Research Topics
Genomes and GenesSpecies | Sharon L NaismithSummaryAffiliation: University of Sydney Country: Australia Publications
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Publications
Does sleep disturbance mediate neuropsychological functioning in older people with depression?Sharon L Naismith
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 94 Mallet Street, Camperdown NSW 2050, Australia
J Affect Disord 116:139-43. 2009..However, the association between sleep disturbance and neuropsychological functioning in depression has not been well evaluated. The current study therefore aimed to investigate these relationships...- Cognitive training in affective disorders improves memory: a preliminary study using the NEAR approachSharon L Naismith
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, NSW, Australia
J Affect Disord 121:258-62. 2010..Some of these changes persist despite antidepressant treatment. While research in other areas of psychiatry has shown cognitive training techniques to be effective, only one study has evaluated this approach in depression... - Enhancing memory in late-life depression: the effects of a combined psychoeducation and cognitive training programSharon L Naismith
Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, NSW, Australia
Am J Geriatr Psychiatry 19:240-8. 2011..To evaluate the efficacy of a multifactorial cognitive training (CT) program for older people with a lifetime history of depressive disorder... 
Disability in major depression related to self-rated and objectively-measured cognitive deficits: a preliminary studySharon L Naismith
Brain and Mind Research Institute, University of Sydney, Camperdown, Australia
BMC Psychiatry 7:32. 2007..This study examined the relationships between self-rated disability in persons with MD and both self-rated and objectively-measured cognitive functioning...
Effect of oral appliance therapy on neurobehavioral functioning in obstructive sleep apnea: a randomized controlled trialSharon L Naismith
Department of Respiratory and Sleep Medicine, St George Hospital, The University of New South Wales, Sydney, Australia
J Clin Sleep Med 1:374-80. 2005..This study aimed to assess the efficacy of a custom-made mandibular advancement splint for the treatment of obstructive sleep apnea with respect to neuropsychological functioning and mood state...- Sleep well, think well: sleep-wake disturbance in mild cognitive impairmentSharon L Naismith
Ageing Brain Centre, Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
J Geriatr Psychiatry Neurol 23:123-30. 2010..This preliminary data suggests that sleep-wake disturbance in nonamnestic forms of MCI is related to cognitive functioning and may be indicative of shared neurobiological underpinnings... - Impaired implicit sequence learning in depression: a probe for frontostriatal dysfunction?Sharon L Naismith
Brain and Mind Research Institute, University of Sydney, Sydney, Australia
Psychol Med 36:313-23. 2006..Consequently, it is ideally suited for testing elements of the frontostriatal model of major depression and performance can be related to key clinical, neuropsychological, vascular and biochemical data... - Fronto-striatal correlates of impaired implicit sequence learning in major depression: an fMRI studySharon L Naismith
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
J Affect Disord 125:256-61. 2010..This study sought to probe the integrity of fronto-striatal circuits using functional magnetic resonance imaging (fMRI) in conjunction with a theoretically-driven motor sequencing implicit learning (IL) task... - Psychomotor slowing in older patients with major depression: Relationships with blood flow in the caudate nucleus and white matter lesionsIan B Hickie
Brain and Mind Research Institute, University of Sydney, Sydney, Australia
Psychiatry Res 155:211-20. 2007..Reduced %rCBF is associated with demonstrable psychomotor slowing and presence of WMLs. While psychomotor slowing is determined in part by subcortical changes, other cortical and illness-dependent factors are likely to be relevant... - Reduced temporal mismatch negativity in late-life depression: an event-related potential index of cognitive deficit and functional disability?Sharon L Naismith
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Australia
J Affect Disord 138:71-8. 2012..This study examined MMN elicited by duration deviant stimuli in older people with lifetime depression, and explored its relationship with neuropsychological functioning and disability... - Reduced mismatch negativity in mild cognitive impairment: associations with neuropsychological performanceLoren Mowszowski
Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia
J Alzheimers Dis 30:209-19. 2012..These findings overall suggest that MMN may be a viable neurophysiological biomarker of underlying disease in this 'at risk' group... - Sleep disturbance relates to neuropsychological functioning in late-life depressionSharon L Naismith
Clinical Research Unit, Brain and Mind Research Institute, Australia
