I C McMillen

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. ncbi request reprint Fetal growth restriction: adaptations and consequences
    I C McMillen
    Department of Physiology, Adelaide University, SA 5005, Australia
    Reproduction 122:195-204. 2001
  2. ncbi request reprint Early embryonic environment, the fetal pituitary-adrenal axis and the timing of parturition
    I C McMillen
    Centre for the Origins of Adult Health, Discipline of Physiology, School of Molecular and Biomedical Sciences, Faculty of Sciences, University of Adelaide, Adelaide, South Australia, Australia
    Endocr Res 30:845-50. 2004
  3. pmc Early origins of obesity: programming the appetite regulatory system
    I Caroline McMillen
    Discipline of Physiology, Centre for the Early Origins of Adult Health, School of Molecular and Biomedical Sciences, University of Adelaide, SA 5005, Australia
    J Physiol 565:9-17. 2005
  4. ncbi request reprint Developmental origins of the metabolic syndrome: prediction, plasticity, and programming
    I Caroline McMillen
    Discipline of Physiology, School of Molecular and Biomeducal Sciences, and Department of Obstetrics and Gynaecology, University of Adelaide, Australia
    Physiol Rev 85:571-633. 2005
  5. ncbi request reprint Prenatal programming of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birth
    I C McMillen
    Discipline of Physiology, School of Molecular and Biomedical Sciences, University of Adelaide, SA 5005, Australia
    Proc Nutr Soc 63:405-12. 2004
  6. ncbi request reprint Maturation of cytokine receptors in preparation for birth
    I C McMillen
    Department of Physiology, Adelaide University, Adelaide, SA 5005, Australia
    Biochem Soc Trans 29:63-8. 2001
  7. ncbi request reprint Impact of restriction of placental and fetal growth on expression of 11beta-hydroxysteroid dehydrogenase type 1 and type 2 messenger ribonucleic acid in the liver, kidney, and adrenal of the sheep fetus
    I C McMillen
    Department of Physiology, University of Adelaide, South Australia, Australia
    Endocrinology 141:539-43. 2000
  8. ncbi request reprint Sex-specific effects of placental restriction on components of the metabolic syndrome in young adult sheep
    J A Owens
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Am J Physiol Endocrinol Metab 292:E1879-89. 2007
  9. ncbi request reprint Determinants of fetal leptin synthesis, fat mass, and circulating leptin concentrations in well-nourished ewes in late pregnancy
    B S Muhlhausler
    Department of Physiology, University of Adelaide, South Australia 5000, Australia
    Endocrinology 144:4947-54. 2003
  10. ncbi request reprint Increased maternal nutrition alters development of the appetite-regulating network in the brain
    B S Muhlhausler
    Research Centre for the Early Origins of Adult Health, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia
    FASEB J 20:1257-9. 2006

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Fetal growth restriction: adaptations and consequences
    I C McMillen
    Department of Physiology, Adelaide University, SA 5005, Australia
    Reproduction 122:195-204. 2001
    ....
  2. ncbi request reprint Early embryonic environment, the fetal pituitary-adrenal axis and the timing of parturition
    I C McMillen
    Centre for the Origins of Adult Health, Discipline of Physiology, School of Molecular and Biomedical Sciences, Faculty of Sciences, University of Adelaide, Adelaide, South Australia, Australia
    Endocr Res 30:845-50. 2004
    ....
  3. pmc Early origins of obesity: programming the appetite regulatory system
    I Caroline McMillen
    Discipline of Physiology, Centre for the Early Origins of Adult Health, School of Molecular and Biomedical Sciences, University of Adelaide, SA 5005, Australia
    J Physiol 565:9-17. 2005
    ..This review summarizes recent work on the expression and localization of the 'appetite regulatory' peptides in the fetal rodent and sheep hypothalamus and their potential role in the early programming of postnatal appetite and obesity...
  4. ncbi request reprint Developmental origins of the metabolic syndrome: prediction, plasticity, and programming
    I Caroline McMillen
    Discipline of Physiology, School of Molecular and Biomeducal Sciences, and Department of Obstetrics and Gynaecology, University of Adelaide, Australia
    Physiol Rev 85:571-633. 2005
    ....
