Geoff McCaughan

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance
    G W McCaughan
    Royal Prince Alfred Hospital, Centenary Institute of Cancer Medicine and Cell Biology and The University of Sydney, Australia
    Immunol Rev 174:172-91. 2000
  2. pmc Factors associated with uptake of treatment for recent hepatitis C virus infection in a predominantly injecting drug user cohort: The ATAHC Study
    J Grebely
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 376 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Drug Alcohol Depend 107:244-9. 2010
  3. doi request reprint Trekking new ground: overcoming medical and social impediments for extended criteria liver transplant recipients
    Geoffrey W McCaughan
    Australian National Liver Transplant Unit, A W Morrow Gastroenterology and Liver Center, Centenary Research Institute, Royal Prince Alfred Hospital, University of Sydney, Newtown, New South Wales, Australia
    Liver Transpl 18:S39-46. 2012
  4. pmc Fibrosis progression in chronic hepatitis C virus infection
    G W McCaughan
    NHMRC Clinical Centre of Research Excellence in Outcomes for Chronic Liver Disease, Centenary Research Institute, University of Sydney, Royal Prince Alfred Hospital, Australia
    Gut 53:318-21. 2004
  5. ncbi request reprint Mechanisms of HCV reinfection and allograft damage after liver transplantation
    Geoffrey W McCaughan
    Liver Immunobiology Laboratory, The AW Morrow Gastroenterology and Liver Centre, Centenary Research Institute, Royal Prince Alfred Hospital, University of Sydney, Missenden Road, Camperdown, NSW 2050, Australia
    J Hepatol 40:368-74. 2004
  6. ncbi request reprint Pathogenesis of hepatitis C virus recurrence in the liver allograft
    Geoffrey W McCaughan
    AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia
    Liver Transpl 8:S7-S13. 2002
  7. doi request reprint Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes
    Geoffrey W McCaughan
    AW Morrow Gastroenterology and Liver Centre, Centenary Institute, Royal Prince Alfred Hospital and Sydney University, Sydney, Australia
    Transplantation 87:1105-11. 2009
  8. doi request reprint Advances in viral hepatitis: 50 years of Australian gastroenterology
    Geoff McCaughan
    AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown NSW 2050, Australia
    J Gastroenterol Hepatol 24:S132-5. 2009
  9. ncbi request reprint Asian Pacific Association for the Study of the Liver consensus statements on the diagnosis, management and treatment of hepatitis C virus infection
    G W McCaughan
    Centenary Research Institute, AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, University of Sydney, NSW 2006, Australia
    J Gastroenterol Hepatol 22:615-33. 2007
  10. doi request reprint Minimal but significant improvement in survival for non-hepatitis C-related adult liver transplant patients beyond the one-year posttransplant mark
    Geoffrey W McCaughan
    Australian National Liver Transplant Unit, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia
    Liver Transpl 16:130-7. 2010

