Grant Morahan

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. doi request reprint Insights into type 1 diabetes provided by genetic analyses
    Grant Morahan
    Centre for Diabetes Research, The Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia
    Curr Opin Endocrinol Diabetes Obes 19:263-70. 2012
  2. pmc Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs
    Grant Morahan
    Centre for Diabetes Research, Western Australian Institute for Medical Research, University of Western Australia, Crawley, Australia
    Diabetes 60:1030-40. 2011
  3. ncbi request reprint Association of variants in the IL12B gene with leprosy and tuberculosis
    G Morahan
    Diabetes Research Centre, Western Australia Institute for Medical Research, Perth, WA, Australia
    Tissue Antigens 69:234-6. 2007
  4. pmc Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium
    G Morahan
    Centre for Diabetes Research, The Western Australian Institute for Medical Research, and Centre for Medical Research, University of Western Australia, 50 Murray Street, Perth, Western Australia 6000, Australia
    Genes Immun 10:S64-8. 2009
  5. doi request reprint Systems genetics can provide new insights in to immune regulation and autoimmunity
    Grant Morahan
    The University of Western Australia, Perth, WA 6000, Australia
    J Autoimmun 31:233-6. 2008
  6. doi request reprint Establishment of "The Gene Mine": a resource for rapid identification of complex trait genes
    Grant Morahan
    Centre for Diabetes Research, The Western Australian Institute for Medical Research, and Centre for Medical Research, University of Western Australia, MRF Building, Level 6, 50 Murray St, Perth, WA 6000, Australia
    Mamm Genome 19:390-3. 2008
  7. pmc Effect of linkage status of affected sib-pairs on the search for novel type 1 diabetes susceptibility genes in the HLA complex
    G Morahan
    Western Australian Institute for Medical Research and Centre for Medical Research, University of Western Australia, Perth, Western Australia, Australia
    Diabetes Obes Metab 11:67-73. 2009
  8. pmc Missingness in the T1DGC MHC fine-mapping SNP data: association with HLA genotype and potential influence on genetic association studies
    I James
    Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, Western Australia, Australia
    Diabetes Obes Metab 11:101-7. 2009
  9. ncbi request reprint Stable or increasing bone mineral density in HIV-infected patients treated with nelfinavir or indinavir
    D Nolan
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Australia
    AIDS 15:1275-80. 2001
  10. pmc Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach
    E McKinnon
    Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, Western Australia, Australia
    Diabetes Obes Metab 11:92-100. 2009

