Michael J Murray
Affiliation: University of Melbourne
Chaturvedi V, Fournier Level A, Cooper H, Murray M. Loss of Neogenin1 in human colorectal carcinoma cells causes a partial EMT and wound-healing response. Sci Rep. 2019;9:4110 pubmed publisher
..These results suggest that loss of NEO1 in carcinomas may contribute to metastasis by promoting a partial EMT and increased motility. ..
Murray M, Southall T, Liu W, Fraval H, Lorensuhewa N, Brand A, et al
. Snail-dependent repression of the RhoGEF pebble is required for gastrulation consistency in Drosophila melanogaster. Dev Genes Evol. 2012;222:361-8 pubmed publisher
..We conclude that pbl levels are precisely regulated to ensure that there is enough protein available for its role in early mesoderm development but not so much as to inhibit the orderly progression of gastrulation. ..
Murray M, Ng M, Fraval H, Tan J, Liu W, Smallhorn M, et al
. Regulation of Drosophila mesoderm migration by phosphoinositides and the PH domain of the Rho GTP exchange factor Pebble. Dev Biol. 2012;372:17-27 pubmed publisher
..Taken together, our results support a model in which interaction of the PH-domain of Pbl with PtdIns(4,5)P2 helps localise it to the plasma membrane which is important for mesoderm migration...
Pert M, Gan M, Saint R, Murray M. Netrins and Frazzled/DCC promote the migration and mesenchymal to epithelial transition of Drosophila midgut cells. Biol Open. 2015;4:233-43 pubmed publisher
..Since a similar effect is seen when endocytosis is inhibited, Netrin and Fra may regulate Integrin turnover. The results suggest Netrin-dependent basal polarisation of Fra is critical for the formation of an epithelium. ..