  5. ncbi request reprint Prenatal programming of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birth
    I C McMillen
    Discipline of Physiology, School of Molecular and Biomedical Sciences, University of Adelaide, SA 5005, Australia
    Proc Nutr Soc 63:405-12. 2004
    ....
  6. ncbi request reprint Maturation of cytokine receptors in preparation for birth
    I C McMillen
    Department of Physiology, Adelaide University, Adelaide, SA 5005, Australia
    Biochem Soc Trans 29:63-8. 2001
    ..We also review the changes that occur in the tissue-specific expression of the PRL and GH receptors before birth which may play an important role in precocial species in the successful transition of the fetus to extra-uterine life...
  7. ncbi request reprint Impact of restriction of placental and fetal growth on expression of 11beta-hydroxysteroid dehydrogenase type 1 and type 2 messenger ribonucleic acid in the liver, kidney, and adrenal of the sheep fetus
    I C McMillen
    Department of Physiology, University of Adelaide, South Australia, Australia
    Endocrinology 141:539-43. 2000
    ..This suggests that there is increased hepatic exposure to cortisol in the growth-restricted fetus, which may be important in the reprogramming of hepatic physiology that occurs after growth restriction in utero...
  8. ncbi request reprint Sex-specific effects of placental restriction on components of the metabolic syndrome in young adult sheep
    J A Owens
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Am J Physiol Endocrinol Metab 292:E1879-89. 2007
    ..These sex differences in the onset and extent of adverse metabolic consequences after prenatal restraint in the sheep are consistent with observations in humans...
  9. ncbi request reprint Determinants of fetal leptin synthesis, fat mass, and circulating leptin concentrations in well-nourished ewes in late pregnancy
    B S Muhlhausler
    Department of Physiology, University of Adelaide, South Australia 5000, Australia
    Endocrinology 144:4947-54. 2003
    ..02; n = 8). These studies provide evidence that fetal glucose and insulin differentially regulate fetal fat deposition and leptin mRNA expression within the fetal perirenal fat depot in the well nourished animal during late gestation...
  10. ncbi request reprint Increased maternal nutrition alters development of the appetite-regulating network in the brain
    B S Muhlhausler
    Research Centre for the Early Origins of Adult Health, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia
    FASEB J 20:1257-9. 2006
    ..05; agouti-related peptide, r2 = 0.39, P<0.01). These findings suggest that exposure to increased nutrition before birth alters the responses of the central appetite regulatory system to signals of increased adiposity after birth...
  11. ncbi request reprint Intrafetal insulin-like growth factor-I infusion stimulates adrenal growth but not steroidogenesis in the sheep fetus during late gestation
    J T Ross
    Discipline of Physiology, School of Health Sciences, University of Adelaide, Adelaide, SA, Australia
    Endocrinology 148:5424-32. 2007
    ..Thus, IGF-I infusion results in a dissociation of adrenal growth and function during late gestation...
  12. ncbi request reprint Differential actions of metyrapone on the fetal pituitary-adrenal axis in the sheep fetus in late gestation
    K E Warnes
    Department of Physiology, University of Adelaide, Adelaide, South Australia 5000, Australia
    Biol Reprod 71:620-8. 2004
    ..Thus, metyrapone administration may represent a unique model that allows the investigation of dissociation of the relative actions of ACTH and cortisol on fetal adrenal steroidogenesis and growth during late gestation...
  13. ncbi request reprint The regulation of prolactin receptor messenger ribonucleic acid levels in the sheep liver before birth: relative roles of the fetal hypothalamus, cortisol, and the external photoperiod
    I D Phillips
    Department of Physiology, University of Adelaide, South Australia, Australia
    Endocrinology 140:1966-71. 1999
    ..These studies provide further insight into the role that the PRL axis may play in the transduction of signals about the external environment to the fetus as it prepares for the transition to extrauterine life...
  14. pmc Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation
    B S Muhlhausler
    Discipline of Physiology, Centre of the Early Origins of Adult Health, School of Molecular and Biomedical Science, The University of Adelaide, Australia
    J Physiol 565:185-95. 2005
    ..These findings demonstrate that increased circulating glucose and insulin regulate gene expression of the neuropeptides within the fetal hypothalamus that are part of the neural network regulating energy balance in adult life...
