G A Murrell

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi Oxygen free radicals and tendon healing
    George A C Murrell
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, Australia
    J Shoulder Elbow Surg 16:S208-14. 2007
  2. pmc Understanding tendinopathies
    G A Murrell
    Orthopaedic Research Institute, St George Hospital, University of New South Wales, Sydney, Australia
    Br J Sports Med 36:392-3. 2002
  3. ncbi Spontaneous recovery of injured Achilles tendon in inducible nitric oxide synthase gene knockout mice
    W Xia
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Kogarah, Sydney, NSW 2217, Australia
    Inflamm Res 55:40-5. 2006
  4. pmc Using nitric oxide to treat tendinopathy
    George A C Murrell
    Orthopaedic Research Institute, University of New South Wales, The St George Hospital, Kogarah, Sydney, New South Wales 2217, Australia
    Br J Sports Med 41:227-31. 2007
  5. ncbi Shoulder instability. Diagnosis and management
    M Callanan
    Sports Medicine and Shoulder Service, Orthopaedic Research Institute, University of New South Wales, St George Hospital Campus, Sydney
    Aust Fam Physician 30:655-61. 2001
  6. ncbi Temporal expression of nitric oxide synthase isoforms in healing Achilles tendon
    J H Lin
    Orthopaedic Research Institute, St. George Hospital Campus, University of New South Wales, Sydney, Australia
    J Orthop Res 19:136-42. 2001
  7. ncbi Antioxidant enzyme peroxiredoxin 5 is upregulated in degenerative human tendon
    M X Wang
    Orthopaedic Research Institute, St. George Hospital, University of New South Wales, 4-10 South Street, Sydney, New South Wales 2217, Australia
    Biochem Biophys Res Commun 284:667-73. 2001
  8. ncbi Nitric oxide synthase isoforms during fracture healing
    W Zhu
    Orthopedic Research Institute, St George Hospital, University of New South Wales, Sydney, Australia
    J Bone Miner Res 16:535-40. 2001
  9. ncbi Advances in the management of traumatic anterior and atraumatic multidirectional shoulder instability
    A Paxinos
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Australia
    Sports Med 31:819-28. 2001
  10. ncbi Reliability of five methods for assessing shoulder range of motion
    K Hayes
    Department of Orthopaedic Surgery, St George Hospital, Kogarah, New South Wales 2217
    Aust J Physiother 47:289-94. 2001

Collaborators

Detail Information

Publications60

  1. ncbi Oxygen free radicals and tendon healing
    George A C Murrell
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, Australia
    J Shoulder Elbow Surg 16:S208-14. 2007
    ..In all 3 clinical trials, there was a significant positive beneficial effect of nitric oxide donation to the clinical symptoms and function of patients with Achilles tendinopathy, tennis elbow, and supraspinatus tendinitis...
  2. pmc Understanding tendinopathies
    G A Murrell
    Orthopaedic Research Institute, St George Hospital, University of New South Wales, Sydney, Australia
    Br J Sports Med 36:392-3. 2002
  3. ncbi Spontaneous recovery of injured Achilles tendon in inducible nitric oxide synthase gene knockout mice
    W Xia
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Kogarah, Sydney, NSW 2217, Australia
    Inflamm Res 55:40-5. 2006
    ..To determine if inducible nitric oxide synthase (iNOS) gene could affect Achilles tendon healing using iNOS gene knockout mice...
  4. pmc Using nitric oxide to treat tendinopathy
    George A C Murrell
    Orthopaedic Research Institute, University of New South Wales, The St George Hospital, Kogarah, Sydney, New South Wales 2217, Australia
    Br J Sports Med 41:227-31. 2007
    ..In humans, in three randomised clinical trials, we have shown that NO delivered via a transdermal patch enhances the subjective and objective recovery of patients with tennis elbow, Achilles tendinosis and supraspinatus tendinosis...
  5. ncbi Shoulder instability. Diagnosis and management
    M Callanan
    Sports Medicine and Shoulder Service, Orthopaedic Research Institute, University of New South Wales, St George Hospital Campus, Sydney
    Aust Fam Physician 30:655-61. 2001
    ..Labral disruptions and capsular laxity can often be restored by minimally invasive (arthroscopic) methods. Rehabilitation aims to enhance the dynamic muscular and proprioceptive restraints to shoulder instability...
