Patrick D McGorry

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. doi request reprint Is early intervention in the major psychiatric disorders justified? Yes
    Patrick D McGorry
    ORYGEN Research Centre, University of Melbourne, Locked Bag 10, Parkville, Victoria, 3052, Australia
    BMJ 337:a695. 2008
  2. ncbi request reprint Association between psychotic experiences and depression in a clinical sample over 6 months
    Alison R Yung
    ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria, Australia
    Schizophr Res 91:246-53. 2007
  3. pmc Clinical classification in mental health at the cross-roads: which direction next?
    Ian B Hickie
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown 2050, Australia
    BMC Med 11:125. 2013
  4. doi request reprint Randomized controlled trial of interventions for young people at ultra-high risk of psychosis: twelve-month outcome
    Patrick D McGorry
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia
    J Clin Psychiatry 74:349-56. 2013
  5. doi request reprint Designing youth mental health services for the 21st century: examples from Australia, Ireland and the UK
    Patrick McGorry
    Orygen Youth Health Research Centre, University of Melbourne, Locked Bag 10, Parkville, Melbourne, Victoria 3052, Australia
    Br J Psychiatry Suppl 54:s30-5. 2013
  6. pmc At issue: Cochrane, early intervention, and mental health reform: analysis, paralysis, or evidence-informed progress?
    Patrick McGorry
    Orygen Youth Health Research Centre, University of Melbourne, Locked Bag 10 35 Poplar Road, Parkville, VIC 3052, Australia
    Schizophr Bull 38:221-4. 2012
  7. pmc The effectiveness of simple psychological and exercise interventions for high prevalence mental health problems in young people: a factorial randomised controlled trial
    Alexandra G Parker
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
    Trials 12:76. 2011
  8. pmc Managing deliberate self-harm in young people: an evaluation of a training program developed for school welfare staff using a longitudinal research design
    Jo Robinson
    Department of Psychiatry, ORYGEN Research Centre, University of Melbourne, Parkville, Australia
    BMC Psychiatry 8:75. 2008
  9. pmc Study protocol: the development of a randomised controlled trial testing a postcard intervention designed to reduce suicide risk among young help-seekers
    Jo Robinson
    Orygen Youth Health Research Centre, Department of Psychiatry, University of Melbourne Locked Bag 10, Victoria, Australia
    BMC Psychiatry 9:59. 2009
  10. ncbi request reprint Clinical staging: a heuristic model for psychiatry and youth mental health
    Patrick D McGorry
    University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 187:S40-2. 2007

Collaborators

Detail Information

Publications130 found, 100 shown here

  1. doi request reprint Is early intervention in the major psychiatric disorders justified? Yes
    Patrick D McGorry
    ORYGEN Research Centre, University of Melbourne, Locked Bag 10, Parkville, Victoria, 3052, Australia
    BMJ 337:a695. 2008
  2. ncbi request reprint Association between psychotic experiences and depression in a clinical sample over 6 months
    Alison R Yung
    ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria, Australia
    Schizophr Res 91:246-53. 2007
    ..It is important to assess depression in those with PLEs and consider the need for treatment of the comorbid depressive syndrome. This may reduce the risk of worsening of PLEs and transition to psychotic disorder...
  3. pmc Clinical classification in mental health at the cross-roads: which direction next?
    Ian B Hickie
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown 2050, Australia
    BMC Med 11:125. 2013
    ..Although this enhanced epidemiology and health services planning, it failed to link broad diagnostic groupings to underlying pathophysiology or specific treatment response...
  4. doi request reprint Randomized controlled trial of interventions for young people at ultra-high risk of psychosis: twelve-month outcome
    Patrick D McGorry
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia
    J Clin Psychiatry 74:349-56. 2013
    ..The aim of this study was to determine which intervention was most effective at preventing transition to psychosis: cognitive therapy plus low-dose risperidone, cognitive therapy plus placebo, or supportive therapy plus placebo...
  5. doi request reprint Designing youth mental health services for the 21st century: examples from Australia, Ireland and the UK
    Patrick McGorry
    Orygen Youth Health Research Centre, University of Melbourne, Locked Bag 10, Parkville, Melbourne, Victoria 3052, Australia
    Br J Psychiatry Suppl 54:s30-5. 2013
    ....
  6. pmc At issue: Cochrane, early intervention, and mental health reform: analysis, paralysis, or evidence-informed progress?
