J P Newnham

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Betamethasone effects on chorioamnionitis induced by intra-amniotic endotoxin in sheep
    John P Newnham
    School of Women s and Infants Health, University of Western Australia, King Edward Memorial Hospital, Bagot Road, Subiaco, Perth, WA 6008, Australia
    Am J Obstet Gynecol 189:1458-66. 2003
  2. ncbi request reprint Is prenatal glucocorticoid administration another origin of adult disease?
    J P Newnham
    Department of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia
    Clin Exp Pharmacol Physiol 28:957-61. 2001
  3. ncbi request reprint The effects of intra-amniotic injection of periodontopathic lipopolysaccharides in sheep
    John P Newnham
    The School of Women s and Infants Health, The University of Western Australia at King Edward Memorial Hospital, Perth, Western Australia
    Am J Obstet Gynecol 193:313-21. 2005
  4. ncbi request reprint Antenatal corticosteroids: the good, the bad and the unknown
    John P Newnham
    The School of Women s Health and Infants Health, The University of Western Australia, King Edward Memorial Hospital, Perth, Western Australia, Australia
    Curr Opin Obstet Gynecol 14:607-12. 2002
  5. ncbi request reprint Effects of repeated prenatal ultrasound examinations on childhood outcome up to 8 years of age: follow-up of a randomised controlled trial
    John P Newnham
    School of Women s and Infants Health, The University of Western Australia at King Edward Memorial Hospital, Subiaco, Western Australia 6008, Australia
    Lancet 364:2038-44. 2004
  6. ncbi request reprint Nutrition and the early origins of adult disease
    John P Newnham
    School of Women s and Infants Health, University of Western Australia, King Edward Memorial Hospital for Women, Subiaco, Perth, Western Australia
    Asia Pac J Clin Nutr 11:S537-42. 2002
  7. ncbi request reprint Antenatal glucocorticoids and growth: single versus multiple doses in animal and human studies
    J P Newnham
    School of Women s and Infants Health, King Edward Memorial Hospital, The University of Western Australia, Perth, Western Australia
    Semin Neonatol 6:285-92. 2001
  8. ncbi request reprint Perinatal and childhood origins of cardiovascular disease
    R C Huang
    School of Medicine and Pharmacology, The University of Western Australia UWA M570, Royal Perth Hospital, Perth, Western Australia, Australia
    Int J Obes (Lond) 31:236-44. 2007
  9. ncbi request reprint Maternal, but not fetal, administration of corticosteroids restricts fetal growth
    J P Newnham
    Department of Obstetrics, Women and Infants Research Foundation at King Edward Memorial Hospital, University of Western Australia, Perth, Australia
    J Matern Fetal Med 8:81-7. 1999
  10. ncbi request reprint Repeated prenatal corticosteroid administration delays myelination of the corpus callosum in fetal sheep
    W L Huang
    Neurobiology Laboratory, Department of Zoology, The University of Western Australia, 6009, Crawley, Australia
    Int J Dev Neurosci 19:415-25. 2001

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Betamethasone effects on chorioamnionitis induced by intra-amniotic endotoxin in sheep
    John P Newnham
    School of Women s and Infants Health, University of Western Australia, King Edward Memorial Hospital, Bagot Road, Subiaco, Perth, WA 6008, Australia
    Am J Obstet Gynecol 189:1458-66. 2003
    ..We describe the effects of intra-amniotic endotoxin on cytokines and white cell responses in the membranes and amniotic fluid and investigate the hypothesis that betamethasone treatment suppresses these responses...
  2. ncbi request reprint Is prenatal glucocorticoid administration another origin of adult disease?
    J P Newnham
    Department of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia
    Clin Exp Pharmacol Physiol 28:957-61. 2001
    ..Further exploration of these models is expected to uncover the mechanisms and lead to effective strategies that may underpin clinical interventions...
  3. ncbi request reprint The effects of intra-amniotic injection of periodontopathic lipopolysaccharides in sheep
    John P Newnham
    The School of Women s and Infants Health, The University of Western Australia at King Edward Memorial Hospital, Perth, Western Australia
    Am J Obstet Gynecol 193:313-21. 2005
    ..The outcomes that were studied included the rates of fetal death and the features of inflammation and lung maturation in survivors...
  4. ncbi request reprint Antenatal corticosteroids: the good, the bad and the unknown
    John P Newnham
    The School of Women s Health and Infants Health, The University of Western Australia, King Edward Memorial Hospital, Perth, Western Australia, Australia
    Curr Opin Obstet Gynecol 14:607-12. 2002
    ..The purpose of this review was to summarize recently published clinical and animal-based studies of antenatal corticosteroids, describe current recommendations for practice, and suggest priority areas for future research...
  5. ncbi request reprint Effects of repeated prenatal ultrasound examinations on childhood outcome up to 8 years of age: follow-up of a randomised controlled trial
    John P Newnham
    School of Women s and Infants Health, The University of Western Australia at King Edward Memorial Hospital, Subiaco, Western Australia 6008, Australia
    Lancet 364:2038-44. 2004
    ..Our aim was to investigate the possible effects of multiple prenatal ultrasound scans on growth and development in childhood. Here, we provide follow-up data of the childrens' development...
  6. ncbi request reprint Nutrition and the early origins of adult disease
    John P Newnham
    School of Women s and Infants Health, University of Western Australia, King Edward Memorial Hospital for Women, Subiaco, Perth, Western Australia
    Asia Pac J Clin Nutr 11:S537-42. 2002
    ....
