J Nikles

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. doi request reprint Aggregated n-of-1 trials of central nervous system stimulants versus placebo for paediatric traumatic brain injury--a pilot study
    Catherine J Nikles
    School of Medicine, The University of Queensland, Ipswich Campus, Building 12, Salisbury Rd, Ipswich 4305, Australia
    Trials 15:54. 2014
  2. pmc Central nervous system stimulants for secondary attention deficit-hyperactivity disorder after paediatric traumatic brain injury: a rationale and protocol for single patient (n-of-1) multiple cross-over trials
    Hugh E J Senior
    Discipline of General Practice, School of Medicine, The University of Queensland, 11 Salisbury Rd, Ipswich 4305, Australia
    BMC Pediatr 13:89. 2013
  3. pmc Using aggregated single patient (N-of-1) trials to determine the effectiveness of psychostimulants to reduce fatigue in advanced cancer patients: a rationale and protocol
    Hugh Ej Senior
    Discipline of General Practice, The University of Queensland, Brisbane, Queensland, Australia
    BMC Palliat Care 12:17. 2013
  4. doi request reprint Prioritising drugs for single patient (n-of-1) trials in palliative care
    J Nikles
    Discipline of General Practice, The University of Queensland, Herston, Brisbane, Queensland, Australia
    Palliat Med 23:623-34. 2009
  5. ncbi request reprint Long-term changes in management following n-of-1 trials of stimulants in attention-deficit/hyperactivity disorder
    C Jane Nikles
    School of Medicine, University of Queensland, Queensland, Australia
    Eur J Clin Pharmacol 63:985-9. 2007
  6. ncbi request reprint An n-of-1 trial service in clinical practice: testing the effectiveness of stimulants for attention-deficit/hyperactivity disorder
    C Jane Nikles
    The University of Queensland, Herston, Queensland 4006, Australia
    Pediatrics 117:2040-6. 2006
  7. ncbi request reprint Bias influencing maternal reports of child behaviour and emotional state
    J M Najman
    School of Social Science, The University of Queensland, Australia
    Soc Psychiatry Psychiatr Epidemiol 36:186-94. 2001
  8. ncbi request reprint Mothers' mental illness and child behavior problems: cause-effect association or observation bias?
    J M Najman
    Department of Anthropology and Sociology, University of Queensland, Australia
    J Am Acad Child Adolesc Psychiatry 39:592-602. 2000
  9. pmc Using n-of-1 trials as a clinical tool to improve prescribing
    C Jane Nikles
    Discipline of General Practice, University of Queensland Medical School, Herston, Queensland 4006, Australia
    Br J Gen Pract 55:175-80. 2005
  10. ncbi request reprint Do individualized medication effectiveness tests (n-of-1 trials) change clinical decisions about which drugs to use for osteoarthritis and chronic pain?
    C Jane Nikles
    Discipline of General Practice, The University of Queensland, Herston, Queensland, Australia
    Am J Ther 12:92-7. 2005

