P A McCombe

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. pmc Gene expression in the spinal cord in female lewis rats with experimental autoimmune encephalomyelitis induced with myelin basic protein
    Hayley R Inglis
    University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia
    PLoS ONE 7:e48555. 2012
  2. doi Female reproductive issues in multiple sclerosis
    Pamela A McCombe
    The University of Queensland Centre for Clinical Research, Royal Brisbane and Women s Hospital, Herston, QLD 4029, Australia
    Mult Scler 19:392-402. 2013
  3. doi Immune and inflammatory responses to stroke: good or bad?
    P A McCombe
    Department of Neurology, Royal Brisbane and Women s Hospital and Neuroimmunology Research Unit, Central Clinical School, University of Queensland, Brisbane, Australia
    Int J Stroke 3:254-65. 2008
  4. pmc Recombinant EPF/chaperonin 10 promotes the survival of O4-positive pro-oligodendrocytes prepared from neonatal rat brain
    P A McCombe
    Central Clinical School, The University of Queensland Royal Brisbane Hospital, Herston, Queensland, Australia
    Cell Stress Chaperones 13:467-74. 2008
  5. doi Bladder dysfunction in multiple sclerosis
    Pamela A McCombe
    Center for Clinical Research, The University of Queensland, Royal Brisbane and Women s Hospital, Herston, QLD, Australia
    Expert Rev Neurother 9:331-40. 2009
  6. ncbi Sexual dimorphism in autoimmune disease
    P A McCombe
    The University of Queensland, Centre for Clinical Research, Royal Brisbane and Women s Hospital, Brisbane, 4029, Australia
    Curr Mol Med 9:1058-79. 2009
  7. doi T cells from patients with Guillain-Barré syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1
    P A McCombe
    Centre for Clinical Research, The Royal Brisbane and Women s Hospital, The University of Queensland, Herston Road, Herston, Queensland 4029, Australia
    J Clin Neurosci 17:537-8. 2010
  8. pmc The Role of immune and inflammatory mechanisms in ALS
    P A McCombe
    The University of Queensland, UQ Centre for Clinical Research, Australia
    Curr Mol Med 11:246-54. 2011
  9. pmc The effect of ageing on human lymphocyte subsets: comparison of males and females
    Jun Yan
    The University of Queensland, UQ Centre for Clinical Research, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Immun Ageing 7:4. 2010
  10. doi Effects of gender in amyotrophic lateral sclerosis
    Pamela A McCombe
    The University of Queensland Centre for Clinical Research, Department of Neurology, Royal Brisbane and Women s Hospital, Herston, Australia
    Gend Med 7:557-70. 2010

Collaborators

Detail Information

Publications33

  1. pmc Gene expression in the spinal cord in female lewis rats with experimental autoimmune encephalomyelitis induced with myelin basic protein
    Hayley R Inglis
    University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia
    PLoS ONE 7:e48555. 2012
    ..EAE induced in the Lewis with myelin basic protein (MBP-EAE) is well characterised, making it an ideal candidate for the analysis of gene expression in this disease model...
  2. doi Female reproductive issues in multiple sclerosis
    Pamela A McCombe
    The University of Queensland Centre for Clinical Research, Royal Brisbane and Women s Hospital, Herston, QLD 4029, Australia
    Mult Scler 19:392-402. 2013
    ..The strong biological effect of pregnancy on MS deserves further study, so that these mechanisms can possibly be replicated as therapies for MS...
  3. doi Immune and inflammatory responses to stroke: good or bad?
    P A McCombe
    Department of Neurology, Royal Brisbane and Women s Hospital and Neuroimmunology Research Unit, Central Clinical School, University of Queensland, Brisbane, Australia
    Int J Stroke 3:254-65. 2008
    ..The possibility that some of the immune response after stroke may be neuroprotective is exciting and suggests that deliberate enhancement of these responses may be a therapeutic option...
