P McGorry

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. pmc Development and evaluation of a youth mental health community awareness campaign - The Compass Strategy
    Annemarie Wright
    ORYGEN Research Centre, University of Melbourne, Locked Bag 10, Parkville, Victoria, Australia
    BMC Public Health 6:215. 2006
  2. ncbi request reprint Early intervention and recovery for young people with early psychosis: consensus statement
    J Bertolote
    International Early Psychosis Association, and ORYGEN Research Centre, Locked Bag 10 35, Poplar Road, Parkville, Victoria 3052, Australia
    Br J Psychiatry Suppl 48:s116-9. 2005
  3. ncbi request reprint Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms
    Patrick D McGorry
    Early Psychosis Prevention and Intervention Centre, Melbourne, Australia
    Arch Gen Psychiatry 59:921-8. 2002
  4. ncbi request reprint Early intervention in psychosis: a new evidence based paradigm
    Patrick D McGorry
    Early Psychosis Prevention and Intervention Centre, Victoria, Australia
    Epidemiol Psichiatr Soc 11:237-47. 2002
  5. ncbi request reprint Early intervention in psychosis: an overdue reform
    Patrick D McGorry
    ORYGEN Research Centre, University of Melbourne, Department of Psychiatry, 35 Poplar Road Parkville 3052, Victoria, Australia
    Aust N Z J Psychiatry 37:393-8. 2003
  6. ncbi request reprint Evaluating the importance of reducing the duration of untreated psychosis
    P D McGorry
    Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 34:S145-9. 2000
  7. ncbi request reprint The nature of schizophrenia: signposts to prevention
    P D McGorry
    Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 34:S14-21. 2000
  8. ncbi request reprint Can we improve the diagnostic efficiency and predictive power of prodromal symptoms for schizophrenia?
    P D McGorry
    Department of Psychiatry, University of Melbourne, Youth Program, Mental Health Services for Kids and Youth, Locked Bag 10, Parkville, Australia
    Schizophr Res 42:91-100. 2000
  9. ncbi request reprint Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventions
    Patrick D McGorry
    Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Aust N Z J Psychiatry 40:616-22. 2006
  10. pmc The "close-in" or ultra high-risk model: a safe and effective strategy for research and clinical intervention in prepsychotic mental disorder
    Patrick D McGorry
    ORYGEN Youth Health and ORYGEN Research Centre incorporating EPPIC and PACE, Parkville, Victoria, Australia
    Schizophr Bull 29:771-90. 2003

Collaborators

Detail Information

Publications100

  1. pmc Development and evaluation of a youth mental health community awareness campaign - The Compass Strategy
    Annemarie Wright
    ORYGEN Research Centre, University of Melbourne, Locked Bag 10, Parkville, Victoria, Australia
    BMC Public Health 6:215. 2006
    ....
  2. ncbi request reprint Early intervention and recovery for young people with early psychosis: consensus statement
    J Bertolote
    International Early Psychosis Association, and ORYGEN Research Centre, Locked Bag 10 35, Poplar Road, Parkville, Victoria 3052, Australia
    Br J Psychiatry Suppl 48:s116-9. 2005
    ....
  3. ncbi request reprint Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms
    Patrick D McGorry
    Early Psychosis Prevention and Intervention Centre, Melbourne, Australia
    Arch Gen Psychiatry 59:921-8. 2002
    ..However, only recently has it been possible to engage people in treatment during this phase...
  4. ncbi request reprint Early intervention in psychosis: a new evidence based paradigm
    Patrick D McGorry
    Early Psychosis Prevention and Intervention Centre, Victoria, Australia
    Epidemiol Psichiatr Soc 11:237-47. 2002
    ..Further, evidence indicates that delay in treatment is positively associated with poorer outcome. This paper puts the case for early intervention in psychosis...
  5. ncbi request reprint Early intervention in psychosis: an overdue reform
    Patrick D McGorry
    ORYGEN Research Centre, University of Melbourne, Department of Psychiatry, 35 Poplar Road Parkville 3052, Victoria, Australia
    Aust N Z J Psychiatry 37:393-8. 2003
    ..To discuss the rationale for early intervention in psychotic disorders and to explore why the widespread implementation of early intervention services has stalled...
  6. ncbi request reprint Evaluating the importance of reducing the duration of untreated psychosis
    P D McGorry
    Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 34:S145-9. 2000
    ..However, its importance has been questioned. This paper aims to present selected issues concerning attempts to reduce DUP and evaluate the impact of these attempts...