  7. ncbi request reprint Antenatal glucocorticoids and growth: single versus multiple doses in animal and human studies
    J P Newnham
    School of Women s and Infants Health, King Edward Memorial Hospital, The University of Western Australia, Perth, Western Australia
    Semin Neonatol 6:285-92. 2001
    ....
  8. ncbi request reprint Perinatal and childhood origins of cardiovascular disease
    R C Huang
    School of Medicine and Pharmacology, The University of Western Australia UWA M570, Royal Perth Hospital, Perth, Western Australia, Australia
    Int J Obes (Lond) 31:236-44. 2007
    ..We sought to identify early life influences on development of obesity, hypertension and dyslipidemia in children...
  9. ncbi request reprint Maternal, but not fetal, administration of corticosteroids restricts fetal growth
    J P Newnham
    Department of Obstetrics, Women and Infants Research Foundation at King Edward Memorial Hospital, University of Western Australia, Perth, Australia
    J Matern Fetal Med 8:81-7. 1999
    ..The purpose of the present study was to investigate and characterize the relative effects on growth of repeated maternal and fetal treatments by study of body, organ, and placental weights...
  10. ncbi request reprint Repeated prenatal corticosteroid administration delays myelination of the corpus callosum in fetal sheep
    W L Huang
    Neurobiology Laboratory, Department of Zoology, The University of Western Australia, 6009, Crawley, Australia
    Int J Dev Neurosci 19:415-25. 2001
    ..68 vs. 0.94 and 0.11 vs. 0.14 microm, P<0.05). Our data suggest that repeated prenatal corticosteroid administration delays myelination of the corpus callosum and that further safety data are needed to evaluate clinical practice...
  11. ncbi request reprint Programming effects in sheep of prenatal growth restriction and glucocorticoid exposure
    T J Moss
    Lotteries Commission Perinatal Research Laboratories, Department of Obstetrics and Gynaecology, The University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Australia 3800
    Am J Physiol Regul Integr Comp Physiol 281:R960-70. 2001
    ..Our data demonstrate that glucocorticoid-induced fetal growth restriction is associated with a transient reduction in postnatal arterial pressure, but glucocorticoid exposure with or without growth restriction alters glucose metabolism...
  12. ncbi request reprint The fetal maturational and inflammatory responses to different routes of endotoxin infusion in sheep
    John P Newnham
    Department of Obstetrics and Gynaecology, University of Western Australia at King Edward Memorial Hospital, Subiaco, Perth, Australia
    Am J Obstet Gynecol 186:1062-8. 2002
    ..This study aimed to explore the mechanisms by which endotoxin matures the lungs by determining whether the route of administration influenced the maturational responses of the fetus...
  13. pmc Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep
    Timothy J M Moss
    School of Women s and Infants Health, University of Western Australia, WA, Australia
    Am J Obstet Gynecol 200:96.e1-6. 2009
    ..The objective of the study was to assess the efficacy of maternal betamethasone for improving preterm lung function in the presence of inflammation induced by amniotic fluid Ureaplasma colonization...
  14. ncbi request reprint Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lung
    Karen E Willet
    Division of Clinical Sciences, Center for Child Health Research, Perth, Australia
    Am J Physiol Lung Cell Mol Physiol 282:L411-20. 2002
    ..Lung compliance, lung volume, and alveolar Sat PC were positively correlated with residual alveolar wash leukocyte numbers 7 days after IL-1 treatment, suggesting a link between lung inflammation and maturation...
  15. ncbi request reprint Maternal cigarette smoking during pregnancy, low birth weight and subsequent blood pressure in early childhood
    K V Blake
    Department of Obstetrics and Gynaecology, University of Western Australia, Crawley
    Early Hum Dev 57:137-47. 2000
    ..The present study is an exploration of a possible causal pathway underlying the birth weight/blood pressure association rather than simply a confirmation of such an association which has been detailed in many other papers...
  16. ncbi request reprint The interactive effects of endotoxin with prenatal glucocorticoids on short-term lung function in sheep
    J P Newnham
    Women and Infants Research Foundation, Department of Obstetrics and Gynecology, University of Western Australia, Perth, Western Australia
    Am J Obstet Gynecol 185:190-7. 2001
    ..These findings provide evidence that the lung maturation induced by glucocorticoids and that induced by endotoxin are mediated by different mechanisms...
  17. ncbi request reprint Statistical measures of foetal growth using linear mixed models applied to the foetal origins hypothesis
    L C Gurrin
    Women and Infants Research Foundation, King Edward Memorial Hospital, P O Box 134, Subiaco, 6008, Western Australia
    Stat Med 20:3391-409. 2001
    ....
  18. ncbi request reprint Adjustment for current weight and the relationship between birth weight and blood pressure in childhood
    K V Blake
    Department of Obstetrics and Gynecology, University of Western Australia, Perth, Australia
    J Hypertens 18:1007-12. 2000
    ..To determine the role of current weight in mediating the relationship between birth weight and blood pressure within the context of the 'fetal origins' hypothesis...
  19. ncbi request reprint Effect of corticosteroids on brain growth in fetal sheep
    W L Huang
    Department of Zoology, The University of Western Australia, Nedlands, Australia
    Obstet Gynecol 94:213-8. 1999
    ..To compare the effects of single and repeated courses of corticosteroids on brain growth in fetal sheep...
