John P Newnham

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Treatment of periodontal disease during pregnancy: a randomized controlled trial
    John P Newnham
    Schools of Women s and Infants Health and Dentistry of The University of Western Australia, Perth, Western Australia
    Obstet Gynecol 114:1239-48. 2009
  2. doi request reprint Early life origins of obesity
    John P Newnham
    School of Women s and Infants Health, The University of Western Australia, 374 Bagot Road, Subiaco, Perth, Western Australia 6008, Australia
    Obstet Gynecol Clin North Am 36:227-44, xii. 2009
  3. doi request reprint Should we be prescribing repeated courses of antenatal corticosteroids?
    John P Newnham
    School of Women s and Infants Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, King Edward Memorial Hospital, Perth, Western Australia, Australia
    Semin Fetal Neonatal Med 14:157-63. 2009
  4. doi request reprint Preterm birth rates in Chinese women in China, Hong Kong and Australia - the price of Westernisation
    John P Newnham
    The School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Aust N Z J Obstet Gynaecol 51:426-31. 2011
  5. pmc Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep
    Timothy J M Moss
    School of Women s and Infants Health, University of Western Australia, WA, Australia
    Am J Obstet Gynecol 200:96.e1-6. 2009
  6. pmc Intra-amniotic administration of E coli lipopolysaccharides causes sustained inflammation of the fetal skin in sheep
    Li Zhang
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Reprod Sci 19:1181-9. 2012
  7. doi request reprint Differential relationships between anthropometry measures and cardiovascular risk factors in boys and girls
    Rae Chi Huang
    The University of Western Australia, School of Medicine and Pharmacology, Western Australia
    Int J Pediatr Obes 6:e271-82. 2011
  8. ncbi request reprint Effects into adulthood of single or repeated antenatal corticosteroids in sheep
    Timothy J M Moss
    School of Women s and Infants Health, The University of Western Australia, Crawley, Australia
    Am J Obstet Gynecol 192:146-52. 2005
  9. ncbi request reprint Ventilation-mediated injury after preterm delivery of Ureaplasma parvum colonized fetal lambs
    Graeme R Polglase
    School of Women s and Infants Health, The University of Western Australia, Subiaco, Western Australia 6009, Australia
    Pediatr Res 67:630-5. 2010
  10. doi request reprint Pre- and postnatal influences on preschool mental health: a large-scale cohort study
    Monique Robinson
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia
    J Child Psychol Psychiatry 49:1118-28. 2008

Collaborators

Detail Information

Publications82

  1. ncbi request reprint Treatment of periodontal disease during pregnancy: a randomized controlled trial
    John P Newnham
    Schools of Women s and Infants Health and Dentistry of The University of Western Australia, Perth, Western Australia
    Obstet Gynecol 114:1239-48. 2009
    ..To investigate whether treating periodontal disease prevents preterm birth and other major complications of pregnancy...
  2. doi request reprint Early life origins of obesity
    John P Newnham
    School of Women s and Infants Health, The University of Western Australia, 374 Bagot Road, Subiaco, Perth, Western Australia 6008, Australia
    Obstet Gynecol Clin North Am 36:227-44, xii. 2009
    ..Understanding the mechanisms and pathways that underpin the early origins of obesity is vital if we are to make progress in addressing this major problem of modern life...
  3. doi request reprint Should we be prescribing repeated courses of antenatal corticosteroids?
    John P Newnham
    School of Women s and Infants Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, King Edward Memorial Hospital, Perth, Western Australia, Australia
    Semin Fetal Neonatal Med 14:157-63. 2009
    ....
  4. doi request reprint Preterm birth rates in Chinese women in China, Hong Kong and Australia - the price of Westernisation
    John P Newnham
    The School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Aust N Z J Obstet Gynaecol 51:426-31. 2011
    ..The rates of preterm birth in Chinese women and the potential effects of differing environments are poorly understood...
  5. pmc Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep
    Timothy J M Moss
    School of Women s and Infants Health, University of Western Australia, WA, Australia
    Am J Obstet Gynecol 200:96.e1-6. 2009
    ..The objective of the study was to assess the efficacy of maternal betamethasone for improving preterm lung function in the presence of inflammation induced by amniotic fluid Ureaplasma colonization...
  6. pmc Intra-amniotic administration of E coli lipopolysaccharides causes sustained inflammation of the fetal skin in sheep
    Li Zhang
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Reprod Sci 19:1181-9. 2012
    ..These novel data suggest that the fetal skin may cause prolonged in utero inflammatory response causally associated with preterm birth...