  7. ncbi request reprint The nature of schizophrenia: signposts to prevention
    P D McGorry
    Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 34:S14-21. 2000
    ..To describe the characteristics of schizophrenia relevant to conducting indicated preventive interventions...
  8. ncbi request reprint Can we improve the diagnostic efficiency and predictive power of prodromal symptoms for schizophrenia?
    P D McGorry
    Department of Psychiatry, University of Melbourne, Youth Program, Mental Health Services for Kids and Youth, Locked Bag 10, Parkville, Australia
    Schizophr Res 42:91-100. 2000
    ..The SPAN technique generated a decision rule that performed equivalently to the single variable 'duration of prodrome'. Implications of these results for future research are discussed...
  9. ncbi request reprint Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventions
    Patrick D McGorry
    Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Aust N Z J Psychiatry 40:616-22. 2006
    ....
  10. pmc The "close-in" or ultra high-risk model: a safe and effective strategy for research and clinical intervention in prepsychotic mental disorder
    Patrick D McGorry
    ORYGEN Youth Health and ORYGEN Research Centre incorporating EPPIC and PACE, Parkville, Victoria, Australia
    Schizophr Bull 29:771-90. 2003
    ..Such research must be conducted in a logical and rigorous manner with the best designs possible, sensitive to input from consumers and caregivers and to ethical considerations...
  11. ncbi request reprint Early intervention in psychotic disorders: beyond debate to solving problems
    Patrick D McGorry
    Department of Psychiatry, University of Melbourne and ORYGEN Research Centre, Locked Bag 10, Parkville, Victoria 3052, Australia
    Br J Psychiatry Suppl 48:s108-10. 2005
    ..Consistent and extensive reform of health systems, with recognition of early intervention as an increasingly evidence-based "best buy", represents one of the key priorities in international mental health...
  12. doi request reprint Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Arch Gen Psychiatry 66:366-76. 2009
    ..It is unknown whether these progressive processes predate the onset of psychosis...
  13. ncbi request reprint Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Australia
    Schizophr Bull 29:831-43. 2003
    ..This finding did not discriminate between those UHR individuals who later became psychotic and those who did not...
  14. ncbi request reprint Cognitively-oriented psychotherapy for early psychosis (COPE). Preliminary results
    H Jackson
    Department of Psychology, School of Behavioural Science, University of Melbourne, Parkville, Victoria, Australia
    Br J Psychiatry Suppl 172:93-100. 1998
    ..Cognitively-oriented psychotherapy for early psychosis (COPE) is aimed at facilitating the adjustment of the person, and at preventing or alleviating secondary morbidity in the wake of the first psychotic episode...
  15. doi request reprint Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 105:236-44. 2008
    ..These findings suggest that the CSP is not a neurodevelopmental marker of psychosis and cast doubt over the notion that it plays a major role in the neurobiology of psychosis...
  16. ncbi request reprint Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals
    Dennis Velakoulis
    Melbourne Neuropsychiatry Centre and Department of Psychiatry, University of Melbourne, Australia
    Arch Gen Psychiatry 63:139-49. 2006
    ..These studies have been limited by small samples and the absence of patients early in the course of illness...
  17. ncbi request reprint Patterns and predictors of substance use disorders and daily tobacco use in first-episode psychosis
    Darryl Wade
    ORYGEN Youth Health and Department of Psychiatry, University of Melbourne, Victoria, Australia
    Aust N Z J Psychiatry 39:892-8. 2005
    ..To investigate the patterns and predictors of substance use disorders (SUD) and daily tobacco use in first-episode psychosis (FEP)...
  18. ncbi request reprint Dysfunction of dorsolateral prefrontal cortex in antipsychotic-naïve schizophreniform psychosis
    Ben J Harrison
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Australia
    Psychiatry Res 148:23-31. 2006
    ....
  19. ncbi request reprint Agreeableness and neuroticism as predictors of relapse after first-episode psychosis: a prospective follow-up study
    John F Gleeson
    Department of Psychology, University of Melbourne, Melbourne, Victoria, Australia
    J Nerv Ment Dis 193:160-9. 2005
    ..Further studies should clarify whether agreeableness is associated with specific biases in processing interpersonal information, and interpersonal behaviors...