Collaborators

Detail Information

Publications11

  1. doi request reprint Aggregated n-of-1 trials of central nervous system stimulants versus placebo for paediatric traumatic brain injury--a pilot study
    Catherine J Nikles
    School of Medicine, The University of Queensland, Ipswich Campus, Building 12, Salisbury Rd, Ipswich 4305, Australia
    Trials 15:54. 2014
    ..Objectives were to determine the efficacy of CNS stimulants for children with TBI, and to calculate the sample size for a larger trial using the Conners' 3 Parent Rating Scales Score as the primary endpoint...
  2. pmc Central nervous system stimulants for secondary attention deficit-hyperactivity disorder after paediatric traumatic brain injury: a rationale and protocol for single patient (n-of-1) multiple cross-over trials
    Hugh E J Senior
    Discipline of General Practice, School of Medicine, The University of Queensland, 11 Salisbury Rd, Ipswich 4305, Australia
    BMC Pediatr 13:89. 2013
    ..There is conflicting evidence on whether treatment with stimulant therapy with medications such as methylphenidate or dexamphetamine will improve the attention and behavior of children with this condition...
  3. pmc Using aggregated single patient (N-of-1) trials to determine the effectiveness of psychostimulants to reduce fatigue in advanced cancer patients: a rationale and protocol
    Hugh Ej Senior
    Discipline of General Practice, The University of Queensland, Brisbane, Queensland, Australia
    BMC Palliat Care 12:17. 2013
    ..The negative impact of fatigue on function (physical, mental, social and spiritual) and quality of life is substantial for many palliative patients as well as their families/carers...
  4. doi request reprint Prioritising drugs for single patient (n-of-1) trials in palliative care
    J Nikles
    Discipline of General Practice, The University of Queensland, Herston, Brisbane, Queensland, Australia
    Palliat Med 23:623-34. 2009
    ..Although not all the drugs used in palliative care are suitable, SPTs provide a potential alternative method of gathering evidence in palliative care...
  5. ncbi request reprint Long-term changes in management following n-of-1 trials of stimulants in attention-deficit/hyperactivity disorder
    C Jane Nikles
    School of Medicine, University of Queensland, Queensland, Australia
    Eur J Clin Pharmacol 63:985-9. 2007
    ..Our objective was to evaluate the long-term impact of n-of-1 trials-within-patient randomised, double-blind, cross-over comparisons of stimulant versus placebo or stimulant-on ADHD management...
  6. ncbi request reprint An n-of-1 trial service in clinical practice: testing the effectiveness of stimulants for attention-deficit/hyperactivity disorder
    C Jane Nikles
    The University of Queensland, Herston, Queensland 4006, Australia
    Pediatrics 117:2040-6. 2006
    ..We sought to describe the clinical use of n-of-1 trials for attention-deficit/hyperactivity disorder in publicly and privately funded family and specialized pediatric practice in Australia...
  7. ncbi request reprint Bias influencing maternal reports of child behaviour and emotional state
    J M Najman
    School of Social Science, The University of Queensland, Australia
    Soc Psychiatry Psychiatr Epidemiol 36:186-94. 2001
    ..We examine two potential sources of bias that may influence reports of a child's behaviour/mental health. The first is the mental or emotional impairment of the respondent; the second concerns gender-related expectations of children...
  8. ncbi request reprint Mothers' mental illness and child behavior problems: cause-effect association or observation bias?
    J M Najman
    Department of Anthropology and Sociology, University of Queensland, Australia
    J Am Acad Child Adolesc Psychiatry 39:592-602. 2000
    ..However, the validity of this finding is in doubt because the majority of these studies have relied on maternal reports as indicators of children's behavior...
  9. pmc Using n-of-1 trials as a clinical tool to improve prescribing
    C Jane Nikles
    Discipline of General Practice, University of Queensland Medical School, Herston, Queensland 4006, Australia
    Br J Gen Pract 55:175-80. 2005
    ..We have investigated the use of these, offered to doctors as individualised medication effectiveness tests (IMETs), as a tool to improve drug prescribing...
  10. ncbi request reprint Do individualized medication effectiveness tests (n-of-1 trials) change clinical decisions about which drugs to use for osteoarthritis and chronic pain?
    C Jane Nikles
    Discipline of General Practice, The University of Queensland, Herston, Queensland, Australia
    Am J Ther 12:92-7. 2005
    ..Our results provide a new (individual) perspective on the well-known recommendation for paracetamol as first-line treatment for chronic pain and demonstrate that it is feasible to provide IMETs nationally by mail and telephone...
  11. ncbi request reprint The role of paracetamol in chronic pain: an evidence-based approach
    C Jane Nikles
    Discipline of General Practice, The University of Queensland, Herston, Herston, Queensland 4006, Australia
    Am J Ther 12:80-91. 2005
    ..In patients with chronic pain, paracetamol can play an important role as an NSAID sparer, with resultant benefits in terms of reduced adverse effects and cost savings...