  15. pmc Maternal undernutrition increases arterial blood pressure in the sheep fetus during late gestation
    L J Edwards
    Department of Physiology, University of Adelaide, South Australia, Australia
    J Physiol 533:561-70. 2001
    ....
  16. ncbi request reprint Effects of leptin on fetal plasma adrenocorticotropic hormone and cortisol concentrations and the timing of parturition in the sheep
    B S J Yuen
    Department of Physiology, University of Adelaide, South Australia, Australia
    Biol Reprod 70:1650-7. 2004
    ..4 - 7.7x, r = 0.38, P < 0.005). This study provides evidence for an endocrine negative feedback loop between leptin and the HPA axis in fetal life...
  17. pmc The effect of intrafetal infusion of metyrapone on arterial blood pressure and on the arterial blood pressure response to angiotensin II in the sheep fetus during late gestation
    K E Warnes
    Departments of Physiology, University of Adelaide, Adelaide, Australia
    J Physiol 552:621-33. 2003
    ..Furthermore there may be a critical window during late gestation when the actions of cortisol contribute to the development of vascular responsiveness to AII...
  18. ncbi request reprint Circulating leptin concentrations are positively related to leptin messenger RNA expression in the adipose tissue of fetal sheep in the pregnant ewe fed at or below maintenance energy requirements during late gestation
    B S J Yuen
    Department of Physiology, Adelaide University, South Australia 5005, Australia
    Biol Reprod 67:911-6. 2002
    ..5x +/- 0.3; r = 0.69, P < 0.05). In summary, the capacity of leptin to act as a signal of moderate maternal undernutrition may be limited before birth in the sheep...
  19. ncbi request reprint Leptin alters the structural and functional characteristics of adipose tissue before birth
    B S J Yuen
    Department of Physiology, Adelaide University, SA 5005, Australia
    FASEB J 17:1102-4. 2003
    ..This is the first demonstration that leptin can act to regulate the lipid storage characteristics, leptin synthetic capacity, and potential thermogenic functions of fat before birth...
  20. doi request reprint No evidence for an enhanced role of endothelial nitric oxide in the maintenance of arterial blood pressure in the IUGR sheep fetus
    J L Dyer
    Discipline of Physiology, University of Adelaide, Adelaide, SA 5005, Australia
    Placenta 30:705-10. 2009
    ..In the PR group, fetuses with lower mean gestational PaO(2) had a lower increase in MAP during l-NAME infusion. Thus we have found no evidence for an enhanced role of NO in the maintenance of MAP in the chronically hypoxemic IUGR fetus...
  21. ncbi request reprint Increased maternal nutrition stimulates peroxisome proliferator activated receptor-gamma, adiponectin, and leptin messenger ribonucleic acid expression in adipose tissue before birth
    B S Muhlhausler
    Sansom Research Institute, University of South Australia, Adelaide 5000, South Australia, Australia
    Endocrinology 148:878-85. 2007
    ....
  22. ncbi request reprint Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies
    L J Edwards
    Discipline of Physiology, School of Molecular and Biomedical Sciences, University of Adelaide, South Australia
    Am J Physiol Regul Integr Comp Physiol 288:R39-45. 2005
    ..Furthermore, we have found that there is an increased fetal adiposity in the twins of ewes that experienced restricted nutrition throughout gestation, and this may be important in the programming of postnatal adiposity...
  23. ncbi request reprint Fetal leptin is a signal of fat mass independent of maternal nutrition in ewes fed at or above maintenance energy requirements
    B S Muhlhausler
    Department of Physiology, Adelaide University, South Australia 5005, Australia
    Biol Reprod 67:493-9. 2002
    ..51x + 1.70; (R = 0.76, P < 0.01). Thus, fetal leptin may play a role as a signal of unilocular fat mass in the fetus when maternal nutrient intake is at or above maintenance requirements...