  4. pmc Recombinant EPF/chaperonin 10 promotes the survival of O4-positive pro-oligodendrocytes prepared from neonatal rat brain
    P A McCombe
    Central Clinical School, The University of Queensland Royal Brisbane Hospital, Herston, Queensland, Australia
    Cell Stress Chaperones 13:467-74. 2008
    ..We also studied the effects of bFGF, PDGF, IGF-1 and insulin as controls. With cpn 10 present, there was enhanced survival of O4(+) cells...
  5. doi Bladder dysfunction in multiple sclerosis
    Pamela A McCombe
    Center for Clinical Research, The University of Queensland, Royal Brisbane and Women s Hospital, Herston, QLD, Australia
    Expert Rev Neurother 9:331-40. 2009
    ..Urgency of micturition is prominent in MS, and better understanding of the receptors involved in bladder sensation suggests possible treatment strategies through inhibiting these receptors...
  6. ncbi Sexual dimorphism in autoimmune disease
    P A McCombe
    The University of Queensland, Centre for Clinical Research, Royal Brisbane and Women s Hospital, Brisbane, 4029, Australia
    Curr Mol Med 9:1058-79. 2009
    ..We assert that sex is a vital variable that must be considered in all immunological studies, as it should be at all levels of biological research...
  7. doi T cells from patients with Guillain-Barré syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1
    P A McCombe
    Centre for Clinical Research, The Royal Brisbane and Women s Hospital, The University of Queensland, Herston Road, Herston, Queensland 4029, Australia
    J Clin Neurosci 17:537-8. 2010
    ..There was significantly increased production of interferon-gamma but not interleukin-5 in response to stimulation with the ganglioside GM1. This could indicate that SFC have a role in pathogenesis of disease...
  8. pmc The Role of immune and inflammatory mechanisms in ALS
    P A McCombe
    The University of Queensland, UQ Centre for Clinical Research, Australia
    Curr Mol Med 11:246-54. 2011
    ..However more recently it has become apparent that an immune response can occur as a response to damage to the nervous system and this can be protective...
  9. pmc The effect of ageing on human lymphocyte subsets: comparison of males and females
    Jun Yan
    The University of Queensland, UQ Centre for Clinical Research, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Immun Ageing 7:4. 2010
    ..CONCLUSION: The cause of the change in percentage of lymphocyte subsets with age, and the different effects on males and females is not fully understood but warrants further study...
  10. doi Effects of gender in amyotrophic lateral sclerosis
    Pamela A McCombe
    The University of Queensland Centre for Clinical Research, Department of Neurology, Royal Brisbane and Women s Hospital, Herston, Australia
    Gend Med 7:557-70. 2010
    ..There is evidence that amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is more common in men than in women and that gender influences the clinical features of the disease. The causes of this are unknown...
  11. doi Growth hormone secretion is correlated with neuromuscular innervation rather than motor neuron number in early-symptomatic male amyotrophic lateral sclerosis mice
    F J Steyn
    School of Biomedical Sciences, University of Queensland, St Lucia 4072, Australia or Prof Chen Chen, School of Biomedical Sciences, University of Queensland, St Lucia 4072, Australia E mail
    Endocrinology 154:4695-706. 2013
    ....
  12. ncbi The relationship between Bayesian motor unit number estimation and histological measurements of motor neurons in wild-type and SOD1(G93A) mice
    S T Ngo
    University of Queensland Centre for Clinical Research, University of Queensland, Australia
    Clin Neurophysiol 123:2080-91. 2012
    ..To assess the relationship between Bayesian MUNE and histological motor neuron counts in wild-type mice and in an animal model of ALS...
  13. pmc Antibody responses to peptides of peripheral nerve myelin proteins P0 and P2 in patients with inflammatory demyelinating neuropathy
    H R Inglis
    Neuroimmunology Research Centre, The University of Queensland, Brisbane, Queensland, Australia
    J Neurol Neurosurg Psychiatry 78:419-22. 2007
    ....