  7. doi request reprint Differential relationships between anthropometry measures and cardiovascular risk factors in boys and girls
    Rae Chi Huang
    The University of Western Australia, School of Medicine and Pharmacology, Western Australia
    Int J Pediatr Obes 6:e271-82. 2011
    ..The aim of the study was to compare commonly used anthropometry for cardiovascular risk factors in 14-year-olds...
  8. ncbi request reprint Effects into adulthood of single or repeated antenatal corticosteroids in sheep
    Timothy J M Moss
    School of Women s and Infants Health, The University of Western Australia, Crawley, Australia
    Am J Obstet Gynecol 192:146-52. 2005
    ..To determine effects of maternal or fetal injections of betamethasone on postnatal growth and arterial pressure...
  9. ncbi request reprint Ventilation-mediated injury after preterm delivery of Ureaplasma parvum colonized fetal lambs
    Graeme R Polglase
    School of Women s and Infants Health, The University of Western Australia, Subiaco, Western Australia 6009, Australia
    Pediatr Res 67:630-5. 2010
    ..Antenatal colonization with UP did not change lung function or modulate the lung injury and inflammation caused by high VT ventilation...
  10. doi request reprint Pre- and postnatal influences on preschool mental health: a large-scale cohort study
    Monique Robinson
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia
    J Child Psychol Psychiatry 49:1118-28. 2008
    ..This study aims to address these challenges in investigating antenatal, perinatal and postnatal risk factors for the development of mental health problems in pre-school children in a cohort of Western Australian children...
  11. ncbi request reprint Intra-amniotic endotoxin induces lung maturation by direct effects on the developing respiratory tract in preterm sheep
    Timothy J M Moss
    School of Women s and Infants Health, University of Western Australia, 35 Stirling Highway, Crawley WA, Perth, Australia
    Am J Obstet Gynecol 187:1059-65. 2002
    ..Our purpose was to determine whether improved preterm lung function caused by intraamniotic endotoxin treatment requires endotoxin entry into the respiratory tract...
  12. pmc Pulmonary vascular and alveolar development in preterm lambs chronically colonized with Ureaplasma parvum
    Graeme R Polglase
    The University of Western Australia, Perth, Australia
    Am J Physiol Lung Cell Mol Physiol 299:L232-41. 2010
    ..We conclude that chronic exposure to U. parvum does not cause sustained effects on air space or vascular development in premature lambs...
  13. ncbi request reprint Variability in preterm lamb lung mechanics after intra-amniotic endotoxin is associated with changes in surfactant pool size and morphometry
    J Jane Pillow
    Centre for Child Health Research, The University of Western Australia, Perth, Australia
    Am J Physiol Lung Cell Mol Physiol 287:L992-8. 2004
    ..Despite the complex cascade of events initiated by antenatal endotoxin exposure, variability in lung tissue mechanics is associated primarily with changes in alveolar Sat PC pool and lung morphology...
  14. pmc Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep
    Timothy J M Moss
    School of Women s and Infants Health, Faculty of Medicine, Dentistry, and Health Sciences, University of Western Australia, Perth, Western Australia, Australia
    Am J Obstet Gynecol 198:122.e1-8. 2008
    ..The objective of the study was to determine the effects in late gestation of Ureaplasma parvum serovar 3 colonization and the effects, preterm, of U. parvum serovar 6...
  15. ncbi request reprint Chorioamnionitis induced by subchorionic endotoxin infusion in sheep
    Timothy J M Moss
    Lotteries Commission Perinatal Research Laboratories, School of Women s and Infants Health, University of Western Australia, Box M094, 35 Stirling Highway, Crawley, WA 6009, Australia
    Am J Obstet Gynecol 189:1771-6. 2003
    ..This study was undertaken to determine whether subchorionic endotoxin infusion causes chorioamnionitis and preterm lung maturation, as occurs after intra-amniotic endotoxin...
  16. pmc Selective exposure of the fetal lung and skin/amnion (but not gastro-intestinal tract) to LPS elicits acute systemic inflammation in fetal sheep
    Matthew W Kemp
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    PLoS ONE 8:e63355. 2013
    ..These novel findings reveal differential fetal organ responses to pro-inflammatory stimulation and shed light on the pathogenesis of fetal systemic inflammation after exposure to chorioamnionitis...
