Brian J Morris

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. pmc XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265
    A Helena Mangs
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, NSW 2006, Australia
    Nucleic Acids Res 34:4976-86. 2006
  2. ncbi request reprint Fluorescence activated cell sorting of transiently transfected As4.1 cells shows renin enhancer directs on/off switching of renin promoter in vitro
    Brian J Morris
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 35:367-71. 2008
  3. ncbi request reprint A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer
    Brian J Morris
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, Building F13, The University of Sydney, NSW 2006, Australia
    J Hypertens 23:1285-309. 2005
  4. ncbi request reprint Cervical human papillomavirus screening by PCR: advantages of targeting the E6/E7 region
    Brian J Morris
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, Sydney, Australia
    Clin Chem Lab Med 43:1171-7. 2005
  5. ncbi request reprint Case number and the financial impact of circumcision in reducing prostate cancer
    Brian J Morris
    School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, New South Wales, Australia
    BJU Int 100:5-6. 2007
  6. ncbi request reprint Cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens
    Brian J Morris
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW, Australia
    Clin Chem Lab Med 45:577-91. 2007
  7. ncbi request reprint RACP's policy statement on infant male circumcision is ill-conceived
    Brian J Morris
    School of Medical Sciences and Institute for Biomedical Research, University of Sydney, New South Wales
    Aust N Z J Public Health 30:16-22; discussion 22-5. 2006
  8. ncbi request reprint HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression
    David J Adams
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, New South Wales 2006, Australia
    J Biol Chem 278:44894-903. 2003
  9. ncbi request reprint No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension
    Adam V Benjafield
    Basic Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, Sydney, Australia
    Am J Hypertens 17:624-8. 2004
  10. doi request reprint Global identification of the genes and pathways differentially expressed in hypothalamus in early and established neurogenic hypertension
    Francine Z Marques
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, New South Wales, Australia
    Physiol Genomics 43:766-71. 2011

Collaborators

Detail Information

Publications69

  1. pmc XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265
    A Helena Mangs
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, NSW 2006, Australia
    Nucleic Acids Res 34:4976-86. 2006
    ..We have thus shown that the spliceosomal component XE7 resembles an SR-related splicing protein, and can influence alternative splicing...
  2. ncbi request reprint Fluorescence activated cell sorting of transiently transfected As4.1 cells shows renin enhancer directs on/off switching of renin promoter in vitro
    Brian J Morris
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 35:367-71. 2008
    ..Limitations of these findings are discussed...
  3. ncbi request reprint A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer
    Brian J Morris
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, Building F13, The University of Sydney, NSW 2006, Australia
    J Hypertens 23:1285-309. 2005
    ..The present review describes how recent experimental strategies have identified key genes and intracellular pathways that are responsible for ageing and longevity...
  4. ncbi request reprint Cervical human papillomavirus screening by PCR: advantages of targeting the E6/E7 region
    Brian J Morris
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, Sydney, Australia
    Clin Chem Lab Med 43:1171-7. 2005
    ..The choice of region used for PCR has implications for HPV screening strategies in the clinical diagnosis and management of cervical cancer...
  5. ncbi request reprint Case number and the financial impact of circumcision in reducing prostate cancer
    Brian J Morris
    School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, New South Wales, Australia
    BJU Int 100:5-6. 2007
  6. ncbi request reprint Cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens
    Brian J Morris
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW, Australia
    Clin Chem Lab Med 45:577-91. 2007
    ..The higher accuracy of HPV testing should lead to improved cervical cancer prevention...
  7. ncbi request reprint RACP's policy statement on infant male circumcision is ill-conceived
    Brian J Morris
    School of Medical Sciences and Institute for Biomedical Research, University of Sydney, New South Wales
    Aust N Z J Public Health 30:16-22; discussion 22-5. 2006
    ..To conduct a critical peer-review of the 2004 Policy Statement on routine male circumcision produced by the Royal Australasian College of Physicians (RACP)...
  8. ncbi request reprint HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression
    David J Adams
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, New South Wales 2006, Australia
    J Biol Chem 278:44894-903. 2003
    ..cAMP-mediated increased REN mRNA stability may involve stimulation of HuR and CP1, whereas REN mRNA decay may involve thiolase-dependent pathways...