  24. ncbi request reprint Responses of the fetal pituitary-adrenal axis to acute and chronic hypoglycemia during late gestation in the sheep
    L J Edwards
    Departments of Physiology, University of Adelaide, Adelaide, South Australia 5005, Australia
    Endocrinology 142:1778-85. 2001
    ..0 mM, before and after 135 days gestation, independently of whether the low glucose concentrations are a consequence of insulin-induced hypoglycemia or maternal nutrient restriction...
  25. ncbi request reprint Postnatal ontogeny of glucose homeostasis and insulin action in sheep
    K L Gatford
    Department of Physiology, University of Adelaide, Adelaide SA 5005, Australia
    Am J Physiol Endocrinol Metab 286:E1050-9. 2004
    ..Nevertheless, the capacity for insulin secretion in the adult reflects that early in life, suggesting that it is determined genetically or by persistent influences of the perinatal environment...
  26. doi request reprint Impact of maternal periconceptional overnutrition on fat mass and expression of adipogenic and lipogenic genes in visceral and subcutaneous fat depots in the postnatal lamb
    L Rattanatray
    Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia 5000, Australia
    Endocrinology 151:5195-205. 2010
    ..Thus, exposure to maternal overnutrition in the periconceptional period alone results in an increased body fat mass in the offspring and that a short period of dietary restriction can reverse this effect...
  27. ncbi request reprint Restriction of placental function alters heart development in the sheep fetus
    J L Morrison
    Center for the Early Origins of Adult Health, Discipline of Physiology, University of Adelaide, Adelaide, SA, Australia
    Am J Physiol Regul Integr Comp Physiol 293:R306-13. 2007
    ....
  28. ncbi request reprint Fetal hypothalamus-pituitary-adrenal axis on the road to parturition
    J Schwartz
    Department of Physiology, The University of Adelaide, South Australia, Australia
    Clin Exp Pharmacol Physiol 28:108-12. 2001
    ....
  29. pmc Periconceptional nutrition and the relationship between maternal body weight changes in the periconceptional period and feto-placental growth in the sheep
    S M MacLaughlin
    Discipline of Physiology, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, Australia
    J Physiol 565:111-24. 2005
    ....
  30. ncbi request reprint Prenatal undernutrition, glucocorticoids and the programming of adult hypertension
    L J Edwards
    Department of Physiology, Adelaide University, South Australia, Australia
    Clin Exp Pharmacol Physiol 28:938-41. 2001
    ....
  31. ncbi request reprint Somatic cell nuclear transfer in the sheep induces placental defects that likely precede fetal demise
    C J Fletcher
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide SA 5005, Australia
    Reproduction 133:243-55. 2007
    ..Thus, cloning by SCNT results in both gross and microscopic placental abnormalities. We speculate that trophoblast apoptosis, shedding, and hemorrhage may be causal in fetal death in ovine clones...
  32. ncbi request reprint Effect of N-proopiomelanocortin (1-77) and (1-49) infusions on adrenal expression of cyclin D1 in the fetal sheep
    C L Coulter
    Dept Physiology, University of Adelaide, SA, Australia
    Endocr Res 28:625-9. 2002
    ..0 Kb) and adrenal weight. In summary, these data do not demonstrate that the rate-limiting cell cycle protein, cyclin D1, is activated to stimulate adrenal growth following infusion of POMC 1-77 in the fetal sheep in late gestation...
  33. ncbi request reprint Metyrapone infusion stimulates adrenal growth without activating the cell cycle or the IGF system in the late gestation fetal sheep
    K E Warnes
    Centre for the Early Origins of Adult Health, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, South Australia, Australia
    Endocr Res 30:535-9. 2004
    ..In summary, in this model of metyrapone-activated adrenal cortical hypertrophy, growth occurs with a suppression of the rate-limiting cell cycle protein and without activation of the IGF system...
  34. ncbi request reprint Maternal undernutrition throughout pregnancy increases adrenocorticotrophin receptor and steroidogenic acute regulatory protein gene expression in the adrenal gland of twin fetal sheep during late gestation
    L J Edwards
    Department of Physiology, University of Adelaide, SA 5005, Adelaide, Australia
    Mol Cell Endocrinol 196:1-10. 2002
    ..This study provides new insights into the potential mechanisms by which alterations of the nutrient environment of the fetus at different stages of gestation may result in differential activation of the fetal HPA axis...