  6. ncbi Temporal expression of nitric oxide synthase isoforms in healing Achilles tendon
    J H Lin
    Orthopaedic Research Institute, St. George Hospital Campus, University of New South Wales, Sydney, Australia
    J Orthop Res 19:136-42. 2001
    ..These findings may prove clinically relevant with respect to strategies for regulating tendon healing...
  7. ncbi Antioxidant enzyme peroxiredoxin 5 is upregulated in degenerative human tendon
    M X Wang
    Orthopaedic Research Institute, St. George Hospital, University of New South Wales, 4-10 South Street, Sydney, New South Wales 2217, Australia
    Biochem Biophys Res Commun 284:667-73. 2001
    ..PRDX5 may play a protective role against oxidative stress during this pathophysiological process...
  8. ncbi Nitric oxide synthase isoforms during fracture healing
    W Zhu
    Orthopedic Research Institute, St George Hospital, University of New South Wales, Sydney, Australia
    J Bone Miner Res 16:535-40. 2001
    ....
  9. ncbi Advances in the management of traumatic anterior and atraumatic multidirectional shoulder instability
    A Paxinos
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Australia
    Sports Med 31:819-28. 2001
    ....
  10. ncbi Reliability of five methods for assessing shoulder range of motion
    K Hayes
    Department of Orthopaedic Surgery, St George Hospital, Kogarah, New South Wales 2217
    Aust J Physiother 47:289-94. 2001
    ..53-0.65) and still photography (Inter-rater Rho = 0.62-0.73; Intra-rater Rho = 0.56-0.61). The tests had standard errors of measurement of between 14 and 25 degrees (inter-rater trial) and 11 and 23 degrees (intra-rater trial)...
  11. ncbi The rotator cuff functional index
    Daryl C Osbahr
    Department of Orthopaedic Surgery, St George Hospital Campus, 4 10, South Street, Kogarah, Sydney, New South Wales 2217, Australia
    Am J Sports Med 34:956-60. 2006
    ..Despite improvements in the clinical assessment of rotator cuff injuries, shortcomings exist in diagnosing rotator cuff tears...
  12. ncbi Topical glyceryl trinitrate treatment of chronic noninsertional achilles tendinopathy. A randomized, double-blind, placebo-controlled trial
    Justin A Paoloni
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, New South Wales, Australia
    J Bone Joint Surg Am 86:916-22. 2004
    ..The goal of the present study was to determine if topical glyceryl trinitrate improves clinical outcome measures in patients with Achilles tendinopathy...
  13. pmc Addition of nitric oxide through nitric oxide-paracetamol enhances healing rat achilles tendon
    George A C Murrell
    Orthopaedic Research Institute, St George Hospital, Research and Education Centre, University of New South Wales, Level 2, 4 10 South Street, Kogarah, Sydney, NSW, 2217, Australia
    Clin Orthop Relat Res 466:1618-24. 2008
    ....
  14. ncbi Topical nitric oxide application in the treatment of chronic extensor tendinosis at the elbow: a randomized, double-blinded, placebo-controlled clinical trial
    Justin A Paoloni
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, New South Wales, Australia
    Am J Sports Med 31:915-20. 2003
    ..No treatment has been universally successful. Topical application of nitric oxide has been used effectively to treat fractures and cutaneous wounds in animal models, presumably by stimulation of collagen synthesis in fibroblasts...
  15. ncbi Treatment of shoulder dislocation: is a sling appropriate?
    George A C Murrell
    Department of Orthopaedic Surgery, St George Hospital, Kogarah, NSW 2217, Australia
    Med J Aust 179:370-1. 2003
    ..Shoulder dislocations, if managed non-operatively, should not be treated by placing arms in a sling. Rather, placing them in a splint or using a pillow so that the the arm is externally rotated should be considered...
  16. ncbi Three-year followup study of topical glyceryl trinitrate treatment of chronic noninsertional Achilles tendinopathy
    Justin Alan Paoloni
    University of New South Wales, Orthopaedic Research Institute, 2nd Floor, 4 10 South St, Kogarah, Sydney, NSW, Australia
    Foot Ankle Int 28:1064-8. 2007
    ..No long-term followup is reported. We aimed to assess if the demonstrated efficacy of this treatment persisted 3 years after discontinuation of therapy...
  17. ncbi Nitric oxide in skeletal muscle: inhibition of nitric oxide synthase inhibits walking speed in rats
    M X Wang
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, Australia
    Nitric Oxide 5:219-32. 2001
    ..Taken together, these results imply that there may be a novel nitric oxide synthase in muscle and that NO. generated from muscle may be important in muscle function...
