitation to render these cells functionally competent to engage in the process of fertilization...
  4. doi request reprint Monotremes provide a key to understanding the evolutionary significance of epididymal sperm maturation
    Brett Nixon
    School of Environmental and Life Sciences, Discipline of Biological Sciences, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    J Androl 32:665-71. 2011
    ....
  5. doi request reprint Proteomic and functional analysis of human sperm detergent resistant membranes
    Brett Nixon
    Reproductive Science Group, University of Newcastle, Callaghan, New South Wales, Australia
    J Cell Physiol 226:2651-65. 2011
    ..Collectively these data afford novel insights into the subcellular localization and potential functions of membrane rafts in human spermatozoa...
  6. doi request reprint The biological significance of detergent-resistant membranes in spermatozoa
    Brett Nixon
    Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, Australia
    J Reprod Immunol 83:8-13. 2009
    ....
  7. doi request reprint Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition
    Kate A Redgrove
    Reproductive Science Group, School of Environmental and Life Sciences, Discipline of Biological Sciences, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    Mol Hum Reprod 19:120-35. 2013
    ..Collectively these data afford novel insights into the sub-cellular localization and potential functions of multimeric protein complexes in human spermatozoa...
  8. doi request reprint Identification of the molecular chaperone, heat shock protein 1 (chaperonin 10), in the reproductive tract and in capacitating spermatozoa in the male mouse
    Andrew Walsh
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 78:983-93. 2008
    ..Collectively, these data invite speculation that a number of molecular chaperones are involved in modification of the sperm surface during capacitation to render these cells functionally competent to engage the process of fertilization...
  9. doi request reprint Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae
    Kate A Redgrove
    Reproductive Science Group, School of Environmental and Life Sciences, Discipline of Biological Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Dev Biol 356:460-74. 2011
    ..Overall, the strategies employed in this study have provided novel, causal insights into the molecular mechanisms that govern sperm-egg interaction...
  10. doi request reprint Investigation of the role of SRC in capacitation-associated tyrosine phosphorylation of human spermatozoa
    Lisa A Mitchell
    Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Mol Hum Reprod 14:235-43. 2008
    ..However, although the inhibition of PKA was also accompanied by a suppression of sperm motility, SRC inhibition did not induce a similar response...
  11. pmc Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa
    Andrew T Reid
    School of Environmental and Life Sciences, Discipline of Biological Sciences, The University of Newcastle, University Drive, Callaghan, New South Wales 2308, Australia
    J Biol Chem 287:37659-72. 2012
    ..On the basis of our collective data, we propose that dynamin could regulate specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa...
  12. doi request reprint The role of molecular chaperones in spermatogenesis and the post-testicular maturation of mammalian spermatozoa
    Matthew D Dun
    School of Environmental and Life Sciences, Discipline of Biological Sciences, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    Hum Reprod Update 18:420-35. 2012
    ....
  13. ncbi request reprint The identification of mouse sperm-surface-associated proteins and characterization of their ability to act as decapacitation factors
    Brett Nixon
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 74:275-87. 2006
    ..Of these proteins, PBP was identified as a primary candidate for a decapacitation factor...
  14. pmc The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction
    Matthew D Dun
    Reproductive Science Group, School of Environmental and Life Sciences, Discipline of Biological Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Biol Chem 286:36875-87. 2011
    ..Collectively, these data provide an important biochemical insight into the molecular basis of sperm-zona pellucida interaction and a plausible explanation for how spermatozoa gain their ability to fertilize...
  15. ncbi request reprint Localization and significance of molecular chaperones, heat shock protein 1, and tumor rejection antigen gp96 in the male reproductive tract and during capacitation and acrosome reaction
    Kelly L Asquith
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 72:328-37. 2005
    ..These data reinforce the notion that these chaperones are intimately involved in the mechanisms by which mammalian spermatozoa both acquire and express their ability to recognize the zona pellucida...
  16. doi request reprint Proteomic insights into the maturation and capacitation of mammalian spermatozoa
    Mark A Baker
    PRC in Reproductive Science, School of Environmental and Life Sciences, University of Newcastle, NSW, Australia
    Syst Biol Reprod Med 58:211-7. 2012
    ..As a result of such advances, insights will be generated that should ultimately lead to significant improvements in our capacity to diagnose and treat the infertile male...
