Research Topics
Genomes and GenesSpecies | E McKinnonSummaryAffiliation: University of Western Australia Country: Australia Publications
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Detail Information
Publications
Establishment of "The Gene Mine": a resource for rapid identification of complex trait genesGrant Morahan
Centre for Diabetes Research, The Western Australian Institute for Medical Research, and Centre for Medical Research, University of Western Australia, MRF Building, Level 6, 50 Murray St, Perth, WA 6000, Australia
Mamm Genome 19:390-3. 2008..The Gene Mine will be a powerful resource for characterization of essentially any mouse phenotype that has a genetic basis...- Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairsGrant Morahan
Centre for Diabetes Research, Western Australian Institute for Medical Research, University of Western Australia, Crawley, Australia
Diabetes 60:1030-40. 2011..Familial clustering of type 1 diabetes has not been explained fully and could arise from many factors, including undetected genetic variation and gene interactions... - Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics ConsortiumG Morahan
Centre for Diabetes Research, The Western Australian Institute for Medical Research, and Centre for Medical Research, University of Western Australia, 50 Murray Street, Perth, Western Australia 6000, Australia
Genes Immun 10:S64-8. 2009..2 genotype was more protective, with relative hazard=0.75. We conclude that while there was no major effect of IL12B polymorphisms on T1D susceptibility in the entire study group, they have an impact on a subset of at-risk individuals... - Association of variants in the IL12B gene with leprosy and tuberculosisG Morahan
Diabetes Research Centre, Western Australia Institute for Medical Research, Perth, WA, Australia
Tissue Antigens 69:234-6. 2007..01) but also more likely to have this in the same haplotype with the high expressing 3'UTR allele (P= 0.0009). These results suggest these infectious diseases may be improved by modulating IL-l2p40 production... - Systems genetics can provide new insights in to immune regulation and autoimmunityGrant Morahan
The University of Western Australia, Perth, WA 6000, Australia
J Autoimmun 31:233-6. 2008..Here, we present preliminary analyses of systems genetics approaches to defining genetic interactions within the thymus, which is the key site for T lymphocyte development and imposition of immunological tolerance... - Effect of linkage status of affected sib-pairs on the search for novel type 1 diabetes susceptibility genes in the HLA complexG Morahan
Western Australian Institute for Medical Research and Centre for Medical Research, University of Western Australia, Perth, Western Australia, Australia
Diabetes Obes Metab 11:67-73. 2009..We investigated whether linkage status at the HLA complex differentially affected transmission of alleles to sibs depending on their HLA or gender linkage status... - Missingness in the T1DGC MHC fine-mapping SNP data: association with HLA genotype and potential influence on genetic association studiesI James
Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, Western Australia, Australia
Diabetes Obes Metab 11:101-7. 2009..1% of the non-null proband SNPs, with a median of 0.3%. We consider factors related to missingness in the T1DGC data and briefly assess its possible influence on association studies... - Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approachE McKinnon
Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, Western Australia, Australia
Diabetes Obes Metab 11:92-100. 2009.... - Stable or increasing bone mineral density in HIV-infected patients treated with nelfinavir or indinavirD Nolan
Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Australia
AIDS 15:1275-80. 2001.... - Evidence-based, multifactorial approach to addressing non-adherence to antiretroviral therapy and improving standards of careS Herrmann
Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, WA, Australia
Intern Med J 38:8-15. 2008.... - Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort studyA Rauch
Centre for Clinical Immunology and Biomedical Statistics, Perth, Australia
Clin Infect Dis 43:99-102. 2006..7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701-negative recipients... - Association between 25-OH vitamin D and insulin is independent of lipoatrophy in HIVE Hammond
Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, Australia
Clin Endocrinol (Oxf) 76:201-6. 2012.... - Killer immunoglobulin-like receptors and HLA act both independently and synergistically to modify HIV disease progressionS Gaudieri
Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Wellington Street, Perth, Western Australia 6000, Australia
Genes Immun 6:683-90. 2005....