Affiliation: University of Queensland
- Fundamental considerations of beta-adrenoceptor subtypes in human heart failurePeter Molenaar
Discipline of Medicine, The University of Queensland, The Prince Charles Hospital Chermside, Queensland 4032, Australia
Trends Pharmacol Sci 26:368-75. 2005..We reconcile this view with the current clinical use and proven benefit of beta-adrenoceptor antagonists...
- Human heart beta-adrenoceptors: beta1-adrenoceptor diversification through 'affinity states' and polymorphismP Molenaar
Department of Medicine, The University of Queensland, The Prince Charles Hospital, Chermside, Queensland, Australia
Clin Exp Pharmacol Physiol 34:1020-8. 2007..Upon segregation of patients into Arg389Gly-beta(1)-adrenoceptors, it was found that carvedilol caused a greater increase in left ventricular ejection faction in patients carrying the Arg389 allele with Arg389Arg > Arg389Gly > Gly389Gly...
- (-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta2 -adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi couplingPeter Molenaar
Department of Medicine, The University of Queensland, The Prince Charles Hospital, Chermside, Queensland, 4032, Australia
Naunyn Schmiedebergs Arch Pharmacol 375:11-28. 2007....
- Both beta(2)- and beta(1)-adrenergic receptors mediate hastened relaxation and phosphorylation of phospholamban and troponin I in ventricular myocardium of Fallot infants, consistent with selective coupling of beta(2)-adrenergic receptors to G(s)-proteinP Molenaar
Department of Medicine, The Prince Charles Hospital, University of Queensland, Australia
Circulation 102:1814-21. 2000..We compared the effects of stimulation of beta(1)- and beta(2)-adrenergic receptors on relaxation and phosphorylation of phospholamban and troponin I in ventricle obtained from infants with tetralogy of Fallot...
- Carvedilol blocks beta2- more than beta1-adrenoceptors in human heartPeter Molenaar
Department of Medicine, The Prince Charles Hospital, University of Queensland, Australia
Cardiovasc Res 69:128-39. 2006..To understand the basis of the effectiveness of carvedilol in heart failure by determining its specific properties at human heart beta1- and beta2-adrenoceptors...
- The human heart endothelin system: ET-1 synthesis, storage, release and effectF D Russell
Department of Medicine, University of Queensland, The Prince Charles Hospital, Chermside, Queensland 4032, Australia
Trends Pharmacol Sci 21:353-9. 2000..The endothelin system might directly support the failing heart but might also contribute to its pathology, providing a basis for the therapeutic use of endothelin receptor antagonists...
- Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failureFraser D Russell
Department of Medicine, University of Queensland, Prince Charles Hospital, Rode Road, Chermside, Queensland 4032, Australia
Am J Physiol Heart Circ Physiol 285:H1576-81. 2003..The findings indicated that hU-II-ir is elevated in the aortic root of CHF patients and that hU-II-ir is cleared at least in part from the microcirculation...
- Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitroPeter Molenaar
National Heart Foundation and Prince Charles Hospital Foundation Cardiovascular Research Centre, Department of Medicine, University of Queensland Chermside, Queensland, Australia
J Am Coll Cardiol 40:1275-82. 2002....
- Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin IIJoan Li
Discipline of Medicine, University of Queensland, The Prince Charles Hospital, Chermside, Qld 4032, Australia
Br J Pharmacol 145:432-40. 2005..PKC may contribute to this effect by increasing levels of phosphorylated calcineurin substrate...
- Cardiac implications for the use of beta2-adrenoceptor agonists for the management of muscle wastingPeter Molenaar
Discipline of Medicine, The University of Queensland, The Prince Charles Hospital, Chermside, Queensland 4032, Australia
Br J Pharmacol 147:583-6. 2006..Their use in clinical practice will also need an understanding of possible effects of activation of human heart beta(2)-adrenoceptors. Consequences could include an increased probability of arrhythmias in susceptible patients...
- Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heartFraser D Russell
Department of Medicine, University of Queensland, The Prince Charles Hospital, Rode Road Chermside, 4032 Queensland, Australia
Cardiovasc Res 63:673-81. 2004..This study investigated signaling pathways that may contribute to the potent positive inotropic effect of human urotensin-II (hU-II) in human isolated right atrial trabeculae obtained from patients with coronary artery disease...