  20. doi request reprint Corpus callosum shape alterations in individuals prior to the onset of psychosis
    Mark Walterfang
    Melbourne Neuropsychiatry Centre and Department of Psychiatry, University of Melbourne, North Western Mental Health Program, Sunshine Hospital, Melbourne, Australia
    Schizophr Res 103:1-10. 2008
    ..These changes may reflect primary pathology of orbitofrontal and medial frontal cortex, or deficits in anterior interhemispheric myelination...
  21. doi request reprint Evidence and implications for early intervention in bipolar disorder
    Michael Berk
    Department of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia
    J Ment Health 19:113-26. 2010
    ..To review the evidence that supports early intervention in the treatment of bipolar disorder...
  22. doi request reprint Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 111:94-102. 2009
    ..Whether these longitudinal changes are features of the disorder or related to treatment with antipsychotic medication remains to be determined...
  23. doi request reprint Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosis
    Mark Walterfang
    Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia
    Psychiatry Res 173:77-82. 2009
    ..This suggests that schizoaffective disorder may represent two interacting illness processes or be mid-way along a continuum of these two broad categories of illness at first psychosis...
  24. doi request reprint Ethyl-eicosapentaenoic acid in first-episode psychosis. A 1H-MRS study
    Gregor E Berger
    Department of Psychiatry, ORYGEN Research Centre, University of Melbourne, Parkville, Australia
    Neuropsychopharmacology 33:2467-73. 2008
    ..Larger confirmatory studies of these postulated metabolic brain effects of E-EPA are warranted...
  25. ncbi request reprint headspace: National Youth Mental Health Foundation: making headway with rural young people and their mental health
    Craig A Hodges
    headspace, National Youth Mental Health Foundation, Parkville, Victoria, Australia
    Aust J Rural Health 15:77-80. 2007
    ..Specific approaches in rural, regional and remote areas will be developed as well as specific programs to involve young Indigenous people...
  26. doi request reprint Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophrenia
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 108:49-56. 2009
    ....
  27. ncbi request reprint Analysis of the initial treatment phase in first-episode psychosis
    P Power
    Early Psychosis Prevention and Intervention Centre, Parkville, Victoria, Australia
    Br J Psychiatry Suppl 172:71-6. 1998
    ..It offers a model for management of first-episode psychosis, utilising principles of early detection, low-dose medication and comprehensive psychosocial interventions within the least restrictive setting...
  28. doi request reprint Anterior cingulate volume in adolescents with first-presentation borderline personality disorder
    Sarah Whittle
    ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 172:155-60. 2009
    ..Longitudinal studies are needed to examine the nature of this abnormality over the course of the disorder...
  29. ncbi request reprint Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group
    Alison R Yung
    Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    Schizophr Res 60:21-32. 2003
    ..The findings support the development of more specific preventive strategies targeting the prodromal phase for some individuals at ultra high risk of schizophrenia...
  30. ncbi request reprint Recognition of depression and psychosis by young Australians and their beliefs about treatment
    Annemarie Wright
    ORYGEN Research Centre, University of Melbourne, Locked Bag 10, Parkville, VIC 3052, Australia
    Med J Aust 183:18-23. 2005
    ..To assess young people's ability to recognise clinically defined depression and psychosis, the types of help they thought appropriate for these problems, their knowledge of appropriate treatments, and their perceptions regarding prognosis...
  31. doi request reprint An MRI study of the superior temporal subregions in first-episode patients with various psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 113:158-66. 2009
    ..Our findings indicate that morphologic abnormalities of the STG gray matter are specific to schizophrenia among various psychotic disorders, implicating its role in the underlying pathophysiology of schizophrenia...
  32. ncbi request reprint Morphology of the paracingulate sulcus and executive cognition in schizophrenia
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, National Neuroscience Facility, Levels 2 and 3, Alan Gilbert Building, 161 Barry St, Carlton South, Victoria 3053, Australia
    Schizophr Res 88:192-7. 2006
    ..This suggests that prior reports of impaired performance on such tasks in schizophrenia may be partly explained by the reduced frequency of a leftward PCS asymmetry in this population...
  33. doi request reprint Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 32:1708-14. 2008
    ....
  34. doi request reprint Intervention in individuals at ultra-high risk for psychosis: a review and future directions
    Patrick D McGorry
    Centre for Youth Mental Health, Orygen Youth Health Research Centre, University of Melbourne, Victoria, Australia
    J Clin Psychiatry 70:1206-12. 2009
    ..This article reviews intervention research in the ultra-high-risk phase of psychotic disorders...