  17. doi request reprint Delivery at 37 weeks' gestation is associated with a higher risk for child behavioural problems
    Monique Robinson
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia
    Aust N Z J Obstet Gynaecol 53:143-51. 2013
    ..Advances in obstetric care have been accompanied by increasing rates of intervention which often involve elective delivery at 37 weeks, soon after term gestation has been achieved...
  18. ncbi request reprint Hepatic glucose regulation and metabolism in adult sheep: effects of prenatal betamethasone
    Deborah M Sloboda
    School of Women s and Infants Health, University of Western Australia, Perth, Australia
    Am J Physiol Endocrinol Metab 289:E721-8. 2005
    ..Prenatal betamethasone exposure results in elevated hepatic G-6-Pase activity in adulthood and may contribute to long-term changes in metabolism...
  19. ncbi request reprint Intra-amniotic corticosteroids for preterm lung maturation in sheep
    Timothy J M Moss
    Lotteries Commission Perinatal Research Laboratories, School of Women s and Infants Health, University of Western Australia, Box M094, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Am J Obstet Gynecol 189:1389-95. 2003
    ..The purpose of this study was to compare efficacy on fetal lung maturation of intra-amniotic betamethasone or budesonide with the efficacy of maternal intramuscular betamethasone...
  20. ncbi request reprint Effects of intra-amniotic endotoxin on lung structure and function two months after term birth in sheep
    Timothy J M Moss
    School of Women s and Infants Health, The University of Western Australia, Perth, Western Australia
    J Soc Gynecol Investig 9:220-5. 2002
    ..Our aim was to determine the effects on lung structure and function after term birth in lambs exposed to intra-amniotic or intra-allantoic endotoxin...
  21. ncbi request reprint Betamethasone effects on chorioamnionitis induced by intra-amniotic endotoxin in sheep
    John P Newnham
    School of Women s and Infants Health, University of Western Australia, King Edward Memorial Hospital, Bagot Road, Subiaco, Perth, WA 6008, Australia
    Am J Obstet Gynecol 189:1458-66. 2003
    ..We describe the effects of intra-amniotic endotoxin on cytokines and white cell responses in the membranes and amniotic fluid and investigate the hypothesis that betamethasone treatment suppresses these responses...
  22. ncbi request reprint The fetal maturational and inflammatory responses to different routes of endotoxin infusion in sheep
    John P Newnham
    Department of Obstetrics and Gynaecology, University of Western Australia at King Edward Memorial Hospital, Subiaco, Perth, Australia
    Am J Obstet Gynecol 186:1062-8. 2002
    ..This study aimed to explore the mechanisms by which endotoxin matures the lungs by determining whether the route of administration influenced the maturational responses of the fetus...
  23. ncbi request reprint Disrupted secretory activation of the mammary gland after antenatal glucocorticoid treatment in sheep
    Jennifer J Henderson
    School of Women s and Infants Health, M550, King Edward Memorial Hospital, The University of Western Australia, Subiaco, Perth, Western Australia 6008, Australia
    Reproduction 136:649-55. 2008
    ..This study demonstrated that, in sheep, antenatal glucocorticoid administration disrupted secretory activation, causing precocious mammary secretion before parturition and compromising postpartum milk production and lamb growth...
  24. ncbi request reprint Experimental intrauterine Ureaplasma infection in sheep
    Timothy J M Moss
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Am J Obstet Gynecol 192:1179-86. 2005
    ..We hypothesized that intra-amniotic ureaplasmas would cause lung inflammation and alter fetal lung development...
  25. ncbi request reprint Differential effects of maternal and fetal betamethasone injections in late-gestation fetal sheep
    Timothy J M Moss
    Lotteries Commission Perinatal Research Laboratories, School of Women s and Infants Health, University of Western Australia, Box M094, 35 Stirling Highway, Crawley, WA 6009, Australia
    J Soc Gynecol Investig 10:474-9. 2003
    ..To determine the effects of single or repeated intramuscular injections of betamethasone, given maternally or directly to the fetus, on chronically catheterized, late-gestation fetal sheep...
  26. doi request reprint Circulating maternal testosterone concentrations at 18 weeks of gestation predict circulating levels of antimüllerian hormone in adolescence: a prospective cohort study
    Roger Hart
    School of Women s and Infants Health, University of Western Australia, and Women and Infants Research Foundation, King Edward Memorial Hospital, Perth, Western Australia, Australia
    Fertil Steril 94:1544-7. 2010
    ....
  27. doi request reprint Hypertensive diseases of pregnancy predict parent-reported difficult temperament in infancy
    Monique Robinson
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia
    J Dev Behav Pediatr 34:174-80. 2013
    ..Recent research has linked hypertensive diseases of pregnancy with adverse neurodevelopmental outcomes in childhood and adulthood. This study aimed to establish whether such effects are observed in infancy...