  35. ncbi request reprint Regulation of leptin synthesis and secretion before birth: implications for the early programming of adult obesity
    I C McMillen
    Research Centre for the Early Origins of Adult Health, Discipline of Physiology, School of Molecular and Biomedical Sciences, University of Adelaide, South Australia 5000, Australia
    Reproduction 131:415-27. 2006
    ..This work is important in determining those initiating mechanisms within the 'fat-brain' axis in early life that precede the development of adult obesity...
  36. ncbi request reprint Placental restriction of fetal growth increases insulin action, growth, and adiposity in the young lamb
    Miles J De Blasio
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
    Endocrinology 148:1350-8. 2007
    ....
  37. doi request reprint Early origins of heart disease: low birth weight and determinants of cardiomyocyte endowment
    K J Botting
    Early Origins of Adult Health Research Group, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia
    Clin Exp Pharmacol Physiol 39:814-23. 2012
    ....
  38. ncbi request reprint Effect of gamma 3 or gamma 2 melanocyte stimulating hormone on steroidogenesis in the fetal sheep during late gestation
    I C McMillen
    Department of Physiology, Monash University, Clayton, Vic, Australia
    Life Sci 44:563-9. 1989
    ....
  39. ncbi request reprint Origins of fetal growth restriction
    J S Robinson
    Department of Obstetrics and Gynaecology, University of Adelaide, SA 5005, Adelaide, Australia
    Eur J Obstet Gynecol Reprod Biol 92:13-9. 2000
    ..However, nutrient supplements improve growth in undernourished women and smoking cessation also improves fetal size and outcome...
  40. ncbi request reprint Impact of maternal undernutrition during the periconceptional period, fetal number, and fetal sex on the development of the hypothalamo-pituitary adrenal axis in sheep during late gestation
    L J Edwards
    Department of Physiology, University of Adelaide, Adelaide 5005, South Australia
    Biol Reprod 66:1562-9. 2002
    ....
  41. doi request reprint Periconceptional nutrition and the early programming of a life of obesity or adversity
    S Zhang
    The Sansom Institute of Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 50000, Australia
    Prog Biophys Mol Biol 106:307-14. 2011
    ..Thus, not all of the effects of dietary restriction in overweight or obese mother in the periconceptional period may be beneficial in the longer term...
  42. ncbi request reprint Role of pituitary POMC-peptides and insulin-like growth factor II in the developmental biology of the adrenal gland
    C L Coulter
    Department of Physiology, Adelaide University, South Australia, Australia
    Arch Physiol Biochem 110:99-105. 2002
    ..These studies provide an understanding of the separate regulatory mechanisms which control activation of adrenal growth and stimulation of adrenal steroidogenesis in the late gestation fetus...
  43. ncbi request reprint Prolactin and the expression of suppressor of cytokine signaling-3 in the sheep adrenal gland before birth
    S Gentili
    Discipline of Physiology, Centre for the Early Origins of Adult Health, School of Molecular and Biomedical Science, Univ of Adelaide, Australia
    Am J Physiol Regul Integr Comp Physiol 291:R1399-405. 2006
    ..We conclude that factors other than PRL act to maintain adrenal SOCS-3 mRNA expression before 133 days gestation but that acute elevations of PRL can act to upregulate adrenal SOCS-3 expression in the sheep fetus during late gestation...
  44. ncbi request reprint Tyrosine hydroxylase protein content in the medulla oblongata of the foetal sheep brain increases in response to acute but not chronic hypoxia
    M B Adams
    Department of Physiology, The University of Adelaide, Adelaide, SA 5005, Australia
    Neurosci Lett 316:63-6. 2001
    ....
  45. doi request reprint Intrauterine growth restriction delays surfactant protein maturation in the sheep fetus
    Sandra Orgeig
    Early Origins of Adult Health Research Group, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia
    Am J Physiol Lung Cell Mol Physiol 298:L575-83. 2010
    ..These data suggest that IUGR fetuses are at significant risk of lung complications, especially if born prematurely...
