Research Topics
| John M MurraySummaryAffiliation: University of New South Wales Country: Australia Publications
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Detail Information
Publications
Integrated HIV DNA accumulates prior to treatment while episomal HIV DNA records ongoing transmission afterwardsJohn M Murray
School of Mathematics and Statistics, University of New South Wales, Sydney, New South Wales, Australia
AIDS 26:543-50. 2012..We investigated the dynamics of HIV RNA and HIV DNA levels after the commencement of raltegravir-based antiretroviral therapy (ART) in primary (PHI) and chronically HIV-infected (CHI) individuals (the PINT study)...
Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment successGlen J McIntyre
Johnson and Johnson Research Pty Ltd, Level 4 Biomedical Building, Australian Technology Park, Eveleigh, NSW 1430, Australia
Virol J 6:184. 2009..However, there is evidence that repeated expression cassettes delivered via lentiviral vectors may be subject to recombination-mediated repeat deletion of 1 or more cassettes...- In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapyTanya Lynn Applegate
Johnson and Johnson Research Pty Ltd, Australian Technology Park, Eveleigh, NSW, Australia
Retrovirology 7:83. 2010..It is now clear that multiple shRNAs will likely be required to suppress infection and prevent the emergence of resistant virus... 
A model of primary HIV-1 infectionJ M Murray
School of Mathematics, University of New South Wales, Sydney, Australia
Math Biosci 154:57-85. 1998..As less memory cells are produced as a result then this compartment decreases and hence so do naive numbers through less reversion of memory cells to the naive phenotype...- Rapidly ageing HIV epidemic among men who have sex with men in AustraliaJohn M Murray
School of Mathematics and Statistics, University of New South Wales, Sydney, NSW 2052, Australia
Sex Health 6:83-6. 2009..To date the rate of ageing has been unquantified, giving rise to uncertainty in the treatment emphasis and burden in this population... - Mathematical modelling of the impact of haematopoietic stem cell-delivered gene therapy for HIVJohn M Murray
School of Mathematics and Statistics, University of New South Wales, Sydney, Australia
J Gene Med 11:1077-86. 2009..Gene therapy represents a new treatment paradigm for HIV that is potentially delivered by a safe, once-only therapeutic intervention... - Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phaseJohn M Murray
National Centre in HIV Epidemiology and Clinical Research, Sydney, NSW 2052, Australia
AIDS 21:2315-21. 2007..To date, there have been no reports investigating the potential for differential effects on viral dynamics with integrase inhibitors relative to current antiretroviral drugs... - The half-life of hepatitis B virionsJohn M Murray
School of Mathematics, University of New South Wales, Sydney 2052, NSW, Australia
Hepatology 44:1117-21. 2006..In conclusion, we find the half-life of HBV virions is approximately 4 hours, significantly shorter than current estimates of 1 day. This new value is consistent with virion half-life estimates for HIV and hepatitis C virus... - Timing of the components of the HIV life cycle in productively infected CD4+ T cells in a population of HIV-infected individualsJohn M Murray
School of Mathematics and Statistics, University of New South Wales, Sydney 2052, NSW, Australia
J Virol 85:10798-805. 2011..The mean estimated half-life of plasma virions was 5 min, significantly shorter than previous estimates... - Increasing HIV diagnoses in Australia among men who have sex with men correlated with the growing number not taking antiretroviral therapyJohn M Murray
School of Mathematics and Statistics, University of New South Wales, Sydney, NSW 2052, Australia
Sex Health 8:304-10. 2011..New HIV diagnoses have also been younger than the average age of those living with HIV. We investigated the degree to which several risk factors could explain this rise in notifications and the younger age profile... - Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twentyJohn M Murray
School of Mathematics, University of NSW, Sydney, Australia
Immunol Cell Biol 81:487-95. 2003..7 year half-life of the productive thymus so that by age 55 only 5% of naive production arises from thymic export... - The impact of behavioural changes on the prevalence of human immunodeficiency virus and hepatitis C among injecting drug usersJohn M Murray
School of Mathematics, University of New South Wales, Sydney NSW 2052, Australia
Int J Epidemiol 32:708-14. 2003..The impact that different needle-sharing behaviour and drug injecting use may have on the future levels of these viruses is uncertain... - The effect of heterogeneity on optimal regimens in cancer chemotherapyJ M Murray
School of Mathematics, University of New South Wales, Sydney, NSW 2052, Australia
Math Biosci 185:73-87. 2003..This has the effect of complicating the calculation of optimal regimens in a clinical setting, and may explain why results in experimental oncology fail to carry over to clinical oncology... - HIV dynamics and integrase inhibitorsJohn M Murray
School of Mathematics and Statistics, University of New South Wales, Sydney, Australia
Antivir Chem Chemother 19:157-64. 2009..Investigation of HIV RNA and HIV DNA levels with an INI will provide better understanding of how these components are generated and maintained under antiretroviral therapy... - Evolution of CD4+ T cell count in HIV-1-infected adults receiving antiretroviral therapy with sustained long-term virological suppressionHelen Byakwaga
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 376 Victoria Street, Darlinghurst, NSW 2010, Australia