J Affect Disord 132:139-45. 2011..Sleep-wake disturbance in older people is a risk factor for depression onset and recurrence. The aim of this study was to determine if objective sleep-wake disturbance in late-life depression relates to neuropsychological functioning... - Sleep disturbances in Parkinson disease and their potential role in heterogeneityDavid G Gunn
Parkinson s Disease Research Clinic, Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
J Geriatr Psychiatry Neurol 23:131-7. 2010..It also emphasizes the need for further studies that explore the heterogeneity of all disease features in PD... - Investigating visual misperceptions in Parkinson's disease: a novel behavioral paradigmJames M Shine
Parkinson s Disease Clinic, Brain and Mind Research Institute, The University of Sydney, New South Wales, Australia
Mov Disord 27:500-5. 2012..We propose that the BPP may offer a novel approach for exploring the neural correlates underlying visual hallucinations and misperceptions in PD... - Neuropsychological clustering highlights cognitive differences in young people presenting with depressive symptomsDaniel F Hermens
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
J Int Neuropsychol Soc 17:267-76. 2011..Distinct neuropsychological profiling may help to predict later psychiatric outcomes and enhance individually-tailored early intervention strategies... - Impaired MMN/P3a complex in first-episode psychosis: cognitive and psychosocial associationsDaniel F Hermens
Clinical Research Unit, Brain and Mind Research Institute, The University of Sydney, Sydney, Australia
Prog Neuropsychopharmacol Biol Psychiatry 34:822-9. 2010..Such deficits in FEP appear to have important links with higher-order cognitive and psychosocial functioning... - Sleep-wake changes and cognition in neurodegenerative diseaseSharon L Naismith
Healthy Brain Ageing Clinic, Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, Sydney, NSW, Australia
Prog Brain Res 190:21-52. 2011..Such research will hopefully lead to targeted early intervention approaches for cognitive decline in older people... - Impaired verbal memory in young adults with unipolar and bipolar depressionDaniel F Hermens
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
Early Interv Psychiatry 4:227-33. 2010..Specifically, deficits in verbal memory have been linked to depression in young people. This study examined whether young adults with unipolar compared with bipolar depression showed similar neurocognitive deficits... - Can older "at risk" adults benefit from psychoeducation targeting healthy brain aging?Louisa M Norrie
Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, NSW, Australia
Int Psychogeriatr 23:413-24. 2011..The current study sought to investigate whether older adults "at risk" of cognitive decline benefit from psychoeducation targeting healthy brain aging... - The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological featuresSharon L Naismith
Ageing Brain Centre, Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
Prog Neurobiol 98:99-143. 2012..Ultimately, future research must aim to evaluate whether basic biomedical knowledge can be successfully translated into enhanced health outcomes via the implementation of early intervention paradigms... - Neuropsychological functioning in Parkinson's disease: differential relationships with self-reported sleep-wake disturbancesSharon L Naismith
Parkinson s Disease Research Clinic, Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, Camperdown, Australia
Mov Disord 26:1537-41. 2011..However, prior studies exploring the association between specific sleep-wake disturbances and neuropsychological functions have been limited... - Early intervention for cognitive decline: is there a role for multiple medical or behavioural interventions?Sharon L Naismith
Brain and Mind Research Institute, The George Institute for International Health, University of Sydney, Sydney, New South Wales, Australia
Early Interv Psychiatry 3:19-27. 2009..Evidence for the beneficial effects of providing relevant interventions is assessed... - Neuropsychological performance in patients with depression is associated with clinical, etiological and genetic risk factorsSharon L Naismith
School of Psychiatry, University of New South Wales, Sydney, Australia
J Clin Exp Neuropsychol 25:866-77. 2003..These findings underscore the need to consider subtypes when investigating neuropsychological deficits in patients with depression... - Anterior cingulate integrity: executive and neuropsychiatric features in Parkinson's diseaseSimon J G Lewis
Ageing Brain Center, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
Mov Disord 27:1262-7. 2012..These results suggest that loss of neuronal integrity within the ACC plays an important role in the pathophysiology underlying executive functioning and visual hallucinations in PD. © 2012 Movement Disorder Society... - Thoughts of death or suicidal ideation are common in young people aged 12 to 30 years presenting for mental health careElizabeth M Scott
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallet Street, Camperdown, NSW 2050, Australia
BMC Psychiatry 12:234. 2012..abstract:.. - Using informant reports to detect cognitive decline in mild cognitive impairmentRuby S M Tsang
Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