  46. ncbi request reprint Impact of periconceptional undernutrition on adrenal growth and adrenal insulin-like growth factor and steroidogenic enzyme expression in the sheep fetus during early pregnancy
    Severence M MacLaughlin
    Discipline of Physiology, School of Molecular and Biomedical Science, University of Adelaide, South Australia, Australia
    Endocrinology 148:1911-20. 2007
    ....
  47. ncbi request reprint Periconceptional nutrition programs development of the cardiovascular system in the fetal sheep
    L J Edwards
    Department of Physiology, University of Adelaide, Adelaide SA 5005, South Australia
    Am J Physiol Regul Integr Comp Physiol 283:R669-79. 2002
    ..This increase occurs concomitantly with an increase in fetal ACTH but is not dependent on activation of the fetal renin-angiotensin system...
  48. ncbi request reprint Perinatal growth and plasma GH profiles in adolescent and adult sheep
    K L Gatford
    Department of Physiology, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Endocrinol 173:151-9. 2002
    ..This suggests that restricted fetal growth and reduced neonatal growth rate in sheep are followed by elevated circulating GH in adolescent and adult males, but GH deficiency or increased GH clearance in adult females...
  49. ncbi request reprint Linking cardiovascular theory to practice in an undergraduate medical curriculum
    J N Hudson
    Department of Physiology, Adelaide University, Adelaide, South Australia 5005, Australia
    Adv Physiol Educ 25:193-201. 2001
    ..Whatever the curriculum learning style, underpinning practice with an understanding of theory remains a desirable feature of medical education...
  50. ncbi request reprint Interaction between bed sharing and other sleep environments during the first six months of life
    Pat Buckley
    Department of Physiology, Adelaide University, 5005, Adelaide, SA, Australia
    Early Hum Dev 66:123-32. 2002
    ..This may be of significance in studies which examine the relationship between bed sharing and sudden infant death syndrome...
  51. ncbi request reprint Chronic maternal fluoxetine infusion in pregnant sheep: effects on the maternal and fetal hypothalamic-pituitary-adrenal axes
    Janna L Morrison
    Department of Obstetrics and Gynecology, British Columbia Research Institute for Children s and Women s Health, Vancouver, British Columbia, Canada
    Pediatr Res 56:40-6. 2004
    ..These results are of particular interest in the context that exposure of the fetus to excess glucocorticoids at critical windows during development has been shown to increase the risk of poor health outcomes in later life...
  52. pmc Restriction of placental growth in sheep impairs insulin secretion but not sensitivity before birth
    Julie A Owens
    Department of Physiology, University of Adelaide, SA, Australia
    J Physiol 584:935-49. 2007
    ....
  53. ncbi request reprint Maternal fluoxetine infusion does not alter fetal endocrine and biophysical circadian rhythms in pregnant sheep
    Janna L Morrison
    Department of Obstetrics and Gynecology, BC Research Institute for Children s and Women s Health, University of British Columbia, Vancouver, BC, Canada
    J Soc Gynecol Investig 12:356-64. 2005
    ..We have therefore investigated the effect of chronic administration of FX on maternal and fetal circadian rhythms in sheep...
  54. doi request reprint Periconceptional undernutrition and being a twin each alter kidney development in the sheep fetus during early gestation
    Severence M MacLaughlin
    Early Origins of Adult Health Research Group, Sansom Institute of Health Research, School of Pharmacy and Medical Sciences, Univ of South Australia, Adelaide, SA 5000, Australia
    Am J Physiol Regul Integr Comp Physiol 298:R692-9. 2010
    ..The kidney of the twin fetus exposed to periconceptional undernutrition may also be less protected from the consequences of glucocorticoid exposure...
  55. ncbi request reprint Placental restriction increases the expression of prostaglandin endoperoxide G/H synthase-2 and EP2 mRNA in the fetal sheep kidney during late gestation
    Sarah J Williams
    Department of Physiology, Adelaide University, Adelaide, South Australia, Australia
    Pediatr Res 52:879-85. 2002
    ....