  20. ncbi request reprint Placental weight and placental ratio as predictors of later blood pressure in childhood
    K V Blake
    Department of Obstetrics and Gynaecology, King Edward Memorial Hospital, Subiaco, Western Australia
    J Hypertens 19:697-702. 2001
    ..The overall evidence for this is, however, inconclusive. The purpose of the present study was to clearly define the relationships between placental weight, placental ratio and subsequent blood pressure during childhood...
  21. ncbi request reprint Reference ranges for blood pressure in preschool Australians, obtained by oscillometry
    K V Blake
    Department of Obstetrics and Gynaecology, University of Western Australia, Crawley, Australia
    J Paediatr Child Health 36:41-6. 2000
    ..To derive reference centiles for blood pressure in children aged 1-6 years which seek to address shortcomings in available reference ranges...
  22. doi request reprint Supervised home-based exercise may attenuate the decline of glucose tolerance in obese pregnant women
    M J Ong
    School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, WA 6009, Australia
    Diabetes Metab 35:418-21. 2009
    ..The purpose of this study was to investigate the effect of a supervised 10-week, home-based, exercise programme, beginning at week 18 of gestation, on glucose tolerance and aerobic fitness in previously sedentary obese women...
  23. ncbi request reprint Predictors of body mass index and associations with cardiovascular risk factors in Australian children: a prospective cohort study
    V Burke
    School of Medicine and Pharmacology, The University of Western Australia, Royal Perth Hospital and Western Australian Institute for Medical Research, Perth, Australia
    Int J Obes (Lond) 29:15-23. 2005
    ..To examine predictors of body mass index (BMI) at the age of 8 y in a prospective study of Australian children...
  24. pmc Pulmonary vascular and alveolar development in preterm lambs chronically colonized with Ureaplasma parvum
    Graeme R Polglase
    The University of Western Australia, Perth, Australia
    Am J Physiol Lung Cell Mol Physiol 299:L232-41. 2010
    ..We conclude that chronic exposure to U. parvum does not cause sustained effects on air space or vascular development in premature lambs...
  25. doi request reprint Expression of glucocorticoid receptor, mineralocorticoid receptor, and 11beta-hydroxysteroid dehydrogenase 1 and 2 in the fetal and postnatal ovine hippocampus: ontogeny and effects of prenatal glucocorticoid exposure
    Deborah M Sloboda
    School of Women s and Infants Health, The University of Western Australia, Perth 6009, Australia
    J Endocrinol 197:213-20. 2008
    ....
  26. ncbi request reprint Is there a relationship to dye determined or ultrasound estimated amniotic fluid volume adjusted percentiles and fetal weight adjusted percentiles?
    Everett F Magann
    Department of Obstetrics and Gynecology, The University of Western Australia, Perth, Australia
    Am J Obstet Gynecol 190:1610-4; discussion 1614-5. 2004
    ..This study was undertaken to determine whether there is a correlation between neonatal birth weight and an estimated or dye-determined amniotic fluid volume...
  27. ncbi request reprint Synthetic glucocorticoids: antenatal administration and long-term implications
    D M Sloboda
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Curr Pharm Des 11:1459-72. 2005
    ..The purpose of this mini-review is to provide a background into the use of antenatal synthetic corticosteroids and to highlight and summarize recently published clinical and animal-based studies...
  28. ncbi request reprint The relationship between maternal and umbilical cord androgen levels and polycystic ovary syndrome in adolescence: a prospective cohort study
    M Hickey
    School of Women s and Infants Health, University of Western Australia, Crawley WA 6009 Perth, Australia
    J Clin Endocrinol Metab 94:3714-20. 2009
    ..The prenatal antecedents of polycystic ovary syndrome (PCOS) are not known, but prenatal androgen exposure is thought to contribute. This has not previously been investigated in large prospective studies of normal human pregnancy...
  29. ncbi request reprint Repeated ultrasound guided fetal injections of corticosteroid alter nervous system maturation in the ovine fetus
    J A Quinlivan
    University Department of Obstetrics and Gynecology, University of Western Australia, Australia
    J Perinat Med 29:112-27. 2001
    ..We have evaluated the effect of repeated fetal administration of betamethasone on nervous system maturation in an ovine model...
  30. ncbi request reprint The effects of overcoming experimental bladder outflow obstruction in fetal sheep
    G J Duncombe
    Women and Infants Research Foundation, Subiaco, Western Australia
    J Matern Fetal Neonatal Med 11:130-7. 2002
    ..To develop an ovine model of fetal bladder outflow obstruction and to investigate the effect on the kidney of surgical relief of the obstruction in the prenatal period...
  31. ncbi request reprint Uising WinBUGS to fit nonlinear mixed models with an application to pharmacokinetic modelling of insulin response to glucose challenge in sheep exposed antenatally to glucocorticoids
    Lyle C Gurrin
    Women and Infants Research Foundation, King Edward Memorial Hospital, Subiaco, Western Australia, Australia
    J Biopharm Stat 13:117-39. 2003
    ..It is argued that the fitting of an appropriate statistical model to complex physiological data does not necessarily proclude a result that has a clear interpretation for clinical scientists...
  32. doi request reprint Evaluation of selection criteria for validating paired umbilical cord blood gas samples: an observational study
    C R H White
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    BJOG 119:857-65. 2012
    ..To compare six validation criteria for umbilical cord blood gas (UCBG) values in vigorous and nonvigorous neonates...
