Research Topics
| J A MyburghSummaryAffiliation: University of New South Wales Country: Australia Publications
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Detail Information
Publications
Norepinephrine: more of a neurohormone than a vasopressorJohn Myburgh
Division of Critical Care and Trauma, The George Institute for Global Health, Level 7, 341 George Street, Sydney 2000, Australia
Crit Care 14:196. 2010..Recent trials represent a perceptible change in clinical practice to preferentially use norepinephrine early in resuscitation to defend the mean arterial pressure and to use norepinephrine as a neurohormone rather than as a vasopressor...
Bench-to-bedside review: the evaluation of complex interventions in critical careAnthony Delaney
Northern Clinical School, Faculty of Medicine, University of Sydney, Intensive Care Unit, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW, 2065, Australia
Crit Care 12:210. 2008..These aspects of study design impact upon the evaluation of complex interventions in critical care. Clinicians should also consider these specific issues when implementing new complex interventions into their practice...
Epinephrine, norepinephrine and dopamine infusions decrease propofol concentrations during continuous propofol infusion in an ovine modelJ A Myburgh
Department of Anaesthesia and Intensive Care, University of Adelaide, Royal Adelaide Hospital, Australia
Intensive Care Med 27:276-82. 2001..To determine the effects of exogenous ramped infusions of epinephrine, norepinephrine and dopamine on arterial and effluent brain blood concentrations of propofol under steady state intravenous anesthesia...
Albumin is a blood product too - is it safe for all patients?John A Myburgh
Faculty of Medicine, University of New South Wales, and Department of Intensive Care Medicine, St George Hospital, Sydney, NSW
Crit Care Resusc 11:67-70. 2009..However, the acquisition costs of albumin and synthetic colloids are more than those of crystalloids, and, as yet, colloids have not been proven to confer substantive benefits over crystalloids such as saline...
A comparison of epinephrine and norepinephrine in critically ill patientsJohn A Myburgh
Department of Intensive Care Medicine, The St George Hospital, Gray Street, Kogarah, Sydney 2217, Australia
Intensive Care Med 34:2226-34. 2008..To determine whether there was a difference between epinephrine and norepinephrine in achieving a mean arterial pressure (MAP) goal in intensive care (ICU) patients...
Standardised terminology for guidelines, protocols, regimens, procedures and processes: the other side of the "bundle"John A Myburgh
Department of Intensive Care Medicine, St George Hospital, Sydney, NSW
Crit Care Resusc 10:152-3. 2008
Catecholamines for shock: the quest for high-quality evidenceJohn A Myburgh
Department of Intensive Care Medicine, St George Hospital, Faculty of Medicine, University of New South Wales, Sydney, NSW
Crit Care Resusc 9:352-6. 2007..The results of such a study would be particularly important in geographical regions where access to inotropes/vasopressors other than adrenaline remains restricted...
Saline or albumin for fluid resuscitation in patients with traumatic brain injuryJohn Myburgh
ANZICS Clinical Trials Group, Level 3, 10 Ievers Terrace, Carlton, VIC 3053, Australia
N Engl J Med 357:874-84. 2007..We conducted a post hoc follow-up study of patients with traumatic brain injury who were enrolled in the study...
An appraisal of selection and use of catecholamines in septic shock - old becomes new againJohn A Myburgh
Department of Intensive Care Medicine, St George Hospital, Sydney, NSW, Australia
Crit Care Resusc 8:353-60. 2006..These may provide additional, important information for evidence-based guidelines, which currently remain of limited clinical utility...
"Triple h" therapy for aneurysmal subarachnoid haemorrhage: real therapy or chasing numbers?J A Myburgh
Department of Intensive Care Medicine, The St George Hospital, Sydney, NSW 2217, Australia
Crit Care Resusc 7:206-12. 2005....
Driving cerebral perfusion pressure with pressors: how, which, when?J A Myburgh
Department of Intensive Care Medicine, The St George Hospital, Sydney, NSW 2217, Australia
Crit Care Resusc 7:200-5. 2005..On the basis of limited animal and human evidence, noradrenaline appears to be the most appropriate catecholamine for traumatic brain injury, although definitive, targeted trials are required...
