Research Topics
Species | E H MorganSummaryAffiliation: University of Western Australia Country: Australia Publications
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Detail Information
Publications
Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent metal transporter 1Torben Moos
Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
J Neurochem 98:1946-58. 2006..However, BCECs at P0 together with those of older age lacked DMT1. In conclusion, BCECs probably mediate iron transport into the brain by segregating iron from transferrin without involvement of DMT1...- Mechanisms of iron transport into rat erythroid cellsE H Morgan
Department of Physiology, University of Western Australia, Nedlands, Western Australia, 6907, Australia
J Cell Physiol 186:193-200. 2001..01-1.0 microM), short incubation times (up to 20 min), and low osmolality (approximately 200 mOsm/kg) during incubation with the NTBI and subsequent washing of the cells... - Mechanisms and regulation of intestinal iron absorptionEvan H Morgan
Department of Physiology, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley 6009, Western Australia
Blood Cells Mol Dis 29:384-99. 2002..These results show the level of expression and intracellular distribution and function of DMT1 respond very quickly to the iron content of the diet as well as being affected by storage iron levels... - Mechanism and developmental changes in iron transport across the blood-brain barrierEvan H Morgan
Department of Physiology, University of Western Australia, Crawley, W A, Australia
Dev Neurosci 24:106-13. 2002..As the animal and brain mature both decrease... - Gene expression of divalent metal transporter 1 and transferrin receptor in duodenum of Belgrade ratsP S Oates
Department of Physiology, University of Western Australia, Nedlands 6907, Western Australia, Australia
Am J Physiol Gastrointest Liver Physiol 278:G930-6. 2000..We conclude that the uptake of transferrin-bound iron by developing enterocytes is largely independent of DMT1... - Transferrin receptor activity and localisation in the rat duodenumP S Oates
Department of Physiology, The University of Western Australia, Nedlands
Pflugers Arch 440:116-24. 2000..We hypothesise that TfR in the supranuclear region of villus enterocytes may play a role in iron absorption... - Iron excretion in iron-overloaded rats following the change from an iron-loaded to an iron-deficient dietP S Oates
Department of Physiology, University of Western Australia, Nedlands, Australia
J Gastroenterol Hepatol 15:665-74. 2000..We report the existence of an iron excretory process that results in the loss of significant amounts of liver iron... - Role of transferrin in iron uptake by the brain: a comparative studyE M Taylor
Department of Physiology, University of Western Australia, Nedlands
J Comp Physiol B 161:521-4. 1991..Also, the decrease in iron uptake by the brain as rats age from 15 days to adulthood is specific for the brain and is not a general effect of the aging process... - Gastrointestinal function, divalent metal transporter-1 expression and intestinal iron absorptionP S Oates
Department of Physiology, The University of Western Australia, Nedlands, Australia
Pflugers Arch 440:496-502. 2000..It is concluded that DMT1 functional activity is determined by de novo synthesis and that the latter is regulated post-transcriptionally by enterocyte iron levels... - Manganese metabolism is impaired in the Belgrade laboratory ratA C Chua
Department of Physiology, University of Western Australia, Nedlands, Australia
J Comp Physiol B 167:361-9. 1997.... - Differences in transferrin receptor function between normal developing and transformed myogenic cells as revealed by differential effects of phorbol ester on receptor distribution and rates of iron uptakeL M Sorokin
Physiology Department, University of Western Australia, Nedlands
J Biol Chem 263:14128-33. 1988.... - Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3S F Drake
School of Medicine and Pharmacology, Fremantle Hospital, University of Western Australia, PO Box 480, Fremantle, 6959, WA, Australia
Am J Physiol Gastrointest Liver Physiol 292:G323-8. 2007..These findings support a model in which TfR2 is a sensor of Fe status and regulates duodenal Fe absorption and liver Fe uptake... - Species specificity of transferrin binding, endocytosis and iron internalization by cultured chick myogenic cellsL M Sorokin
Department of Physiology, University of Western Australia, Nedlands
J Comp Physiol B 158:559-66. 1988..abstract truncated at 250 words).. - The transferrin homologue, melanotransferrin (p97), is rapidly catabolized by the liver of the rat and does not effectively donate iron to the brainDes R Richardson
Children s Cancer Institute Australia for Medical Research, Iron Metabolism and Chelation Program, PO Box 81, High Street, Randwick, Sydney, New South Wales 2031
Biochim Biophys Acta 1690:124-33. 2004..It is concluded that compared to Tf, sMTf plays little or no role in Fe supply to the brain and erythropoietic tissue. However, a small amount of sMTf was taken up from the plasma by the brain and a far greater amount by the liver... - The metabolism of neuronal iron and its pathogenic role in neurological disease: reviewTorben Moos
Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
Ann N Y Acad Sci 1012:14-26. 2004..More knowledge about iron metabolism in normal and diseased neurons is warranted as this may identify pharmaceutical targets to improve neuronal iron management... - The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brainTorben Moos
Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
J Neurochem 88:233-45. 2004..The existence of the mutated DMT1 molecule in neurones suggests that the low cerebral iron uptake in b/b rats derives from a reduced neuronal uptake rather than an impaired iron transport through the blood-brain barrier... - Iron and magnesium exchange via the low affinity iron transporter in rabbit erythroid cells-exchange rates and the action of valinomycin, diethylstilbestrol and protein kinase inhibitorsDonna L Savigni
Department of Physiology, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
Biochim Biophys Acta 1616:156-64. 2003..The inhibition produced by the protein kinase inhibitors indicate that phosphorylation of the transporter or an associated protein by protein tyrosine kinase is probably required to activate the transporter... - Iron and transition metal transport into erythrocytes mediated by nifedipine degradation products and related compoundsDonna L Savigni
Department of Physiology, The University of Western Australia, 35 Stirling Highway, Crawley, Australia
Biochem Pharmacol 65:1215-26. 2003..Also, because the lactam to which NN is converted in vivo is inactive, it is unlikely that nifedipine will affect iron metabolism after therapeutic administration... - A morphological study of the developmentally regulated transport of iron into the brainTorben Moos
Department of Medical Anatomy, Panum Institute, University of Copenhagen, Denmark
Dev Neurosci 24:99-105. 2002.... - Effect of iron status on DMT1 expression in duodenal enterocytes from beta2-microglobulin knockout miceTorben Moos
Department of Medical Anatomy, University of Copenhagen, DK 2200 Copenhagen, Denmark
Am J Physiol Gastrointest Liver Physiol 283:G687-94. 2002..These data suggest that the observed effects were due to the state of iron deficiency in mucosal cells rather than genetic defect... 
Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouseDebbie Trinder
Department of Medicine, University of Western Australia and Western Australian Institute for Medical Research, Perth 6009, Western Australia, Australia
Proc Natl Acad Sci U S A 99:5622-6. 2002..These data support the hypothesis that HFE regulates duodenal uptake of transferrin-bound iron from plasma, and that this mechanism of sensing body iron status, as reflected in plasma iron levels, is impaired in HH...- Iron trafficking inside the brainTorben Moos
Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
J Neurochem 103:1730-40. 2007..Oligodendrocytes also lack transferrin receptors. They probably take up non-transferrin bound iron that gets incorporated in newly synthesized transferrin, which may play an important role for intracellular iron transport...