  35. pmc Progressive brain structural changes mapped as psychosis develops in 'at risk' individuals
    Daqiang Sun
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
    Schizophr Res 108:85-92. 2009
    ..We hypothesized that progressive volume loss occurs in prefrontal regions during the transition to psychosis...
  36. doi request reprint Back to the future: predicting and reshaping the course of psychotic disorder
    Patrick D McGorry
    ORYGEN Research Centre and Department of Psychiatry, University of Melbourne, 35 Poplar Rd, Parkville, Victoria, Australia
    Arch Gen Psychiatry 65:25-7. 2008
  37. ncbi request reprint Clinical staging: a heuristic and practical strategy for new research and better health and social outcomes for psychotic and related mood disorders
    Patrick D McGorry
    Orygen Youth Health Centre for Youth Mental Health, University of Melbourne, Australia
    Can J Psychiatry 55:486-97. 2010
    ....
  38. ncbi request reprint Increased prefrontal cerebral blood flow in first-episode schizophrenia following treatment: longitudinal positron emission tomography study
    Warrick J Brewer
    ORYGEN Research Centre, Locked Bag 10, Parkville, VIC 3052, Australia and Early Psychosis Prevention and Intervention Centre, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
    Aust N Z J Psychiatry 41:129-35. 2007
    ..The objective of the current study was to investigate executive-control related neural activity from first onset of the illness through to symptom stabilization...
  39. ncbi request reprint Early intervention in psychotic disorders: detection and treatment of the first episode and the critical early stages
    Patrick D McGorry
    ORYGEN Research Centre, Melbourne, Vic, Australia
    Med J Aust 187:S8-10. 2007
    ..Fully fledged, specialised early intervention services should be established, with full integration with local communities, as well as enhanced primary care systems focused on young people...
  40. ncbi request reprint The specialist youth mental health model: strengthening the weakest link in the public mental health system
    Patrick D McGorry
    University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 187:S53-6. 2007
    ..Alternative approaches to creating this capacity should be urgently developed and evaluated, and sustained reform informed by evidence as well as values...
  41. doi request reprint Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorder
    Andrew M Chanen
    ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 163:116-25. 2008
    ..Hippocampal and amygdala volume reductions observed in adult BPD samples might develop during the course of the disorder, although longitudinal studies are needed to examine this...
  42. doi request reprint Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individuals
    Alex Fornito
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne, Carlton South, Victoria, Australia
    Biol Psychiatry 64:758-65. 2008
    ..In this study, we characterized prepsychotic ACC abnormalities in a sample of individuals at ultra-high-risk (UHR) for psychosis...
  43. doi request reprint Attentional set-shifting ability in first-episode and established schizophrenia: Relationship to working memory
    Christos Pantelis
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Sunshine Hospital, St Albans, Victoria 3021, Australia
    Schizophr Res 112:104-13. 2009
    ..Longitudinal studies assessing these cognitive functions from illness onset or in prepsychotic individuals are required...
  44. doi request reprint Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorder
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, School of Behavioural Science, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053, Australia
    Br J Psychiatry 194:426-33. 2009
    ....
  45. doi request reprint Early intervention for adolescents with borderline personality disorder: quasi-experimental comparison with treatment as usual
    Andrew M Chanen
    Orygen Youth Health Research Centre, University of Melbourne, Locked Bag10, Parkville, VIC 3052, Australia
    Aust N Z J Psychiatry 43:397-408. 2009
    ..The aim of the present study was to compare the effectiveness of specialized team-based early intervention for borderline personality disorder (BPD) with treatment as usual...
  46. doi request reprint Neuroprotective effects of ethyl-eicosapentaenoic acid in first episode psychosis: a longitudinal T2 relaxometry pilot study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne, Australia
    Psychiatry Res 182:180-2. 2010
    ..There was an increase in T(2) in the placebo group but not in the E-EPA group, suggesting a neuroprotective effect of E-EPA treatment. In addition, the smaller the increase in T(2), the greater the improvement in negative symptoms...
  47. doi request reprint Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigation
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Neurobiol Dis 33:354-7. 2009
    ..This study provides further evidence of significant perturbations in brain GSH in first episode psychosis, and supports a broader involvement of GSH in the pathophysiology of schizophrenia...
  48. doi request reprint Early intervention for adolescents with borderline personality disorder using cognitive analytic therapy: randomised controlled trial
    Andrew M Chanen
    ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Australia
    Br J Psychiatry 193:477-84. 2008
    ..No accepted intervention exists for borderline personality disorder presenting in adolescence...