- Urotensin-II-converting enzyme activity of furin and trypsin in human cells in vitroFraser D Russell
Department of Medicine, University of Queensland, The Prince Charles Hospital, Chermside, Queensland, Australia
J Pharmacol Exp Ther 310:209-14. 2004..Aprotinin-sensitive UCE activity was detected in blood, suggesting that an endogenous serine protease such as trypsin may also contribute to proteolysis of hU-II prohormone, if the prohormone is secreted into the circulation...
- Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilolLu Chen
Department of Medicine, The University of Queensland, Brisbane, Queensland, Australia
Pharmacogenet Genomics 17:941-9. 2007..We aimed to determine whether these polymorphisms contribute to variability in response to carvedilol in patients with chronic heart failure...
- The 'state' of beta-adrenoceptorsPeter Molenaar
The National Heart Foundation, Chermside, Queensland 4032, Australia
Br J Pharmacol 140:1-2. 2003
- Cardiostimulant effects of urotensin-II in human heart in vitroF D Russell
The National Heart Foundation and Prince Charles Hospital Foundation Cardiovascular Research Centre, Department of Medicine, The Prince Charles Hospital, Chermside, Queensland 4032, Australia
Br J Pharmacol 132:5-9. 2001..hU-II (20 nM) increased tone (17.9% of the response to 90 mM KCI) in 7/7 tissues from 1 patient, with no response detected in 8/8 tissues from 2 patients. hU-II is a potent cardiac stimulant with low efficacy...
- Beta2-adrenoceptor polymorphisms and obstructive airway diseases: important issues of study designIan A Yang
Department of Thoracic Medicine, The Prince Charles Hospital, and School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
Clin Exp Pharmacol Physiol 34:1029-36. 2007..Enhancing these study design factors will provide high-quality evidence regarding the biological and clinical importance of beta(2)-adrenoceptor pharmacogenomics in asthma and COPD...
- The effects of both noradrenaline and CGP12177, mediated through human beta1 -adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cellsAlberto Kaumann
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK
Naunyn Schmiedebergs Arch Pharmacol 375:123-31. 2007..Neither CHO cells nor the rat ventricle are appropriate models for the beta1 -adrenoceptor-evoked signalling to PDE3 observed in human atrium...
- Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failureTrond Brattelid
Department of Pharmacology, University of Oslo, P O Box 1057 Blindern, 0316 Oslo, Norway
Naunyn Schmiedebergs Arch Pharmacol 370:157-66. 2004..We conclude that phosphodiesterase inhibition uncovers functional ventricular 5-HT(4) receptors, coupled to a PKA pathway, through which 5-HT enhances contractility, hastens relaxation and can potentially cause arrhythmias...
- Intrinsic sympathomimetic activity of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta1-adrenoceptor in human atrium and recombinant receptorsShirin S Joseph
Department of Physiology, University of Cambridge, Downing Street, CB2 3EG, Cambridge, UK
Naunyn Schmiedebergs Arch Pharmacol 368:496-503. 2003..In contrast, (-)-pindolol blocks the effects of catecholamines through a high-affinity site of the beta(1)-adrenoceptor. beta(3)-Adrenoceptors are not involved in the atrial effects of (-)-pindolol...
- (-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the beta 1-adrenoceptorDoreen Sarsero
Department of Pharmacology, University of Melbourne, Melbourne, Australia
Naunyn Schmiedebergs Arch Pharmacol 367:10-21. 2003..The reduction in heart failure of atrial inotropic potency of (-)-CGP 12177, as well as of the high-affinity and low-affinity binding sites for (-)-[3H]CGP 12177, is consistent with the beta1-adrenoceptor nature of these sites...
- Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: effects in human, rat and guinea-pig tissues in vitro and in pigs in vitroKenneth D Winkel
Department of Pharmacology, The University of Melbourne, Melbourne, Victoria, Australia
Clin Exp Pharmacol Physiol 32:777-88. 2005..The venom may also contain a 'direct' vasoconstrictor component. These observations explain, at least in part, the clinical features of the potentially deadly Irukandji syndrome...
- Cardiovascular actions of human urotensin II--considerations for hypertensionFraser D Russell
Naunyn Schmiedebergs Arch Pharmacol 369:271-3. 2004
- The low-affinity site of the beta1-adrenoceptor and its relevance to cardiovascular pharmacologyAlberto J Kaumann
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Physiology Building, Cambridge, Cambridge CB2 3EG, UK
Pharmacol Ther 118:303-36. 2008..Non-conventional partial agonists may be beneficial for the treatment of peripheral autonomic neuropathy but probably due to their arrhythmic propensities, may be harmful for the treatment of chronic heart failure...