Int Psychogeriatr 24:967-73. 2012.... - Frontal lobe changes occur early in the course of affective disorders in young peopleJim Lagopoulos
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
BMC Psychiatry 12:4. 2012..Contrasts were carried out between controls subjects and patients cohorts with attenuated syndromes and discrete disorders, separately... - Utilising functional MRI (fMRI) to explore the freezing phenomenon in Parkinson's diseaseJames M Shine
Parkinson s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales 2050, Australia
J Clin Neurosci 18:807-10. 2011..The results of this single study highlight the potential utility of this approach in elucidating the underlying neural correlate of freezing behaviour in PD... - The specific contributions of set-shifting to freezing of gait in Parkinson's diseaseSharon L Naismith
Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia
Mov Disord 25:1000-4. 2010..This was apparent even after controlling for slowed processing speed, disease stage and depressive symptoms. The results support the recently proposed hypothesis for the pathophysiology underlying FOG in PD... - Serotonin transporter gene status predicts caudate nucleus but not amygdala or hippocampal volumes in older persons with major depressionIan B Hickie
Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
J Affect Disord 98:137-42. 2007.... - How does social functioning in the early stages of psychosis relate to depression and social anxiety?Catherine Chudleigh
Clinical Research Unit, Brain and Mind Research Institute, New South Wales, Australia
Early Interv Psychiatry 5:224-32. 2011.... - Neuropsychological and socio-occupational functioning in young psychiatric outpatients: a longitudinal investigationRico S C Lee
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
PLoS ONE 8:e58176. 2013..The current study extended these findings to young and early-course psychiatric outpatients, with the aim of identifying cognitive markers that predict later socio-occupational functioning... - Applying clinical staging to young people who present for mental health careIan B Hickie
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales
Early Interv Psychiatry 7:31-43. 2013.... - The impact of gender on early ill-health retirement in people with heart disease and depressionMatt B Paradise
Brain and Mind Research Institute, The University of Sydney, Camperdown, Australia
Aust N Z J Psychiatry 46:249-56. 2012..Given the deleterious effects of ill-health retirement, identifying at-risk groups is important for guiding targeted interventions... - Visual misperceptions and hallucinations in Parkinson's disease: dysfunction of attentional control networks?James M Shine
Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, Sydney, NSW, Australia
Mov Disord 26:2154-9. 2011.... - How well do caregivers detect mild cognitive change in Parkinson's disease?Sharon L Naismith
Parkinson s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
Mov Disord 26:161-4. 2011..The capacity for caregivers to rate mild cognitive change in PD may be useful to assist in early screening and intervention approaches... - "DASH" symptoms in patients with Parkinson's disease: red flags for early cognitive declineSharon L Naismith
Parkinson s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia
J Clin Neurosci 18:352-5. 2011..The DASH score may represent a simple screening method for highlighting early cognitive decline, which in turn is associated with the development of dementia in PD... - The relationship between actigraphically defined sleep disturbance and REM sleep behaviour disorder in Parkinson's DiseaseSharon L Naismith
Parkinson s Disease Research Clinic, Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, 94 Mallett St, Camperdown, NSW 2050, Australia
Clin Neurol Neurosurg 112:420-3. 2010..In this study, we sought to evaluate the utility of actigraphy for examining symptoms of rapid eye movement sleep behaviour disorder (RSBD)... - Disability is already pronounced in young people with early stages of affective disorders: data from an early intervention serviceBlake A Hamilton
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, 2050 Australia
J Affect Disord 131:84-91. 2011..This study examined patient self-reported disability in young people attending a designated early intervention service... - Microstructural white matter changes in the corpus callosum of young people with bipolar disorder: a diffusion tensor imaging studyJim Lagopoulos
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, Australia
PLoS ONE 8:e59108. 2013..Our findings provide evidence of microstructural white matter changes early in the course of illness within the corpus callosum and the nature of these changes suggest they are associated with abnormalities in the myelination of axons... - Mismatch negativity/P3a complex in young people with psychiatric disorders: a cluster analysisManreena Kaur
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
PLoS ONE 7:e51871. 2012..A data driven approach may help to further elucidate novel patterns of MMN/P3a amplitudes that characterise distinct subgroups in patients with emerging psychiatric disorders... - Distinguishing young people with emerging bipolar disorders from those with unipolar depressionElizabeth M Scott