  28. pmc Inflammation of the fetal ovine skin following in utero exposure to Ureaplasma parvum
    Matthew W Kemp
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Reprod Sci 18:1128-37. 2011
    ..These novel findings provide further support for the role of the fetal skin in the development of fetal inflammation and the preterm birth that may follow...
  29. ncbi request reprint Expression of glucocorticoid receptor, mineralocorticoid receptor, and 11beta-hydroxysteroid dehydrogenase 1 and 2 in the fetal and postnatal ovine hippocampus: ontogeny and effects of prenatal glucocorticoid exposure
    Deborah M Sloboda
    School of Women s and Infants Health, The University of Western Australia, Perth 6009, Australia
    J Endocrinol 197:213-20. 2008
    ....
  30. doi request reprint Effect of preterm birth and antenatal corticosteroid treatment on lactogenesis II in women
    Jennifer J Henderson
    School of Women s and Infants Health, University of Western Australia, Crawley, Western Australia, Australia
    Pediatrics 121:e92-100. 2008
    ..The onset of copious milk secretion after birth is known as lactogenesis II. The objective of this study was to investigate the effect of preterm birth and antenatal corticosteroids on the timing of lactogenesis II after birth...
  31. doi request reprint Benefits of introducing universal umbilical cord blood gas and lactate analysis into an obstetric unit
    Christopher R H White
    The University of Western Australia, Perth, Australia
    Aust N Z J Obstet Gynaecol 50:318-28. 2010
    ..However, there's debate whether umbilical cord blood gas analysis (UC-BGA) should be conducted on some or all deliveries...
  32. ncbi request reprint The effects of intra-amniotic injection of periodontopathic lipopolysaccharides in sheep
    John P Newnham
    The School of Women s and Infants Health, The University of Western Australia at King Edward Memorial Hospital, Perth, Western Australia
    Am J Obstet Gynecol 193:313-21. 2005
    ..The outcomes that were studied included the rates of fetal death and the features of inflammation and lung maturation in survivors...
  33. ncbi request reprint Prenatal betamethasone exposure results in pituitary-adrenal hyporesponsiveness in adult sheep
    Deborah M Sloboda
    Forrest Fetal Research Scientist, School of Women s and Infants Health, The Univ of Western Australia, King Edward Memorial Hospital, Subiaco, Western Australia, Australia
    Am J Physiol Endocrinol Metab 292:E61-70. 2007
    ..These data suggest that maternal, but not fetal, betamethasone administration results in adrenal suppression in adulthood...
  34. ncbi request reprint Breastfeeding and overweight: longitudinal analysis in an Australian birth cohort
    Valerie Burke
    University of Western Australia, School of Medicine and Pharmacology, Royal Perth Hospital, Perth, Australia
    J Pediatr 147:56-61. 2005
    ..To examine adiposity in relation to breastfeeding using longitudinal analysis in an Australian birth cohort...
  35. doi request reprint Effects of tail docking and castration on stress responses in lambs and the influence of prenatal glucocorticoid treatment
    Shaofu Li
    School of Women s and Infants Health, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Reprod Fertil Dev 25:1020-5. 2013
    ..These findings describe the stress responses to these common agricultural interventions and suggest that long-term development of the HPA axis in females is altered by prenatal exposure to dexamethasone...
  36. ncbi request reprint Maternal and intra-amniotic corticosteroid effects on lung morphometry in preterm lambs
    Graeme R Polglase
    School of Women s and Infants Health, The University of Western Australia, Crawley, Western Australia, 6009, Australia
    Pediatr Res 62:32-6. 2007
    ..Similar structural changes induced by intra-amniotic corticosteroids and maternal intramuscular betamethasone were associated with improvements in lung function at 2 and 7 d...
  37. ncbi request reprint Effects of antenatal corticosteroids on urinary markers of the initiation of lactation in pregnant women
    Jennifer J Henderson
    School of Women s and Infants Health, The University of Western Australia, King Edward Memorial Hospital, Subiaco, Western Australia, Australia
    Breastfeed Med 4:201-6. 2009
    ..This study aimed to investigate the effects of antenatal corticosteroid treatment on mammary secretion during pregnancy in women...