The effect of infusions of adrenaline, noradrenaline and dopamine on cerebral autoregulation under propofol anaesthesia in an ovine modelJohn A Myburgh
Department of Anaesthesia and Intensive Care, University of Adelaide and Royal Adelaide Hospital, 5000 Adelaide, Australia
Intensive Care Med 29:817-24. 2003..To compare the effects of infusions of adrenaline, noradrenaline and dopamine on cerebral autoregulation under steady-state propofol anaesthesia with the awake state...
The cerebrovascular effects of adrenaline, noradrenaline and dopamine infusions under propofol and isoflurane anaesthesia in sheepJ A Myburgh
Department of Anaesthesia and Intensive Care, University of Adelaide, Adelaide, South Australia
Anaesth Intensive Care 30:725-33. 2002....
The effect of infusions of adrenaline, noradrenaline and dopamine on cerebral autoregulation under isoflurane anaesthesia in an ovine modelJ A Myburgh
Department of Anaesthesia and Intensive Care, University of Adelaide, Adelaide, South Australia
Anaesth Intensive Care 31:259-66. 2003..The concomitant administration of isoflurane and the catecholamines was not associated with altered autoregulatory function compared to the awake state...
Crisis management during anaesthesia: pulmonary oedemaM J Chapman
Intensive Care Unit, Royal Adelaide Hospital, and University of Adelaide, Adelaide, South Australia, Australia
Qual Saf Health Care 14:e8. 2005..CONCLUSION: Successful recognition and management of perioperative pulmonary oedema is likely with the application of the structured algorithm and specific sub-algorithm approach outlined in this study...
Cerebrovascular carbon dioxide reactivity in sheep: effect of propofol or isoflurane anaesthesiaJ A Myburgh
Department of Anaesthesia and Intensive Care, University of Adelaide, South Australia
Anaesth Intensive Care 30:413-21. 2002..67, 2.06-3.28, 95% CI) and isoflurane (mean 2.82, 219-3.45, 95% CI) cohorts were more predictable. However, there was no significant difference between these anaesthetic agents with respect to the CO2 reactivity of cerebral blood flow...
Crisis management during anaesthesia: sepsisJ A Myburgh
University of New South Wales, Director of Research, Department of Intensive Care Medicine, The St. George Hospital, Sydney, Australia
Qual Saf Health Care 14:e22. 2005....
International albumin use: 1995 to 2006D Jones
Critical Care and Trauma Division, The George Institute for International Health, Sydney, New South Wales, Australia
Anaesth Intensive Care 38:266-73. 2010..Whether these practice changes have resulted in a net health gain or in harm requires further research...
Australasian resuscitation of sepsis evaluation (ARISE): A multi-centre, prospective, inception cohort studySandra L Peake
University of Adelaide, South Australia, Australia
Resuscitation 80:811-8. 2009..Determine current resuscitation practices and outcomes in patients presenting to the emergency department (ED) with sepsis and hypoperfusion or septic shock in Australia and New Zealand (ANZ)...
Epidemiology and 12-month outcomes from traumatic brain injury in australia and new zealandJohn A Myburgh
Department of Intensive Care, The St George Hospital, Sydney, Australia
J Trauma 64:854-62. 2008..An epidemiologic profile of traumatic brain injury (TBI) in Australia and New Zealand was obtained following the publication of international evidence-based guidelines...
Analysis of blood glucose measurements using capillary and arterial blood samples in intensive care patientsAtul Kulkarni
Department of Intensive Care Medicine, St. George Hospital, Gray Street, Kogarah, 2217 Sydney, Australia
Intensive Care Med 31:142-5. 2005..However, in patients with systemic hypoperfusion, the accuracy of agreement between these two measurement techniques may be such that that biochemical hypoglycaemia (<2.5 mmol/l, 44.9 mg/dl) may go undetected if used interchangeably...
The evidence for small-volume resuscitation with hyperoncotic albumin in critical illnessJohn A Myburgh
Division of Critical Care and Trauma, The George Institute for International Health, Sydney, 2050, Australia
Crit Care 12:143. 2008....
The case for adrenalineJohn A Myburgh
Crit Care Resusc 10:178-9. 2008