    Patrick McGorry
    Orygen Youth Health Research Centre, University of Melbourne, Locked Bag 10 35 Poplar Road, Parkville, VIC 3052, Australia
    Schizophr Bull 38:221-4. 2012
    ..The recent Cochrane review on early intervention in psychosis provides an opportunity to consider these issues and their wider significance...
  7. pmc The effectiveness of simple psychological and exercise interventions for high prevalence mental health problems in young people: a factorial randomised controlled trial
    Alexandra G Parker
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
    Trials 12:76. 2011
    ....
  8. pmc Managing deliberate self-harm in young people: an evaluation of a training program developed for school welfare staff using a longitudinal research design
    Jo Robinson
    Department of Psychiatry, ORYGEN Research Centre, University of Melbourne, Parkville, Australia
    BMC Psychiatry 8:75. 2008
    ..The current study aimed to design, deliver and evaluate a training course specifically for school staff...
  9. pmc Study protocol: the development of a randomised controlled trial testing a postcard intervention designed to reduce suicide risk among young help-seekers
    Jo Robinson
    Orygen Youth Health Research Centre, Department of Psychiatry, University of Melbourne Locked Bag 10, Victoria, Australia
    BMC Psychiatry 9:59. 2009
    ..The aim of the study is to test a postcard intervention among people aged 15-24 who presented to mental health services but are not accepted, yet are at risk of suicide...
  10. ncbi request reprint Clinical staging: a heuristic model for psychiatry and youth mental health
    Patrick D McGorry
    University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 187:S40-2. 2007
    ..Young people with emerging mental and substance use disorders could be the main beneficiaries...
  11. doi request reprint Back to the future: predicting and reshaping the course of psychotic disorder
    Patrick D McGorry
    ORYGEN Research Centre and Department of Psychiatry, University of Melbourne, 35 Poplar Rd, Parkville, Victoria, Australia
    Arch Gen Psychiatry 65:25-7. 2008
  12. ncbi request reprint Early intervention in psychotic disorders: detection and treatment of the first episode and the critical early stages
    Patrick D McGorry
    ORYGEN Research Centre, Melbourne, Vic, Australia
    Med J Aust 187:S8-10. 2007
    ..Fully fledged, specialised early intervention services should be established, with full integration with local communities, as well as enhanced primary care systems focused on young people...
  13. ncbi request reprint Clinical staging: a heuristic and practical strategy for new research and better health and social outcomes for psychotic and related mood disorders
    Patrick D McGorry
    Orygen Youth Health Centre for Youth Mental Health, University of Melbourne, Australia
    Can J Psychiatry 55:486-97. 2010
    ....
  14. ncbi request reprint The specialist youth mental health model: strengthening the weakest link in the public mental health system
    Patrick D McGorry
    University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 187:S53-6. 2007
    ..Alternative approaches to creating this capacity should be urgently developed and evaluated, and sustained reform informed by evidence as well as values...
  15. pmc Transition to adulthood: the critical period for pre-emptive, disease-modifying care for schizophrenia and related disorders
    Patrick McGorry
    Centre for Youth Mental Health, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Bull 37:524-30. 2011
    ....
  16. ncbi request reprint A clinical trials agenda for testing interventions in earlier stages of psychotic disorders
    Patrick D McGorry
    University of Melbourne, Melbourne, Vic
    Med J Aust 190:S33-6. 2009
    ..It provides the opportunity for conducting large multisite clinical trials in young people with emerging major mental disorders...
  17. ncbi request reprint headspace: Australia's National Youth Mental Health Foundation--where young minds come first
    Patrick D McGorry
    University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 187:S68-70. 2007
    ....
  18. doi request reprint Age of onset and timing of treatment for mental and substance use disorders: implications for preventive intervention strategies and models of care
    Patrick D McGorry
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
    Curr Opin Psychiatry 24:301-6. 2011
    ..To provide an update of the recent studies on the age of onset of the major mental illnesses, with a special focus on the prospects for prevention and early intervention...
  19. doi request reprint Staging in neuropsychiatry: a heuristic model for understanding, prevention and treatment
    Patrick D McGorry
    Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia
    Neurotox Res 18:244-55. 2010
    ....
  20. doi request reprint Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Arch Gen Psychiatry 66:366-76. 2009
    ..It is unknown whether these progressive processes predate the onset of psychosis...
  21. ncbi request reprint Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 105:236-44. 2008
    ..These findings suggest that the CSP is not a neurodevelopmental marker of psychosis and cast doubt over the notion that it plays a major role in the neurobiology of psychosis...