  49. doi request reprint Vocational intervention in first-episode psychosis: individual placement and support v. treatment as usual
    Eoin Killackey
    Department of Psychology, School of Behavioural Science, The University of Melbourne, Australia
    Br J Psychiatry 193:114-20. 2008
    ..Unemployment is a major problem for people with first-episode psychosis and schizophrenia. This has repercussions for the economy, social functioning and illness prognosis...
  50. doi request reprint Non-pharmacological management of antipsychotic-induced weight gain: systematic review and meta-analysis of randomised controlled trials
    Mario Alvarez-Jimenez
    ORYGEN Research Centre, University of Melbourne, Victoria, Australia
    Br J Psychiatry 193:101-7. 2008
    ..Antipsychotic-induced weight gain is a major concern in the treatment of psychosis. The efficacy of non-pharmacological interventions as well as the optimal intervention approach for this side-effect remain unclear...
  51. doi request reprint Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophrenia
    Luca Cocchi
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Schizophr Res 115:163-72. 2009
    ....
  52. ncbi request reprint Association between psychotic experiences and depression in a clinical sample over 6 months
    Alison R Yung
    ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria, Australia
    Schizophr Res 91:246-53. 2007
    ..It is important to assess depression in those with PLEs and consider the need for treatment of the comorbid depressive syndrome. This may reduce the risk of worsening of PLEs and transition to psychotic disorder...
  53. doi request reprint The reliability and validity of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) in first-episode psychosis
    Leanne Hides
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville Melbourne, Victoria 3052, Australia
    Addict Behav 34:821-5. 2009
    ..This study aims to determine the reliability and validity of the ASSIST for detecting substance use disorders in first-episode psychosis...
  54. ncbi request reprint Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis
    Warrick J Brewer
    ORYGEN Research Centre, Melbourne, Australia
    Am J Psychiatry 162:71-8. 2005
    ..While cognitive deficits are frequently reported in psychotic disorders, it is unclear whether these impairments predate the onset of illness and to what extent they are predictive of later transition to psychosis...
  55. ncbi request reprint Early intervention in first-episode psychosis--the impact of a community development campaign
    Helen Krstev
    Early Psychosis Prevention and Intervention Centre, Locked Bag 10, Parkville VIC 3052, Australia
    Soc Psychiatry Psychiatr Epidemiol 39:711-9. 2004
    ..Substantial delays in providing access to treatment in first-episode psychosis have been well documented. The present study examines the impact of strategies aimed at improving access and reducing delays...
  56. ncbi request reprint Seasonality of symptom onset in first-episode schizophrenia
    Nicholas Owens
    Early Psychosis Prevention and Intervention Centre, Mental Health Service for Kids and Youth, Parkville, Vic, Australia
    Psychol Med 33:163-7. 2003
    ....
  57. ncbi request reprint Influence of gender on mental health literacy in young Australians
    Sue M Cotton
    ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 40:790-6. 2006
    ..To determine the effects of gender on mental health literacy in young people between 12 and 25 years of age...
  58. ncbi request reprint Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosis
    Belinda Garner
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
    Biol Psychiatry 58:417-23. 2005
    ..We examined pituitary volume before the onset of psychosis in subjects who were at ultra-high risk (UHR) for developing psychosis...
  59. ncbi request reprint Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophrenia
    Christos Pantelis
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Sunshine Hospital, Victoria
    Schizophr Bull 31:672-96. 2005
    ....
  60. ncbi request reprint Clinical staging: a heuristic model for psychiatry and youth mental health
    Patrick D McGorry
    University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 187:S40-2. 2007
    ..Young people with emerging mental and substance use disorders could be the main beneficiaries...
  61. ncbi request reprint Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people
    Alison R Yung
    ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria, Australia
    Schizophr Res 84:57-66. 2006
    ..This may be a due to the sample being a more general one, not identified as possibly "prodromal". Other potential causes of this reduction in transition are also explored...
  62. ncbi request reprint Early and late neurodevelopmental disturbances in schizophrenia and their functional consequences
    Christos Pantelis
    Cognitive Neuropsychiatry Research and Academic Unit, Sunshine Hospital, 176 Furlong Road, St Albans, 3021, Victoria, Australia
    Aust N Z J Psychiatry 37:399-406. 2003
    ..In this paper we review the timing of structural changes in schizophrenia and argue that schizophrenia is a neuro-developmental disorder with limited progressive brain changes occurring during the evolution and early phase of psychosis...
