Peter Molenaar

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi request reprint Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitro
    Peter Molenaar
    National Heart Foundation and Prince Charles Hospital Foundation Cardiovascular Research Centre, Department of Medicine, University of Queensland Chermside, Queensland, Australia
    J Am Coll Cardiol 40:1275-82. 2002
  2. ncbi request reprint Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart
    Fraser D Russell
    Department of Medicine, University of Queensland, The Prince Charles Hospital, Rode Road Chermside, 4032 Queensland, Australia
    Cardiovasc Res 63:673-81. 2004
  3. ncbi request reprint Fundamental considerations of beta-adrenoceptor subtypes in human heart failure
    Peter Molenaar
    Discipline of Medicine, The University of Queensland, The Prince Charles Hospital Chermside, Queensland 4032, Australia
    Trends Pharmacol Sci 26:368-75. 2005
  4. ncbi request reprint Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol
    Lu Chen
    Department of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    Pharmacogenet Genomics 17:941-9. 2007
  5. pmc Cardiac implications for the use of beta2-adrenoceptor agonists for the management of muscle wasting
    Peter Molenaar
    Discipline of Medicine, The University of Queensland, The Prince Charles Hospital, Chermside, Queensland 4032, Australia
    Br J Pharmacol 147:583-6. 2006
  6. pmc Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II
    Joan Li
    Discipline of Medicine, University of Queensland, The Prince Charles Hospital, Chermside, Qld 4032, Australia
    Br J Pharmacol 145:432-40. 2005
  7. ncbi request reprint Urotensin-II-converting enzyme activity of furin and trypsin in human cells in vitro
    Fraser D Russell
    Department of Medicine, University of Queensland, The Prince Charles Hospital, Chermside, Queensland, Australia
    J Pharmacol Exp Ther 310:209-14. 2004
  8. ncbi request reprint Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure
    Fraser D Russell
    Department of Medicine, University of Queensland, Prince Charles Hospital, Rode Road, Chermside, Queensland 4032, Australia
    Am J Physiol Heart Circ Physiol 285:H1576-81. 2003
  9. pmc The 'state' of beta-adrenoceptors
    Peter Molenaar
    The National Heart Foundation, Chermside, Queensland 4032, Australia
    Br J Pharmacol 140:1-2. 2003
  10. ncbi request reprint (-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta2 -adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling
    Peter Molenaar
    Department of Medicine, The University of Queensland, The Prince Charles Hospital, Chermside, Queensland, 4032, Australia
    Naunyn Schmiedebergs Arch Pharmacol 375:11-28. 2007

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitro
    Peter Molenaar
    National Heart Foundation and Prince Charles Hospital Foundation Cardiovascular Research Centre, Department of Medicine, University of Queensland Chermside, Queensland, Australia
    J Am Coll Cardiol 40:1275-82. 2002
    ....
  2. ncbi request reprint Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart
    Fraser D Russell
    Department of Medicine, University of Queensland, The Prince Charles Hospital, Rode Road Chermside, 4032 Queensland, Australia
    Cardiovasc Res 63:673-81. 2004
    ..This study investigated signaling pathways that may contribute to the potent positive inotropic effect of human urotensin-II (hU-II) in human isolated right atrial trabeculae obtained from patients with coronary artery disease...
  3. ncbi request reprint Fundamental considerations of beta-adrenoceptor subtypes in human heart failure
    Peter Molenaar
    Discipline of Medicine, The University of Queensland, The Prince Charles Hospital Chermside, Queensland 4032, Australia
    Trends Pharmacol Sci 26:368-75. 2005
    ..We reconcile this view with the current clinical use and proven benefit of beta-adrenoceptor antagonists...
  4. ncbi request reprint Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol
    Lu Chen
    Department of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    Pharmacogenet Genomics 17:941-9. 2007
    ..We aimed to determine whether these polymorphisms contribute to variability in response to carvedilol in patients with chronic heart failure...
  5. pmc Cardiac implications for the use of beta2-adrenoceptor agonists for the management of muscle wasting
    Peter Molenaar
    Discipline of Medicine, The University of Queensland, The Prince Charles Hospital, Chermside, Queensland 4032, Australia
    Br J Pharmacol 147:583-6. 2006
    ..Their use in clinical practice will also need an understanding of possible effects of activation of human heart beta(2)-adrenoceptors. Consequences could include an increased probability of arrhythmias in susceptible patients...
  6. pmc Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II
    Joan Li
    Discipline of Medicine, University of Queensland, The Prince Charles Hospital, Chermside, Qld 4032, Australia
    Br J Pharmacol 145:432-40. 2005
    ..PKC may contribute to this effect by increasing levels of phosphorylated calcineurin substrate...
  7. ncbi request reprint Urotensin-II-converting enzyme activity of furin and trypsin in human cells in vitro
    Fraser D Russell
    Department of Medicine, University of Queensland, The Prince Charles Hospital, Chermside, Queensland, Australia
    J Pharmacol Exp Ther 310:209-14. 2004
    ..Aprotinin-sensitive UCE activity was detected in blood, suggesting that an endogenous serine protease such as trypsin may also contribute to proteolysis of hU-II prohormone, if the prohormone is secreted into the circulation...
