James D Moffatt
Affiliation: University of Melbourne
- Effects of inhaled thrombin receptor agonists in miceJames D Moffatt
Sackler Institute of Pulmonary Pharmacology, GKT School of Biomedical Sciences, Kings College London, 5th Floor Hodgkin Building, Guy s Campus, London SE1 9RT
Br J Pharmacol 143:269-75. 2004..In conclusion, exogenous thrombin has only a modest acute inflammatory action in the lung that appears to be mediated by PAR(4) and involve release of TNF-alpha from an unknown source...
- Protease-activated receptor-2 activating peptide SLIGRL inhibits bacterial lipopolysaccharide-induced recruitment of polymorphonuclear leukocytes into the airways of miceJames D Moffatt
Department of Pharmacology, The University of Melbourne, Parkville, Victoria, Australia
Am J Respir Cell Mol Biol 26:680-4. 2002..These findings suggest that PAR2 agonists may be useful therapeutic molecules in pulmonary inflammatory diseases...
- Protease-activated receptor-2 peptides activate neurokinin-1 receptors in the mouse isolated tracheaHugh T Abey
Department of Pharmacology, The University of Melbourne, Parkville, Australia
J Pharmacol Exp Ther 317:598-605. 2006..Such a potential lack of specificity of these commonly used peptides needs to be considered when roles for PAR(2) in airway function in health and disease are determined...
- Enzymatic activation of endothelial protease-activated receptors is dependent on artery diameter in human and porcine isolated coronary arteriesJustin R Hamilton
Department of Pharmacology, University of Melbourne, Victoria 3010, Australia
Br J Pharmacol 136:492-501. 2002....
- Pharmacologically distinct intracellular calcium pools regulate tonic and oscillatory responses in porcine thoracic ductJames D Moffatt
Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia
J Cardiovasc Pharmacol 43:83-92. 2004....
- Role of the epithelium and acetylcholine in mediating the contraction to 5-hydroxytryptamine in the mouse isolated tracheaJames D Moffatt
Sackler Institute of Pulmonary Pharmacology, King s College London, London
Br J Pharmacol 141:1159-66. 2004..This phenomenon should be borne in mind in when interpreting studies of murine models of airway disease...
- Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challengeKristin N Kornerup
The Sackler Institute of Pulmonary Pharmacology, GKT School of Biomedical Sciences, 5th Floor Hodgkin Building, Guy's Campus, London SE1 1UL
Br J Pharmacol 144:1011-6. 2005..These results suggest that the A2B receptor mediates the I(SC) response to adenosine in the mouse trachea. This receptor does not appear to be regulated in a standard asthma model...
- Activation of corticotropin-releasing factor receptor-2 causes bronchorelaxation and inhibits pulmonary inflammation in miceJames D Moffatt
The Sackler Institute of Pulmonary Pharmacology, King s College London, Guy s Campus, London, UK
FASEB J 20:1877-9. 2006..Therefore, CRF(2) agonists appear to have both bronchorelaxant and anti-inflammatory activities and might represent an interesting therapeutic approach to the treatment of inflammatory lung diseases...