  63. ncbi request reprint Recovery style and outcome in first-episode psychosis
    Katherine N Thompson
    Early Psychosis Prevention and Intervention Centre EPPIC, Australia
    Schizophr Res 62:31-6. 2003
    ..The capacity for recovery style to change challenges the suggestion it is a personality trait and raises the need for psychoeducation and other psychological interventions that could improve outcome...
  64. ncbi request reprint Efficacy of amisulpride in treating primary negative symptoms in first-episode psychosis: a pilot study
    Brendan P Murphy
    ORYGEN Youth Heath, Melbourne, Australia
    Hum Psychopharmacol 21:511-7. 2006
    ..We undertook a prospective, open-label pilot trial to investigate the use of amisulpride in the treatment of young people with FEP characterised by primary negative symptoms...
  65. ncbi request reprint Course of substance misuse and daily tobacco use in first-episode psychosis
    Darryl Wade
    ORYGEN Youth Health, Locked Bag 10, Parkville, VIC 3052, Australia
    Schizophr Res 81:145-50. 2006
    ..Study of the course of substance misuse and daily tobacco use in first-episode psychosis may enhance detection and treatment of these substance-related problems...
  66. ncbi request reprint Implications of lipid biology for the pathogenesis of schizophrenia
    Gregor E Berger
    Early Psychosis Prevention and Intervention Centre, MH SKY EPPIC, Victoria
    Aust N Z J Psychiatry 36:355-66. 2002
    ..Both aspects are proposed as being important in the pathogenesis of schizophrenia. The purpose of this paper is to examine the implications of lipid biology, in particular the role of essential fatty acids (EFA), for schizophrenia...
  67. ncbi request reprint Cannabis use is not associated with the development of psychosis in an 'ultra' high-risk group
    Lisa J Phillips
    Personal Assessment and Chris Evaluation PACE Clinic, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 36:800-6. 2002
    ..The association between cannabis use and the development of a first psychotic episode was studied in a group of 100 young people identified as being at very high risk for the onset of psychosis...
  68. ncbi request reprint Non-reduction in hippocampal volume is associated with higher risk of psychosis
    Lisa J Phillips
    PACE Clinic, Department of Psychiatry, University of Melbourne, 35 Poplar Road, Victoria 3052, Parkville, Australia
    Schizophr Res 58:145-58. 2002
    ..Alternatively, selection factors associated with the UHR cohort may have created a bias in the results. Replication of these results is required in other high-risk cohorts...
  69. ncbi request reprint Cognitively oriented psychotherapy for early psychosis (COPE): a 1-year follow-up
    H Jackson
    Early Psychosis Prevention and Intervention Centre EPPIC, Departments of Psychology and Psychiatry, University of Melbourne, Australia
    Br J Clin Psychol 40:57-70. 2001
    ..Cognitively oriented psychotherapy for early psychosis (COPE) is aimed at facilitating the adjustment of the person, and at preventing or alleviating secondary morbidity in the wake of the first psychotic episode...
  70. ncbi request reprint Neurobiological findings in early phase schizophrenia
    D Copolov
    The Mental Health Research Institute of Victoria, 155 Oak St, Parkville, Victoria, Australia
    Brain Res Brain Res Rev 31:157-65. 2000
    ..Although there is a growing literature on first episode psychosis, there is a striking dearth of information on the neurobiology of the prodrome...
  71. ncbi request reprint Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features
    Alison R Yung
    Department of Psychiatry, University of Melbourne and ORYGEN Research Centre, Australia
    Schizophr Res 67:131-42. 2004
    ..This indicated prevention approach could be further developed and preventive strategies in the psychoses refined...
  72. doi request reprint Is early intervention in the major psychiatric disorders justified? Yes
    Patrick D McGorry
    ORYGEN Research Centre, University of Melbourne, Locked Bag 10, Parkville, Victoria, 3052, Australia
    BMJ 337:a695. 2008
  73. doi request reprint Familial psychopathology in the First Episode Psychosis Outcome Study
    Katherine I Morley
    ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Victoria, Australia
    Aust N Z J Psychiatry 42:617-26. 2008
    ....
  74. ncbi request reprint Diagnostic stability 18 months after treatment initiation for first-episode psychosis
    Benno G Schimmelmann
    Centre for Psychosocial Medicine, Clinic for Child and Adolescent Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Clin Psychiatry 66:1239-46. 2005
    ..2) Comparison between those patients who shifted from DSM-IV schizophreniform disorder to schizophrenia or schizo-affective disorder and those whose diagnosis of schizophreniform disorder remained stable...