  33. doi request reprint Antepartum bleeding of unknown origin in the second half of pregnancy and pregnancy outcomes
    R A McCormack
    Department of Obstetrics and Gynaecology, School of Women s and Infants Health, University of Western Australia, Perth, Western Australia, Australia
    BJOG 115:1451-7. 2008
    ..The purpose of our investigation was to evaluate factor(s) associated with unexplained antepartum bleeding of unknown origin (ABUO) after 24 weeks of pregnancy and correlate unexplained haemorrhage with maternal and perinatal outcomes...
  34. ncbi request reprint Second trimester placental location as a predictor of an adverse pregnancy outcome
    E F Magann
    Department of Obstetrics and Gynecology, University of Western Australia, Perth, Australia
    J Perinatol 27:9-14. 2007
    ..To determine if the second trimester placental location is associated with perinatal outcomes...
  35. ncbi request reprint Repeated prenatal corticosteroid administration delays astrocyte and capillary tight junction maturation in fetal sheep
    W L Huang
    Neurobiology Laboratory, Department of Zoology, University of Western Australia, WA 6009, Crawley, Australia
    Int J Dev Neurosci 19:487-93. 2001
    ..65%, P<0.05). Our data suggest that repeated corticosteroids delay both astrocyte and capillary tight junction maturation. The implications for clinical practice are as yet unknown...
  36. ncbi request reprint Pre-pregnancy body mass index and pregnancy outcomes
    D A Doherty
    School of Women s and Infants Health, The University of Western Australia at King Edward Memorial Hospital, Australia
    Int J Gynaecol Obstet 95:242-7. 2006
    ..To determine the effect of maternal pre-pregnancy BMI on pregnancy outcomes...
  37. ncbi request reprint Repeated maternal glucocorticoid administration and the developing liver in fetal sheep
    D M Sloboda
    School of Women s and Infants Health, University of Western Australia, Perth, Australia
    J Endocrinol 175:535-43. 2002
    ..We speculate that this could affect expression of glucocorticoid-dependent hepatic enzymes involved with the regulation of glucose production and HPA responsiveness...
  38. ncbi request reprint Repeated prenatal corticosteroids delay myelination in the ovine central nervous system
    S A Dunlop
    Department of Zoology, University of Western Australia, Nedlands
    J Matern Fetal Med 6:309-13. 1997
    ..Clinical practice should balance the known beneficial effects on lung maturation of a single course of corticosteroid against the potential damage to the CNS of repeated courses...
  39. ncbi request reprint Intra-amniotic corticosteroids for preterm lung maturation in sheep
    Timothy J M Moss
    Lotteries Commission Perinatal Research Laboratories, School of Women s and Infants Health, University of Western Australia, Box M094, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Am J Obstet Gynecol 189:1389-95. 2003
    ..The purpose of this study was to compare efficacy on fetal lung maturation of intra-amniotic betamethasone or budesonide with the efficacy of maternal intramuscular betamethasone...
  40. doi request reprint Treatment of periodontal disease during pregnancy: a randomized controlled trial
    John P Newnham
    Schools of Women s and Infants Health and Dentistry of The University of Western Australia, Perth, Western Australia
    Obstet Gynecol 114:1239-48. 2009
    ..To investigate whether treating periodontal disease prevents preterm birth and other major complications of pregnancy...
  41. ncbi request reprint Hepatic glucose regulation and metabolism in adult sheep: effects of prenatal betamethasone
    Deborah M Sloboda
    School of Women s and Infants Health, University of Western Australia, Perth, Australia
    Am J Physiol Endocrinol Metab 289:E721-8. 2005
    ..Prenatal betamethasone exposure results in elevated hepatic G-6-Pase activity in adulthood and may contribute to long-term changes in metabolism...
  42. ncbi request reprint Breastfeeding and overweight: longitudinal analysis in an Australian birth cohort
    Valerie Burke
    University of Western Australia, School of Medicine and Pharmacology, Royal Perth Hospital, Perth, Australia
    J Pediatr 147:56-61. 2005
    ..To examine adiposity in relation to breastfeeding using longitudinal analysis in an Australian birth cohort...
  43. ncbi request reprint Intra-amniotic endotoxin induces lung maturation by direct effects on the developing respiratory tract in preterm sheep
    Timothy J M Moss
    School of Women s and Infants Health, University of Western Australia, 35 Stirling Highway, Crawley WA, Perth, Australia
    Am J Obstet Gynecol 187:1059-65. 2002
    ..Our purpose was to determine whether improved preterm lung function caused by intraamniotic endotoxin treatment requires endotoxin entry into the respiratory tract...
  44. ncbi request reprint Effects into adulthood of single or repeated antenatal corticosteroids in sheep
    Timothy J M Moss
    School of Women s and Infants Health, The University of Western Australia, Crawley, Australia
    Am J Obstet Gynecol 192:146-52. 2005
    ..To determine effects of maternal or fetal injections of betamethasone on postnatal growth and arterial pressure...
  45. ncbi request reprint Effects of antenatal corticosteroids on urinary markers of the initiation of lactation in pregnant women
    Jennifer J Henderson
    School of Women s and Infants Health, The University of Western Australia, King Edward Memorial Hospital, Subiaco, Western Australia, Australia
    Breastfeed Med 4:201-6. 2009
    ..This study aimed to investigate the effects of antenatal corticosteroid treatment on mammary secretion during pregnancy in women...