  9. ncbi request reprint No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension
    Adam V Benjafield
    Basic Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, Sydney, Australia
    Am J Hypertens 17:624-8. 2004
    ..96); intron 16 variant 0.20 versus 0.19 in female subjects (P =.72) and 0.17 versus 0.17 in male subjects (P =.95). Haplotype analysis was also negative. These data provide little support for ACE2 in genetic predisposition to HT...
  10. doi request reprint Global identification of the genes and pathways differentially expressed in hypothalamus in early and established neurogenic hypertension
    Francine Z Marques
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, New South Wales, Australia
    Physiol Genomics 43:766-71. 2011
    ....
  11. ncbi request reprint No association with hypertension of CLCNKB and TNFRSF1B polymorphisms at a hypertension locus on chromosome 1p36
    Helen J L Speirs
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, Australia
    J Hypertens 23:1491-6. 2005
    ..Here we performed association studies in a well-characterized cohort of hypertensives and normotensives whose blood pressure status matched that of both their parents...
  12. doi request reprint ZRANB2 localizes to supraspliceosomes and influences the alternative splicing of multiple genes in the transcriptome
    Yee Hwa J Yang
    School of Mathematics and Statistics, The University of Sydney, Sydney, NSW, 2006, Australia
    Mol Biol Rep 40:5381-95. 2013
    ..Several of these have been implicated in tumor development. In conclusion ZRANB2 is part of the supraspliceosome and causes differential splicing of numerous primary transcripts, some of which might have a role in cancer. ..
  13. pmc Genes influencing circadian differences in blood pressure in hypertensive mice
    Francine Z Marques
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, Australia
    PLoS ONE 6:e19203. 2011
    ..The findings may assist in the elucidation of the mechanism for the morning surge in BP in essential hypertension...
  14. ncbi request reprint The effect of resveratrol on a cell model of human aging
    Maurizio Stefani
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, New South Wales 2006, Australia
    Ann N Y Acad Sci 1114:407-18. 2007
    ..Serum deprivation and high confluency caused nuclear translocation of the SIRT1-regulated transcription factor FOXO3a. Our data indicate resveratrol's actions might cause FOXO recruitment to the nucleus...
  15. ncbi request reprint Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension
    Helen J L Speirs
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, Sydney, NSW 2006, Australia
    J Hypertens 22:931-6. 2004
    ..To perform association studies of polymorphisms of the potential candidate essential hypertension (HT) genes GRK4, PTP1B and HSD3B1...
  16. ncbi request reprint WNK4 intron 10 polymorphism is not associated with hypertension
    Helen J L Speirs
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Institute of Biomedical Research, University of Sydney, NSW, Australia
    Hypertension 43:766-8. 2004
    ..In conclusion, our study provides no support for an association of the intron 10 variant of WNK4 with essential hypertension in the Anglo-Australian population studied...
  17. ncbi request reprint Renin enhancer is critical for control of renin gene expression and cardiovascular function
    David J Adams
    School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia
    J Biol Chem 281:31753-61. 2006
    ..In conclusion, the renin enhancer is critical for renin gene expression and physiological sequelae, including response to alteration in salt intake. The REKO mouse may be useful as a low renin expression model...
  18. ncbi request reprint Overweight, but not hypertension, is associated with SAH polymorphisms in Caucasians with essential hypertension
    Adam V Benjafield
    Basic and Clinical Genomics Laboratory, School of Medical Science and Institute for Biomedical Research, The University of Sydney, Sydney, Australia
    Hypertens Res 26:591-5. 2003
    ..01-0.04), although these lost their statistical significance after correction for multiple comparisons. In conclusion, the present data offers support for variation in SAH having a role in predisposition to overweight in hypertensives...
  19. ncbi request reprint WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo
    M Andrea Markus
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Building F13, The University of Sydney, NSW 2006, Australia
    Exp Cell Res 312:3379-88. 2006
    ..We found that overexpressed WT1(+KTS) abrogated this effect of RBM4 on splice-site selection, whereas WT1(-KTS) did not. We conclude that the (+KTS) form of WT1 is able to inhibit the effect of RBM4 on alternative splicing...
  20. pmc Review: a critical evaluation of arguments opposing male circumcision for HIV prevention in developed countries
    Brian J Morris
    School of Medical Sciences and Bosch Institute, University of Sydney, NSW, Australia
    AIDS Care 24:1565-75. 2012
    ..The scientific evidence indicates that medical MC is safe and effective. Its favourable risk/benefit ratio and cost/benefit support the advantages of medical MC...
  21. doi request reprint Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs
    Francine Z Marques
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Building F13, University of Sydney, Sydney, New South Wales 2006, Australia
    Hypertension 58:1093-8. 2011
    ..Renin, CD36, and other mRNAs, as well as miRNAs and associated pathways identified in the present study, provide novel insights into hypertension etiology...
  22. pmc Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs
    M Andrea Markus
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, Australia
    PLoS ONE 6:e28926. 2011
    ..Our results suggest that resveratrol might be an attractive small molecule to treat diseases in which aberrant splicing has been implicated, and justify more extensive research on the effects of resveratrol on the splicing machinery...
  23. ncbi request reprint Renin enhancer is crucial for full response in Renin expression to an in vivo stimulus
    M Andrea Markus
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Building F13, University of Sydney, NSW 2006, Australia
    Hypertension 50:933-8. 2007
    ..In conclusion, the renin enhancer is critical for replenishment of renin stores and response in renin to a chronic in vivo stimulus...
  24. ncbi request reprint Circumcision rates in the United States: rising or falling? What effect might the new affirmative pediatric policy statement have?
    Brian J Morris
    School of Medical Sciences, University of Sydney, Sydney, NSW, Australia Electronic address
    Mayo Clin Proc 89:677-86. 2014
    ..Campaigns should prioritize population subgroups with lower circumcision prevalence and a higher burden of diseases that can be ameliorated by circumcision. ..
  25. pmc The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences
    Fionna E Loughlin
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney NSW 2006, Australia
    Proc Natl Acad Sci U S A 106:5581-6. 2009
    ..The ZnFs of ZRANB2 therefore define another class of RNA-binding domain, advancing our understanding of RNA recognition and emphasizing the versatility of ZnF domains in molecular recognition...
  26. doi request reprint Meta-analysis of genome-wide gene expression differences in onset and maintenance phases of genetic hypertension
    Francine Z Marques
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, New South Wales, Australia
    Hypertension 56:319-24. 2010
    ..Our meta-analysis has revealed many new genes for which the expression is altered in hypertension, so pointing to novel potential causative, maintenance, and responsive mechanisms and pathways...
  27. pmc Should male circumcision be advocated for genital cancer prevention?
    Brian J Morris
    Molecular Medical Sciences, University of Sydney, Australia
    Asian Pac J Cancer Prev 13:4839-42. 2012
    ..Male circumcision can reduce cervical, penile and possibly prostate cancer. Promotion of both HPV vaccination and male circumcision will synergistically maximize genital cancer prevention...
  28. pmc A 'snip' in time: what is the best age to circumcise?
    Brian J Morris
    School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia
    BMC Pediatr 12:20. 2012
    ..This is an important issue for many parents, but also pediatricians, other doctors, policy makers, public health authorities, medical bodies, and males themselves...
  29. ncbi request reprint Genome-wide scan for hypertension in Sydney Sibships: the GENIHUSS study
    Adam V Benjafield
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, Sydney, Australia
    Am J Hypertens 18:828-32. 2005
    ..Our study adds to findings of HT loci emanating from genome scans...
  30. pmc Resveratrol in prevention and treatment of common clinical conditions of aging
    M Andrea Markus
    School of Medical Sciences, Bosch Institute, The University of Sydney, Sydney, NSW, Australia
    Clin Interv Aging 3:331-9. 2008
    ....
  31. pmc Recommendation by a law body to ban infant male circumcision has serious worldwide implications for pediatric practice and human rights
    Michael J Bates
    School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia
    BMC Pediatr 13:136. 2013
    ..The acceptance of this recommendation would create a precedent for legislation elsewhere in the world, thereby posing a threat to pediatric practice, parental responsibilities and freedoms, and public health...
  32. ncbi request reprint ZRANB2: structural and functional insights into a novel splicing protein
    A Helena Mangs
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Building F13, The University of Sydney, NSW 2006, Australia
    Int J Biochem Cell Biol 40:2353-7. 2008
    ..ZRANB2 is one of 20 genes up-regulated in grade III ovarian serous papillary carcinoma. Here, we review current knowledge surrounding ZRANB2...
  33. ncbi request reprint The structure of the zinc finger domain from human splicing factor ZNF265 fold
    Craig A Plambeck
    Basic and Clinical Genomics Laboratory, School of Medical Science, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 278:22805-11. 2003
    ..Taken together, these results define a new RNA-binding motif and should provide insight into the functions of the >100 uncharacterized proteins in the sequence data bases that contain this domain...
  34. doi request reprint The molecular basis of longevity, and clinical implications
    Francine Z Marques
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Building F13, The University of Sydney, NSW 2006, Australia
    Maturitas 65:87-91. 2010
    ....
  35. pmc Dietary approaches that delay age-related diseases
    Arthur V Everitt
    Centre for Education and Research on Ageing and ANZAC Research Institute, University of Sydney, Concord Repatriation General Hospital, Concord, NSW, Australia
    Clin Interv Aging 1:11-31. 2006
    ..Furthermore, there are studies suggesting that nutrition in childhood and even in the fetus may influence the later development of aging diseases and lifespan...
  36. ncbi request reprint Lark is the splicing factor RBM4 and exhibits unique subnuclear localization properties
    M Andrea Markus
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute for Biomedical Research, The University of Sydney, Sydney, Australia
    DNA Cell Biol 25:457-64. 2006
    ..In conclusion, RBM4 and Lark are the same protein, are localized in speckles and nucleoli, but can redistribute to perinucleolar clusters, consistent with a novel subnuclear pathway...
  37. ncbi request reprint Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S variant
    Ruby C Y Lin
    Department of Physiology, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, Sydney, Australia
    Obes Res 11:802-8. 2003
    ..To determine whether the N363S variant in the glucocorticoid receptor (encoded by nuclear receptor subfamily 3, group C, member 1: NR3C1) is associated with obesity, type 2 diabetes, or hypertension...
  38. ncbi request reprint Essential hypertension: genes and dreams
    Brian J Morris
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, Sydney, Australia
    Clin Chem Lab Med 41:834-44. 2003
    ..The dream, however, of using this information in clinical genetic testing could turn out to be a nightmare. Thus at present the hype surrounding genes for complex polygenic diseases like hypertension far exceeds the reality...
  39. doi request reprint Circumcision and lifetime risk of urinary tract infection: a systematic review and meta-analysis
    Brian J Morris
    School of Medical Sciences and Bosch Institute, University of Sydney, New South Wales, Australia
    J Urol 189:2118-24. 2013
    ..Thus, any intervention that might prevent urinary tract infection would be expected to reduce suffering and medical costs...
  40. doi request reprint RBM4: a multifunctional RNA-binding protein
    M Andrea Markus
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Building F13, The University of Sydney, Sydney, NSW 2006, Australia
    Int J Biochem Cell Biol 41:740-3. 2009
    ..Here we review current information about the function of RBM4 and its localization within the cell. We then speculate about its possible relationship to disease...
  41. doi request reprint Resveratrol: cellular actions of a potent natural chemical that confers a diversity of health benefits
    Francine Z Marques
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Building F13, The University of Sydney, Sydney, NSW 2006, Australia
    Int J Biochem Cell Biol 41:2125-8. 2009
    ..Resveratrol and the new compounds are the subject of clinical trials to determine their consumer safety and suitability for the prevention and treatment of most common diseases of aging...
  42. ncbi request reprint Tumor necrosis factor receptor 2 mRNA in rat models of hypertension
    Ruby C Y Lin
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, Sydney, NSW 2006, Australia
    Am J Hypertens 16:685-8. 2003
    ..The ACTH-induced HT was not affected by huTNFR:Fc coadministration. The findings thus offer no support for altered Tnfr2 expression in the rat models studied...
  43. ncbi request reprint Renin: from 'pro' to promoter
    Brian J Morris
    Department of Physiology, School of Biomedical Sciences, Institute for Biomedical Research F13, The University of Sydney, NSW 2006, Australia
    Bioessays 25:520-7. 2003
    ..The renin molecule, its gene and molecular control are now very well understood, but more fine details on the topic of renin continue to emerge to delight 'reninologists' and others...
  44. ncbi request reprint Why circumcision is a biomedical imperative for the 21(st) century
    Brian J Morris
    School of Medical Sciences and Bosch Institute, Building F13, The University of Sydney, Sydney, New South Wales 2006, Australia
    Bioessays 29:1147-58. 2007
    ..Most women prefer the circumcised penis for appearance, hygiene and sex. Given the convincing epidemiological evidence and biological support, routine circumcision should be highly recommended by all health professionals...
  45. doi request reprint Commentary on resveratrol and hormesis: resveratrol--a hormetic marvel in waiting?
    Francine Z Marques
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Anderson Stuart Building, University of Sydney, Australia
    Hum Exp Toxicol 29:1026-8. 2010
    ....
  46. pmc The Strong Protective Effect of Circumcision against Cancer of the Penis
    Brian J Morris
    School of Medical Sciences and Bosch Institute, Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia
    Adv Urol 2011:812368. 2011
    ..Given that adverse consequences of medical male circumcision, especially when performed in infancy, are rare, this simple prophylactic procedure should be promoted...
  47. ncbi request reprint Association of a functional inducible nitric oxide synthase promoter variant with complications in type 2 diabetes
    Brian J Morris
    Basic and Clinical Genomics Laboratory, Department of Physiology and Institute for Biomedical Research, The University of Sydney, New South Wales, 2006, Australia
    J Mol Med (Berl) 80:96-104. 2002
    ..Thus the '+' allele of the NOS2A promoter variant may confer higher iNOS expression, and could contribute to complications of type 2 diabetes, especially in the approximately 5% of patients homozygous for this variant...
  48. ncbi request reprint A distinct subclass of mammalian striated myosins: structure and molecular evolution of "superfast" or masticatory myosin heavy chain
    Han Qin
    Department of Physiology and Institute for Biomedical Research, Building F13, The University of Sydney, Sydney, NSW 2006, Australia
    J Mol Evol 55:544-52. 2002
    ..During the mammalian radiation, some taxa continued to express it, while others adapted to new types of food and eating habits by replacing masticatory MyHC with more appropriate isoforms normally found in limb and cardiac muscles...
  49. ncbi request reprint Haplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertension
    Natasha N Kumar
    Department of Physiology, School of Medical Sciences, and Institute for Biomedical Research, The University of Sydney, Sydney, Australia
    J Hypertens 21:1331-7. 2003
    ..We therefore investigated CYP11B2 polymorphisms T-344C, T4986C and A6547G for association with essential HT. This included haplotype analysis and measurement of plasma aldosterone levels...
  50. pmc Hormesis as a pro-healthy aging intervention in human beings?
    Francine Z Marques
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, NSW 2006, Australia
    Dose Response 8:28-33. 2009
    ..Moderate-intensity exercise, weight management and healthy diet ameliorate diseases of aging to increase lifespan and this could involve hormesis...
  51. ncbi request reprint Association analysis of polymorphisms at the interleukin-1 locus in essential hypertension
    Ruby C Y Lin
    Basic and Clinical Genomics Laboratory, Department of Physiology and Institute for Biomedical Research, The University of Sydney, Sydney, New South Wales, Australia
    Am J Med Genet 107:311-6. 2002
    ..10 in HT, respectively (chi(2) = 11, P = 0.004). In conclusion, no association of the IL1B C(- 31)T with HT was found, whereas combined frequency of the minor alleles of the IL1RN polymorphism was increased in the HT cohort studied...
  52. ncbi request reprint Critique of "chromosome 17 and the inducible nitric oxide synthase gene in human essential hypertension" by Rutherford et al., Human Genetics, published online September 2001
    Brian J Morris
    Department of Physiology and Institute for Biomedical Research, Building F13, The University of Sydney, NSW 2006, Australia
    Hum Genet 110:98-9; discusion 100-3. 2002
  53. ncbi request reprint Genomic profiling of the neuronal target genes of the plasticity-related transcription factor -- Zif268
    Allan B James
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    J Neurochem 95:796-810. 2005
    ..Our findings suggest that altered expression of these genes following Zif268 induction may be a key component of long lasting plasticity in the CNS...
  54. ncbi request reprint Circumcision in Australia: prevalence and effects on sexual health
    Brian J Morris
    Int J STD AIDS 18:69-70. 2007
  55. ncbi request reprint Egr-1 modulation of synapsin I expression: permissive effect of forskolin via cAMP
    Allan B James
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow, Scotland G12 8QQ, UK
    Cell Signal 16:1355-62. 2004
    ..These results suggest that Egr-1 transactivation during neuronal plasticity may rely on a permissive effect of cAMP...
  56. ncbi request reprint Climate not cultivars in the NO-ing of red wines
    Brian J Morris
    J Hypertens 25:501-3. 2007
  57. ncbi request reprint Circumcision rate too low?
    Brian J Morris
    ANZ J Surg 74:386-7; author reply 388. 2004
  58. pmc BRCTx is a novel, highly conserved RAD18-interacting protein
    David J Adams
    The Wellcome Trust Sanger Institute Hinxton, Cambs CB10 1SA, United Kingdom
    Mol Cell Biol 25:779-88. 2005
    ..We conclude that, although highly conserved, Brctx is not essential for the above-mentioned processes and may be redundant...
  59. ncbi request reprint Circumcision for phimosis and other medical indications in Western Australian boys
    Brian J Morris
    Med J Aust 178:588-9; author reply 589-90. 2003
  60. ncbi request reprint Impairment in perceptual attentional set-shifting following PCP administration: a rodent model of set-shifting deficits in schizophrenia
    Alice Egerton
    Yoshitomi Research Institute of Neuroscience in Glasgow YRING, University of Glasgow, G12 8QQ, UK
    Psychopharmacology (Berl) 179:77-84. 2005
    ..A pharmacological model producing equivalent deficits in rodents may enable the development of novel therapeutic strategies for effective treatment of cognitive impairments in schizophrenia...
  61. ncbi request reprint Induction of metabolic hypofunction and neurochemical deficits after chronic intermittent exposure to phencyclidine: differential modulation by antipsychotic drugs
    Susan M Cochran
    Yoshitomi Research Institute of Neuroscience in Glasgow, University of Glasgow, UK
    Neuropsychopharmacology 28:265-75. 2003
    ....
  62. ncbi request reprint Re: cost analysis of neonatal circumcision in a large health maintenance organization
    Brian J Morris
    J Urol 176:2315-6; author reply 2317-9. 2006
  63. ncbi request reprint Restored plasticity in a mouse model of neurofibromatosis type 1 via inhibition of hyperactive ERK and CREB
    Clare Guilding
    Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Eur J Neurosci 25:99-105. 2007
    ....
  64. ncbi request reprint Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction
    Zhiyong Yang
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne, VIC 8008, Australia
    Circulation 115:1269-74. 2007
    ..We have found that normotensive siblings of subjects with essential hypertension have impaired endothelial function accompanied by altered arginine metabolism...
  65. ncbi request reprint Regulation of neuronal cdc20 (p55cdc) expression by the plasticity-related transcription factor zif268
    Ann Marie Conway
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    Synapse 61:463-8. 2007
    ....
  66. ncbi request reprint Fine-touch pressure thresholds in the adult penis
    Jake H Waskett
    BJU Int 99:1551-2. 2007
  67. ncbi request reprint Reduced cardiovascular reactivity to stress but not feeding in renin enhancer knockout mice
    Kristy Jackson
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Am J Hypertens 20:893-9. 2007
    ..In this study, we examined whether the renin enhancer deficit alters the acute pressor response to emotional stress in mice...
  68. ncbi request reprint Regulation of the neuronal proteasome by Zif268 (Egr1)
    Allan B James
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 26:1624-34. 2006
    ....
  69. ncbi request reprint Does angiotensin interact with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice?
    Sally Martin
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville Melbourne, Victoria 3052, Australia
    Neuropharmacology 54:399-404. 2008
    ..Our previous results on the effects of reduced ACE activity could be explained by mechanisms other than angiotensin, such as effects on enkephalin or bradykinin metabolism...