  75. doi request reprint Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort
    Benno G Schimmelmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstrasse 174, 45147 Essen, Germany
    J Psychiatr Res 42:982-90. 2008
    ..To assess the impact of duration of untreated psychosis (DUP) on baseline and 18-month follow-up characteristics controlling for relevant confounders in an epidemiological first-episode psychosis (FEP) cohort...
  76. ncbi request reprint The relationship between duration of untreated psychosis and outcome: an eight-year prospective study
    Meredith G Harris
    ORYGEN Research Centre and Department of Psychiatry, The University of Melbourne, Locked Bag 10, Parkville, Victoria 3052, Australia
    Schizophr Res 79:85-93. 2005
    ....
  77. ncbi request reprint Olfactory sensitivity through the course of psychosis: Relationships to olfactory identification, symptomatology and the schizophrenia odour
    Warrick J Brewer
    ORYGEN Research Centre, Melbourne, Victoria, Australia
    Psychiatry Res 149:97-104. 2007
    ..This may be linked to olfactory habituation effects, abnormal chemical processing or a genetic predisposition...
  78. ncbi request reprint Risperidone and haloperidol in first-episode psychosis: a long-term randomized trial
    Nina Schooler
    Hurwich Professor, Bar Ilan University, Ramat Gan, Israel
    Am J Psychiatry 162:947-53. 2005
    ..Thus, initial treatment of active symptoms and subsequent relapse prevention are central goals of pharmacotherapy. This study compared long-term effectiveness of risperidone versus haloperidol in first-episode psychosis patients...
  79. ncbi request reprint Australian mental health reform: time for real outcomes
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, PO Box M160, Camperdown, NSW 2050, Australia
    Med J Aust 182:401-6. 2005
    ..New independent and national reporting systems on the progress of mental health reform are urgently required...
  80. ncbi request reprint Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States
    Alison R Yung
    Department of Psychiatry, University of Melbourne, Melbourne, Australia
    Aust N Z J Psychiatry 39:964-71. 2005
    ..This paper describes the pilot evaluation of the CAARMS...
  81. ncbi request reprint Symptomatic and functional outcome 12 months after a first episode of psychotic mania: barriers to recovery in a catchment area sample
    Philippe Conus
    Département Universitaire de Psychiatrie CHUV, Universite de Lausanne, Prilly, Switzerland
    Bipolar Disord 8:221-31. 2006
    ..Such studies have been conducted in selected samples with restrictive measures of outcome. We aimed to explore outcome and its predictors in a catchment area sample of first-episode psychotic mania of DSM-III-R bipolar I disorder...
  82. ncbi request reprint Prevention and early intervention for borderline personality disorder
    Andrew M Chanen
    ORYGEN Research Centre, University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 187:S18-21. 2007
    ..Early intervention programs will need to be realistic in their aims, require change in clinician attitudes and service systems, and must be mindful of the risk of iatrogenic harm...
  83. ncbi request reprint Fractionation of verbal memory impairment in schizophrenia and schizophreniform psychosis
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, c National Neuroscience Facility, Carlton, Melbourne, Victoria, Australia
    Aust N Z J Psychiatry 41:732-9. 2007
    ..The impact of antipsychotic medications is also unclear. The purpose of the present paper was to investigate verbal memory performance in established schizophrenia (SZ) and first-episode schizophreniform psychosis (FE)...
  84. ncbi request reprint Increased access to evidence-based primary mental health care: will the implementation match the rhetoric?
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    Med J Aust 187:100-3. 2007
    ..The responsibility for achieving the best outcome does not lie only with governments. To date, the professions have not placed enough emphasis on systematically adopting evidence-based forms of collaborative care...
  85. ncbi request reprint Pre-treatment, baseline, and outcome differences between early-onset and adult-onset psychosis in an epidemiological cohort of 636 first-episode patients
    Benno G Schimmelmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstr 174, 45147 Essen, Germany
    Schizophr Res 95:1-8. 2007
    ..To assess pre-treatment, baseline, and outcome differences of patients with early- (onset<age 18) and adult-onset (onset>or=age 18) psychosis in an epidemiological cohort of first-episode patients...
