Lyn M Moir

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. doi request reprint Transforming growth factor beta 1 increases fibronectin deposition through integrin receptor alpha 5 beta 1 on human airway smooth muscle
    Lyn M Moir
    Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    J Allergy Clin Immunol 121:1034-9.e4. 2008
  2. doi request reprint The phosphoinositide 3'-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle
    Qi Ge
    Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia
    J Cell Physiol 227:3044-52. 2012
  3. doi request reprint β2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers
    Kyoko Niimi
    Cell Biology Group, Woolcock Institute of Medical Research, School of Medical Sciences, The Univ of Sydney, Sydney, NSW, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L334-42. 2012
  4. doi request reprint TGFβ1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells: the role of Smad2/3
    Qi Ge
    Respiratory Research Group, Discipline of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia
    J Cell Physiol 225:846-54. 2010
  5. pmc β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D
    Thomas Trian
    Cell Biology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    PLoS ONE 6:e20000. 2011
  6. doi request reprint Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function
    Lyn M Moir
    Woolcock Institute of Medical Research, Sydney, Australia
    J Pharmacol Exp Ther 337:557-66. 2011
  7. pmc Fibulin-1 is increased in asthma--a novel mediator of airway remodeling?
    Justine Y Lau
    Cooperative Research Centre for Asthma and Airways, Sydney, New South Wales, Australia
    PLoS ONE 5:e13360. 2010
  8. doi request reprint Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness
    Janette K Burgess
    Respiratory Research Group, Discipline of Pharmacology, Bosch Building, D05, University of Sydney, Sydney, NSW, Australia 2006
    Am J Respir Crit Care Med 181:106-15. 2010
  9. doi request reprint Differential expression of peroxisome proliferator activated receptor gamma and cyclin D1 does not affect proliferation of asthma- and non-asthma-derived airway smooth muscle cells
    Justine Y Lau
    Cooperative Research Centre for Asthma and Airways, The University of Sydney, Sydney, New South Wales, Australia
    Respirology 15:303-12. 2010
  10. doi request reprint Tissue and matrix influences on airway smooth muscle function
    Janette K Burgess
    Discipline of Pharmacology, Bosch Institute, University of Sydney, Sydney, Australia
    Pulm Pharmacol Ther 22:379-87. 2009