  46. ncbi request reprint Fetal responses to intra-amniotic endotoxin in sheep
    Ilias Nitsos
    Department of Obstetrics and Gynaecology, University of Western Australia, Crawley 6009, WA, Australia
    J Soc Gynecol Investig 9:80-5. 2002
    ....
  47. doi request reprint Early life origins of obesity
    John P Newnham
    School of Women s and Infants Health, The University of Western Australia, 374 Bagot Road, Subiaco, Perth, Western Australia 6008, Australia
    Obstet Gynecol Clin North Am 36:227-44, xii. 2009
    ..Understanding the mechanisms and pathways that underpin the early origins of obesity is vital if we are to make progress in addressing this major problem of modern life...
  48. ncbi request reprint Prenatal betamethasone exposure results in pituitary-adrenal hyporesponsiveness in adult sheep
    Deborah M Sloboda
    Forrest Fetal Research Scientist, School of Women s and Infants Health, The Univ of Western Australia, King Edward Memorial Hospital, Subiaco, Western Australia, Australia
    Am J Physiol Endocrinol Metab 292:E61-70. 2007
    ..These data suggest that maternal, but not fetal, betamethasone administration results in adrenal suppression in adulthood...
  49. ncbi request reprint Periodontal disease and adverse pregnancy outcomes
    Alexis Shub
    School of Women s and Infants Health, The University of Western Australia, Perth, Western Australia
    J Matern Fetal Neonatal Med 19:521-8. 2006
    ..Three large randomized controlled trials of treatment of periodontal disease are underway and may provide confirmation of the importance of periodontal disease in causing complications of pregnancy...
  50. doi request reprint Pre- and postnatal influences on preschool mental health: a large-scale cohort study
    Monique Robinson
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia
    J Child Psychol Psychiatry 49:1118-28. 2008
    ..This study aims to address these challenges in investigating antenatal, perinatal and postnatal risk factors for the development of mental health problems in pre-school children in a cohort of Western Australian children...
  51. ncbi request reprint Effects of intra-amniotic endotoxin on lung structure and function two months after term birth in sheep
    Timothy J M Moss
    School of Women s and Infants Health, The University of Western Australia, Perth, Western Australia
    J Soc Gynecol Investig 9:220-5. 2002
    ..Our aim was to determine the effects on lung structure and function after term birth in lambs exposed to intra-amniotic or intra-allantoic endotoxin...
  52. doi request reprint Effect of preterm birth and antenatal corticosteroid treatment on lactogenesis II in women
    Jennifer J Henderson
    School of Women s and Infants Health, University of Western Australia, Crawley, Western Australia, Australia
    Pediatrics 121:e92-100. 2008
    ..The onset of copious milk secretion after birth is known as lactogenesis II. The objective of this study was to investigate the effect of preterm birth and antenatal corticosteroids on the timing of lactogenesis II after birth...
  53. ncbi request reprint Experimental intrauterine Ureaplasma infection in sheep
    Timothy J M Moss
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Am J Obstet Gynecol 192:1179-86. 2005
    ..We hypothesized that intra-amniotic ureaplasmas would cause lung inflammation and alter fetal lung development...
  54. doi request reprint Perceptions by medical students of their educational environment for obstetrics and gynaecology in metropolitan and rural teaching sites
    Dianne F Carmody
    The University of Western Australia, Western Australia, Women and Infants Research Foundation, Western Australia
    Med Teach 31:e596-602. 2009
    ..Medical student education in Western Australia is expanding to secondary level metropolitan hospitals and rural sites to accommodate workforce demands and increasing medical student numbers...
  55. pmc Exposure to in utero lipopolysaccharide induces inflammation in the fetal ovine skin
    Matthew W Kemp
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Reprod Sci 18:88-98. 2011
    ..These novel data strongly suggests that the fetal skin acts as an important mediator of the fetal inflammatory response and as such may contribute to preterm birth...
  56. ncbi request reprint Pharmacokinetics of betamethasone after maternal or fetal intramuscular administration
    Timothy J M Moss
    Lotteries Commission Perinatal Research Laboratories, School of Women s and Infants Health, University of Western Australia, Box M094, 35 Stirling Highway, Crawley, WA 6009, Australia
    Am J Obstet Gynecol 189:1751-7. 2003
    ..The purpose of this study was to determine the pharmacokinetics of betamethasone in maternal and fetal circulations after maternal or fetal intramuscular administration...
  57. ncbi request reprint Chorioamnionitis induced by subchorionic endotoxin infusion in sheep
    Timothy J M Moss
    Lotteries Commission Perinatal Research Laboratories, School of Women s and Infants Health, University of Western Australia, Box M094, 35 Stirling Highway, Crawley, WA 6009, Australia
    Am J Obstet Gynecol 189:1771-6. 2003
    ..This study was undertaken to determine whether subchorionic endotoxin infusion causes chorioamnionitis and preterm lung maturation, as occurs after intra-amniotic endotoxin...
  58. ncbi request reprint Indicators of fetal growth do not independently predict blood pressure in 8-year-old Australians: a prospective cohort study
    Valerie Burke
    The University of Western Australia, School of Medicine and Pharmacology, Royal Perth Hospital and Western Australian Institute for Medical Research, Perth, Australia
    Hypertension 43:208-13. 2004
    ....
  59. doi request reprint Benefits of introducing universal umbilical cord blood gas and lactate analysis into an obstetric unit
    Christopher R H White
    The University of Western Australia, Perth, Australia
    Aust N Z J Obstet Gynaecol 50:318-28. 2010
    ..However, there's debate whether umbilical cord blood gas analysis (UC-BGA) should be conducted on some or all deliveries...