  14. ncbi Effects of cyclosporin A treatment on clinical course and inflammatory cell apoptosis in experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein
    P A McCombe
    Department of Medicine, The University of Queensland, Royal Brisbane Hospital, Australia
    J Neuroimmunol 97:60-9. 1999
    ..2+ encephalitogenic T cells that normally occurs during spontaneous recovery from acute EAE...
  15. ncbi The roles of Fas, Fas ligand and Bcl-2 in T cell apoptosis in the central nervous system in experimental autoimmune encephalomyelitis
    C A White
    Department of Medicine, The University of Queensland, Royal Brisbane Hospital, Australia
    J Neuroimmunol 82:47-55. 1998
    ..2+ T cells to apoptosis in the CNS in EAE. These findings support the hypothesis that autoreactive T cells are eliminated from the CNS during spontaneous recovery from EAE by activation-induced apoptosis involving the Fas pathway...
  16. ncbi Cytokine expression by inflammatory cells obtained from the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis induced by inoculation with myelin basic protein and adjuvants
    P A McCombe
    Department of Medicine, The University of Queensland, Australia
    J Neuroimmunol 88:30-8. 1998
    ..This study indicates that IL-2, IL-4, IL-10 and IFN-gamma are expressed by inflammatory cells in the spinal cord in EAE, with the relative expression of all cytokines being high during late clinical recovery...
  17. ncbi Cyclosporin A treatment modulates cytokine mRNA expression by inflammatory cells extracted from the spinal cord of rats with experimental autoimmune encephalomyelitis induced by inoculation with myelin basic protein
    J Harness
    Neuroimmunology Research Unit, Department of Medicine, The University of Queensland, Australia
    J Neurol Sci 187:7-16. 2001
    ..It is possible that these changes in cytokine mRNA expression contribute to the modulation of the clinical course of EAE that is produced by CsA treatment...
  18. ncbi Early pregnancy factor treatment suppresses the inflammatory response and adhesion molecule expression in the spinal cord of SJL/J mice with experimental autoimmune encephalomyelitis and the delayed-type hypersensitivity reaction to trinitrochlorobenzene
    Bing Zhang
    Department of Surgery, The University of Queensland, Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    J Neurol Sci 212:37-46. 2003
    ..These results indicate that suppression of immunological mechanisms by rEPF plays a major role in the reduction of clinical signs of disease in experimental autoimmune encephalomyelitis (EAE)...
  19. ncbi The effects of pregnancy on myelin basic protein-induced experimental autoimmune encephalomyelitis in Lewis rats: suppression of clinical disease, modulation of cytokine expression in the spinal cord inflammatory infiltrate and suppression of lymphocyte p
    J Harness
    Department of Medicine, The University of Queensland, Brisbane, Australia
    Am J Reprod Immunol 46:405-12. 2001
    ..CONCLUSION: Circulating humoral factors and alteration in cytokine production by inflammatory cells may contribute to the suppression of EAE in pregnant rats...
  20. ncbi Studies of HLA associations in male and female patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)
    Pamela A McCombe
    Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Brisbane, Australia
    J Neuroimmunol 180:172-7. 2006
    ..This suggests that sex-related factors may interact with the risk associated with carriage of HLA-DR2 for development of CIDP...
  21. ncbi Effect of gender on T-cell proliferative responses to myelin proteolipid protein antigens in patients with multiple sclerosis and controls
    Judith M Greer
    Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Australia
    J Autoimmun 22:345-52. 2004
    ..We suggest that this may be relevant to the higher prevalence of MS in women...
  22. ncbi Early pregnancy factor suppresses the infiltration of lymphocytes and macrophages in the spinal cord of rats during experimental autoimmune encephalomyelitis but has no effect on apoptosis
    Stavrosia Athanasas-Platsis
    Department of Medicine, The University of Queensland, Royal Brisbane Hospital, Queensland 4029, Australia
    J Neurol Sci 214:27-36. 2003
    ..These results suggest that EPF treatment reduces the numbers of lymphocytes and macrophages in the CNS, possibly through an effect on cell trafficking...