Detail Information

Publications22

  1. doi request reprint Transforming growth factor beta 1 increases fibronectin deposition through integrin receptor alpha 5 beta 1 on human airway smooth muscle
    Lyn M Moir
    Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    J Allergy Clin Immunol 121:1034-9.e4. 2008
    ..Altered expression of the integrin receptors, such as the fibronectin receptor alpha(5)beta(1), might be implicated in extracellular matrix accumulation in airway remodeling in asthma...
  2. doi request reprint The phosphoinositide 3'-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle
    Qi Ge
    Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia
    J Cell Physiol 227:3044-52. 2012
    ....
  3. doi request reprint β2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers
    Kyoko Niimi
    Cell Biology Group, Woolcock Institute of Medical Research, School of Medical Sciences, The Univ of Sydney, Sydney, NSW, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L334-42. 2012
    ..This leads us to speculate that continual therapy with β2AR agonists is unlikely to cause PDE4-mediated tachyphylaxis...
  4. doi request reprint TGFβ1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells: the role of Smad2/3
    Qi Ge
    Respiratory Research Group, Discipline of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia
    J Cell Physiol 225:846-54. 2010
    ..Understanding the mechanism of aberrant pro-inflammatory cytokine production in asthmatic airways will allow the development of alternative ways to control airway inflammation...
  5. pmc β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D
    Thomas Trian
    Cell Biology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    PLoS ONE 6:e20000. 2011
    ..In addition, some studies have suggested impaired β-agonist induced ASM relaxation in asthmatics, but the mechanism is not known...
  6. doi request reprint Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function
    Lyn M Moir
    Woolcock Institute of Medical Research, Sydney, Australia
    J Pharmacol Exp Ther 337:557-66. 2011
    ..In addition, PIK75 decreased cell survival in TGFβ-stimulated asthmatic, but not nonasthmatic, ASM cells. In conclusion, specific PI3K isoforms may play a role in pathophysiological events relevant to airway wall remodeling...
  7. pmc Fibulin-1 is increased in asthma--a novel mediator of airway remodeling?
    Justine Y Lau
    Cooperative Research Centre for Asthma and Airways, Sydney, New South Wales, Australia
    PLoS ONE 5:e13360. 2010
    ..There are four isoforms in humans (A-D) of which fibulin-1C and 1D predominate. The objective of this study was to study the expression of fibulin-1 in volunteers with and without asthma, and to examine its function in vitro...
  8. doi request reprint Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness
    Janette K Burgess
    Respiratory Research Group, Discipline of Pharmacology, Bosch Building, D05, University of Sydney, Sydney, NSW, Australia 2006
    Am J Respir Crit Care Med 181:106-15. 2010
    ..Collagen IV is decreased in the airway basement membrane in asthma. It has six alpha chains, of which the noncollagenous domain-1 domains have endogenous antiangiogenic properties...
  9. doi request reprint Differential expression of peroxisome proliferator activated receptor gamma and cyclin D1 does not affect proliferation of asthma- and non-asthma-derived airway smooth muscle cells
    Justine Y Lau
    Cooperative Research Centre for Asthma and Airways, The University of Sydney, Sydney, New South Wales, Australia
    Respirology 15:303-12. 2010
    ..In the presence of FBS, PPARgamma levels were higher in subconfluent asthma-derived cells but lower in confluent cells compared with non-asthma-derived. However, PPARgamma activation did not alter cell proliferation...
  10. doi request reprint Tissue and matrix influences on airway smooth muscle function
    Janette K Burgess
    Discipline of Pharmacology, Bosch Institute, University of Sydney, Sydney, Australia
    Pulm Pharmacol Ther 22:379-87. 2009
    ..This review summarises our current understanding of the influence of the ECM on ASM function...
  11. ncbi request reprint A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro
    Janette K Burgess
    Department of Pharmacology, University of Sydney, NSW, Australia
    J Allergy Clin Immunol 118:649-57. 2006
    ..Airway smooth muscle (ASM) cells may contribute to airway remodeling through the release of growth factors, cytokines, and extracellular matrix (ECM) proteins. The effect of current asthma therapies on this release is not known...
  12. pmc Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma
    Hisako Matsumoto
    Discipline of Pharmacology, University of Sydney, NSW 2006, Australia
    Thorax 62:848-54. 2007
    ..The purpose of this study was to establish a method to measure contraction of ASM cells by embedding them into a collagen gel, and to compare the contraction between subjects with and without asthma...
  13. pmc LF-15 & T7, synthetic peptides derived from tumstatin, attenuate aspects of airway remodelling in a murine model of chronic OVA-induced allergic airway disease
    Karryn T Grafton
    Woolcock Institute of Medical Research, Sydney, New South Wales, Australia Discipline of Pharmacology, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 9:e85655. 2014
    ..This study assessed the anti-angiogenic properties of smaller peptides derived from tumstatin, which contain the interface tumstatin uses to interact with the αVβ3 integrin...
  14. pmc TSC2 modulates cell adhesion and migration via integrin-α1β1
    Lyn M Moir
    Cell Biology, Woolcock Institute of Medical Research, PO Box M77, Missenden Rd, NSW, 2050, Australia
    Am J Physiol Lung Cell Mol Physiol 303:L703-10. 2012
    ..Together, these data demonstrate that TSC2 controls cell migration, attachment, and spreading through the α1β1-integrin receptor and thus suggest a potential therapeutic target for the treatment of increased cell invasiveness in LAM...
  15. pmc Combined Beta-agonists and corticosteroids do not inhibit extracellular matrix protein production in vitro
    Qi Ge
    Division of Cell Biology, Woolcock Institute of Medical Research, Sydney, P O Box M77, Missenden Road, NSW 2050, Australia
    J Allergy (Cairo) 2012:403059. 2012
    ..TGFβ1-induced IL-6 release was inhibited by the combination of drugs. Conclusion. Current combination asthma therapies are unable to prevent or reverse remodeling events regulated by ASM cells...
  16. ncbi request reprint Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle
    Alaina J Ammit
    Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia
    Am J Physiol Lung Cell Mol Physiol 292:L199-206. 2007
    ..As levels of sIL-6Ralpha are increased in asthma, this demonstration of IL-6 trans-signaling in ASM has relevance to the development of airway remodeling...
  17. ncbi request reprint Rhinovirus-induced exacerbations of asthma: How is the {beta}2-adrenoceptor implicated?
    Thomas Trian
    The University of Sydney, NSW, Australia
    Am J Respir Cell Mol Biol 43:227-33. 2010
    ....
  18. pmc Effects of β(2) Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts
    David Van Ly
    Respiratory Research Group, Discipline of Pharmacology, The University of Sydney, Sydney, NSW 2006, Australia
    J Allergy (Cairo) 2011:457169. 2011
    ..Dimethylfumarate increased RV replication whilst other drugs did not alter RV replication. These data suggest that inhibition of NF-κB alone is unlikely to be an effective treatment compared to current asthma therapeutics...
  19. ncbi request reprint Contractility and phenotype of human bronchiole smooth muscle after prolonged fetal bovine serum exposure
    Lyn M Moir
    Department of Asthma, Allergy and Respiratory Science, The Guy s King s and St Thomas School of Medicine, King s College London, United Kingdom
    Exp Lung Res 29:339-59. 2003
    ....
  20. ncbi request reprint Repeated allergen inhalation induces cytoskeletal remodeling in smooth muscle from rat bronchioles
    Clare G McVicker
    King s College London School of Medicine, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, London, United Kingdom
    Am J Respir Cell Mol Biol 36:721-7. 2007
    ..Such a mechanism may have relevance for AHR found in allergic asthma...
  21. ncbi request reprint Repeated allergen inhalation induces phenotypic modulation of smooth muscle in bronchioles of sensitized rats
    Lyn M Moir
    Department of Asthma, Allergy and Respiratory Science, The Guy s, King s and St Thomas School of Medicine, King s College London, London SE1 9RT, UK
    Am J Physiol Lung Cell Mol Physiol 284:L148-59. 2003
    ..Thus, OA exposure induces structural changes in bronchiole ASM content and in agonist responsiveness ex vivo that resemble remodeling in asthma...
  22. ncbi request reprint Proliferative aspects of airway smooth muscle
    Stuart J Hirst
    Department of Asthma, Allergy and Respiratory Science, Guy s, King s and St Thomas School of Medicine, Guy s Hospital Campus, King s College London, United Kingdom
    J Allergy Clin Immunol 114:S2-17. 2004
    ..The maximum response of fluticasone propionate against thrombin-induced proliferation is increased when it is combined with salmeterol...