  60. ncbi request reprint Variability in preterm lamb lung mechanics after intra-amniotic endotoxin is associated with changes in surfactant pool size and morphometry
    J Jane Pillow
    Centre for Child Health Research, The University of Western Australia, Perth, Australia
    Am J Physiol Lung Cell Mol Physiol 287:L992-8. 2004
    ..Despite the complex cascade of events initiated by antenatal endotoxin exposure, variability in lung tissue mechanics is associated primarily with changes in alveolar Sat PC pool and lung morphology...
  61. pmc Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep
    Timothy J M Moss
    School of Women s and Infants Health, Faculty of Medicine, Dentistry, and Health Sciences, University of Western Australia, Perth, Western Australia, Australia
    Am J Obstet Gynecol 198:122.e1-8. 2008
    ..The objective of the study was to determine the effects in late gestation of Ureaplasma parvum serovar 3 colonization and the effects, preterm, of U. parvum serovar 6...
  62. doi request reprint Circulating maternal testosterone concentrations at 18 weeks of gestation predict circulating levels of antim├╝llerian hormone in adolescence: a prospective cohort study
    Roger Hart
    School of Women s and Infants Health, University of Western Australia, and Women and Infants Research Foundation, King Edward Memorial Hospital, Perth, Western Australia, Australia
    Fertil Steril 94:1544-7. 2010
    ....
  63. doi request reprint Ventilation-mediated injury after preterm delivery of Ureaplasma parvum colonized fetal lambs
    Graeme R Polglase
    School of Women s and Infants Health, The University of Western Australia, Subiaco, Western Australia 6009, Australia
    Pediatr Res 67:630-5. 2010
    ..Antenatal colonization with UP did not change lung function or modulate the lung injury and inflammation caused by high VT ventilation...
  64. doi request reprint Brief report: a preliminary study of fetal head circumference growth in autism spectrum disorder
    Andrew J O Whitehouse
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, 100 Roberts Road, Subiaco, Perth, WA, 6008, Australia
    J Autism Dev Disord 41:122-9. 2011
    ..These preliminary findings suggest that further investigation of fetal growth in ASD is warranted...
  65. ncbi request reprint Lung function, arterial pressure and growth in sheep during early postnatal life following single and repeated prenatal corticosteroid treatments
    Timothy J M Moss
    Department of Obstetrics and Gynaecology, The University of Western Australia, 35 Stirling Highway, WA, 6009 Crawley, Australia
    Early Hum Dev 66:11-24. 2002
    ....
  66. doi request reprint Should we be prescribing repeated courses of antenatal corticosteroids?
    John P Newnham
    School of Women s and Infants Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, King Edward Memorial Hospital, Perth, Western Australia, Australia
    Semin Fetal Neonatal Med 14:157-63. 2009
    ....
  67. doi request reprint Preterm birth, infection, and inflammation advances from the study of animal models
    Matthew W Kemp
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Reprod Sci 17:619-28. 2010
    ..Herein, we review important developments in our understanding of the link between preterm birth and fetal inflammation subsequent to infection, gained from studies undertaken in animal models...
  68. doi request reprint Hypertensive diseases of pregnancy and the development of behavioral problems in childhood and adolescence: the Western Australian Pregnancy Cohort Study
    Monique Robinson
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia
    J Pediatr 154:218-24. 2009
    ..To examine whether maternal gestational hypertension and preeclampsia are associated with behavioral problems in offspring throughout childhood and early adolescence...
  69. ncbi request reprint Free testosterone levels in umbilical-cord blood predict infant head circumference in females
    Andrew J O Whitehouse
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Dev Med Child Neurol 52:e73-7. 2010
    ..We report the association between circulating fetal androgen levels, measured from umbilical-cord blood at birth, and a proxy measure of brain growth: head circumference...
  70. doi request reprint Disrupted secretory activation of the mammary gland after antenatal glucocorticoid treatment in sheep
    Jennifer J Henderson
    School of Women s and Infants Health, M550, King Edward Memorial Hospital, The University of Western Australia, Subiaco, Perth, Western Australia 6008, Australia
    Reproduction 136:649-55. 2008
    ..This study demonstrated that, in sheep, antenatal glucocorticoid administration disrupted secretory activation, causing precocious mammary secretion before parturition and compromising postpartum milk production and lamb growth...
  71. doi request reprint Prenatal determinants of uterine volume and ovarian reserve in adolescence
    Roger Hart
    School of Women s and Infants Health, University of Western Australia, Perth, Western Australia 6008, Australia
    J Clin Endocrinol Metab 94:4931-7. 2009
    ..Antenatal events such as restricted fetal growth and maternal tobacco smoking are hypothesized to impact on reproductive function in later life, although not studied in a large prospective normal pregnancy population to date...
  72. ncbi request reprint Early gestational intra-amniotic endotoxin: lung function, surfactant, and morphometry
    Timothy J M Moss
    School of Women s and Infants Health and Centre for Child Health Research, University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 165:805-11. 2002
    ....
  73. ncbi request reprint Estimation of the Doppler ultrasound maximal umbilical waveform envelope: I. Estimation method
    Dorota A Doherty
    Mathematics and Statistics, Murdoch University, Murdoch, WA, Australia
    Ultrasound Med Biol 28:1251-9. 2002
    ..The method has been developed with special reference to umbilical blood flow images, but it can be used directly to model blood flow in other low-resistance vessels or adapted for other vessels with different shape characteristics...