  38. doi request reprint Maternal-amniotic-fetal distribution of macrolide antibiotics following intravenous, intramuscular, and intraamniotic administration in late pregnant sheep
    Jeffrey A Keelan
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Am J Obstet Gynecol 204:546.e10-7. 2011
    ..The objective of the study was to explore the maternal-fetal pharmacokinetics of intraamniotic (IA), intravenous (IV), or intramuscular (IM) administration of erythromycin or azithromycin in a pregnant sheep model...
  39. doi request reprint Fetal responses to lipopolysaccharide-induced chorioamnionitis alter immune and airway responses in 7-week-old sheep
    Andrea J X Lee
    School of Women s and Infant s Health, The University of Western Australia, Perth, Australia
    Am J Obstet Gynecol 204:364.e17-24. 2011
    ..We hypothesized that fetal innate immune responses to lipopolysaccharide-induced chorioamnionitis would alter postnatal systemic immune and airway responsiveness...
  40. ncbi request reprint Early gestational intra-amniotic endotoxin: lung function, surfactant, and morphometry
    Timothy J M Moss
    School of Women s and Infants Health and Centre for Child Health Research, University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 165:805-11. 2002
    ....
  41. doi request reprint Fetal androgen exposure and pragmatic language ability of girls in middle childhood: implications for the extreme male-brain theory of autism
    Andrew J O Whitehouse
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Subiaco, Western Australia, Australia
    Psychoneuroendocrinology 35:1259-64. 2010
    ..These novel findings are discussed with reference to the 'extreme male-brain' theory of autism...
  42. ncbi request reprint Intrauterine Candida albicans infection elicits severe inflammation in fetal sheep
    Matthew S Payne
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Pediatr Res 75:716-22. 2014
    ..in preterm birth and fetal injury, as a result of their colonization of either the vagina and/or the amniotic cavity. We hypothesized that intraamniotic Candida albicans would cause a vigorous, acute fetal inflammatory response...
  43. ncbi request reprint Free testosterone levels in umbilical-cord blood predict infant head circumference in females
    Andrew J O Whitehouse
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Dev Med Child Neurol 52:e73-7. 2010
    ..We report the association between circulating fetal androgen levels, measured from umbilical-cord blood at birth, and a proxy measure of brain growth: head circumference...
  44. pmc Exposure to in utero lipopolysaccharide induces inflammation in the fetal ovine skin
    Matthew W Kemp
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Reprod Sci 18:88-98. 2011
    ..These novel data strongly suggests that the fetal skin acts as an important mediator of the fetal inflammatory response and as such may contribute to preterm birth...
  45. ncbi request reprint Nutrition and the early origins of adult disease
    John P Newnham
    School of Women s and Infants Health, University of Western Australia, King Edward Memorial Hospital for Women, Subiaco, Perth, Western Australia
    Asia Pac J Clin Nutr 11:S537-42. 2002
    ....
  46. ncbi request reprint Pharmacokinetics of betamethasone after maternal or fetal intramuscular administration
    Timothy J M Moss
    Lotteries Commission Perinatal Research Laboratories, School of Women s and Infants Health, University of Western Australia, Box M094, 35 Stirling Highway, Crawley, WA 6009, Australia
    Am J Obstet Gynecol 189:1751-7. 2003
    ..The purpose of this study was to determine the pharmacokinetics of betamethasone in maternal and fetal circulations after maternal or fetal intramuscular administration...
  47. ncbi request reprint Accurate prediction of hypoxic-ischaemic encephalopathy at delivery: a cohort study
    Christopher R H White
    School of Women s and Infants Health, The University of Western Australia
    J Matern Fetal Neonatal Med 25:1653-9. 2012
    ..Hypoxic-ischaemic encephalopathy (HIE) is a major acute neurologic manifestation of perinatal asphyxia associated with significant mortality and morbidity. The study aimed to develop a simple, accurate method of predicting HIE at delivery...
  48. doi request reprint The effect of time, temperature and storage device on umbilical cord blood gas and lactate measurement: a randomized controlled trial
    Christopher R H White
    School of Women s and Infants Health, The University of Western Australia, Perth, Western Australia, Australia
    J Matern Fetal Neonatal Med 25:587-94. 2012
    ..Factors often delay analysis of cord blood allowing values to change. Consequently, this study evaluates the impact of time, temperature and method of storage on umbilical blood gas and lactate analyses...
  49. doi request reprint The effects of dexamethasone treatment in early gestation on hypothalamic-pituitary-adrenal responses and gene expression at 7 months of postnatal age in sheep
    Shaofu Li
    School of Women s and Infants Health, The University of Western Australia, Western Australia, Australia
    Reprod Sci 19:260-70. 2012
    ..The results indicate that exposure to glucocorticoids in early pregnancy produces persisting and sex-dependent effects on the hypothalamic-pituitary-adrenal axis at 7 months of age...