  23. doi Reduced levels of interleukin 33 and increased levels of soluble ST2 in subjects with amyotrophic lateral sclerosis
    C Y Lin
    The University of Queensland Centre for Clinical Research, Australia
    J Neuroimmunol 249:93-5. 2012
    ..However the levels of IL-33 could also be lower due to effects of sST2 which acts as a receptor for IL-33. The levels of sST2 could reflect inflammation in ALS...
  24. doi Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic stroke
    P Singh
    The University of Queensland, UQ Centre for Clinical Research, Australia
    J Neurol Sci 304:117-21. 2011
    ..Blood pNfH levels that reflect the severity of ischaemic stroke, are correlated with outcome and rise during the weeks after stroke. This may be a useful measure of tissue damage in stroke...
  25. pmc T cell reactivity to P0, P2, PMP-22, and myelin basic protein in patients with Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy
    P A Csurhes
    Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Brisbane, Australia
    J Neurol Neurosurg Psychiatry 76:1431-9. 2005
    ....
  26. ncbi Body mass index and dietary intervention: implications for prognosis of amyotrophic lateral sclerosis
    S T Ngo
    School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia University of Queensland Centre for Clinical Research, University of Queensland, Herston, Queensland, Australia
    J Neurol Sci 340:5-12. 2014
    ....
  27. doi Impairments to the GH-IGF-I axis in hSOD1G93A mice give insight into possible mechanisms of GH dysregulation in patients with amyotrophic lateral sclerosis
    F J Steyn
    School of Biomedical Sciences, University of Queensland, St Lucia 4072, Australia
    Endocrinology 153:3735-46. 2012
    ..This is the first account of disrupted GH secretion in a transgenic mouse model of ALS. These observations are essential for the development of effective GH and IGF-I targeted therapies in ALS...
  28. ncbi The stimulus-response curve and motor unit variability in normal subjects and subjects with amyotrophic lateral sclerosis
    R D Henderson
    Department of Neurology, Royal Brisbane and Women s Hospital, Brisbane, Queensland 4029, Australia
    Muscle Nerve 34:34-43. 2006
    ..The stimulus-response curve shows differences between normal and ALS subjects and provides information on MU activation and variability throughout the curve...
  29. doi Increased levels of activated T-cells and reduced levels of CD4/CD25+ cells in peripheral blood of Guillain-Barré syndrome patients compared to controls
    J Harness
    Neuroimmunology Research Unit, Central Clinical School, The University of Queensland, Brisbane, Queensland, Australia
    J Clin Neurosci 15:1031-5. 2008
    ..We therefore suggest that in GBS there are increased activated T-cells and disturbances in regulatory T-cells and T-cell apoptosis...
  30. doi Immune activation in the peripheral blood of patients with acute ischemic stroke
    Jun Yan
    The University of Queensland, Centre for Clinical Research, Brisbane, Australia
    J Neuroimmunol 206:112-7. 2009
    ..There was also an increase in the percentage of CCR7+ T cells. There were no significant differences in the activation of other cell types. In conclusion, there is evidence of immune activation and Treg cells in acute ischaemic stroke...
  31. ncbi Increased circulating T cell reactivity to GM1 ganglioside in patients with Guillain-Barré syndrome
    Peter A Csurhes
    Department of Medicine, The University of Queensland, Brisbane, Australia
    J Clin Neurosci 12:409-15. 2005
    ..We suggest that T cell reactivity to gangliosides might play a contributory role in the pathogenesis of GBS and perhaps CIDP...
  32. ncbi Postural orthostatic tachycardia syndrome: an underrecognized disorder
    J D Pandian
    Department of Neurology, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Intern Med J 37:529-35. 2007
    ..The aim was to study the clinical symptomatology, results of autonomic testing and outcome in patients with POTS...
  33. ncbi Increased circulating T cell reactivity to GM3 and GQ1b gangliosides in primary progressive multiple sclerosis
    Michael P Pender
    Department of Medicine, The University of Queensland, Queensland, Australia
    J Clin Neurosci 10:63-6. 2003
    ..These findings suggest that ganglioside-specific T cells may contribute to the axonal damage in primary progressive MS...