  56. ncbi request reprint Steroidogenic acute regulatory protein expression is decreased in the adrenal gland of the growth-restricted sheep fetus during late gestation
    Catherine L Coulter
    Department of Physiology, Medical School Building, University of Adelaide, North Terrace, Adelaide, South Australia 5005, Australia
    Biol Reprod 67:584-90. 2002
    ..Our data also suggest that the stimulation of adrenal growth and steroidogenesis in the growth-restricted fetus may not be ACTH dependent...
  57. ncbi request reprint Differential regulation of suppressor of cytokine signaling-3 in the liver and adipose tissue of the sheep fetus in late gestation
    Sheridan Gentili
    Centre for the Early Origins of Adult Health, Discipline of Physiology, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, South Australia, Australia
    Am J Physiol Regul Integr Comp Physiol 290:R1044-51. 2006
    ..Thus SOCS-3 is differentially expressed and regulated in key fetal tissues and may play an important and tissue-specific role in the regulation of cellular proliferation and differentiation before birth...
  58. ncbi request reprint Adrenal TGFbeta1 mRNA levels fall during late gestation and are not regulated by cortisol in the sheep fetus
    Catherine L Coulter
    Department of Physiology, Medical School Building, The University of Adelaide, Adelaide, SA 5005, Australia
    Mol Cell Endocrinol 206:85-91. 2003
    ..The maintenance of low adrenal TGFbeta1 expression during late gestation is not dependent, however, on stimulation by the fetal hypothalamic-pituitary axis...
  59. pmc Differential effects of the early and late intrauterine environment on corticotrophic cell development
    Timothy G Butler
    Department of Physiology, University of Adelaide, Adelaide, South Australia, Australia
    J Clin Invest 110:783-91. 2002
    ..These patterns of altered corticotroph development are important given the central roles of the hypothalamo-pituitary-adrenal axis in the fetal adaptive response to intrauterine stress and in the early programming of adult disease...
  60. ncbi request reprint Circadian rhythms in sleep and wakefulness and in salivary melatonin and cortisol concentrations in mothers of term and preterm infants
    I C McMillen
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Sleep 16:624-31. 1993
    ..m. and 10 a.m. in both the term and preterm groups.(ABSTRACT TRUNCATED AT 250 WORDS)..
  61. doi request reprint Intrauterine growth restriction and the sex specific programming of leptin and peroxisome proliferator-activated receptor gamma (PPARgamma) mRNA expression in visceral fat in the lamb
    Jaime A Duffield
    Discipline of Physiology, The University of Adelaide, Adelaide, South Australia 5005, Australia
    Pediatr Res 66:59-65. 2009
    ..The differential effect of sex and IUGR on PPARgamma and leptin expression in visceral fat may be important in the subsequent development of visceral obesity and the insulin resistant phenotype in later life...
  62. pmc Hypothalamic input is required for development of normal numbers of thyrotrophs and gonadotrophs, but not other anterior pituitary cells in late gestation sheep
    Eva Szarek
    Discipline of Physiology, School of Molecular and Biomedical Sciences, University of Adelaide, Adelaide, Australia
    J Physiol 586:1185-94. 2008
    ..Development of a distinct population of gonadotrophs, expressing only LH, appears to be subject to alternative mechanisms...
  63. ncbi request reprint Cortisol infusion decreases renin, but not PGHS-2, EP2, or EP4 mRNA expression in the kidney of the fetal sheep at days 109-116
    Sarah J Williams
    Department of Physiology, Adelaide University, Australia
    Pediatr Res 55:637-44. 2004
    ..During nephrogenesis, the insensitivity of PGHS-2, EP(2), and EP(4) expression to down-regulation by cortisol may permit continued PG regulation of renal development and urine formation...
  64. doi request reprint Periconceptional undernutrition in normal and overweight ewes leads to increased adrenal growth and epigenetic changes in adrenal IGF2/H19 gene in offspring
    Song Zhang
    Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia
    FASEB J 24:2772-82. 2010
    ..Determining the appropriate approach to weight loss in the periconceptional period may therefore be important in overweight or obese women seeking to become pregnant...
  65. ncbi request reprint Subpopulations of corticotrophs in the sheep pituitary during late gestation: effects of development and placental restriction
    Kirsten Farrand
    Discipline of Physiology, School of Molecular and Biomedical Sciences, University of Adelaide, North Terrace, Adelaide 5005, Australia
    Endocrinology 147:4762-71. 2006
    ....