  50. ncbi request reprint Chronic exposure to intra-amniotic lipopolysaccharide affects the ovine fetal brain
    Ilias Nitsos
    School of Women s and Infants Health, The University of Western Australia, Crawley, Western Australia, Australia
    J Soc Gynecol Investig 13:239-47. 2006
    ..We aimed to determine if prolonged exposure to intrauterine inflammation caused by intra-amniotic infusion of lipopolysaccharide (LPS) would affect the fetal brain...
  51. ncbi request reprint Repeated maternal intramuscular or intraamniotic erythromycin incompletely resolves intrauterine Ureaplasma parvum infection in a sheep model of pregnancy
    Matthew W Kemp
    School of Women s and Infants Health, University of Western Australia, Perth, WA, Australia
    Am J Obstet Gynecol 211:134.e1-9. 2014
    ..We used a sheep model of intrauterine Ureaplasma spp infection to investigate the efficacy of repeated maternal intramuscular and intraamniotic erythromycin treatment to eradicate such an infection...
  52. ncbi request reprint Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms
    Monique Robinson
    Telethon Kids Institute, The University of Western Australia, PO Box 855, West Perth, Perth, WA, 6872, Australia
    Arch Womens Ment Health 17:213-9. 2014
    ..Low vitamin D during pregnancy is a risk factor for the development of postpartum depression symptoms. ..
  53. pmc Androgen concentrations in umbilical cord blood and their association with maternal, fetal and obstetric factors
    Jeffrey A Keelan
    School of Women s and Infants Health, King Edward Memorial Hospital, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 7:e42827. 2012
    ..Caution should be exercised when interpreting previously-published data that have not taken all of these factors into account...
  54. pmc Fetal head circumference growth in children with specific language impairment
    Andrew J O Whitehouse
    Centre for Child Health Research, University of Western Australia, Perth, Australia
    Arch Dis Child 97:49-51. 2012
    ..To characterise fetal brain growth in children with specific language impairment (SLI)...
  55. ncbi request reprint Periodontal disease and adverse pregnancy outcomes
    Alexis Shub
    School of Women s and Infants Health, The University of Western Australia, Perth, Western Australia
    J Matern Fetal Neonatal Med 19:521-8. 2006
    ..Three large randomized controlled trials of treatment of periodontal disease are underway and may provide confirmation of the importance of periodontal disease in causing complications of pregnancy...
  56. doi request reprint Preterm birth, infection, and inflammation advances from the study of animal models
    Matthew W Kemp
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Reprod Sci 17:619-28. 2010
    ..Herein, we review important developments in our understanding of the link between preterm birth and fetal inflammation subsequent to infection, gained from studies undertaken in animal models...
  57. ncbi request reprint Uising WinBUGS to fit nonlinear mixed models with an application to pharmacokinetic modelling of insulin response to glucose challenge in sheep exposed antenatally to glucocorticoids
    Lyle C Gurrin
    Women and Infants Research Foundation, King Edward Memorial Hospital, Subiaco, Western Australia, Australia
    J Biopharm Stat 13:117-39. 2003
    ..It is argued that the fitting of an appropriate statistical model to complex physiological data does not necessarily proclude a result that has a clear interpretation for clinical scientists...
  58. ncbi request reprint Polymyxin B agonist capture therapy for intrauterine inflammation: proof-of-principle in a fetal ovine model
    Masatoshi Saito
    1School of Women s and Infants Health, The University of Western Australia, Perth, Western Australia
    Reprod Sci 21:623-31. 2014
    ..They suggest the potential for agonist capture as a conceptual means of resolving the proparturition inflammation caused by infection of the amniotic cavity. ..
  59. doi request reprint Attitudes and barriers to the introduction of umbilical cord blood gas and lactate analysis at birth
    Christopher R H White
    School of Women s and Infants Health, The University of Western Australia, Perth, Western Australia, Australia
    Aust N Z J Obstet Gynaecol 53:271-6. 2013
    ..Despite a growing body of evidence demonstrating the value of universal umbilical cord blood gas analysis (UCBGA), there remains reluctance in some maternity units to adopt universal testing...
  60. doi request reprint Preterm birth aetiology 2004-2008. Maternal factors associated with three phenotypes: spontaneous preterm labour, preterm pre-labour rupture of membranes and medically indicated preterm birth
    Jennifer J Henderson
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    J Matern Fetal Neonatal Med 25:642-7. 2012
    ....