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallet Street, Camperdown, NSW 2050, Australia
J Affect Disord 144:208-15. 2013..To facilitate early intervention, there is a need to distinguish unipolar versus bipolar illness trajectories in adolescents and young adults with adult-type mood disorders... - A systematic review of the impact of adherence on the effectiveness of e-therapiesLiesje Donkin
Brain and Mind Research Institute, The University of Sydney, Camperdown, Australia
J Med Internet Res 13:e52. 2011..Understanding the role of adherence may be crucial to understanding how program usage influences the effectiveness of e-therapy interventions... - The role of mild depression in sleep disturbance and quality of life in Parkinson's diseaseSharon L Naismith
Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
J Neuropsychiatry Clin Neurosci 22:384-9. 2010..Overall, these data highlight the need to screen patients for even mild levels of depression because its relationship with sleep and quality of life are evident early in the disease course... - Internet-based treatment for older adults with depression and co-morbid cardiovascular disease: protocol for a randomised, double-blind, placebo controlled trialNicole L Cockayne
Brain and Mind Research Institute, The University of Sydney, Camperdown NSW, Australia
BMC Psychiatry 11:10. 2011.... - Early intervention for cognitive decline: can cognitive training be used as a selective prevention technique?Loren Mowszowski
Department of Psychology, Macquarie University, Sydney, NSW, Australia
Int Psychogeriatr 22:537-48. 2010..It also considers the underlying mechanism of CT, namely that which suggests that CT acts via promoting neuroplasticity... - Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor loadJames M Shine
Parkinson s Disease Clinic, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
PLoS ONE 8:e52602. 2013.... - Delayed sleep phase in young people with unipolar or bipolar affective disordersRébecca Robillard
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, New South Wales, Australia
J Affect Disord 145:260-3. 2013..Despite marked changes in circadian rhythms during the normal course of adolescence and young adulthood, less is known about changes in the 24-h sleep-wake cycle in young persons with mood disorders... - Targeted primary care-based mental health services for young AustraliansElizabeth M Scott
Clinical Research Unit, Brain and Mind Research Institute, Sydney, NSW
Med J Aust 196:136-40. 2012.... - Correlating anterior insula gray matter volume changes in young people with clinical and neurocognitive outcomes: an MRI studySean N Hatton
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
BMC Psychiatry 12:45. 2012..This study examined the relationship between anterior insula GMV, clinical symptom severity and neuropsychological performance in a heterogeneous cohort of young people presenting for mental health care... - Review of emotion recognition in mild cognitive impairmentDonna McCade
Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, Sydney, N S W, Australia
Dement Geriatr Cogn Disord 32:257-66. 2011..While dysfunction in emotion recognition is sometimes apparent with aging, and is frequently evident in Alzheimer's disease, it is unclear whether individuals who have a high risk of developing dementia exhibit demonstrable changes... - A novel paradigm for modelling freezing of gait in Parkinson's diseaseSharon L Naismith
Brain and Mind Research Institute, The University of Sydney, Level 4, Building F, 94 Mallett Street, Camperdown, New South Wales 2050, Australia
J Clin Neurosci 17:984-7. 2010..We believe this paradigm is capable of accurately modelling FOG and will have validity in future functional neuroimaging and therapeutic intervention studies... - Subjective memory complaints, vascular risk factors and psychological distress in the middle-aged: a cross-sectional studyMatt B Paradise
Brain and Mind Research Institute, The University of Sydney, Camperdown, NSW 2050, Australia
BMC Psychiatry 11:108. 2011..We therefore aimed to test the hypothesis that vascular risk factors were associated with SMC, independent of psychological distress, in a middle-aged community-dwelling population... - Amphetamine psychosis: a model for studying the onset and course of psychosisDaniel F Hermens
Brain and Mind Research Institute, University of Sydney, Sydney, NSW
Med J Aust 190:S22-5. 2009..It is possible that the same approach may be used in young people known to be at risk of schizophrenia and related disorders, by informing models that involve other environmental or genetic risks... - Electroconvulsive therapy-induced persistent retrograde amnesia: could it be minimised by ketamine or other pharmacological approaches?Emily M Gregory-Roberts
Brain and Mind Research Institute, University of Sydney, Australia
J Affect Disord 126:39-45. 2010..This review examines mechanisms for electroconvulsive therapy-induced retrograde amnesia, and evaluates the suitability of the anaesthetic ketamine for preventing this amnestic outcome...