  22. ncbi request reprint Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States
    Alison R Yung
    Department of Psychiatry, University of Melbourne, Melbourne, Australia
    Aust N Z J Psychiatry 39:964-71. 2005
    ..This paper describes the pilot evaluation of the CAARMS...
  23. ncbi request reprint Validation of "prodromal" criteria to detect individuals at ultra high risk of psychosis: 2 year follow-up
    Alison R Yung
    ORYGEN Research Centre and University of Melbourne, Department of Psychiatry, Parkville 3052, Victoria, Australia
    Schizophr Res 105:10-7. 2008
    ..Previous trials and biological research have been predicated on the view that certain "ultra high risk" (UHR) criteria detect "the prodrome", but there is a need to test the validity of these criteria...
  24. ncbi request reprint Prediction of functional outcome 18 months after a first psychotic episode: a proton magnetic resonance spectroscopy study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton, Melbourne, Victoria 3053, Australia
    Arch Gen Psychiatry 63:969-76. 2006
    ..These studies have generally been negative, perhaps because gray and white matter volumes inaccurately assess the underlying dysfunction that might be predictive of outcome...
  25. doi request reprint The EPPIC follow-up study of first-episode psychosis: longer-term clinical and functional outcome 7 years after index admission
    Lisa P Henry
    ORYGEN Research Centre, Locked Bag 10, Parkville, Melbourne, Victoria, 3052, Australia
    J Clin Psychiatry 71:716-28. 2010
    ..To describe the longer-term clinical and functional outcome of a large, epidemiologic representative cohort of individuals experiencing a first episode of psychosis...
  26. doi request reprint The HYPE Clinic: an early intervention service for borderline personality disorder
    Andrew M Chanen
    Orygen Youth Health Research Centre, The University of Melbourne, and ORYGEN Youth Health Clinical Program, NorthWestern Mental Health, Melbourne, Australia
    J Psychiatr Pract 15:163-72. 2009
    ..It uses an integrated, team-based intervention model comprising time-limited cognitive analytic therapy as developed by Ryle, case management, and general psychiatric care. The HYPE intervention is supported by effectiveness data...
  27. ncbi request reprint Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorder
    Andrew M Chanen
    ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 163:116-25. 2008
    ..Hippocampal and amygdala volume reductions observed in adult BPD samples might develop during the course of the disorder, although longitudinal studies are needed to examine this...
  28. ncbi request reprint A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naïve and early-treated first episode psychosis
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Schizophr Res 102:163-70. 2008
    ..Seemingly illness-related Cr/PCr elevations were also specific to the diagnosis of schizophrenia-spectrum disorder and seem worthy of future study...
  29. ncbi request reprint Ethyl-eicosapentaenoic acid in first-episode psychosis. A 1H-MRS study
    Gregor E Berger
    Department of Psychiatry, ORYGEN Research Centre, University of Melbourne, Parkville, Australia
    Neuropsychopharmacology 33:2467-73. 2008
    ..Larger confirmatory studies of these postulated metabolic brain effects of E-EPA are warranted...
  30. ncbi request reprint Predictors of adherence to cognitive-behavioural therapy in first-episode psychosis
    Mario Alvarez-Jimenez
    Orygen Youth Health Research Centre, Melbourne, Victoria, Australia
    Can J Psychiatry 54:710-8. 2009
    ..To investigate predictors of adherence with a cognitive-behavioural intervention in first-episode psychosis (FEP) patients...
  31. doi request reprint Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorder
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, School of Behavioural Science, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053, Australia
    Br J Psychiatry 194:426-33. 2009
    ....
  32. ncbi request reprint Neuroprotective effects of ethyl-eicosapentaenoic acid in first episode psychosis: a longitudinal T2 relaxometry pilot study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne, Australia
    Psychiatry Res 182:180-2. 2010
    ..There was an increase in T(2) in the placebo group but not in the E-EPA group, suggesting a neuroprotective effect of E-EPA treatment. In addition, the smaller the increase in T(2), the greater the improvement in negative symptoms...
  33. ncbi request reprint Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individuals
    Alex Fornito
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne, Carlton South, Victoria, Australia
    Biol Psychiatry 64:758-65. 2008
    ..In this study, we characterized prepsychotic ACC abnormalities in a sample of individuals at ultra-high-risk (UHR) for psychosis...
  34. doi request reprint Enhancing treatment fidelity in psychotherapy research: novel approach to measure the components of cognitive behavioural therapy for relapse prevention in first-episode psychosis
    Mario Alvarez-Jimenez
    ORYGEN Research Centre and University of Melbourne, Parkville, Australia
    Aust N Z J Psychiatry 42:1013-20. 2008
    ..e. therapy phases) of the individual intervention of a psychotherapy clinical trial (the EPISODE II trial)...
  35. ncbi request reprint Hippocampal pathology in individuals at ultra-high risk for psychosis: a multi-modal magnetic resonance study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Vic, Australia
    Neuroimage 52:62-8. 2010
    ..However, standard measures of neuroanatomical disturbance do not appear to be predictive of later transition, and instead are likely to be non-specific and common in cases that later develop a non-psychotic disorder...
  36. doi request reprint Randomized controlled trial of interventions for young people at ultra high risk for psychosis: 6-month analysis
    Alison R Yung
    ORYGEN Research Centre and University of Melbourne, Department of Psychiatry, 35 Poplar Rd, Parkville 3052, Victoria, Australia
    J Clin Psychiatry 72:430-40. 2011
    ..However, it is unclear which of these treatments are most effective, how long treatment should be given, and whether effects will be sustained over a prolonged period...
  37. ncbi request reprint Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophrenia
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 108:49-56. 2009
    ....
  38. doi request reprint Outcome in early-onset schizophrenia revisited: findings from the Early Psychosis Prevention and Intervention Centre long-term follow-up study
    G Paul Amminger
    Orygen Youth Health Centre for Youth Mental Health, 35 Poplar Road, Parkville, VIC 3052, Australia
    Schizophr Res 131:112-9. 2011
    ..To compare the long-term outcome in individuals with early-onset (before age 18) and adult-onset schizophrenia spectrum disorder who were initially diagnosed and treated in the same clinical center...
  39. ncbi request reprint Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals
    Dennis Velakoulis
    Melbourne Neuropsychiatry Centre and Department of Psychiatry, University of Melbourne, Australia
    Arch Gen Psychiatry 63:139-49. 2006
    ..These studies have been limited by small samples and the absence of patients early in the course of illness...
  40. doi request reprint Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosis
    Mark Walterfang
    Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia
    Psychiatry Res 173:77-82. 2009
    ..This suggests that schizoaffective disorder may represent two interacting illness processes or be mid-way along a continuum of these two broad categories of illness at first psychosis...
  41. doi request reprint Corpus callosum shape alterations in individuals prior to the onset of psychosis
    Mark Walterfang
    Melbourne Neuropsychiatry Centre and Department of Psychiatry, University of Melbourne, North Western Mental Health Program, Sunshine Hospital, Melbourne, Australia
    Schizophr Res 103:1-10. 2008
    ..These changes may reflect primary pathology of orbitofrontal and medial frontal cortex, or deficits in anterior interhemispheric myelination...
  42. doi request reprint Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 32:1708-14. 2008
    ....
  43. doi request reprint An MRI study of pituitary volume and parasuicidal behavior in teenagers with first-presentation borderline personality disorder
    Martina Jovev
    ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 162:273-7. 2008
    ..Further studies are required using direct neuroendocrine measures and exploring other parameters of self-injurious behavior, such as recency of self-injurious behavior, intent to die and medical threat...
  44. ncbi request reprint Increased prefrontal cerebral blood flow in first-episode schizophrenia following treatment: longitudinal positron emission tomography study
    Warrick J Brewer
    ORYGEN Research Centre, Locked Bag 10, Parkville, VIC 3052, Australia and Early Psychosis Prevention and Intervention Centre, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
    Aust N Z J Psychiatry 41:129-35. 2007
    ..The objective of the current study was to investigate executive-control related neural activity from first onset of the illness through to symptom stabilization...
  45. doi request reprint A preliminary evaluation of the validity of at-risk criteria for bipolar disorders in help-seeking adolescents and young adults
    Andreas Bechdolf
    ORYGEN Youth Health, Department of Youth Mental Health, University of Melbourne, Australia
    J Affect Disord 127:316-20. 2010
    ..In the current study, the predictive validity of these criteria were tested in help-seeking adolescents and young adults...
  46. doi request reprint Cognitive decline following psychosis onset: data from the PACE clinic
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053 Australia
    Br J Psychiatry Suppl 51:s52-7. 2007
    ..The origin of cognitive impairments in psychotic disorders is still unclear. Although some deficits are apparent prior to the onset of frank illness, it is unknown if they progress...
  47. doi request reprint Evidence and implications for early intervention in bipolar disorder
    Michael Berk
    Department of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia
    J Ment Health 19:113-26. 2010
    ..To review the evidence that supports early intervention in the treatment of bipolar disorder...
  48. doi request reprint Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophrenia
    Luca Cocchi
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Schizophr Res 115:163-72. 2009
    ....
  49. doi request reprint Randomized controlled trial of interventions for young people at ultra-high risk of psychosis: study design and baseline characteristics
    Lisa J Phillips
    Department of Psychology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Aust N Z J Psychiatry 43:818-29. 2009
    ..Results of three clinical trials have been published that provide mixed support for the effectiveness of psychological and pharmacological interventions in preventing the onset of psychotic disorder...
  50. ncbi request reprint Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis
    Warrick J Brewer
    ORYGEN Research Centre, Melbourne, Australia
    Am J Psychiatry 162:71-8. 2005
    ..While cognitive deficits are frequently reported in psychotic disorders, it is unclear whether these impairments predate the onset of illness and to what extent they are predictive of later transition to psychosis...
  51. pmc Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis
    Warrick J Brewer
    ORYGEN Research Centre and Early Psychosis Prevention and Intervention Centre, EPPIC, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Bull 32:538-55. 2006
    ..Delineation of the relationship between specific cognitive ability and symptoms from data-driven approaches may improve our understanding of the role of cognition during psychosis onset...
  52. ncbi request reprint Superior temporal gyrus volume in teenagers with first-presentation borderline personality disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Psychiatry Res 182:73-6. 2010
    ..Our preliminary findings might reflect the neurobiological heterogeneity of the disorder...
  53. ncbi request reprint Caudate nucleus volume in individuals at ultra-high risk of psychosis: a cross-sectional magnetic resonance imaging study
    Katrina L Hannan
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
    Psychiatry Res 182:223-30. 2010
    ..Future research should examine changes longitudinally together with analysis of shape to assess subregions of the caudate that connect with prefrontal cortex...
  54. doi request reprint An MRI study of the superior temporal subregions in first-episode patients with various psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 113:158-66. 2009
    ..Our findings indicate that morphologic abnormalities of the STG gray matter are specific to schizophrenia among various psychotic disorders, implicating its role in the underlying pathophysiology of schizophrenia...
  55. ncbi request reprint Attentional set-shifting ability in first-episode and established schizophrenia: Relationship to working memory
    Christos Pantelis
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Sunshine Hospital, St Albans, Victoria 3021, Australia
    Schizophr Res 112:104-13. 2009
    ..Longitudinal studies assessing these cognitive functions from illness onset or in prepsychotic individuals are required...
  56. doi request reprint Early Psychosis Prevention and Intervention Centre long-term follow-up study of first-episode psychosis: methodology and baseline characteristics
    Lisa P Henry
    ORYGEN Research Centre, University of Melbourne, Melbourne, Victoria, Australia
    Early Interv Psychiatry 1:49-60. 2007
    ..This paper reports the rationale, methodology and baseline characteristics of a large long-term follow-up study of first-episode psychosis from a geographically defined catchment area...
  57. doi request reprint Early intervention for adolescents with borderline personality disorder using cognitive analytic therapy: randomised controlled trial
    Andrew M Chanen
    ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Australia
    Br J Psychiatry 193:477-84. 2008
    ..No accepted intervention exists for borderline personality disorder presenting in adolescence...
  58. doi request reprint Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 111:94-102. 2009
    ..Whether these longitudinal changes are features of the disorder or related to treatment with antipsychotic medication remains to be determined...
  59. ncbi request reprint Course of substance misuse and daily tobacco use in first-episode psychosis
    Darryl Wade
    ORYGEN Youth Health, Locked Bag 10, Parkville, VIC 3052, Australia
    Schizophr Res 81:145-50. 2006
    ..Study of the course of substance misuse and daily tobacco use in first-episode psychosis may enhance detection and treatment of these substance-related problems...
  60. ncbi request reprint Neuroprotective effects of low-dose lithium in individuals at ultra-high risk for psychosis. A longitudinal MRI/MRS study
    Gregor E Berger
    Orygen Youth Health Research Centre, Locked Bag 10, Parkville, Victoria, 3052, Australia
    Curr Pharm Des 18:570-5. 2012
    ..To investigate if low-dose lithium may counteract the microstructural and metabolic brain changes proposed to occur in individuals at ultra-high risk (UHR) for psychosis...
  61. doi request reprint Corpus callosum morphology and relationship to orbitofrontal and lateral ventricular volume in teenagers with first-presentation borderline personality disorder
    Mark Walterfang
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Psychiatry Res 183:30-7. 2010
    ..We predicted that a first-presentation BPD cohort who demonstrated orbitofrontal cortex (OFC) reductions would show regional reductions in the anterior corpus callosum...
  62. doi request reprint Insular cortex volume and impulsivity in teenagers with first-presentation borderline personality disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:1395-400. 2009
    ..Further studies are needed to clarify whether the potential relationship between the insular cortex volume and impulsivity is specific to BPD...
  63. ncbi request reprint From neuroprogression to neuroprotection: implications for clinical care
    Michael Berk
    Department of Clinical and Biomedical Sciences Barwon Health, University of Melbourne, Melbourne, Vic
    Med J Aust 193:S36-40. 2010
    ..These developments need to be combined with service initiatives to maximise the opportunities for early diagnosis and intervention...
  64. ncbi request reprint Intervention in individuals at ultra-high risk for psychosis: a review and future directions
    Patrick D McGorry
    Centre for Youth Mental Health, Orygen Youth Health Research Centre, University of Melbourne, Victoria, Australia
    J Clin Psychiatry 70:1206-12. 2009
    ..This article reviews intervention research in the ultra-high-risk phase of psychotic disorders...
  65. doi request reprint The effect of atypical antipsychotics on pituitary gland volume in patients with first-episode psychosis: a longitudinal MRI study
    John Paul Nicolo
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Schizophr Res 116:49-54. 2010
    ..Qualifying and quantifying the effect of atypical antipsychotics on the volume of the pituitary gland will determine whether this measure is valid as a future estimate of HPA-axis activation in psychotic populations...
  66. doi request reprint Relational memory in first episode psychosis: implications for progressive hippocampal dysfunction after illness onset
    Cali F Bartholomeusz
    National Neuroscience Facility, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Carlton South, Victoria, Australia
    Aust N Z J Psychiatry 45:206-13. 2011
    ....
  67. doi request reprint Diagnostic specificity of the insular cortex abnormalities in first-episode psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:651-7. 2009
    ..These findings suggest that the widespread volume reduction of the insular cortex is specific to established schizophrenia, implicating its role in the neurobiology of clinical characteristics associated with schizophrenia...
  68. ncbi request reprint Surface-based morphometry of the anterior cingulate cortex in first episode schizophrenia
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
    Hum Brain Mapp 29:478-89. 2008
    ....
  69. ncbi request reprint Olfactory sensitivity through the course of psychosis: Relationships to olfactory identification, symptomatology and the schizophrenia odour
    Warrick J Brewer
    ORYGEN Research Centre, Melbourne, Victoria, Australia
    Psychiatry Res 149:97-104. 2007
    ..This may be linked to olfactory habituation effects, abnormal chemical processing or a genetic predisposition...
  70. ncbi request reprint PACE: a specialised service for young people at risk of psychotic disorders
    Alison R Yung
    PACE Clinic, ORYGEN Youth Health, Melbourne, Vic, Australia
    Med J Aust 187:S43-6. 2007
    ....
  71. ncbi request reprint Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Australia
    Schizophr Bull 29:831-43. 2003
    ..This finding did not discriminate between those UHR individuals who later became psychotic and those who did not...
  72. ncbi request reprint Pattern and correlates of inpatient admission during the initial acute phase of first-episode psychosis
    Darryl Wade
    ORYGEN Youth Health and Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 40:429-36. 2006
    ..The second aim was to determine whether the pattern of inpatient admission during this period was associated with remission of psychotic symptoms or inpatient service use at 15-month follow-up...
  73. ncbi request reprint Dysfunction of dorsolateral prefrontal cortex in antipsychotic-naïve schizophreniform psychosis
    Ben J Harrison
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Australia
    Psychiatry Res 148:23-31. 2006
    ....
  74. doi request reprint Anterior cingulate volume in adolescents with first-presentation borderline personality disorder
    Sarah Whittle
    ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 172:155-60. 2009
    ..Longitudinal studies are needed to examine the nature of this abnormality over the course of the disorder...
  75. doi request reprint Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigation
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Neurobiol Dis 33:354-7. 2009
    ..This study provides further evidence of significant perturbations in brain GSH in first episode psychosis, and supports a broader involvement of GSH in the pathophysiology of schizophrenia...
  76. ncbi request reprint Patterns and predictors of substance use disorders and daily tobacco use in first-episode psychosis
    Darryl Wade
    ORYGEN Youth Health and Department of Psychiatry, University of Melbourne, Victoria, Australia
    Aust N Z J Psychiatry 39:892-8. 2005
    ..To investigate the patterns and predictors of substance use disorders (SUD) and daily tobacco use in first-episode psychosis (FEP)...
  77. ncbi request reprint Agreeableness and neuroticism as predictors of relapse after first-episode psychosis: a prospective follow-up study
    John F Gleeson
    Department of Psychology, University of Melbourne, Melbourne, Victoria, Australia
    J Nerv Ment Dis 193:160-9. 2005
    ..Further studies should clarify whether agreeableness is associated with specific biases in processing interpersonal information, and interpersonal behaviors...
  78. ncbi request reprint headspace: National Youth Mental Health Foundation: making headway with rural young people and their mental health
    Craig A Hodges
    headspace, National Youth Mental Health Foundation, Parkville, Victoria, Australia
    Aust J Rural Health 15:77-80. 2007
    ..Specific approaches in rural, regional and remote areas will be developed as well as specific programs to involve young Indigenous people...
  79. ncbi request reprint Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group
    Alison R Yung
    Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    Schizophr Res 60:21-32. 2003
    ..The findings support the development of more specific preventive strategies targeting the prodromal phase for some individuals at ultra high risk of schizophrenia...
  80. ncbi request reprint Recognition of depression and psychosis by young Australians and their beliefs about treatment
    Annemarie Wright
    ORYGEN Research Centre, University of Melbourne, Locked Bag 10, Parkville, VIC 3052, Australia
    Med J Aust 183:18-23. 2005
    ..To assess young people's ability to recognise clinically defined depression and psychosis, the types of help they thought appropriate for these problems, their knowledge of appropriate treatments, and their perceptions regarding prognosis...
  81. ncbi request reprint Morphology of the paracingulate sulcus and executive cognition in schizophrenia
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, National Neuroscience Facility, Levels 2 and 3, Alan Gilbert Building, 161 Barry St, Carlton South, Victoria 3053, Australia
    Schizophr Res 88:192-7. 2006
    ..This suggests that prior reports of impaired performance on such tasks in schizophrenia may be partly explained by the reduced frequency of a leftward PCS asymmetry in this population...
  82. pmc Progressive brain structural changes mapped as psychosis develops in 'at risk' individuals
    Daqiang Sun
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
    Schizophr Res 108:85-92. 2009
    ..We hypothesized that progressive volume loss occurs in prefrontal regions during the transition to psychosis...
  83. pmc Development and evaluation of a youth mental health community awareness campaign - The Compass Strategy
    Annemarie Wright
    ORYGEN Research Centre, University of Melbourne, Locked Bag 10, Parkville, Victoria, Australia
    BMC Public Health 6:215. 2006
    ....
  84. doi request reprint Group programmes in early intervention services
    Sue M Cotton
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, Australia
    Early Interv Psychiatry 5:259-66. 2011
    ....
  85. ncbi request reprint Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms
    Patrick D McGorry
    Early Psychosis Prevention and Intervention Centre, Melbourne, Australia
    Arch Gen Psychiatry 59:921-8. 2002
    ..However, only recently has it been possible to engage people in treatment during this phase...
  86. ncbi request reprint Cannabis use is not associated with the development of psychosis in an 'ultra' high-risk group
    Lisa J Phillips
    Personal Assessment and Chris Evaluation PACE Clinic, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 36:800-6. 2002
    ..The association between cannabis use and the development of a first psychotic episode was studied in a group of 100 young people identified as being at very high risk for the onset of psychosis...
  87. ncbi request reprint Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people
    Alison R Yung
    ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria, Australia
    Schizophr Res 84:57-66. 2006
    ..This may be a due to the sample being a more general one, not identified as possibly "prodromal". Other potential causes of this reduction in transition are also explored...
  88. pmc Preventing the second episode: a systematic review and meta-analysis of psychosocial and pharmacological trials in first-episode psychosis
    Mario Alvarez-Jimenez
    Department of Psychiatry, Marques de Valdecilla Public Foundation Research Institute FMV IFIMAV Av Valdecilla s n, 39009, Santander, Spain
    Schizophr Bull 37:619-30. 2011
    ..This study sought to undertake a systematic review and meta-analysis of randomized controlled trials (RCTs) to determine the effectiveness of pharmacological and non-pharmacological interventions to prevent relapse in FEP patients...
  89. ncbi request reprint Early intervention in first-episode psychosis--the impact of a community development campaign
    Helen Krstev
    Early Psychosis Prevention and Intervention Centre, Locked Bag 10, Parkville VIC 3052, Australia
    Soc Psychiatry Psychiatr Epidemiol 39:711-9. 2004
    ..Substantial delays in providing access to treatment in first-episode psychosis have been well documented. The present study examines the impact of strategies aimed at improving access and reducing delays...