Detail Information

Publications18

  1. doi request reprint Insights into type 1 diabetes provided by genetic analyses
    Grant Morahan
    Centre for Diabetes Research, The Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia
    Curr Opin Endocrinol Diabetes Obes 19:263-70. 2012
    ....
  2. pmc Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs
    Grant Morahan
    Centre for Diabetes Research, Western Australian Institute for Medical Research, University of Western Australia, Crawley, Australia
    Diabetes 60:1030-40. 2011
    ..Familial clustering of type 1 diabetes has not been explained fully and could arise from many factors, including undetected genetic variation and gene interactions...
  3. ncbi request reprint Association of variants in the IL12B gene with leprosy and tuberculosis
    G Morahan
    Diabetes Research Centre, Western Australia Institute for Medical Research, Perth, WA, Australia
    Tissue Antigens 69:234-6. 2007
    ..01) but also more likely to have this in the same haplotype with the high expressing 3'UTR allele (P= 0.0009). These results suggest these infectious diseases may be improved by modulating IL-l2p40 production...
  4. pmc Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium
    G Morahan
    Centre for Diabetes Research, The Western Australian Institute for Medical Research, and Centre for Medical Research, University of Western Australia, 50 Murray Street, Perth, Western Australia 6000, Australia
    Genes Immun 10:S64-8. 2009
    ..2 genotype was more protective, with relative hazard=0.75. We conclude that while there was no major effect of IL12B polymorphisms on T1D susceptibility in the entire study group, they have an impact on a subset of at-risk individuals...
  5. doi request reprint Systems genetics can provide new insights in to immune regulation and autoimmunity
    Grant Morahan
    The University of Western Australia, Perth, WA 6000, Australia
    J Autoimmun 31:233-6. 2008
    ..Here, we present preliminary analyses of systems genetics approaches to defining genetic interactions within the thymus, which is the key site for T lymphocyte development and imposition of immunological tolerance...
  6. doi request reprint Establishment of "The Gene Mine": a resource for rapid identification of complex trait genes
    Grant Morahan
    Centre for Diabetes Research, The Western Australian Institute for Medical Research, and Centre for Medical Research, University of Western Australia, MRF Building, Level 6, 50 Murray St, Perth, WA 6000, Australia
    Mamm Genome 19:390-3. 2008
    ..The Gene Mine will be a powerful resource for characterization of essentially any mouse phenotype that has a genetic basis...
  7. pmc Effect of linkage status of affected sib-pairs on the search for novel type 1 diabetes susceptibility genes in the HLA complex
    G Morahan
    Western Australian Institute for Medical Research and Centre for Medical Research, University of Western Australia, Perth, Western Australia, Australia
    Diabetes Obes Metab 11:67-73. 2009
    ..We investigated whether linkage status at the HLA complex differentially affected transmission of alleles to sibs depending on their HLA or gender linkage status...
  8. pmc Missingness in the T1DGC MHC fine-mapping SNP data: association with HLA genotype and potential influence on genetic association studies
    I James
    Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, Western Australia, Australia
    Diabetes Obes Metab 11:101-7. 2009
    ..1% of the non-null proband SNPs, with a median of 0.3%. We consider factors related to missingness in the T1DGC data and briefly assess its possible influence on association studies...
  9. ncbi request reprint Stable or increasing bone mineral density in HIV-infected patients treated with nelfinavir or indinavir
    D Nolan
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Australia
    AIDS 15:1275-80. 2001
    ....
  10. pmc Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach
    E McKinnon
    Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, Western Australia, Australia
    Diabetes Obes Metab 11:92-100. 2009
    ....
  11. doi request reprint Directed differentiation of embryonic stem cells allows exploration of novel transcription factor genes for pancreas development
    Jing Sui
    Centre for Diabetes Research, The Western Australian Institute for Medical Research, University of Western Australia, 50 Murray St Rear, Perth, WA 6000, Australia
    Stem Cell Rev 8:803-12. 2012
    ..The dynamic expression of representative known and novel genes was confirmed by quantitative real time RT-PCR analysis. This strategy may be modified to study novel regulatory molecules for development of other tissue and organ systems...
  12. ncbi request reprint Evidence-based, multifactorial approach to addressing non-adherence to antiretroviral therapy and improving standards of care
    S Herrmann
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, WA, Australia
    Intern Med J 38:8-15. 2008
    ....
  13. doi request reprint Quantification of insulin gene expression during development of pancreatic islet cells
    Fang Xu Jiang
    Centre for Diabetes Research, Western Australian Institute for Medical Research, Perth, Australia
    Pancreas 39:201-8. 2010
    ..We here aimed to quantify insulin gene transcripts during development...
  14. ncbi request reprint Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study
    A Rauch
    Centre for Clinical Immunology and Biomedical Statistics, Perth, Australia
    Clin Infect Dis 43:99-102. 2006
    ..7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701-negative recipients...
  15. pmc Definition of high-risk type 1 diabetes HLA-DR and HLA-DQ types using only three single nucleotide polymorphisms
    Cao Nguyen
    Centre for Diabetes Research, The Western Australian Institute for Medical Research, Perth, Western Australia, Australia
    Diabetes 62:2135-40. 2013
    ..001. We confirmed the reliability of these SNPs by 10-fold cross-validation. Our approach predicts HLA-DR/DQ types relevant to T1D more accurately than existing methods and is rapid and cost-effective...
  16. doi request reprint Association between 25-OH vitamin D and insulin is independent of lipoatrophy in HIV
    E Hammond
    Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, Australia
    Clin Endocrinol (Oxf) 76:201-6. 2012
    ....
  17. doi request reprint Pancreatic stem cells: from possible to probable
    Fang Xu Jiang
    Centre for Diabetes Research, Western Australian Institute for Medical Research, The University of Western Australia, 50 Murray St Rear, Perth, WA 6000, Australia
    Stem Cell Rev 8:647-57. 2012
    ..However, the existence of PSC has been hotly debated for many years. In this review, we will discuss the latest development and future perspectives of PSC research, giving readers an overview of this controversial but important area...
  18. ncbi request reprint Killer immunoglobulin-like receptors and HLA act both independently and synergistically to modify HIV disease progression
    S Gaudieri
    Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Wellington Street, Perth, Western Australia 6000, Australia
    Genes Immun 6:683-90. 2005
    ....