S K Nilsson
Affiliation: University of Melbourne
- Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgment at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitroSusan K Nilsson
Stem Cell Biology Laboratory, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
Blood 101:856-62. 2003..Collectively, these data describe an important yet previously unrecognized role for HA in the biology of primitive hemopoietic progenitor cells...
- Hemopoietic stem cells with higher hemopoietic potential reside at the bone marrow endosteumDavid N Haylock
Australian Stem Cell Centre, Victoria, Australia
Stem Cells 25:1062-9. 2007....
- Cells capable of bone production engraft from whole bone marrow transplants in nonablated miceS K Nilsson
Cancer Center and the Department of Cell Biology, University of Massachusetts Medical Center, Worcester, Massachusetts 01605, USA
J Exp Med 189:729-34. 1999..Transplanted cells were also detected as flattened bone lining cells on the periosteal bone surface...
- Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell nichesS K Nilsson
Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
Blood 97:2293-9. 2001..Together, these data strongly support historical evidence of the presence of endosteal hemopoietic stem cell niches...
- Transplantable stem cells: home to specific nichesSusan K Nilsson
Stem Cell Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia
Curr Opin Hematol 11:102-6. 2004....
- Recent Australian experience with hemopoietic stem and progenitor cell expansionS K Nilsson
Australian Stem Cell Center, Clayton, Melbourne, Australia
Cytotherapy 9:231-5. 2007..The first was an attempt to deliver a gene therapy for treatment of HIV and the second an attempt to improve rates of hemopoietic recovery with ex vivo generated myeloid cells...
- Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factorJ P Levesque
Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
Blood 98:1289-97. 2001....
- Granulocyte-macrophage colony-stimulating factor is not responsible for the correction of hematopoietic deficiencies in the maturing op/op mouseS K Nilsson
Sir Donald and Lady Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Melbourne, Australia
Blood 86:66-72. 1995..This finding suggests that an alternate regulatory factor can be involved in macrophage and osteoclast commitment, differentiation, and function in vivo...
- Age-related changes in extramedullary hematopoiesis in the spleen of normal and perturbed osteopetrotic (op/op) miceS K Nilsson
Cell Biology Group, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
Exp Hematol 22:377-83. 1994..The response of these mice to a 5-fluorouracil (5-FU) cytotoxic challenge suggested that this pool of primitive progenitor cells acted as a hematopoietic reserve capable of rapidly responding to hematopoietic perturbation...
- Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrowJean Pierre Levesque
Mater Medical Research Institute, Raymond Terrace, Aubigny Place, South Brisbane, QLD, Australia
Stem Cells 25:1954-65. 2007..Disclosure of potential conflicts of interest is found at the end of this article...
- Hemopoietic stem cell engraftmentSusan K Nilsson
Stem Cell Biology Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Exp Hematol 34:123-9. 2006
- Stem cell regulation by the hematopoietic stem cell nicheDavid N Haylock
Stem Cell Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia
Cell Cycle 4:1353-5. 2005....
- Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cellsSusan K Nilsson
Stem Cell Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria, Australia, 3000
Blood 106:1232-9. 2005..These data therefore provide strong evidence that Opn is an important component of the HSC niche which participates in HSC location and as a physiologic-negative regulator of HSC proliferation...
- Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow regionRebecca L Driessen
Stem Cell Laboratories, Peter MacCallum Cancer Centre, A Beckett Street, Melbourne, Victoria 3000, Australia
Exp Hematol 31:1284-91. 2003..In addition, in vivo SCF has been shown to play a role in cell mobilization and migration. The aim of this study was to determine if SCF is an integral component of the hemopoietic "niche" of the bone marrow in situ...
- The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancerLishanthi Udabage
Laboratory for Hyaluronan Research, Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
Exp Cell Res 310:205-17. 2005..There was a correlation between elevated levels of HA synthesis, CD44 expression and cancer cell migration thereby highlighting the pivotal role that HA metabolism plays in the aggressive breast cancer phenotype...
- Gene expression, synthesis and degradation of hyaluronan during differentiation of 3T3-L1 adipocytesPeter G Allingham
Cooperative Research Centre for Cattle and Beef Quality, CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD 4067, Australia
Arch Biochem Biophys 452:83-91. 2006....
- Osteopontin: a bridge between bone and bloodDavid N Haylock
Niche Laboratory, Australian Stem Cell Centre, Monash University, Clayton, Vic, Australia
Br J Haematol 134:467-74. 2006..Through osteoblasts and their cell surface and expressed proteins including Opn, bone is able to regulate the tissue that resides within it. In doing so, Opn can be considered a bridge between bone and blood...
- Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancerLishanthi Udabage
Laboratory for Hyaluronan Research, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
Cancer Res 65:6139-50. 2005..Collectively, these unique results strongly implicate the central role of HAS2 in the initiation and progression of breast cancer, potentially highlighting the co-dependency between HAS2, CD44, and HYAL2 expression...
- The role of hyaluronic acid in hemopoietic stem cell biologyDavid N Haylock
Australian Stem Cell Centre, PO Box 8002, Monash University LPO, Victoria 3168, Australia
Regen Med 1:437-45. 2006....
- Expansion of umbilical cord blood for clinical transplantationDavid N Haylock
Australian Stem Cell Centre, P O Box 8002, Monash University LPO, Victoria 3168, Australia
Curr Stem Cell Res Ther 2:324-35. 2007....