E H Morgan

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Mechanisms and regulation of intestinal iron absorption
    Evan H Morgan
    Department of Physiology, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley 6009, Western Australia
    Blood Cells Mol Dis 29:384-99. 2002
  2. ncbi request reprint Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent metal transporter 1
    Torben Moos
    Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
    J Neurochem 98:1946-58. 2006
  3. ncbi request reprint Mechanisms of iron transport into rat erythroid cells
    E H Morgan
    Department of Physiology, University of Western Australia, Nedlands, Western Australia, 6907, Australia
    J Cell Physiol 186:193-200. 2001
  4. ncbi request reprint Mechanism and developmental changes in iron transport across the blood-brain barrier
    Evan H Morgan
    Department of Physiology, University of Western Australia, Crawley, W A, Australia
    Dev Neurosci 24:106-13. 2002
  5. ncbi request reprint Gene expression of divalent metal transporter 1 and transferrin receptor in duodenum of Belgrade rats
    P S Oates
    Department of Physiology, University of Western Australia, Nedlands 6907, Western Australia, Australia
    Am J Physiol Gastrointest Liver Physiol 278:G930-6. 2000
  6. ncbi request reprint Transferrin receptor activity and localisation in the rat duodenum
    P S Oates
    Department of Physiology, The University of Western Australia, Nedlands
    Pflugers Arch 440:116-24. 2000
  7. ncbi request reprint Iron excretion in iron-overloaded rats following the change from an iron-loaded to an iron-deficient diet
    P S Oates
    Department of Physiology, University of Western Australia, Nedlands, Australia
    J Gastroenterol Hepatol 15:665-74. 2000
  8. ncbi request reprint Role of transferrin in iron uptake by the brain: a comparative study
    E M Taylor
    Department of Physiology, University of Western Australia, Nedlands
    J Comp Physiol B 161:521-4. 1991
  9. ncbi request reprint Gastrointestinal function, divalent metal transporter-1 expression and intestinal iron absorption
    P S Oates
    Department of Physiology, The University of Western Australia, Nedlands, Australia
    Pflugers Arch 440:496-502. 2000
  10. ncbi request reprint Manganese metabolism is impaired in the Belgrade laboratory rat
    A C Chua
    Department of Physiology, University of Western Australia, Nedlands, Australia
    J Comp Physiol B 167:361-9. 1997

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Mechanisms and regulation of intestinal iron absorption
    Evan H Morgan
    Department of Physiology, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley 6009, Western Australia
    Blood Cells Mol Dis 29:384-99. 2002
    ..These results show the level of expression and intracellular distribution and function of DMT1 respond very quickly to the iron content of the diet as well as being affected by storage iron levels...
  2. ncbi request reprint Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent metal transporter 1
    Torben Moos
    Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
    J Neurochem 98:1946-58. 2006
    ..However, BCECs at P0 together with those of older age lacked DMT1. In conclusion, BCECs probably mediate iron transport into the brain by segregating iron from transferrin without involvement of DMT1...
  3. ncbi request reprint Mechanisms of iron transport into rat erythroid cells
    E H Morgan
    Department of Physiology, University of Western Australia, Nedlands, Western Australia, 6907, Australia
    J Cell Physiol 186:193-200. 2001
    ..01-1.0 microM), short incubation times (up to 20 min), and low osmolality (approximately 200 mOsm/kg) during incubation with the NTBI and subsequent washing of the cells...
  4. ncbi request reprint Mechanism and developmental changes in iron transport across the blood-brain barrier
    Evan H Morgan
    Department of Physiology, University of Western Australia, Crawley, W A, Australia
    Dev Neurosci 24:106-13. 2002
    ..As the animal and brain mature both decrease...
  5. ncbi request reprint Gene expression of divalent metal transporter 1 and transferrin receptor in duodenum of Belgrade rats
    P S Oates
    Department of Physiology, University of Western Australia, Nedlands 6907, Western Australia, Australia
    Am J Physiol Gastrointest Liver Physiol 278:G930-6. 2000
    ..We conclude that the uptake of transferrin-bound iron by developing enterocytes is largely independent of DMT1...
  6. ncbi request reprint Transferrin receptor activity and localisation in the rat duodenum
    P S Oates
    Department of Physiology, The University of Western Australia, Nedlands
    Pflugers Arch 440:116-24. 2000
    ..We hypothesise that TfR in the supranuclear region of villus enterocytes may play a role in iron absorption...
  7. ncbi request reprint Iron excretion in iron-overloaded rats following the change from an iron-loaded to an iron-deficient diet
    P S Oates
    Department of Physiology, University of Western Australia, Nedlands, Australia
    J Gastroenterol Hepatol 15:665-74. 2000
    ..We report the existence of an iron excretory process that results in the loss of significant amounts of liver iron...
  8. ncbi request reprint Role of transferrin in iron uptake by the brain: a comparative study
    E M Taylor
    Department of Physiology, University of Western Australia, Nedlands
    J Comp Physiol B 161:521-4. 1991
    ..Also, the decrease in iron uptake by the brain as rats age from 15 days to adulthood is specific for the brain and is not a general effect of the aging process...