  17. ncbi request reprint Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition
    Kelly L Asquith
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    J Cell Sci 117:3645-57. 2004
    ....
  18. pmc The molecular chaperone HSPA2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition
    Kate A Redgrove
    Priority Research Centre in Reproductive Science, School of Environmental and Life Sciences, Discipline of Biological Sciences, The University of Newcastle, Callaghan, New South Wales, Australia
    PLoS ONE 7:e50851. 2012
    ....
  19. doi request reprint Chronic exposure to acrylamide induces DNA damage in male germ cells of mice
    Belinda J Nixon
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Toxicol Sci 129:135-45. 2012
    ..01 µg/ml (0.001 mg/kg bodyweight/day). The results of this study are the first to demonstrate that chronic exposure to acrylamide, at doses equivalent to human exposures, generates DNA damage in male germ cells of mice...
  20. ncbi request reprint Role of the epididymis in sperm competition
    Russell C Jones
    Discipline of Biological Sciences, The University of Newcastle, Callaghan 2308, Australia
    Asian J Androl 9:493-9. 2007
    ....
  21. ncbi request reprint Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa
    Brett Nixon
    Reproductive Science Group, University of Newcastle, Callaghan, NSW 2308, Australia
    J Cell Sci 118:4865-77. 2005
    ..Collectively, these data provide the first evidence that a receptor-mediated signal transduction pathway triggers human sperm capacitation and identifies PECAM-1 as the probable initiator of this second messenger cascade...
  22. ncbi request reprint Proteomic changes in mammalian spermatozoa during epididymal maturation
    R John Aitken
    The ARC Centre of Excellence in Biotechnology and Development, University of Newcastle, Newcastle, NSW 2308, Australia
    Asian J Androl 9:554-64. 2007
    ..At least in rodent species, activation of sperm mitochondria appears to be a particularly important part of epididymal maturation...
  23. doi request reprint Melatonin prevents postovulatory oocyte aging in the mouse and extends the window for optimal fertilization in vitro
    Tessa Lord
    Priority Research Centre for Reproductive Biology, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Biol Reprod 88:67. 2013
    ..01). We conclude that melatonin may be a useful tool in a clinical setting to prevent the time-dependent deterioration of oocyte quality following prolonged culture in vitro...
  24. pmc A unique combination of male germ cell miRNAs coordinates gonocyte differentiation
    Skye C McIver
    ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    PLoS ONE 7:e35553. 2012
    ..These targets converge on the key downstream cell cycle regulator Cyclin D1, indicating that a unique combination of male germ cell miRNAs coordinate the differentiation and maintenance of pluripotency in germ cells...
  25. pmc Cellular mechanisms regulating sperm-zona pellucida interaction
    Andrew T Reid
    Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Asian J Androl 13:88-96. 2011
    ....
  26. doi request reprint Staying alive: PI3K pathway promotes primordial follicle activation and survival in response to 3MC-induced ovotoxicity
    Alexander P Sobinoff
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Toxicol Sci 128:258-71. 2012
    ....
  27. doi request reprint Understanding the Villain: DMBA-induced preantral ovotoxicity involves selective follicular destruction and primordial follicle activation through PI3K/Akt and mTOR signaling
    Alexander P Sobinoff
    Reproductive Science Group, School of Environmental and Life Sciences
    Toxicol Sci 123:563-75. 2011
    ..Our results reveal a novel mechanism of DMBA-induced preantral ovotoxicity involving selective immature follicle destruction and primordial follicle activation involving downstream members of the PI3K/Akt and mTOR signaling pathways...
  28. ncbi request reprint Identification of RARhoGAP, a novel putative RhoGAP gene expressed in male germ cells
    Benjamin J Curry
    Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Genomics 84:406-18. 2004
    ..We postulate that RARhoGAP may be involved in rearrangements of the cytoskeleton and cell signaling events that occur during spermatogenesis...
