E A McLaughlin

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. doi request reprint Is there a role for immunocontraception?
    E A McLaughlin
    Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Mol Cell Endocrinol 335:78-88. 2011
  2. doi request reprint Awakening the oocyte: controlling primordial follicle development
    Eileen A McLaughlin
    Reproductive Science Group, School of Environmental and Life Sciences and ARC Centre of Excellence in Biotechnology and Development, University of Newcastle, Callaghan, New South Wales, Australia
    Reproduction 137:1-11. 2009
  3. doi request reprint Scrambled and fried: cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress
    A P Sobinoff
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Toxicol Appl Pharmacol 271:156-67. 2013
  4. doi request reprint Intracellular signalling during female gametogenesis
    A P Sobinoff
    Priority Research Centre in Chemical Biology, School of Environmental and Life Sciences, University of Newcastle, Callaghan NSW2308, Australia
    Mol Hum Reprod 19:265-78. 2013
  5. ncbi request reprint Molecular mechanisms of sperm capacitation: progesterone-induced secondary calcium oscillations reflect the attainment of a capacitated state
    R J Aitken
    RC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences, University of Newcastle, Callaghan, NSW 2708, Australia
    Soc Reprod Fertil Suppl 63:273-93. 2007
  6. doi request reprint The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis
    S C McIver
    ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Andrology 1:517-29. 2013
  7. doi request reprint Jumping the gun: smoking constituent BaP causes premature primordial follicle activation and impairs oocyte fusibility through oxidative stress
    A P Sobinoff
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW2308, Australia
    Toxicol Appl Pharmacol 260:70-80. 2012
  8. doi request reprint Composition and significance of detergent resistant membranes in mouse spermatozoa
    Brett Nixon
    Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    J Cell Physiol 218:122-34. 2009
  9. ncbi request reprint Analysis of lipid peroxidation in human spermatozoa using BODIPY C11
    R John Aitken
    ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences, University of Newcastle, NSW, Australia
    Mol Hum Reprod 13:203-11. 2007
  10. ncbi request reprint Cis-unsaturated fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa
    R John Aitken
    Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Clin Endocrinol Metab 91:4154-63. 2006

Collaborators

  • Robert J Aitken
  • Janet E Holt
  • Brett Nixon
  • Mark A Baker
  • Nongnuj Tanphaichitr
  • Peter Koopman
  • A P Sobinoff
  • J M Sutherland
  • S C McIver
  • S D Roman
  • Benjamin J Curry
  • Kelly L Asquith
  • Adam J Koppers
  • Geoffry N De Iuliis
  • M D Dun
  • C Fitzsimmons
  • Daniel G Blackmore
  • A G Jarnicki
  • K L Loveland
  • A McCluskey
  • P M Hansbro
  • E L Beckett
  • R Kitazawa
  • D L Russell
  • B Emmett
  • R L Robker
  • V Pye
  • R A Keightley
  • A L Anderson
  • K L Asquith
  • E G Bromfield
  • Jane M Finnie
  • M J Mahony
  • J Clulow
  • Jordana K Wingate
  • Amanda J Harman
  • Rosa M Baleato
  • Hua Su
  • Estelle G Law
  • Lucan R Baillie
  • Lynda Dierkx