  86. ncbi request reprint Medium term follow-up of a randomized controlled trial of interventions for young people at ultra high risk of psychosis
    Lisa J Phillips
    Department of Psychology, University of Melbourne, Vic, 3010 Australia
    Schizophr Res 96:25-33. 2007
    ....
  87. ncbi request reprint Issues for DSM-V: clinical staging: a heuristic pathway to valid nosology and safer, more effective treatment in psychiatry
    Patrick D McGorry
    Am J Psychiatry 164:859-60. 2007
  88. ncbi request reprint Surface-based morphometry of the anterior cingulate cortex in first episode schizophrenia
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
    Hum Brain Mapp 29:478-89. 2008
    ....
  89. ncbi request reprint PACE: a specialised service for young people at risk of psychotic disorders
    Alison R Yung
    PACE Clinic, ORYGEN Youth Health, Melbourne, Vic, Australia
    Med J Aust 187:S43-6. 2007
    ....
  90. ncbi request reprint Exciting career opportunity beckons! Early intervention and vocational rehabilitation in first-episode psychosis: employing cautious optimism
    Eoin J Killackey
    Department of Psychology, University of Melbourne, ORYGEN Research Centre, Parkville, Melbourne, Victoria, Australia
    Aust N Z J Psychiatry 40:951-62. 2006
    ....
  91. ncbi request reprint headspace: Australia's National Youth Mental Health Foundation--where young minds come first
    Patrick D McGorry
    University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 187:S68-70. 2007
    ....
  92. ncbi request reprint Recent approaches to psychological interventions for people at risk of psychosis
    Andreas Bechdolf
    Early Recognition and Intervention, Centre for Mental Crises FETZ, Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    Eur Arch Psychiatry Clin Neurosci 256:159-73. 2006
    ....
  93. pmc Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis
    Warrick J Brewer
    ORYGEN Research Centre and Early Psychosis Prevention and Intervention Centre, EPPIC, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Bull 32:538-55. 2006
    ..Delineation of the relationship between specific cognitive ability and symptoms from data-driven approaches may improve our understanding of the role of cognition during psychosis onset...
  94. doi request reprint Morphology of the corpus callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illness
    Mark Walterfang
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne North Western Mental Health Program, Sunshine Hospital, Royal Melbourne Hospital, Melbourne corrected
    Br J Psychiatry 192:429-34. 2008
    ..The shape of the corpus callosum may differ in schizophrenia, although no study has compared first-episode with established illness...
  95. ncbi request reprint Belief in dealing with depression alone: results from community surveys of adolescents and adults
    Anthony F Jorm
    ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Australia
    J Affect Disord 96:59-65. 2006
    ..Community surveys have found that some people believe that it is better to deal with depression alone rather than seek help. However, there has been little research into the characteristics of this group...
  96. ncbi request reprint Stress, the hippocampus and the hypothalamic-pituitary-adrenal axis: implications for the development of psychotic disorders
    Lisa J Phillips
    Department of Psychology, University of Melbourne, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 40:725-41. 2006
    ..This paper summarizes and discusses evidence supporting a role for HPA-axis dysfunction in the early phase of schizophrenia and related disorders...
  97. doi request reprint Cognitive decline following psychosis onset: data from the PACE clinic
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053 Australia
    Br J Psychiatry Suppl 51:s52-7. 2007
    ..The origin of cognitive impairments in psychotic disorders is still unclear. Although some deficits are apparent prior to the onset of frank illness, it is unknown if they progress...
  98. ncbi request reprint Pattern of lifetime Axis I morbidity among a treated sample of first-episode psychosis patients
    Sarah Bendall
    ORYGEN Research Centre, Parkville, Victoria, Australia
    Psychopathology 41:90-5. 2008
    ..The current study examined Axis I psychiatric comorbidity in 62 people being treated for FEP...
  99. ncbi request reprint Prediction of functional outcome 18 months after a first psychotic episode: a proton magnetic resonance spectroscopy study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton, Melbourne, Victoria 3053, Australia
    Arch Gen Psychiatry 63:969-76. 2006
    ..These studies have generally been negative, perhaps because gray and white matter volumes inaccurately assess the underlying dysfunction that might be predictive of outcome...
  100. ncbi request reprint Impact of severity of substance use disorder on symptomatic and functional outcome in young individuals with first-episode psychosis
    Darryl Wade
    Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    J Clin Psychiatry 68:767-74. 2007
    ..To investigate whether severity of substance use disorder is independently associated with 15-month symptomatic or functional outcome in young individuals with first-episode psychosis...