  9. ncbi request reprint Gastrointestinal function, divalent metal transporter-1 expression and intestinal iron absorption
    P S Oates
    Department of Physiology, The University of Western Australia, Nedlands, Australia
    Pflugers Arch 440:496-502. 2000
    ..It is concluded that DMT1 functional activity is determined by de novo synthesis and that the latter is regulated post-transcriptionally by enterocyte iron levels...
  10. ncbi request reprint Manganese metabolism is impaired in the Belgrade laboratory rat
    A C Chua
    Department of Physiology, University of Western Australia, Nedlands, Australia
    J Comp Physiol B 167:361-9. 1997
    ....
  11. ncbi request reprint Differences in transferrin receptor function between normal developing and transformed myogenic cells as revealed by differential effects of phorbol ester on receptor distribution and rates of iron uptake
    L M Sorokin
    Physiology Department, University of Western Australia, Nedlands
    J Biol Chem 263:14128-33. 1988
    ....
  12. ncbi request reprint Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3
    S F Drake
    School of Medicine and Pharmacology, Fremantle Hospital, University of Western Australia, PO Box 480, Fremantle, 6959, WA, Australia
    Am J Physiol Gastrointest Liver Physiol 292:G323-8. 2007
    ..These findings support a model in which TfR2 is a sensor of Fe status and regulates duodenal Fe absorption and liver Fe uptake...
  13. ncbi request reprint Species specificity of transferrin binding, endocytosis and iron internalization by cultured chick myogenic cells
    L M Sorokin
    Department of Physiology, University of Western Australia, Nedlands
    J Comp Physiol B 158:559-66. 1988
    ..abstract truncated at 250 words)..
  14. ncbi request reprint The transferrin homologue, melanotransferrin (p97), is rapidly catabolized by the liver of the rat and does not effectively donate iron to the brain
    Des R Richardson
    Children s Cancer Institute Australia for Medical Research, Iron Metabolism and Chelation Program, PO Box 81, High Street, Randwick, Sydney, New South Wales 2031
    Biochim Biophys Acta 1690:124-33. 2004
    ..It is concluded that compared to Tf, sMTf plays little or no role in Fe supply to the brain and erythropoietic tissue. However, a small amount of sMTf was taken up from the plasma by the brain and a far greater amount by the liver...
  15. ncbi request reprint The metabolism of neuronal iron and its pathogenic role in neurological disease: review
    Torben Moos
    Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
    Ann N Y Acad Sci 1012:14-26. 2004
    ..More knowledge about iron metabolism in normal and diseased neurons is warranted as this may identify pharmaceutical targets to improve neuronal iron management...
  16. ncbi request reprint The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain
    Torben Moos
    Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
    J Neurochem 88:233-45. 2004
    ..The existence of the mutated DMT1 molecule in neurones suggests that the low cerebral iron uptake in b/b rats derives from a reduced neuronal uptake rather than an impaired iron transport through the blood-brain barrier...
  17. ncbi request reprint Iron and magnesium exchange via the low affinity iron transporter in rabbit erythroid cells-exchange rates and the action of valinomycin, diethylstilbestrol and protein kinase inhibitors
    Donna L Savigni
    Department of Physiology, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Biochim Biophys Acta 1616:156-64. 2003
    ..The inhibition produced by the protein kinase inhibitors indicate that phosphorylation of the transporter or an associated protein by protein tyrosine kinase is probably required to activate the transporter...
  18. ncbi request reprint Iron and transition metal transport into erythrocytes mediated by nifedipine degradation products and related compounds
    Donna L Savigni
    Department of Physiology, The University of Western Australia, 35 Stirling Highway, Crawley, Australia
    Biochem Pharmacol 65:1215-26. 2003
    ..Also, because the lactam to which NN is converted in vivo is inactive, it is unlikely that nifedipine will affect iron metabolism after therapeutic administration...
  19. ncbi request reprint A morphological study of the developmentally regulated transport of iron into the brain
    Torben Moos
    Department of Medical Anatomy, Panum Institute, University of Copenhagen, Denmark
    Dev Neurosci 24:99-105. 2002
    ....
  20. ncbi request reprint Effect of iron status on DMT1 expression in duodenal enterocytes from beta2-microglobulin knockout mice
    Torben Moos
    Department of Medical Anatomy, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Am J Physiol Gastrointest Liver Physiol 283:G687-94. 2002
    ..These data suggest that the observed effects were due to the state of iron deficiency in mucosal cells rather than genetic defect...
  21. pmc Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse
    Debbie Trinder
    Department of Medicine, University of Western Australia and Western Australian Institute for Medical Research, Perth 6009, Western Australia, Australia
    Proc Natl Acad Sci U S A 99:5622-6. 2002
    ..These data support the hypothesis that HFE regulates duodenal uptake of transferrin-bound iron from plasma, and that this mechanism of sensing body iron status, as reflected in plasma iron levels, is impaired in HH...
  22. ncbi request reprint Iron trafficking inside the brain
    Torben Moos
    Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    J Neurochem 103:1730-40. 2007
    ..Oligodendrocytes also lack transferrin receptors. They probably take up non-transferrin bound iron that gets incorporated in newly synthesized transferrin, which may play an important role for intracellular iron transport...