AIDS Res Hum Retroviruses 25:756-76. 2009..Our results point to an advantage to commencing ART at higher CD4+ T cell strata. These data should be considered when estimating the optimal time to initiate ART... - Impact of treatment with raltegravir during primary or chronic HIV infection on RNA decay characteristics and the HIV viral reservoirKersten K Koelsch
The Kirby Institute, University of New South Wales, Sydney, Australia
AIDS 25:2069-78. 2011..In most patients, rebound upon treatment cessation is prompt. We assessed whether early treatment with raltegravir can impact on the formation of the viral reservoir... - Significant reduction in HIV prevalence according to male circumcision intervention in sub-Saharan AfricaGregory J Londish
School of Mathematics and Statistics, University of New South Wales, Sydney 2052 NSW, Australia
Int J Epidemiol 37:1246-53. 2008..The exact benefits of this intervention are uncertain. Moreover if MC is not feasible for the whole male population, which groups should be targeted?.. - Minimal impact of circumcision on HIV acquisition in men who have sex with menGregory J Londish
School of Mathematics and Statistics, University of New South Wales, Sydney, NSW 2052, Australia
Sex Health 7:463-70. 2010..We examined the potential impact of circumcision on an HIV epidemic within a population of MSM... - T-lymphocyte perturbation following large-scale apheresis and hematopoietic stem cell transplantation in HIV-infected individualsBorislav Savkovic
School of Mathematics and Statistics, University of New South Wales, Sydney 2052, Australia
Clin Immunol 144:159-71. 2012..5% of the pool of CD4+ T lymphocytes that traffic to PB... - Dynamics of hepatitis B virus clearance in chimpanzeesJohn M Murray
School of Mathematics, University of New South Wales, Sydney NSW 2052, Australia
Proc Natl Acad Sci U S A 102:17780-5. 2005.... - The burden of HIV-associated neurocognitive impairment in Australia and its estimates for the futureLucette A Cysique
Brain Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Sex Health 8:541-50. 2011..There are currently no estimates of the future burden of neurocognitive disease in this population... - Optimal targeting of Hepatitis C virus treatment among injecting drug users to those not enrolled in methadone maintenance programsIrmgard Zeiler
Drug Policy Modelling Program, National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
Drug Alcohol Depend 110:228-33. 2010..This work used mathematical modelling to explore effective policy for Hepatitis C virus (HCV) treatment in Australia in the context of methadone maintenance treatment (MMT)... - The prevalence of sexually transmitted infections in Papua New Guinea: a systematic review and meta-analysisAndrew Vallely
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
PLoS ONE 5:e15586. 2010..As sexually transmitted infections (STIs) may be important co-factors in HIV transmission nationally, it is timely to conduct a systematic review of STI prevalences to inform national policy on sexual health and HIV/STI prevention... - Stochastic model of in-vivo X4 emergence during HIV infection: implications for the CCR5 inhibitor maravirocBorislav Savkovic
School of Mathematics and Statistics, University of New South Wales, Sydney, Australia
PLoS ONE 7:e38755. 2012..These results underscore the clinical importance for careful selection of BT when CCR5 blockers are administered in-vivo... - Explaining the Determinants of First Phase HIV Decay Dynamics through the Effects of Stage-dependent Drug ActionJames B Gilmore
School of Mathematics and Statistics, University of New South Wales, Sydney, New South Wales, Australia The Climate Change Research Centre, University of New South Wales, Sydney, New South Wales, Australia
PLoS Comput Biol 9:e1002971. 2013..The level at which this slowing occurs is a better indicator of drug efficacy than the slope of the initial decay... - Findings regarding reduced prevalence with hepatitis C treatment are still valid: A reply to Vickerman et alJohn M Murray
School of Mathematics and Statistics, University of New South Wales, Sydney 2052, NSW, Australia National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney 2052, NSW, Australia
Drug Alcohol Depend 113:86-7. 2011..Our original findings suggest that policy should preferentially direct treatment to current injectors... - Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patientsTassilo Volz
Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
Gastroenterology 133:843-52. 2007.... - Changing transmission fitness of drug-resistant human immunodeficiency virus against a background of evolving antiretroviral therapyJohn M Murray
J Infect Dis 188:1258; author reply 1258-9. 2003 - Virologic determinants of success after structured treatment interruptions of antiretrovirals in acute HIV-1 infectionSharon R Lewin
Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
J Acquir Immune Defic Syndr 47:140-47. 2008..Commencing ARVs during primary HIV-1 infection (PHI) may limit the size of the latent pool and lead to improved control of viral replication during structured treatment interruption (STI)... - Virion half-life in chronic hepatitis B infection is strongly correlated with levels of viremiaMaura Dandri
Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Hepatology 48:1079-86. 2008.... - Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapyWeidong Yang
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Brain Res Mol Brain Res 124:70-8. 2004..Our results support the hypothesis that 5-HT(2C)R mRNA editing has causative relevance in the pathophysiology of depression associated with cytokine therapy...