Research Topics
Species | E A McLaughlinSummaryAffiliation: University of Newcastle Country: Australia Publications
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Detail Information
Publications
Awakening the oocyte: controlling primordial follicle developmentEileen A McLaughlin
Reproductive Science Group, School of Environmental and Life Sciences and ARC Centre of Excellence in Biotechnology and Development, University of Newcastle, Callaghan, New South Wales, Australia
Reproduction 137:1-11. 2009....- Is there a role for immunocontraception?E A McLaughlin
Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Mol Cell Endocrinol 335:78-88. 2011..We conclude that the specifications for a safe, effective, reversible vaccine are more likely to be met in animals than man... 
Molecular mechanisms of sperm capacitation: progesterone-induced secondary calcium oscillations reflect the attainment of a capacitated stateR J Aitken
RC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences, University of Newcastle, Callaghan, NSW 2708, Australia
Soc Reprod Fertil Suppl 63:273-93. 2007..The secondary calcium oscillations created via these channels do not induce acrosomal exocytosis per se but may prime the cells so that this event is rapidly triggered when the spermatozoa make contact with the zona pellucida...- Jumping the gun: smoking constituent BaP causes premature primordial follicle activation and impairs oocyte fusibility through oxidative stressA P Sobinoff
Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW2308, Australia
Toxicol Appl Pharmacol 260:70-80. 2012..This study highlights BaP as a key compound which may be partially responsible for the documented effects of cigarette smoke on follicular development and sub-fertility... - Composition and significance of detergent resistant membranes in mouse spermatozoaBrett Nixon
Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia
J Cell Physiol 218:122-34. 2009.... - Cis-unsaturated fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoaR John Aitken
Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
J Clin Endocrinol Metab 91:4154-63. 2006..This study investigated whether a causative relationship exists between these two attributes of impaired semen quality... - CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovaryJanet E Holt
Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Dev Biol 293:449-60. 2006..By retaining follicles in an unactivated state, SDF1/CXCR4 signaling may play an important role in maintaining the size and longevity of the primordial follicle pool... - Identification and characterization of a novel Mt-retrotransposon highly represented in the female mouse germlineJanet E Holt
Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Genomics 87:490-9. 2006..Together with in silico data, we predict Mtfull plays an essential role in folliculogenesis through regulation of gene expression... - Redox activity associated with the maturation and capacitation of mammalian spermatozoaR John Aitken
ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences, University of Newcastle, New South Wales, Australia
Free Radic Biol Med 36:994-1010. 2004.... - Analysis of lipid peroxidation in human spermatozoa using BODIPY C11R John Aitken
ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences, University of Newcastle, NSW, Australia
Mol Hum Reprod 13:203-11. 2007..We conclude that BODIPY C(11) is an extremely useful probe for indexing peroxidative damage in human spermatozoa... - miRNA and mammalian male germ cellsS C McIver
ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, Australia
Hum Reprod Update 18:44-59. 2012..However, targeted knockdown of specific miRNA molecules has the potential to form both anti-oncogenic reagents and underpin the basis for novel contraceptive technologies... - Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian primordial follicle activationJ M Sutherland
Priority Research Centre in Reproductive Science, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia
J Cell Physiol 227:1188-98. 2012.... - Identification of cytochrome P450-reductase as the enzyme responsible for NADPH-dependent lucigenin and tetrazolium salt reduction in rat epididymal sperm preparationsMark A Baker
ARC Centre of Excellence in Biotechnology and Development, Reproductive Science Group, School of Environmental and Life Sciences, and Hunter Medical Research Institute, University of Newcastle, Callaghan, New South Wales 2308, Australia
Biol Reprod 71:307-18. 2004..These results emphasize the importance of the direct NADPH-dependent reduction of superoxide-sensitive probes by cytochrome P450-reductase even though this enzyme does not, on its own accord, produce reactive oxygen species... - Definitive evidence for the nonmitochondrial production of superoxide anion by human spermatozoaGeoffry N De Iuliis
Centre of Excellence in Biotechnology and Development and Discipline of Biological Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
J Clin Endocrinol Metab 91:1968-75. 2006.... - Investigation of the expression and functional significance of the novel mouse sperm protein, a disintegrin and metalloprotease with thrombospondin type 1 motifs number 10 (ADAMTS10)M D Dun
Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, Australia
Int J Androl 35:572-89. 2012..Overall, these studies support the notion that sperm-oocyte interactions involve considerable functional redundancy and identify ADAMTS10 as a novel candidate in the mediation of these fundamentally important events... - Localization and significance of molecular chaperones, heat shock protein 1, and tumor rejection antigen gp96 in the male reproductive tract and during capacitation and acrosome reactionKelly L Asquith
Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
Biol Reprod 72:328-37. 2005..These data reinforce the notion that these chaperones are intimately involved in the mechanisms by which mammalian spermatozoa both acquire and express their ability to recognize the zona pellucida... - Identification of RARhoGAP, a novel putative RhoGAP gene expressed in male germ cellsBenjamin J Curry
Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Genomics 84:406-18. 2004..We postulate that RARhoGAP may be involved in rearrangements of the cytoskeleton and cell signaling events that occur during spermatogenesis... - Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoaAdam J Koppers
Discipline of Biological Sciences, University of Newcastle Callaghan, New South Wales 2308, Australia
J Clin Endocrinol Metab 93:3199-207. 2008..Male infertility has been linked with the excessive generation of reactive oxygen species (ROS) by defective spermatozoa. However, the subcellular origins of this activity are unclear... - Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognitionKelly L Asquith
Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
J Cell Sci 117:3645-57. 2004.... - Optimisation of handling, activation and assessment procedures for Bufo marinus spermatozoaC Fitzsimmons
School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Reprod Fertil Dev 19:594-601. 2007..0 mM theophylline. The present study has improved protocols for the handling of anuran sperm during pre- and post-cryopreservation procedures... - New insights into the molecular mechanisms of sperm-egg interactionB Nixon
Reproductive Science Group, ARC Centre of Excellence in Biotechnology and Development, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Cell Mol Life Sci 64:1805-23. 2007..Herein, we describe two models indicating the plethora of highly orchestrated molecular interactions underlying successful sperm zona binding and sperm oocyte fusion... - Contraceptive vaccinesEileen A McLaughlin
ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences, University of Newcastle, Callaghan NSW2308, Australia
Expert Opin Biol Ther 3:829-41. 2003.... - Characterization of structure and expression of the Dzip1 gene in the rat and mouseBenjamin J Curry
Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Genomics 87:275-85. 2006.... - Biosynthesis of the canine zona pellucida requires the integrated participation of both oocytes and granulosa cellsDaniel G Blackmore
Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
Biol Reprod 71:661-8. 2004....