  74. doi request reprint Fetal androgen exposure and pragmatic language ability of girls in middle childhood: implications for the extreme male-brain theory of autism
    Andrew J O Whitehouse
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Subiaco, Western Australia, Australia
    Psychoneuroendocrinology 35:1259-64. 2010
    ..These novel findings are discussed with reference to the 'extreme male-brain' theory of autism...
  75. ncbi request reprint Maternal and intra-amniotic corticosteroid effects on lung morphometry in preterm lambs
    Graeme R Polglase
    School of Women s and Infants Health, The University of Western Australia, Crawley, Western Australia, 6009, Australia
    Pediatr Res 62:32-6. 2007
    ..Similar structural changes induced by intra-amniotic corticosteroids and maternal intramuscular betamethasone were associated with improvements in lung function at 2 and 7 d...
  76. ncbi request reprint Differential effects of maternal and fetal betamethasone injections in late-gestation fetal sheep
    Timothy J M Moss
    Lotteries Commission Perinatal Research Laboratories, School of Women s and Infants Health, University of Western Australia, Box M094, 35 Stirling Highway, Crawley, WA 6009, Australia
    J Soc Gynecol Investig 10:474-9. 2003
    ..To determine the effects of single or repeated intramuscular injections of betamethasone, given maternally or directly to the fetus, on chronically catheterized, late-gestation fetal sheep...
  77. ncbi request reprint Estimation of the Doppler ultrasound umbilical maximal waveform envelope: II. Prediction of fetal distress
    Dorota A Doherty
    Department of Mathematics and Statistics, Murdoch University, Murdoch WA, Australia
    Ultrasound Med Biol 28:1261-70. 2002
    ..Our data suggest that prediction of IUGR at 18 pregnancy weeks can be much improved when the waveform shape is captured with a number of summary statistics in addition to resistance indices...
  78. ncbi request reprint Chronic exposure to intra-amniotic lipopolysaccharide affects the ovine fetal brain
    Ilias Nitsos
    School of Women s and Infants Health, The University of Western Australia, Crawley, Western Australia, Australia
    J Soc Gynecol Investig 13:239-47. 2006
    ..We aimed to determine if prolonged exposure to intrauterine inflammation caused by intra-amniotic infusion of lipopolysaccharide (LPS) would affect the fetal brain...
  79. doi request reprint Low-moderate prenatal alcohol exposure and risk to child behavioural development: a prospective cohort study
    M Robinson
    Telethon Institute for Child Health Research, Centre for Child Health Research, Perth, Australia
    BJOG 117:1139-50. 2010
    ..To examine the association of fetal alcohol exposure during pregnancy with child and adolescent behavioural development...
  80. ncbi request reprint Effectiveness and safety of a structured swimming program in previously sedentary women during pregnancy
    A M Lynch
    School of Human Movement and Exercise Science, University of Western Australia, Perth, Australia
    J Matern Fetal Neonatal Med 14:163-9. 2003
    ..To determine whether undertaking a swimming program in sedentary women during pregnancy would improve maternal fitness without adverse fetal consequences...
  81. ncbi request reprint Discovering the mechanisms of fetal programming
    John P Newnham
    School of Women s and Infants Health, The University of Western Australia, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, Western Australia 6008, Australia
    Clin Sci (Lond) 103:641-2. 2002
  82. ncbi request reprint Repeated antenatal corticosteroids: effects on cerebral palsy and childhood behavior
    Noel P French
    Department of Neonatal Paediatrics, King Edward Memorial Hospital, Subiaco, Perth, Australia
    Am J Obstet Gynecol 190:588-95. 2004
    ..This study was undertaken to determine the effects of repeated courses of antenatal corticosteroids on childhood behavior and disabilities, including cognitive delay and cerebral palsy...
  83. ncbi request reprint Maternal periodontal disease and perinatal mortality
    Alexis Shub
    School Women s and Infants Health, University of Western Australia, Perth, Western Australia, Australia
    Aust N Z J Obstet Gynaecol 49:130-6. 2009
    ..Periodontal disease has been associated with increased perinatal mortality...
  84. pmc Prenatal ultrasound biometry related to subsequent blood pressure in childhood
    K V Blake
    Department of Obstetrics and Gynaecology, The University of Western Australia, Subiaco, Australia
    J Epidemiol Community Health 56:713-8. 2002
    ..To relate measures of fetal growth/size other than birth weight with subsequent blood pressure measured on the same individuals within the context of the "fetal origins of adult disease"...
  85. ncbi request reprint Maternal physiological responses to swimming training during the second trimester of pregnancy
    Ann Maree Lynch
    School of Human Movement and Exercise Science, The University of Western Australia, Crawley, Western Australia, Australia
    Res Sports Med 15:33-45. 2007
    ..Further, all women remained healthy, with no adverse outcomes for mother or baby...
  86. ncbi request reprint Maternal betamethasone administration reduces binucleate cell number and placental lactogen in sheep
    Thorsten Braun
    Department of Physiology and Obstetrics and Gynecology, University of Toronto, MSB, 1 King s College Circle, Toronto, Ontario, Canada
    J Endocrinol 194:337-47. 2007
    ..These data may suggest a placental role in growth restrictive effects of prenatal maternal BET exposure through alterations in placental output of oPL, a key metabolic hormone of pregnancy...