  29. doi request reprint DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress
    Geoffry N De Iuliis
    ARC Centre of Excellence in Biotechnology and Development and Hunter Medical Research Institute, Discipline of Biological Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 81:517-24. 2009
    ..These results clearly highlight the importance of oxidative stress in the induction of sperm DNA damage and carry significant implications for the clinical management of this condition...
  30. ncbi request reprint The role of molecular chaperones in mouse sperm-egg interactions
    Brett Nixon
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, Australia
    Mol Cell Endocrinol 240:1-10. 2005
    ....
  31. ncbi request reprint Rabbit epididymal secretory proteins. I. Characterization and hormonal regulation
    Brett Nixon
    Department of Biological Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Biol Reprod 67:133-9. 2002
    ..Seven of the proteins gained were about the same molecular weight as proteins secreted by the epididymis (M(r) 94 000, 52 000, 38 000, 36 000, 22 000, 20 000, and 13 000) and were analyzed using N-terminal amino acid microsequencing...
  32. doi request reprint Adding insult to injury: effects of xenobiotic-induced preantral ovotoxicity on ovarian development and oocyte fusibility
    Alexander P Sobinoff
    Reproductive Science Group, Callaghan, New South Wales 2308, Australia
    Toxicol Sci 118:653-66. 2010
    ..5-15 mg/kg/day) neonatal exposure to xenobiotics causing long-term reactive oxygen species-induced oocyte dysfunction...
  33. doi request reprint Capacitation in the presence of methyl-β-cyclodextrin results in enhanced zona pellucida-binding ability of stallion spermatozoa
    Elizabeth G Bromfield
    School of Environmental and Life Sciences, Priority Research Centre for Reproductive Biology, Discipline of Biological Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Reproduction 147:153-66. 2014
    ..Collectively, these results highlight the importance of efficient cholesterol removal in priming stallion spermatozoa for ZP binding in vitro. ..
  34. doi request reprint The function of chaperone proteins in the assemblage of protein complexes involved in gamete adhesion and fusion processes
    Elizabeth G Bromfield
    Priority Research Centre in Reproductive Science, School of Environmental and Life Sciences, Discipline of Biological Sciences, The University of Newcastle, Callaghan, New South Wales 2308, Australia
    Reproduction 145:R31-42. 2013
    ....
  35. doi request reprint Post-testicular sperm maturation and identification of an epididymal protein in the Japanese quail (Coturnix coturnix japonica)
    Brett Nixon
    Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, University Drive, Callaghan, New South Wales 2308, Australia
    Reproduction 147:265-77. 2014
    ..It is suggested that hemoglobin may support sperm metabolism in the quail epididymis, aid in motility, and/or serve as an antioxidant. ..
  36. doi request reprint Sperm capacitation: a distant landscape glimpsed but unexplored
    R John Aitken
    Priority Research Centre for Reproductive Biology, Discipline of Biological Sciences, Faculty of Science and IT, University of Newcastle, and Hunter Medical Research Institute, Callaghan, NSW 2308, Australia
    Mol Hum Reprod 19:785-93. 2013
    ..Progress in this area has been enhanced by IVF technology pioneered by Bob Edwards and will ultimately facilitate the design of safe, effective culture conditions for optimization of this revolutionary therapy. ..
  37. ncbi request reprint Rabbit epididymal secretory proteins. III. Molecular cloning and characterization of the complementary DNA for REP38
    Brett Nixon
    Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, Canberra, ACT 2601, Australia
    Biol Reprod 67:147-53. 2002
    ..Although REP38-c1 mRNA was detected only in the rabbit epididymis, database searches indicated homology with two rat testis specific cDNAs, KTT4 and odf2, which encode sperm outer dense fiber proteins...
  38. ncbi request reprint Rabbit epididymal secretory proteins. II. Immunolocalization and sperm association of REP38
    Brett Nixon
    Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, Canberra, ACT 2601, Australia
    Biol Reprod 67:140-6. 2002
    ..When tested in vitro, anti-REP38 IgG reduced the percentage of ova fertilized in a concentration-dependent manner, apparently by blocking sperm-egg fusion...
  39. pmc Genome analysis of the platypus reveals unique signatures of evolution
    Wesley C Warren
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 453:175-83. 2008
    ..Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation...