Ruth Morley

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi Birthweight and coronary heart disease in a cohort born 1857-1900 in Melbourne, Australia
    Ruth Morley
    Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics, and Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Int J Epidemiol 35:880-5. 2006
  2. ncbi Trends in birthweight between 1857 and 1883, in Melbourne, Australia
    Ruth Morley
    Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics, and Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Paediatr Perinat Epidemiol 17:236-43. 2003
  3. ncbi Maternal dietary intake in twin pregnancies: does it diminish towards term?
    Ruth Morley
    University of Melbourne Department of Paediatrics, Melbourne, Victoria, Australia
    Twin Res Hum Genet 9:656-8. 2006
  4. ncbi Fetal origins of adult disease
    Ruth Morley
    Department of Paediatrics and Murdoch Children s Research Institute, University of Melbourne, Flemington Road, Parkville, Victoria 3070, Australia
    Semin Fetal Neonatal Med 11:73-8. 2006
  5. ncbi Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size
    Ruth Morley
    Clinical Epidemiology University of Melbourne Department of Pediatrics, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    J Clin Endocrinol Metab 91:906-12. 2006
  6. ncbi Association between erythropoietin in cord blood of twins and size at birth: does it relate to gestational factors or to factors during labor or delivery?
    Ruth Morley
    Department of Pediatrics, University of Melbourne, and Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Pediatr Res 57:680-4. 2005
  7. ncbi Can we generalise from findings in twins?
    Ruth Morley
    Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics, and Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Paediatr Perinat Epidemiol 19:54-9. 2005
  8. ncbi Studies of twins: what can they tell us about the fetal origins of adult disease?
    Ruth Morley
    Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics, Melbourne, Australia
    Paediatr Perinat Epidemiol 19:2-7. 2005
  9. ncbi Maternal calcium supplementation and cardiovascular risk factors in twin offspring
    Ruth Morley
    Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics and Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Int J Epidemiol 33:1304-9. 2004
  10. ncbi Maternal birthweight and outcome of twin pregnancy
    Ruth Morley
    Department of Paediatrics, University of Melbourne, Victoria, Australia
    Paediatr Perinat Epidemiol 21:501-6. 2007

Detail Information

Publications44

  1. ncbi Birthweight and coronary heart disease in a cohort born 1857-1900 in Melbourne, Australia
    Ruth Morley
    Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics, and Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Int J Epidemiol 35:880-5. 2006
    ..The widely observed association between birth size and risk of later coronary heart disease (CHD) has not been examined in an impoverished pre-20th century birth cohort...
  2. ncbi Trends in birthweight between 1857 and 1883, in Melbourne, Australia
    Ruth Morley
    Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics, and Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Paediatr Perinat Epidemiol 17:236-43. 2003
    ..Our findings highlight the difficulty of capturing lifestyle factors using routinely collected data, and the need for historical expertise when examining historical data...
  3. ncbi Maternal dietary intake in twin pregnancies: does it diminish towards term?
    Ruth Morley
    University of Melbourne Department of Paediatrics, Melbourne, Victoria, Australia
    Twin Res Hum Genet 9:656-8. 2006
    ..We cannot exclude change in energy intake or diet composition before 29 weeks or after 35 weeks of twin gestation...
  4. ncbi Fetal origins of adult disease
    Ruth Morley
    Department of Paediatrics and Murdoch Children s Research Institute, University of Melbourne, Flemington Road, Parkville, Victoria 3070, Australia
    Semin Fetal Neonatal Med 11:73-8. 2006
    ..Nevertheless there is a need to understand the underlying causal pathways, and the utility of studies of twins and possible mechanisms are discussed...
  5. ncbi Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size
    Ruth Morley
    Clinical Epidemiology University of Melbourne Department of Pediatrics, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    J Clin Endocrinol Metab 91:906-12. 2006
    ..There is inconsistent evidence that maternal 25-hydroxyvitamin D [25-(OH)D] deficiency may impair fetal growth...
  6. ncbi Association between erythropoietin in cord blood of twins and size at birth: does it relate to gestational factors or to factors during labor or delivery?
    Ruth Morley
    Department of Pediatrics, University of Melbourne, and Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Pediatr Res 57:680-4. 2005
    ..There was no evidence of an association between birth weight SDS and pair mean log EPO, indicating that the association is entirely due to fetus-specific rather than pair-specific factors...
  7. ncbi Can we generalise from findings in twins?
    Ruth Morley
    Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics, and Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Paediatr Perinat Epidemiol 19:54-9. 2005
    ..Placentation and issues relating to infertility and its treatment need to be recorded and, together with gestation length, may need to be taken into account in analyses...
  8. ncbi Studies of twins: what can they tell us about the fetal origins of adult disease?
    Ruth Morley
    Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics, Melbourne, Australia
    Paediatr Perinat Epidemiol 19:2-7. 2005
    ..We tabulate published data and conclude that differences in methodology and analyses preclude informative meta-analysis, and that analysis of pooled data would provide more useful information...
  9. ncbi Maternal calcium supplementation and cardiovascular risk factors in twin offspring
    Ruth Morley
    Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics and Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Int J Epidemiol 33:1304-9. 2004
    ..There is evidence that maternal calcium supplementation may result in lower offspring blood pressure. We hypothesized that maternal calcium supplementation also influences other cardiovascular risk factors...
  10. ncbi Maternal birthweight and outcome of twin pregnancy
    Ruth Morley
    Department of Paediatrics, University of Melbourne, Victoria, Australia
    Paediatr Perinat Epidemiol 21:501-6. 2007
    ..Nevertheless, our sample size was modest and this finding needs to be confirmed in a larger cohort...
  11. ncbi Neurodevelopment in children born small for gestational age: a randomized trial of nutrient-enriched versus standard formula and comparison with a reference breastfed group
    Ruth Morley
    Medical Research Council Childhood Nutrition Research Centre, Institute of Child Health, London, United Kingdom
    Pediatrics 113:515-21. 2004
    ..We have shown that nutrient enrichment of formula fed to term SGA infants improves their growth and hypothesized that it also would improve their neurodevelopmental outcome...
  12. ncbi Studies of twins: can they shed light on the fetal origins of adult disease hypothesis?
    Ruth Morley
    Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics, and Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Twin Res 6:520-5. 2003
    ..Generalisability of findings in twins is debated. We suggest that findings in monochorionic twins (or in the absence of chorionicity data, those from monozygotic twins) need to be interpreted with caution...
  13. doi The Peri/postnatal Epigenetic Twins Study (PETS)
    Yuk Jing Loke
    Department of Paediatrics, Royal Children s Hospital, Melbourne, Australia
    Twin Res Hum Genet 16:13-20. 2013
    ....
  14. doi Maternal vitamin D predominates over genetic factors in determining neonatal circulating vitamin D concentrations
    Boris Novakovic
    Cancer and Disease Epigenetics Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Australia
    Am J Clin Nutr 96:188-95. 2012
    ..There are multiple potential regulators of neonatal vitamin D status of environmental, genetic, and epigenetic origins. The relation between these factors and circulating neonatal vitamin D has yet to be fully characterized...
  15. doi Adiposity gain during childhood, ACE I/D polymorphisms and metabolic outcomes
    Anne Louise Ponsonby
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
    Obesity (Silver Spring) 16:2141-7. 2008
    ..Further work is required to confirm and extend these findings...
  16. pmc DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta
    Boris Novakovic
    Developmental Epigenetics, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    J Biol Chem 285:9583-93. 2010
    ..This strongly implicates epigenetic regulation of the DNMT gene family in the establishment of the unique epigenetic profile of extraembryonic tissue in humans...
  17. ncbi Double-blind, randomized trial of long-chain polyunsaturated fatty acid supplementation in formula fed to preterm infants
    Mary S Fewtrell
    MRC Childhood Nutrition Research Center, Institute of Child Health, London, United Kingdom
    Pediatrics 110:73-82. 2002
    ....
  18. pmc Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence
    Lavinia Gordon
    Bioinformatics Unit, Murdoch Childrens Research Institute, Parkville, Victoria 3052, Australia
    Genome Res 22:1395-406. 2012
    ..This is the first study to analyze DNA methylation on a genome scale in twins at birth, further highlighting the importance of the intrauterine environment on shaping the neonatal epigenome...
  19. doi Association between early-life factors and risk of child-onset Crohn's disease among Victorian children born 1983-1998: a birth cohort study
    Anne Louise Ponsonby
    Murdoch Childrens Research Institute, Royal Childrens Hospital, Melbourne, Victoria, Australia
    Inflamm Bowel Dis 15:858-66. 2009
    ..Our objective was to examine the temporal change in CD incidence by period of birth and the extent that this could be attributed to perinatal characteristics associated with higher CD risk...
  20. pmc Maternal alcohol intake and offspring pulse wave velocity
    Ruth Morley
    Department of Paediatrics, University of Melbourne, Clayton, Vic, Australia
    Neonatology 97:204-11. 2010
    ..In human adults, alcohol intake affects arterial stiffness...
  21. doi A health transition: birth weights, households and survival in an Australian working-class population sample born 1857-1900
    Janet Mccalman
    School of Population Health, University of Melbourne, Victoria, Australia
    Soc Sci Med 66:1070-83. 2008
    ..We conclude that this is an early example of a successful public health intervention...
  22. doi Variation in associations between allelic variants of the vitamin D receptor gene and onset of type 1 diabetes mellitus by ambient winter ultraviolet radiation levels: a meta-regression analysis
    Anne Louise Ponsonby
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Am J Epidemiol 168:358-65. 2008
    ..They suggest that environmental UVR may influence the association between VDR genotype and T1DM risk. Further work on VDR polymorphisms and T1DM should concomitantly examine the roles of past UVR exposure and vitamin D status...
  23. ncbi Regression models for twin studies: a critical review
    John B Carlin
    Clinical Epidemiology and Biostatistics Unit, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Int J Epidemiol 34:1089-99. 2005
    ..We recommend the use of a general model that includes separate regression coefficients for within-twin-pair and between-pair effects, and provide guidelines for the interpretation of estimates obtained under this model...
  24. doi DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome
    Miina Ollikainen
    Developmental Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Hum Mol Genet 19:4176-88. 2010
    ..This has implications for the effects of maternal environment on the development of the newborn epigenome and supports an epigenetic mechanism for the previously described phenomenon of 'fetal programming' of disease risk...
  25. doi Maternal vitamin D deficiency leads to cardiac hypertrophy in rat offspring
    Oksan Gezmish
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    Reprod Sci 17:168-76. 2010
    ..This may lead to altered cardiac function later in life...
  26. ncbi Infant nutrition and stereoacuity at age 4-6 y
    Atul Singhal
    Medical Research Council Childhood Nutrition Research Center, Institute of Child Health, London, United Kingdom
    Am J Clin Nutr 85:152-9. 2007
    ....
  27. ncbi Postnatal evaluation of vitamin D and bone health in women who were vitamin D-deficient in pregnancy, and in their infants
    Katherine Thomson
    Royal Children s Hospital, Parkville, Vic, Australia
    Med J Aust 181:486-8. 2004
    ..To determine the postnatal vitamin D status and bone health of women identified as vitamin D-deficient in pregnancy, and of their infants...
  28. ncbi Mothers' health and babies' weights: the biology of poverty at the Melbourne Lying-in Hospital, 1857-83
    Janet Mccalman
    Department of History and Philosophy of Science, University of Melbourne, Australia
    Soc Hist Med 16:39-56. 2003
    ..This data set reveals the biological effects differential social conditions can inflict, even within an otherwise affluent society...
  29. doi A convergent model for placental dysfunction encompassing combined sub-optimal one-carbon donor and vitamin D bioavailability
    Richard Saffery
    Department of Paediatrics, Developmental Epigenetics, Murdoch Childrens Research Institute, University of Melbourne, Parkville, Victoria 3052, Australia
    Med Hypotheses 73:1023-8. 2009
    ....
  30. ncbi Blood pressure in late adolescence and very low birth weight
    Lex W Doyle
    Department of Obstetrics and Gynecology, University of Melbourne, Melbourne, Australia
    Pediatrics 111:252-7. 2003
    ....
  31. ncbi Is birthweight a good marker for gestational exposures that increase the risk of adult disease?
    Ruth Morley
    Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    Paediatr Perinat Epidemiol 16:194-9. 2002
    ..From a public health point of view, we suggest that future research in this field should focus on modifiable gestational exposures that may be linked to adult disease, whether or not they influence size at birth...
  32. ncbi Prematurity at birth and adolescent depressive disorder
    George C Patton
    Murdoch Children s Research Institute, Centre for Adolescent Health, Parkville, Victoria, Australia
    Br J Psychiatry 184:446-7. 2004
    ..2% (95% CI 11.1-20.5) v. 1.8% (95% CI 1.6-2.1) in those with normal deliveries. Physiological adaptations in utero before full term may be implicated causally in some cases of depression in adolescence...
  33. doi 'Are you asking me if we had sex to conceive?' To whom do parents of twins disclose mode of conception and what do they feel about being asked?
    Supriya Raj
    University of Melbourne Department of Paediatrics, Royal Children s Hospital, Flemington Road, Parkville, Vic, Australia
    Twin Res Hum Genet 10:886-91. 2007
    ..Further, the question 'are your twins natural?' should be avoided. We believe the question 'Did you need medical help to conceive your twins', followed up with specific questions, is more acceptable...
  34. pmc Prospects for epigenetic epidemiology
    Debra L Foley
    Orygen Youth Health Research Centre and Department of Psychiatry, University of Melbourne, Australia
    Am J Epidemiol 169:389-400. 2009
    ..Methodological considerations for epidemiologic studies that seek to include epigenetic analysis are also discussed...
  35. ncbi Australian Twin Registry: a nationally funded resource for medical and scientific research, incorporating match and WATCH
    John L Hopper
    Australian Twin Registry, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Twin Res Hum Genet 9:707-11. 2006
    ..Consistent with its mission statement, the long-term goal of the ATR is to make twin studies a standard component of medical and scientific research...
  36. pmc Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface
    Boris Novakovic
    Developmental Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital, and Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia
    J Biol Chem 284:14838-48. 2009
    ..This study strongly suggests that epigenetic decoupling of vitamin D feedback catabolism plays an important role in maximizing active vitamin D bioavailability at the fetomaternal interface...
  37. doi Propensity scores: from naive enthusiasm to intuitive understanding
    Elizabeth Williamson
    Murdoch Childrens Research Institute, Melbourne, Australia
    Stat Methods Med Res 21:273-93. 2012
    ..We therefore end with a discussion of the relative advantages and disadvantages of each...
  38. ncbi Breast feeding and cognitive outcome in children born prematurely
    Ruth Morley
    University of Melbourne, Dept of Paediatrics, Royal Children s Hospital, Parkville, Victoria, Australia
    Adv Exp Med Biol 503:77-82. 2002
  39. ncbi Randomized, double-blind trial of long-chain polyunsaturated fatty acid supplementation with fish oil and borage oil in preterm infants
    Mary S Fewtrell
    MRC Childhood Nutrition Research Centre, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    J Pediatr 144:471-9. 2004
    ..To test the efficacy and safety of long-chain polyunsaturated fatty acid (LCPUFA) supplementation with gamma-linolenic acid, a precursor of arachidonic acid, and docosahexaenoic acid in preterm infants...
  40. ncbi Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statement
    Craig Munns
    The Children s Hospital at Westmead, Sydney, NSW, Australia
    Med J Aust 185:268-72. 2006
    ..High-dose bolus therapy (300,000-500,000 IU) should be considered for children over 12 months of age if compliance or absorption issues are suspected...
  41. doi Maternal vitamin D in pregnancy may influence not only offspring bone mass but other aspects of musculoskeletal health and adiposity
    Julie A Pasco
    Epidemiology and Biostatistics Unit, Department of Clinical and Biomedical Sciences Barwon Health, The University of Melbourne, Australia
    Med Hypotheses 71:266-9. 2008
    ..We suggest that there is a clear rationale for randomised clinical trials to assess the potential benefits and harmful effects of vitamin D supplementation during pregnancy...
  42. ncbi Vitamin D deficiency during pregnancy and lactation stimulates nephrogenesis in rat offspring
    Noori Maka
    Department of Anatomy and Cell Biology, Monash University, Post Office Box 13C, Clayton, Victoria 3800, Australia
    Pediatr Nephrol 23:55-61. 2008
    ..576 x 10(-4) mm(3) and 8.178+/-0.247 x 10(-4) mm(3), respectively; P=0.03). We concluded that maternal vitamin D deficiency in rats appears to stimulate nephrogenesis. Whether this confers a renal functional advantage or not is unknown...
  43. ncbi Twins and fetal origins hypothesis: within-pair analyses
    Terence Dwyer
    Lancet 359:2205-6. 2002
  44. ncbi A review of policies on alcohol use during pregnancy in Australia and other English-speaking countries, 2006. Comment
    Ruth Morley
    Med J Aust 187:315; author reply 316. 2007