  61. doi request reprint Obesity and the developmental origins of health and disease
    Matthew W Kemp
    School of Women s and Infants Health, The University of Western Australia, Subiaco, Western Australia, Australia
    J Paediatr Child Health 48:86-90. 2012
    ..Here, we review the evolution of 'the developmental origins of health and disease' as a concept and discuss recent advances in the association of specific stimuli to obesity, an epidemic cause of human morbidity and mortality...
  62. pmc Lifecourse childhood adiposity trajectories associated with adolescent insulin resistance
    Rae Chi Huang
    School of Medicine and Pharmacology, The University of Western Australia, Royal Perth Hospital, Perth, Australia
    Diabetes Care 34:1019-25. 2011
    ..In light of the obesity epidemic, we aimed to characterize novel childhood adiposity trajectories from birth to age 14 years and to determine their relation to adolescent insulin resistance...
  63. ncbi request reprint Prenatal determinants of uterine volume and ovarian reserve in adolescence
    Roger Hart
    School of Women s and Infants Health, University of Western Australia, Perth, Western Australia 6008, Australia
    J Clin Endocrinol Metab 94:4931-7. 2009
    ..Antenatal events such as restricted fetal growth and maternal tobacco smoking are hypothesized to impact on reproductive function in later life, although not studied in a large prospective normal pregnancy population to date...
  64. ncbi request reprint Is there a relationship to dye determined or ultrasound estimated amniotic fluid volume adjusted percentiles and fetal weight adjusted percentiles?
    Everett F Magann
    Department of Obstetrics and Gynecology, The University of Western Australia, Perth, Australia
    Am J Obstet Gynecol 190:1610-4; discussion 1614-5. 2004
    ..This study was undertaken to determine whether there is a correlation between neonatal birth weight and an estimated or dye-determined amniotic fluid volume...
  65. ncbi request reprint Effects of repeated prenatal ultrasound examinations on childhood outcome up to 8 years of age: follow-up of a randomised controlled trial
    John P Newnham
    School of Women s and Infants Health, The University of Western Australia at King Edward Memorial Hospital, Subiaco, Western Australia 6008, Australia
    Lancet 364:2038-44. 2004
    ..Our aim was to investigate the possible effects of multiple prenatal ultrasound scans on growth and development in childhood. Here, we provide follow-up data of the childrens' development...
  66. doi request reprint The over-estimation of risk in pregnancy
    Monique Robinson
    Telethon Institute for Child Health Research, The University of Western Australia, Perth, Australia
    J Psychosom Obstet Gynaecol 32:53-8. 2011
    ..Ultimately obstetric care is complex and efforts to avoid pre-natal risk exposure based on heightened perceptions of threat may do more harm than the perceived threat itself...
  67. ncbi request reprint Periodontal disease: a potential modifiable risk factor limiting conception
    Roger Hart
    School of Women s and Infants Health, The University of Western Australia, Perth, WA 6008, Australia
    Hum Reprod 27:1332-42. 2012
    ..To date, there are no published studies describing the influence of PD on a woman's time to conceive (TTC)...
  68. ncbi request reprint Antenatal corticosteroids: the good, the bad and the unknown
    John P Newnham
    The School of Women s Health and Infants Health, The University of Western Australia, King Edward Memorial Hospital, Perth, Western Australia, Australia
    Curr Opin Obstet Gynecol 14:607-12. 2002
    ..The purpose of this review was to summarize recently published clinical and animal-based studies of antenatal corticosteroids, describe current recommendations for practice, and suggest priority areas for future research...
  69. ncbi request reprint Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lung
    Karen E Willet
    Division of Clinical Sciences, Center for Child Health Research, Perth, Australia
    Am J Physiol Lung Cell Mol Physiol 282:L411-20. 2002
    ..Lung compliance, lung volume, and alveolar Sat PC were positively correlated with residual alveolar wash leukocyte numbers 7 days after IL-1 treatment, suggesting a link between lung inflammation and maturation...
  70. ncbi request reprint Maternal periodontal disease and perinatal mortality
    Alexis Shub
    School Women s and Infants Health, University of Western Australia, Perth, Western Australia, Australia
    Aust N Z J Obstet Gynaecol 49:130-6. 2009
    ..Periodontal disease has been associated with increased perinatal mortality...