  18. ncbi Expression of urokinase-type plasminogen activator and its receptor is up-regulated during tendon healing
    Wei Xia
    Orthopaedic Research Institute, The St George Hospital, University of New South Wales, Kogarah, Sydney, NSW 2217, Australia
    J Orthop Res 21:819-25. 2003
    ..These findings show for the first time that uPA, and especially its receptor uPAR, are up-regulated during tendon healing...
  19. ncbi Topical glyceryl trinitrate application in the treatment of chronic supraspinatus tendinopathy: a randomized, double-blinded, placebo-controlled clinical trial
    Justin A Paoloni
    Orthopaedic Research Institute, Research and Education Centre, St George Hospital, 2nd Floor, 4 South Street, Kogarah, Sydney, 2217 Australia
    Am J Sports Med 33:806-13. 2005
    ..Topical glyceryl trinitrate therapy has previously demonstrated short-term pain reduction in patients with supraspinatus tendinopathy...
  20. ncbi Adenovirus-mediated gene transfer to healing tendon--enhanced efficiency using a gelatin sponge
    Quan Dai
    The Orthopaedic Research Institute, University of New South Wales, St George Hospital Campus, Sydney, NSW, Australia
    J Orthop Res 21:604-9. 2003
    ..The results demonstrate that adenovirus can be used to deliver a gene of interest to cultured human rotator cuff tendon cells and healing tendon, with gelatin sponge implantation enhancing adenoviral transfection efficiency in vivo...
  21. ncbi The accuracy and reliability of a novel handheld dynamic indentation probe for analysing articular cartilage
    R C Appleyard
    Orthopaedic Research Institute, St George Hospital, University of New South Wales, Australia
    Phys Med Biol 46:541-50. 2001
    ..The system was shown to be an accurate and reliable tool for rapidly assessing the dynamic biomechanical properties of articular cartilage, while being small enough to be used arthroscopically...
  22. ncbi The cell specific temporal expression of nitric oxide synthase isoforms during achilles tendon healing
    J Lin
    Orthopaedic Research Institute, University of New South Wales, Sydney, Australia
    Inflamm Res 50:515-22. 2001
    ..The sequential pattern of NOS expression in healing fibroblasts suggests that each NOS isoform may play a different role in the healing process and provides opportunities to modify tendon healing in the clinical setting...
  23. ncbi Gene expression changes in SNAP-stimulated and iNOS-transfected tenocytes--expression of extracellular matrix genes and its implications for tendon-healing
    Timothy J Molloy
    Orthopaedic Research Institute, St George Hospital, University of New South Wales, Kogarah, Sydney, NSW 2217, Australia
    J Orthop Res 24:1869-82. 2006
    ..These findings will be of use when optimizing the dose of NO delivery in further work investigating NO as potential treatment of tendon injuries...
  24. ncbi The Orthopaedic Research Institute-Tennis Elbow Testing System: A modified chair pick-up test-interrater and intrarater reliability testing and validity for monitoring lateral epicondylosis
    Justin A Paoloni
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Australia
    J Shoulder Elbow Surg 13:72-7. 2004
    ..This system could be used for routine clinical monitoring of patients with lateral epicondylosis...
  25. pmc Heat shock protein and apoptosis in supraspinatus tendinopathy
    Neal L Millar
    Orthopaedic Research Institute, Department of Orthopaedic Surgery, St George Hospital Campus, University of New South Wales, 4 10 South Street, Kogarah, NSW, 2217, Australia
    Clin Orthop Relat Res 466:1569-76. 2008
    ..This finding suggests heat shock proteins play a role in the cascade of stress-activated programmed cell death and degeneration in tendinopathy and may provide a novel target in preventing tendinopathies...
  26. ncbi Frog glue enhances rotator cuff repair in a laboratory cadaveric model
    Neal L Millar
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Kogarah, New South Wales, Australia
    J Shoulder Elbow Surg 18:639-45. 2009
    ..The unique properties of this frog glue (strong, flexible and sets in water) may ultimately lead to its use as an adjunct to rotator cuff repair in humans...
  27. ncbi The rotator cuff: biological adaptations to its environment
    Hilary L Malcarney
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Kogarah, New South Wales, Australia
    Sports Med 33:993-1002. 2003
    ..While many of these characteristics appear to be adaptive and occur in the healthy rotator cuff, some may predispose the tendon complex to pathology...