  87. ncbi request reprint Endotoxin-induced chorioamnionitis modulates innate immunity of monocytes in preterm sheep
    Boris W Kramer
    University Children s Hospital, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Am J Respir Crit Care Med 171:73-7. 2005
    ..Modulation of fetal innate immune responses by exposure to inflammation may alter subsequent immune adaptation after birth...
  88. ncbi request reprint Maternal glucocorticoids increase endotoxin-induced lung inflammation in preterm lambs
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 284:L633-42. 2003
    ..These results have implications for lung inflammation and bronchopulmonary dysplasia in preterm infants exposed to chorioamnionitis and maternal glucocorticoids...
  89. ncbi request reprint Chronic endotoxin exposure does not cause sustained structural abnormalities in the fetal sheep lungs
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, Div of Pulmonary Biology, University of Cincinnati College of Medicine, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 288:L966-74. 2005
    ..Contrary to our hypothesis, a prolonged fetal exposure to intra-amniotic endotoxin caused mild persistent inflammation but did not lead to progressive structural abnormalities in lungs of near-term gestation lambs...
  90. ncbi request reprint Differential effects of maternal betamethasone and cortisol on lung maturation and growth in fetal sheep
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, and the School of Women s and Infant s Health, University of Western Australia
    Am J Obstet Gynecol 188:22-8. 2003
    ..We asked whether maternal or fetal cortisol treatments induced fetal lung maturation and growth restriction compared with betamethasone and whether medroxyprogesterone (MPA) influenced lung maturation...
  91. ncbi request reprint Antenatal betamethasone changes cord blood monocyte responses to endotoxin in preterm lambs
    Boris W Kramer
    University Children s Hospital, 97080 Wurzburg, Germany
    Pediatr Res 55:764-8. 2004
    ..The time-dependent changes in maternal betamethasone modulation of the responses of fetal monocytes may influence immune function of the preterm lamb after delivery...
  92. pmc Betamethasone for lung maturation: testing dose and formulation in fetal sheep
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Am J Obstet Gynecol 197:523.e1-6. 2007
    ..We evaluated lung maturation responses to the mixture of betamethasone phosphate (Beta-PO4) + betamethasone acetate (Beta-Ac) in comparison to Beta-PO4 or Beta-Ac in fetal sheep...
  93. pmc Recruited inflammatory cells mediate endotoxin-induced lung maturation in preterm fetal lambs
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 172:1315-21. 2005
    ..In preterm lambs, intraamniotic endotoxin and interleukin 1 (IL-1) induce lung inflammation followed by lung maturation...
  94. ncbi request reprint Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitis
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    J Immunol 179:8491-9. 2007
    ..The findings have implications for preterm infants exposed to chorioamnionitis for both responses to lung injury and postnatal nosocomial infections...
  95. ncbi request reprint Oxidative stress in fetal lambs exposed to intra-amniotic endotoxin in a chorioamnionitis model
    Fook Choe Cheah
    Department of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Res 63:274-9. 2008
    ..Surfactant protein A and B mRNAs were highest at 2 d, suggesting that oxidative stress did not contribute to the lung maturation response. A modest lung oxidative stress in chorioamnionitis could contribute to bronchopulmonary dysplasia...
  96. doi request reprint Maternal betamethasone and chorioamnionitis induce different collagenases during lung maturation in fetal sheep
    David G Sweet
    Department of Child Health, The Queen s University of Belfast, UK
    Neonatology 94:79-86. 2008
    ..The effectors of this antenatally-induced lung maturation are not understood. Matrix metalloproteinases (MMPs) 2 and 9 are type-IV collagenases that can degrade alveolar basement membranes...
  97. ncbi request reprint Repeated prenatal corticosteroids reduce glial fibrillary acidic protein in the ovine central nervous system
    Julie A Quinlivan
    Department of Obstetrics and Gynecology, Melbourne University, Victoria, Australia
    J Perinat Med 30:209-19. 2002
    ..We have evaluated the effect of prenatal corticosteroid upon ovine GFAP...
  98. pmc Repeated betamethasone treatment of pregnant sheep programs persistent reductions in circulating IGF-I and IGF-binding proteins in progeny
    Kathryn L Gatford
    Research Centre for Early Origins of Adult Disease, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide SA 5005, Australia
    Am J Physiol Endocrinol Metab 295:E170-8. 2008
    ..We conclude that repeated exposure to synthetic glucocorticoids in utero programs the IGF axis before and after birth, which may contribute to the adverse effects of betamethasone exposure on growth and metabolism...
  99. ncbi request reprint Endotoxin-induced maturation of monocytes in preterm fetal sheep lung
    Boris W Kramer
    University Hospital Maastricht, Maastricht, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 293:L345-53. 2007
    ..Intra-amniotic endotoxin induced lung monocytes to develop into functionally mature cells consistent with macrophages. These findings have implications for lung immune responses after exposure to chorioamnionitis...
  100. pmc Improving outcomes in pregnancy
    John P Newnham
    BMJ 334:807-8. 2007
  101. ncbi request reprint Prostaglandins and mechanisms of preterm birth
    John R G Challis
    Department of Physiology, CIHR Group in Fetal and Neonatal Health and Development, CIHR Institute of Human Development, Child and Youth Health, University of Toronto, Medical Sciences Building, Suite 3368, Toronto M5S 1A8, Canada
    Reproduction 124:1-17. 2002
    ..In these circumstances, increased concentrations of maternal cortisol may cross into the fetal compartment, contributing to growth restriction and programming later life disease...