  71. doi request reprint Brief report: a preliminary study of fetal head circumference growth in autism spectrum disorder
    Andrew J O Whitehouse
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, 100 Roberts Road, Subiaco, Perth, WA, 6008, Australia
    J Autism Dev Disord 41:122-9. 2011
    ..These preliminary findings suggest that further investigation of fetal growth in ASD is warranted...
  72. doi request reprint Hypertensive diseases of pregnancy and the development of behavioral problems in childhood and adolescence: the Western Australian Pregnancy Cohort Study
    Monique Robinson
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia
    J Pediatr 154:218-24. 2009
    ..To examine whether maternal gestational hypertension and preeclampsia are associated with behavioral problems in offspring throughout childhood and early adolescence...
  73. ncbi request reprint Repeated antenatal corticosteroids: effects on cerebral palsy and childhood behavior
    Noel P French
    Department of Neonatal Paediatrics, King Edward Memorial Hospital, Subiaco, Perth, Australia
    Am J Obstet Gynecol 190:588-95. 2004
    ..This study was undertaken to determine the effects of repeated courses of antenatal corticosteroids on childhood behavior and disabilities, including cognitive delay and cerebral palsy...
  74. ncbi request reprint Estimation of the Doppler ultrasound umbilical maximal waveform envelope: II. Prediction of fetal distress
    Dorota A Doherty
    Department of Mathematics and Statistics, Murdoch University, Murdoch WA, Australia
    Ultrasound Med Biol 28:1261-70. 2002
    ..Our data suggest that prediction of IUGR at 18 pregnancy weeks can be much improved when the waveform shape is captured with a number of summary statistics in addition to resistance indices...
  75. ncbi request reprint Estimation of the Doppler ultrasound maximal umbilical waveform envelope: I. Estimation method
    Dorota A Doherty
    Mathematics and Statistics, Murdoch University, Murdoch, WA, Australia
    Ultrasound Med Biol 28:1251-9. 2002
    ..The method has been developed with special reference to umbilical blood flow images, but it can be used directly to model blood flow in other low-resistance vessels or adapted for other vessels with different shape characteristics...
  76. ncbi request reprint Fetal responses to intra-amniotic endotoxin in sheep
    Ilias Nitsos
    Department of Obstetrics and Gynaecology, University of Western Australia, Crawley 6009, WA, Australia
    J Soc Gynecol Investig 9:80-5. 2002
    ....
  77. ncbi request reprint Indicators of fetal growth do not independently predict blood pressure in 8-year-old Australians: a prospective cohort study
    Valerie Burke
    The University of Western Australia, School of Medicine and Pharmacology, Royal Perth Hospital and Western Australian Institute for Medical Research, Perth, Australia
    Hypertension 43:208-13. 2004
    ....
  78. ncbi request reprint Lung function, arterial pressure and growth in sheep during early postnatal life following single and repeated prenatal corticosteroid treatments
    Timothy J M Moss
    Department of Obstetrics and Gynaecology, The University of Western Australia, 35 Stirling Highway, WA, 6009 Crawley, Australia
    Early Hum Dev 66:11-24. 2002
    ....
  79. doi request reprint Perceptions by medical students of their educational environment for obstetrics and gynaecology in metropolitan and rural teaching sites
    Dianne F Carmody
    The University of Western Australia, Western Australia, Women and Infants Research Foundation, Western Australia
    Med Teach 31:e596-602. 2009
    ..Medical student education in Western Australia is expanding to secondary level metropolitan hospitals and rural sites to accommodate workforce demands and increasing medical student numbers...
  80. ncbi request reprint Does magnesium sulfate reduce the short- and long-term requirements for pain relief after caesarean delivery? A double-blind placebo-controlled trial
    Michael J Paech
    Department of Anesthesiology, King Edward Memorial Hospital, The University of Western Australia, Perth, Australia
    Am J Obstet Gynecol 194:1596-602; discussion 1602-3. 2006
    ..The purpose of this study was to determine whether magnesium sulfate decreases postoperative pain and analgesic consumption...
  81. ncbi request reprint Discovering the mechanisms of fetal programming
    John P Newnham
    School of Women s and Infants Health, The University of Western Australia, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, Western Australia 6008, Australia
    Clin Sci (Lond) 103:641-2. 2002
  82. ncbi request reprint Maternal physiological responses to swimming training during the second trimester of pregnancy
    Ann Maree Lynch
    School of Human Movement and Exercise Science, The University of Western Australia, Crawley, Western Australia, Australia
    Res Sports Med 15:33-45. 2007
    ..Further, all women remained healthy, with no adverse outcomes for mother or baby...