  28. ncbi Reliability of a new shoulder laxometer to assess inferior glenohumeral joint translation
    M L Sein
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Australia
    Br J Sports Med 42:178-82. 2008
    ..This study tested the reliability of the ORI laxometer, a newly developed non-invasive device for testing inferior translation of the humeral head in humans...
  29. ncbi Familial slipped capital femoral epiphysis: a report and considerations in management
    A Diwan
    Department of Orthopaedic Surgery, St George Hospital, Sydney, New South Wales, Australia
    Aust N Z J Surg 68:647-9. 1998
    ..Familial inheritance of slipped capital femoral epiphysis (SCFE) is known. It has not been described in non-identical twins. A family where the mother and three of five siblings developed SCFE were investigated and managed...
  30. ncbi The effects of time course after anterior cruciate ligament injury in correlation with meniscal and cartilage loss
    G A Murrell
    Department of Orthopaedic Surgery, St. George Hospital Campus, University of New South Wales, Sydney, Australia
    Am J Sports Med 29:9-14. 2001
    ....
  31. doi Repair of partial-thickness rotator cuff tears: a biomechanical analysis of footprint contact pressure and strength in an ovine model
    Karin S Peters
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, Australia
    Arthroscopy 26:877-84. 2010
    ..The purpose of this study was to determine whether transtendon repair by use of a novel small-diameter knotless anchor showed enhanced mechanical properties compared with tear completion and repair...
  32. ncbi Shoulder instability: management and rehabilitation
    Kimberley Hayes
    Sports Medicine and Shoulder Service, Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, Australia
    J Orthop Sports Phys Ther 32:497-509. 2002
    ..This paper reviews the nonoperative treatment and the postoperative management of patients with various classifications of shoulder instability...
  33. ncbi Nitric oxide enhances collagen synthesis in cultured human tendon cells
    Wei Xia
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Kogarah, Sydney, New South Wales 2217, Australia
    J Orthop Res 24:159-72. 2006
    ..These results may explain, in part, at least, the beneficial effects of NO donors in animal models and during the treatment of tendonopathies in human clinical trials. ...
  34. ncbi A randomised clinical trial evaluating the efficacy of physiotherapy after rotator cuff repair
    Kimberley Hayes
    St George Hospital, University of New South Wales, Australia
    Aust J Physiother 50:77-83. 2004
    ..On the basis of these results, outcomes for subjects allocated to individualised physiotherapy treatment after rotator cuff repair are no better than for subjects allocated to a standardised home exercise regime...
  35. ncbi Clinical examination of the unstable shoulder
    Anthony Tzannes
    Sports Medicine and Shoulder Service, Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, New South Wales, Australia
    Sports Med 32:447-57. 2002
    ..The apprehension sign and its variations (augmentation, relocation and release) have reasonable inter-examiner reliability (intraclass correlation coefficient 0.5 to 0.7) and are highly predictive for anterior instability (LR 8 to 100)...
  36. pmc Open versus two forms of arthroscopic rotator cuff repair
    Neal L Millar
    Department of Orthopaedic Surgery, Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, 4 10 South Street, Kogarah, Sydney, NSW 2217, Australia
    Clin Orthop Relat Res 467:966-78. 2009
    ..An intact cuff on ultrasound corresponded to better results for supraspinatus strength, patient outcomes, and rotator cuff functional ability...
  37. ncbi Localization of nitric oxide synthases during fracture healing
    Wei Zhu
    Orthopedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, Australia
    J Bone Miner Res 17:1470-7. 2002
    ..In summary, the,expression of NOS isoforms during fracture healing was time dependent and cellular distinctive...
  38. ncbi Oxidative stress-induced c-Jun N-terminal kinase (JNK) activation in tendon cells upregulates MMP1 mRNA and protein expression
    Fang Wang
    Orthopaedic Research Institute, St George Hospital, University of New South Wales, ORI Level 2, 4 10 South Street, Kogarah, NSW 2217, Sydney, Australia
    J Orthop Res 25:378-89. 2007
    ..Results from the current study indicated that stress activated JNK plays an important role in tendon matrix degradation, possibly through upregulating of MMP1...
  39. pmc Reliability of MRI assessment of supraspinatus tendinopathy
    Mya Lay Sein
    Orthopaedic Research Institute, University of New South Wales, St George Hospital, Sydney, New South Wales, Australia
    Br J Sports Med 41:e9. 2007
    ..To determine the interobserver and intraobserver reliability of the interpretation of MRIs for supraspinatus tendinosis...