  90. ncbi request reprint Non-reduction in hippocampal volume is associated with higher risk of psychosis
    Lisa J Phillips
    PACE Clinic, Department of Psychiatry, University of Melbourne, 35 Poplar Road, Victoria 3052, Parkville, Australia
    Schizophr Res 58:145-58. 2002
    ..Alternatively, selection factors associated with the UHR cohort may have created a bias in the results. Replication of these results is required in other high-risk cohorts...
  91. ncbi request reprint Implications of lipid biology for the pathogenesis of schizophrenia
    Gregor E Berger
    Early Psychosis Prevention and Intervention Centre, MH SKY EPPIC, Victoria
    Aust N Z J Psychiatry 36:355-66. 2002
    ..Both aspects are proposed as being important in the pathogenesis of schizophrenia. The purpose of this paper is to examine the implications of lipid biology, in particular the role of essential fatty acids (EFA), for schizophrenia...
  92. ncbi request reprint Recovery style and outcome in first-episode psychosis
    Katherine N Thompson
    Early Psychosis Prevention and Intervention Centre EPPIC, Australia
    Schizophr Res 62:31-6. 2003
    ..The capacity for recovery style to change challenges the suggestion it is a personality trait and raises the need for psychoeducation and other psychological interventions that could improve outcome...
  93. ncbi request reprint Early and late neurodevelopmental disturbances in schizophrenia and their functional consequences
    Christos Pantelis
    Cognitive Neuropsychiatry Research and Academic Unit, Sunshine Hospital, 176 Furlong Road, St Albans, 3021, Victoria, Australia
    Aust N Z J Psychiatry 37:399-406. 2003
    ..In this paper we review the timing of structural changes in schizophrenia and argue that schizophrenia is a neuro-developmental disorder with limited progressive brain changes occurring during the evolution and early phase of psychosis...
  94. ncbi request reprint Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosis
    Belinda Garner
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
    Biol Psychiatry 58:417-23. 2005
    ..We examined pituitary volume before the onset of psychosis in subjects who were at ultra-high risk (UHR) for developing psychosis...
  95. ncbi request reprint Non-pharmacological management of antipsychotic-induced weight gain: systematic review and meta-analysis of randomised controlled trials
    Mario Alvarez-Jimenez
    ORYGEN Research Centre, University of Melbourne, Victoria, Australia
    Br J Psychiatry 193:101-7. 2008
    ..Antipsychotic-induced weight gain is a major concern in the treatment of psychosis. The efficacy of non-pharmacological interventions as well as the optimal intervention approach for this side-effect remain unclear...
  96. ncbi request reprint The reliability and validity of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) in first-episode psychosis
    Leanne Hides
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville Melbourne, Victoria 3052, Australia
    Addict Behav 34:821-5. 2009
    ..This study aims to determine the reliability and validity of the ASSIST for detecting substance use disorders in first-episode psychosis...
  97. ncbi request reprint Efficacy of amisulpride in treating primary negative symptoms in first-episode psychosis: a pilot study
    Brendan P Murphy
    ORYGEN Youth Heath, Melbourne, Australia
    Hum Psychopharmacol 21:511-7. 2006
    ..We undertook a prospective, open-label pilot trial to investigate the use of amisulpride in the treatment of young people with FEP characterised by primary negative symptoms...
  98. doi request reprint Early intervention for adolescents with borderline personality disorder: quasi-experimental comparison with treatment as usual
    Andrew M Chanen
    Orygen Youth Health Research Centre, University of Melbourne, Locked Bag10, Parkville, VIC 3052, Australia
    Aust N Z J Psychiatry 43:397-408. 2009
    ..The aim of the present study was to compare the effectiveness of specialized team-based early intervention for borderline personality disorder (BPD) with treatment as usual...
  99. ncbi request reprint Vocational intervention in first-episode psychosis: individual placement and support v. treatment as usual
    Eoin Killackey
    Department of Psychology, School of Behavioural Science, The University of Melbourne, Australia
    Br J Psychiatry 193:114-20. 2008
    ..Unemployment is a major problem for people with first-episode psychosis and schizophrenia. This has repercussions for the economy, social functioning and illness prognosis...
  100. ncbi request reprint Seasonality of symptom onset in first-episode schizophrenia
    Nicholas Owens
    Early Psychosis Prevention and Intervention Centre, Mental Health Service for Kids and Youth, Parkville, Vic, Australia
    Psychol Med 33:163-7. 2003
    ....