  66. doi request reprint Placental restriction of fetal growth decreases IGF1 and leptin mRNA expression in the perirenal adipose tissue of late gestation fetal sheep
    Jaime A Duffield
    Discipline of Physiology, School of Molecular and Biomedical Sciences, The University of Adelaide, SA, Australia
    Am J Physiol Regul Integr Comp Physiol 294:R1413-9. 2008
    ....
  67. pmc Restriction of placental growth results in greater hypotensive response to alpha-adrenergic blockade in fetal sheep during late gestation
    Li Danielson
    Centre for the Early Origins of Adult Health, Discipline of Physiology, School of Molecular and Biomedical Sciences, University of Adelaide, Adelaide, SA 5005, Australia
    J Physiol 563:611-20. 2005
    ....
  68. pmc Intrauterine growth restriction and differential patterns of hepatic growth and expression of IGF1, PCK2, and HSDL1 mRNA in the sheep fetus in late gestation
    Sheridan Gentili
    Early Origins of Adult Health Research Group, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, South Australia, Australia
    Biol Reprod 80:1121-7. 2009
    ..The present study highlights that intrahepatic responses to fetal substrate restriction may exist that protect the liver from decreased growth and, potentially, from a decreased responsiveness to the actions of insulin in postnatal life...
  69. doi request reprint Developmental origins of adult health and disease: the role of periconceptional and foetal nutrition
    I Caroline McMillen
    Early Origins of Adult Health Research Group, Sansom Research Institute, School of Pharmacy and Medical Science, University of South Australia, Adelaide, SA, Australia
    Basic Clin Pharmacol Toxicol 102:82-9. 2008
    ..In this context, the physiological responses to relative overnutrition in early life may directly contribute to an intergenerational cycle of obesity...
  70. ncbi request reprint Postnatal growth and circulating ACTH and cortisol concentrations during the first month of life in cloned lambs
    Lisa Edwards
    Department of Physiology, University of Adelaide, Adelaide, SA 5005, Australia
    Endocrinology 143:3699-702. 2002
    ..The growth of cloned lambs however was not different to controls. These findings demonstrate that endocrine development may be altered in apparently "normal" clones...
  71. ncbi request reprint Restricted fetal growth and lung development: a morphometric analysis of pulmonary structure
    Jill Lipsett
    Department of Histopathology, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    Pediatr Pulmonol 41:1138-45. 2006
    ..Structural alterations associated with PR and poor fetal growth may be important in the pathogenesis of impaired lung function associated with IUGR...
  72. pmc Opioid receptor stimulation suppresses the adrenal medulla hypoxic response in sheep by actions on Ca(2+) and K(+) channels
    Damien J Keating
    Discipline of Physiology, University of Adelaide, Adelaide 5005, Australia
    J Physiol 555:489-502. 2004
    ....
  73. pmc Effects of maternal hypoxia or nutrient restriction during pregnancy on endothelial function in adult male rat offspring
    Sarah J Williams
    Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada T6G 2S2
    J Physiol 565:125-35. 2005
    ..Distinct effects following reduced maternal oxygen versus nutrition suggest that decreased oxygen supply during fetal life may specifically impact adult vascular function...
  74. ncbi request reprint Impact of periconceptional undernutrition on the development of the hypothalamo-pituitary-adrenal axis: does the timing of parturition start at conception?
    Severence M MacLaughlin
    The Sansom Research Institute, School of Pharmacy and Medical Sciences, University of South Australia, SA, Australia
    Curr Drug Targets 8:880-7. 2007
    ....
  75. doi request reprint The faroes statement: human health effects of developmental exposure to chemicals in our environment
    Philippe Grandjean
    Basic Clin Pharmacol Toxicol 102:73-5. 2008
  76. ncbi request reprint Differential effects of maternal hypoxia or nutrient restriction on carotid and femoral vascular function in neonatal rats
    Sarah J Williams
    Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB, Canada
    Am J Physiol Regul Integr Comp Physiol 288:R360-7. 2005
    ....