  40. ncbi Restore orthobiologic implant: not recommended for augmentation of rotator cuff repairs
    Judie R Walton
    Sports Medicine and Shoulder Service, Orthopaedic Research Institute, University of New South Wales, St George Hospital, Sydney, New South Wales, Australia
    J Bone Joint Surg Am 89:786-91. 2007
    ..We carried out a study to determine whether patients who received this xenograft to augment a rotator cuff repair exhibited greater shoulder strength, shoulder function, and/or resistance to retearing...
  41. ncbi A comparison of clinical estimation, ultrasonography, magnetic resonance imaging, and arthroscopy in determining the size of rotator cuff tears
    Lawrence Bryant
    St George Hospital Campus, University of New South Wales, Sydney, Australia
    J Shoulder Elbow Surg 11:219-24. 2002
    ..41; P =.02) than the other methods. Each method underestimated rotator cuff tear size by 12%, 30%, 33%, and 38%, respectively. No method was able to determine the size of partial-thickness rotator cuff tears (r < 0.02)...
  42. ncbi Reliability of 3 methods for assessing shoulder strength
    Kimberley Hayes
    Department of Orthopaedic Surgery, St George Hospital Campus, University of New South Wales, Kogarah 2217, Sydney, NSW Australia
    J Shoulder Elbow Surg 11:33-9. 2002
    ..002). In summary, the handheld dynamometer was the most reliable and discriminatory means for assessing strength of the rotator cuff in symptomatic subjects...
  43. pmc Treatment of tendinopathy: what works, what does not, and what is on the horizon
    Brett M Andres
    Orthopaedic Research Institute, St George Hospital, University of New South Wales, Level 2 Research and Education Building, 4 10 South Street, Kogarah, Sydney, NSW, 2217, Australia
    Clin Orthop Relat Res 466:1539-54. 2008
    ..Surgery remains the last option due to the morbidity and inconsistent outcomes. The ideal treatment for tendinopathy remains unclear...
  44. ncbi Early inflammatory reaction after rotator cuff repair with a porcine small intestine submucosal implant: a report of 4 cases
    Hilary L Malcarney
    Department of Orthopaedic Surgery, St George Hospital, University of New South Wales, Sydney, Australia
    Am J Sports Med 33:907-11. 2005
    ..Porcine small intestine submucosal grafts have been successful in enhancing soft tissue repair, as demonstrated by animal studies. Currently, there are no reports of the use of such implants in human rotator cuff repair...
  45. ncbi The unstable shoulder in the adolescent athlete
    Judie Walton
    Sports Medicine and Shoulder Service and the Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, Australia
    Am J Sports Med 30:758-67. 2002
    ..The aim of rehabilitation is to enhance the dynamic muscular and proprioceptive restraints to shoulder instability...
  46. ncbi Meniscal and chondral loss in the anterior cruciate ligament injured knee
    Hugh P Jones
    Department of Orthopaedic Surgery, St George Hospital Campus, Kogarah, New South Wales, Australia
    Sports Med 33:1075-89. 2003
    ....
  47. ncbi Rotator cuff repair with bioabsorbable screws: An in vivo and ex vivo investigation
    Craig A Cummins
    Orthopaedic Research Institute, Kogarah, Australia
    Arthroscopy 19:239-48. 2003
    ..Type of Study: In vivo clinical outcomes investigation, and ex vivo biomechanical study...
  48. ncbi Apoptosis in rotator cuff tendonopathy
    Jun Yuan
    Orthopaedic Research Institute, St George Hospital Campus, 4 10 South Street, University of New, South Wales, Sydney, NSW 2217, Australia
    J Orthop Res 20:1372-9. 2002
    ..Cells undergoing apoptosis in rotator cuff were mainly fibroblast-like cells. These finding indicate that apoptosis may play an important role in the pathogenesis of rotator cuff degeneration...
  49. ncbi Expression and regulation of peroxiredoxin 5 in human osteoarthritis
    Min Xia Wang
    Orthopaedic Research Institute, St George Hospital, University of New South Wales, Sydney, NSW, Australia
    FEBS Lett 531:359-62. 2002
    ..The present study suggests that PRDX5 may play a protective role against oxidative stress in human cartilage...