Detail Information

Publications27

  1. doi request reprint Is there a role for immunocontraception?
    E A McLaughlin
    Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Mol Cell Endocrinol 335:78-88. 2011
    ..We conclude that the specifications for a safe, effective, reversible vaccine are more likely to be met in animals than man...
  2. doi request reprint Awakening the oocyte: controlling primordial follicle development
    Eileen A McLaughlin
    Reproductive Science Group, School of Environmental and Life Sciences and ARC Centre of Excellence in Biotechnology and Development, University of Newcastle, Callaghan, New South Wales, Australia
    Reproduction 137:1-11. 2009
    ....
  3. doi request reprint Scrambled and fried: cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress
    A P Sobinoff
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Toxicol Appl Pharmacol 271:156-67. 2013
    ..Our results provide a preliminary model of cigarette smoke induced sub-fertility through cyp2e1 bioactivation and oxidative stress, resulting in developing follicle depletion and oocyte dysfunction. ..
  4. doi request reprint Intracellular signalling during female gametogenesis
    A P Sobinoff
    Priority Research Centre in Chemical Biology, School of Environmental and Life Sciences, University of Newcastle, Callaghan NSW2308, Australia
    Mol Hum Reprod 19:265-78. 2013
    ....
  5. ncbi request reprint Molecular mechanisms of sperm capacitation: progesterone-induced secondary calcium oscillations reflect the attainment of a capacitated state
    R J Aitken
    RC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences, University of Newcastle, Callaghan, NSW 2708, Australia
    Soc Reprod Fertil Suppl 63:273-93. 2007
    ..The secondary calcium oscillations created via these channels do not induce acrosomal exocytosis per se but may prime the cells so that this event is rapidly triggered when the spermatozoa make contact with the zona pellucida...
  6. doi request reprint The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis
    S C McIver
    ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Andrology 1:517-29. 2013
    ..These findings indicate that CXCL12 expression in the human testis may selectively influence seminoma migration and metastasis, correlating with its importance in gonocyte and spermatogonial stem cell biology...
  7. doi request reprint Jumping the gun: smoking constituent BaP causes premature primordial follicle activation and impairs oocyte fusibility through oxidative stress
    A P Sobinoff
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW2308, Australia
    Toxicol Appl Pharmacol 260:70-80. 2012
    ..This study highlights BaP as a key compound which may be partially responsible for the documented effects of cigarette smoke on follicular development and sub-fertility...
  8. doi request reprint Composition and significance of detergent resistant membranes in mouse spermatozoa
    Brett Nixon
    Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    J Cell Physiol 218:122-34. 2009
    ....
  9. ncbi request reprint Analysis of lipid peroxidation in human spermatozoa using BODIPY C11
    R John Aitken
    ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences, University of Newcastle, NSW, Australia
    Mol Hum Reprod 13:203-11. 2007
    ..We conclude that BODIPY C(11) is an extremely useful probe for indexing peroxidative damage in human spermatozoa...
  10. ncbi request reprint Cis-unsaturated fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa
    R John Aitken
    Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Clin Endocrinol Metab 91:4154-63. 2006
    ..This study investigated whether a causative relationship exists between these two attributes of impaired semen quality...
  11. ncbi request reprint CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary
    Janet E Holt
    Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Dev Biol 293:449-60. 2006
    ..By retaining follicles in an unactivated state, SDF1/CXCR4 signaling may play an important role in maintaining the size and longevity of the primordial follicle pool...
  12. ncbi request reprint Identification and characterization of a novel Mt-retrotransposon highly represented in the female mouse germline
    Janet E Holt
    Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Genomics 87:490-9. 2006
    ..Together with in silico data, we predict Mtfull plays an essential role in folliculogenesis through regulation of gene expression...
  13. ncbi request reprint Redox activity associated with the maturation and capacitation of mammalian spermatozoa
    R John Aitken
    ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences, University of Newcastle, New South Wales, Australia
    Free Radic Biol Med 36:994-1010. 2004
    ....
  14. doi request reprint miRNA and mammalian male germ cells
    S C McIver
    ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, Australia
    Hum Reprod Update 18:44-59. 2012