  8. ncbi request reprint Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure
    Fraser D Russell
    Department of Medicine, University of Queensland, Prince Charles Hospital, Rode Road, Chermside, Queensland 4032, Australia
    Am J Physiol Heart Circ Physiol 285:H1576-81. 2003
    ..The findings indicated that hU-II-ir is elevated in the aortic root of CHF patients and that hU-II-ir is cleared at least in part from the microcirculation...
  9. pmc The 'state' of beta-adrenoceptors
    Peter Molenaar
    The National Heart Foundation, Chermside, Queensland 4032, Australia
    Br J Pharmacol 140:1-2. 2003
  10. ncbi request reprint (-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta2 -adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling
    Peter Molenaar
    Department of Medicine, The University of Queensland, The Prince Charles Hospital, Chermside, Queensland, 4032, Australia
    Naunyn Schmiedebergs Arch Pharmacol 375:11-28. 2007
    ....
  11. ncbi request reprint Beta2-adrenoceptor polymorphisms and obstructive airway diseases: important issues of study design
    Ian A Yang
    Department of Thoracic Medicine, The Prince Charles Hospital, and School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    Clin Exp Pharmacol Physiol 34:1029-36. 2007
    ..Enhancing these study design factors will provide high-quality evidence regarding the biological and clinical importance of beta(2)-adrenoceptor pharmacogenomics in asthma and COPD...
  12. ncbi request reprint (-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the beta 1-adrenoceptor
    Doreen Sarsero
    Department of Pharmacology, University of Melbourne, Melbourne, Australia
    Naunyn Schmiedebergs Arch Pharmacol 367:10-21. 2003
    ..The reduction in heart failure of atrial inotropic potency of (-)-CGP 12177, as well as of the high-affinity and low-affinity binding sites for (-)-[3H]CGP 12177, is consistent with the beta1-adrenoceptor nature of these sites...
  13. ncbi request reprint Intrinsic sympathomimetic activity of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta1-adrenoceptor in human atrium and recombinant receptors
    Shirin S Joseph
    Department of Physiology, University of Cambridge, Downing Street, CB2 3EG, Cambridge, UK
    Naunyn Schmiedebergs Arch Pharmacol 368:496-503. 2003
    ..In contrast, (-)-pindolol blocks the effects of catecholamines through a high-affinity site of the beta(1)-adrenoceptor. beta(3)-Adrenoceptors are not involved in the atrial effects of (-)-pindolol...
  14. ncbi request reprint Carvedilol blocks beta2- more than beta1-adrenoceptors in human heart
    Peter Molenaar
    Department of Medicine, The Prince Charles Hospital, University of Queensland, Australia
    Cardiovasc Res 69:128-39. 2006
    ..To understand the basis of the effectiveness of carvedilol in heart failure by determining its specific properties at human heart beta1- and beta2-adrenoceptors...
  15. ncbi request reprint The effects of both noradrenaline and CGP12177, mediated through human beta1 -adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells
    Alberto Kaumann
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK
    Naunyn Schmiedebergs Arch Pharmacol 375:123-31. 2007
    ..Neither CHO cells nor the rat ventricle are appropriate models for the beta1 -adrenoceptor-evoked signalling to PDE3 observed in human atrium...
  16. ncbi request reprint Cardiovascular actions of human urotensin II--considerations for hypertension
    Fraser D Russell
    Naunyn Schmiedebergs Arch Pharmacol 369:271-3. 2004
  17. ncbi request reprint Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: effects in human, rat and guinea-pig tissues in vitro and in pigs in vitro
    Kenneth D Winkel
    Department of Pharmacology, The University of Melbourne, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 32:777-88. 2005
    ..The venom may also contain a 'direct' vasoconstrictor component. These observations explain, at least in part, the clinical features of the potentially deadly Irukandji syndrome...
  18. ncbi request reprint Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure
    Trond Brattelid
    Department of Pharmacology, University of Oslo, P O Box 1057 Blindern, 0316 Oslo, Norway
    Naunyn Schmiedebergs Arch Pharmacol 370:157-66. 2004
    ..We conclude that phosphodiesterase inhibition uncovers functional ventricular 5-HT(4) receptors, coupled to a PKA pathway, through which 5-HT enhances contractility, hastens relaxation and can potentially cause arrhythmias...
  19. doi request reprint The low-affinity site of the beta1-adrenoceptor and its relevance to cardiovascular pharmacology
    Alberto J Kaumann
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Physiology Building, Cambridge, Cambridge CB2 3EG, UK
    Pharmacol Ther 118:303-36. 2008
    ..Non-conventional partial agonists may be beneficial for the treatment of peripheral autonomic neuropathy but probably due to their arrhythmic propensities, may be harmful for the treatment of chronic heart failure...