  50. ncbi Deletion of iNOS gene impairs mouse fracture healing
    Yasemin Baldik
    Orthopaedic Research Institute, St George Hospital, 4 10 South Street, University of New South Wales, Kogarah, Sydney, NSW 2217, Australia
    Bone 37:32-6. 2005
    ..These data indicate that iNOS is important in mouse fracture healing. However, the clinical utility of NOS gene therapy to enhance fracture healing will need further evaluation...
  51. ncbi Cell death and tendinopathy
    Jun Yuan
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, NSW 2217, Australia
    Clin Sports Med 22:693-701. 2003
    ....
  52. ncbi An evaluation of the effects of the extent of capsular release and of postoperative therapy on the temporal outcomes of adhesive capsulitis
    Divya Bhargav Diwan
    Sports Medicine and Shoulder Service, Orthopedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, Australia
    Arthroscopy 21:1105-13. 2005
    ..To evaluate effects of the extent of surgical release and of postoperative physiotherapy on the outcomes of this procedure...
  53. ncbi Mode of failure for rotator cuff repair with suture anchors identified at revision surgery
    Craig A Cummins
    Lake Cook Orthopaedic Associates, Barrington, IL 60010, USA
    J Shoulder Elbow Surg 12:128-33. 2003
    ..This suggests that the weak link in rotator cuff repairs with suture anchors and horizontal mattress sutures, as determined at revision surgery, is the tendon-suture interface...
  54. ncbi Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts
    Jun Yuan
    Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, 4 10 South Street, Sydney, NSW 2217, Australia
    Biochim Biophys Acta 1641:35-41. 2003
    ..The data suggest that oxidative stress-induced apoptosis in human tendon fibroblasts is mediated via pathway(s) that includes release of cytochrome c from mitochondria to the cytosol and activation of caspase-3...
  55. pmc The basic science of tendinopathy
    Yinghua Xu
    Orthopaedic Research Institute, The St George Hospital, University of New South Wales, Level 2, 4 10 South Street, Kogarah, Sydney, NSW, 2217, Australia
    Clin Orthop Relat Res 466:1528-38. 2008
    ..The management strategies might involve agents or cells that induce tendon stem cell proliferation, repair and restoration of matrix integrity...
  56. ncbi Overexpression of antioxidant enzyme peroxiredoxin 5 protects human tendon cells against apoptosis and loss of cellular function during oxidative stress
    Jun Yuan
    Orthopaedic Research Institute, St George Hospital Campus, 4 10 South Street, University of New South Wales, Sydney, NSW 2217, Australia
    Biochim Biophys Acta 1693:37-45. 2004
    ..Results from our study indicate that the antioxidant enzyme PRDX5 plays a protective role in human tendon cells against oxidative stress by reducing apoptosis and maintaining collagen synthesis...
  57. ncbi The effects of thermal capsular shrinkage on the outcomes of arthroscopic stabilization for primary anterior shoulder instability
    Shiyi Chen
    Department of Orthopaedic Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China
    Am J Sports Med 33:705-11. 2005
    ..The effectiveness of arthroscopic thermal capsulorrhaphy in the prevention of recurrent instability in primary anterior stabilization is undetermined...
  58. ncbi Supplementation of rotator cuff repair with a bioresorbable scaffold
    Jason L Koh
    Department of Orthopaedic Surgery, Northwestern University Medical School, 645 North Michigan Avenue, Chicago, IL 60611, USA
    Am J Sports Med 30:410-3. 2002
    ..Repair of a torn rotator cuff should have sufficient initial strength of the fixation to permit appropriate rehabilitation...
  59. ncbi Interferon-alpha (Intron A) upregulates urokinase-type plasminogen activator receptor gene expression
    Shanshan Wu
    Division of Molecular Medicine, John Curtin School of Medical Research, The Australian National University, G P O Box 334, Canberra, ACT 0200, Australia
    Cancer Immunol Immunother 51:248-54. 2002
    ..Both sodium butyrate and amiloride inhibited the uPAR mRNA levels induced by IFN-alpha or IFN-gamma. These results may provide useful information for the treatment of patients receiving IFN-alpha or IFN-gamma...
  60. ncbi Rotator cuff repair: an ex vivo analysis of suture anchor repair techniques on initial load to failure
    Craig A Cummins
    Lake Cook Orthopedic Associates, Barrington, Illinois, USA
    Arthroscopy 21:1236-41. 2005
    ..To determine the best combination of anchors and suture techniques for repairing torn rotator cuff tendons...