    ..However, targeted knockdown of specific miRNA molecules has the potential to form both anti-oncogenic reagents and underpin the basis for novel contraceptive technologies...
  15. doi request reprint Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian primordial follicle activation
    J M Sutherland
    Priority Research Centre in Reproductive Science, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    J Cell Physiol 227:1188-98. 2012
    ....
  16. ncbi request reprint Identification of cytochrome P450-reductase as the enzyme responsible for NADPH-dependent lucigenin and tetrazolium salt reduction in rat epididymal sperm preparations
    Mark A Baker
    ARC Centre of Excellence in Biotechnology and Development, Reproductive Science Group, School of Environmental and Life Sciences, and Hunter Medical Research Institute, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 71:307-18. 2004
    ..These results emphasize the importance of the direct NADPH-dependent reduction of superoxide-sensitive probes by cytochrome P450-reductase even though this enzyme does not, on its own accord, produce reactive oxygen species...
  17. ncbi request reprint Definitive evidence for the nonmitochondrial production of superoxide anion by human spermatozoa
    Geoffry N De Iuliis
    Centre of Excellence in Biotechnology and Development and Discipline of Biological Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Clin Endocrinol Metab 91:1968-75. 2006
    ..However, the source of the free radicals responsible for such damage is still unresolved...
  18. doi request reprint Investigation of the expression and functional significance of the novel mouse sperm protein, a disintegrin and metalloprotease with thrombospondin type 1 motifs number 10 (ADAMTS10)
    M D Dun
    Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, Australia
    Int J Androl 35:572-89. 2012
    ..Overall, these studies support the notion that sperm-oocyte interactions involve considerable functional redundancy and identify ADAMTS10 as a novel candidate in the mediation of these fundamentally important events...
  19. ncbi request reprint Identification of RARhoGAP, a novel putative RhoGAP gene expressed in male germ cells
    Benjamin J Curry
    Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Genomics 84:406-18. 2004
    ..We postulate that RARhoGAP may be involved in rearrangements of the cytoskeleton and cell signaling events that occur during spermatogenesis...
  20. ncbi request reprint Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition
    Kelly L Asquith
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    J Cell Sci 117:3645-57. 2004
    ....
  21. ncbi request reprint Localization and significance of molecular chaperones, heat shock protein 1, and tumor rejection antigen gp96 in the male reproductive tract and during capacitation and acrosome reaction
    Kelly L Asquith
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 72:328-37. 2005
    ..These data reinforce the notion that these chaperones are intimately involved in the mechanisms by which mammalian spermatozoa both acquire and express their ability to recognize the zona pellucida...
  22. doi request reprint Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa
    Adam J Koppers
    Discipline of Biological Sciences, University of Newcastle Callaghan, New South Wales 2308, Australia
    J Clin Endocrinol Metab 93:3199-207. 2008
    ..Male infertility has been linked with the excessive generation of reactive oxygen species (ROS) by defective spermatozoa. However, the subcellular origins of this activity are unclear...
  23. ncbi request reprint Optimisation of handling, activation and assessment procedures for Bufo marinus spermatozoa
    C Fitzsimmons
    School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Reprod Fertil Dev 19:594-601. 2007
    ..0 mM theophylline. The present study has improved protocols for the handling of anuran sperm during pre- and post-cryopreservation procedures...
  24. ncbi request reprint New insights into the molecular mechanisms of sperm-egg interaction
    B Nixon
    Reproductive Science Group, ARC Centre of Excellence in Biotechnology and Development, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Cell Mol Life Sci 64:1805-23. 2007
    ..Herein, we describe two models indicating the plethora of highly orchestrated molecular interactions underlying successful sperm zona binding and sperm oocyte fusion...
  25. ncbi request reprint Contraceptive vaccines
    Eileen A McLaughlin
    ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences, University of Newcastle, Callaghan NSW2308, Australia
    Expert Opin Biol Ther 3:829-41. 2003
    ....
  26. ncbi request reprint Characterization of structure and expression of the Dzip1 gene in the rat and mouse
    Benjamin J Curry
    Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Genomics 87:275-85. 2006
    ....
  27. ncbi request reprint Biosynthesis of the canine zona pellucida requires the integrated participation of both oocytes and granulosa cells
    Daniel G Blackmore
    Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 71:661-8. 2004
    ....