Detail Information

Publications74

  1. ncbi request reprint Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance
    G W McCaughan
    Royal Prince Alfred Hospital, Centenary Institute of Cancer Medicine and Cell Biology and The University of Sydney, Australia
    Immunol Rev 174:172-91. 2000
    ..This review touches on these diverse aspects of liver function and disease...
  2. pmc Factors associated with uptake of treatment for recent hepatitis C virus infection in a predominantly injecting drug user cohort: The ATAHC Study
    J Grebely
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 376 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Drug Alcohol Depend 107:244-9. 2010
    ..Decisions about whether to initiate treatment for recently acquired HCV were mainly driven by clinical factors, rather than factors related to sociodemographics or injecting behaviors...
  3. doi request reprint Trekking new ground: overcoming medical and social impediments for extended criteria liver transplant recipients
    Geoffrey W McCaughan
    Australian National Liver Transplant Unit, A W Morrow Gastroenterology and Liver Center, Centenary Research Institute, Royal Prince Alfred Hospital, University of Sydney, Newtown, New South Wales, Australia
    Liver Transpl 18:S39-46. 2012
    ..3. Physio-social issues require written guidelines and patient advocates. 4. Methadone maintenance therapy per se is not a contra-indication to liver transplantation...
  4. pmc Fibrosis progression in chronic hepatitis C virus infection
    G W McCaughan
    NHMRC Clinical Centre of Research Excellence in Outcomes for Chronic Liver Disease, Centenary Research Institute, University of Sydney, Royal Prince Alfred Hospital, Australia
    Gut 53:318-21. 2004
    ..However, it is recognised that some patients do not progress while others rapidly develop significant fibrosis. Here, we review studies that have assessed factors that could influence this rate of fibrotic progression...
  5. ncbi request reprint Mechanisms of HCV reinfection and allograft damage after liver transplantation
    Geoffrey W McCaughan
    Liver Immunobiology Laboratory, The AW Morrow Gastroenterology and Liver Centre, Centenary Research Institute, Royal Prince Alfred Hospital, University of Sydney, Missenden Road, Camperdown, NSW 2050, Australia
    J Hepatol 40:368-74. 2004
  6. ncbi request reprint Pathogenesis of hepatitis C virus recurrence in the liver allograft
    Geoffrey W McCaughan
    AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia
    Liver Transpl 8:S7-S13. 2002
    ..7. More studies are required to examine and distinguish allograft rejection in the setting of HCV infection from HCV infection alone...
  7. doi request reprint Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes
    Geoffrey W McCaughan
    AW Morrow Gastroenterology and Liver Centre, Centenary Institute, Royal Prince Alfred Hospital and Sydney University, Sydney, Australia
    Transplantation 87:1105-11. 2009
    ....
  8. doi request reprint Advances in viral hepatitis: 50 years of Australian gastroenterology
    Geoff McCaughan
    AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown NSW 2050, Australia
    J Gastroenterol Hepatol 24:S132-5. 2009
    ..This review outlines some of these contributions...
  9. ncbi request reprint Asian Pacific Association for the Study of the Liver consensus statements on the diagnosis, management and treatment of hepatitis C virus infection
    G W McCaughan
    Centenary Research Institute, AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, University of Sydney, NSW 2006, Australia
    J Gastroenterol Hepatol 22:615-33. 2007
  10. doi request reprint Minimal but significant improvement in survival for non-hepatitis C-related adult liver transplant patients beyond the one-year posttransplant mark
    Geoffrey W McCaughan
    Australian National Liver Transplant Unit, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia
    Liver Transpl 16:130-7. 2010
    ..In conclusion, although overall survival following liver transplantation in adults seems to be improving over time, the long-term results are not, particularly in HCV patients...
  11. ncbi request reprint Asian perspectives on viral hepatitis: hepatitis C virus infection
    G W McCaughan
    AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    J Gastroenterol Hepatol 15:G90-3. 2000
    ..Finally, liver transplantation for advanced HCV infection with cirrhosis is an option via cadaveric and living donor programmes...
  12. ncbi request reprint Effects of immunosuppression and organ transplantation on the natural history and immunopathogenesis of hepatitis C virus infection
    G W McCaughan
    The AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia
    Transpl Infect Dis 2:166-85. 2000
    ..Also, the role played by immunosuppression and organ transplantation in modifying the course of the infection and the pathogenesis of liver injury will be discussed...
  13. pmc Adherence to treatment for recently acquired hepatitis C virus (HCV) infection among injecting drug users
    Jason Grebely
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    J Hepatol 55:76-85. 2011
    ..We assessed 80/80 adherence (≥80% of PEG-IFN doses, ≥80% treatment), on-treatment adherence, and treatment completion in a study of treatment of recent HCV infection (ATAHC)...
  14. pmc Characteristics and treatment outcomes among HIV-infected individuals in the Australian Trial in Acute Hepatitis C
    G V Matthews
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    Clin Infect Dis 48:650-8. 2009
    ..Enrollment is open to both human immunodeficiency virus (HIV)-infected and -uninfected individuals. The aim of this article was to evaluate characteristics and virological outcomes among HIV-infected individuals enrolled in ATAHC...
  15. ncbi request reprint Usage and outcomes of deceased donor liver allografts with preprocurement injury from blunt trauma
    Irma Laurentia Antonia Geenen
    Australian National Liver Transplantation Unit, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Liver Transpl 15:321-5. 2009
    ..Strategies to deal with trauma include resection of the right lobe if required. Use of deceased donor livers with injury is a safe way to expand the donor pool...
  16. pmc Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection
    Jason Grebely
    National Centre in HIV Epidemiology and Clinical Research NCHECR, University of New South Wales UNSW, Sydney, Australia
    Hepatology 52:1216-24. 2010
    ..Early therapeutic intervention could be recommended for individuals with unfavorable IL28B genotypes...
  17. ncbi request reprint Liver transplantation utilizing pediatric cadaver donor livers
    Hideaki Tanaka
    Liver Transplantation Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Pediatr Transplant 9:47-51. 2005
    ..Vascular complications and chronic rejection tend to be more common in pediatric recipients, whilst patient mortality and graft loss from acute rejection are more common in adult recipients...
  18. ncbi request reprint Molecular approaches to the side effects of immunosuppressive drugs
    Geoff McCaughan
    The A W Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown NSW 2050, Australia
    Transplantation 78:1114-5. 2004
  19. ncbi request reprint Lamivudine plus low-dose hepatitis B immunoglobulin to prevent recurrent hepatitis B following liver transplantation
    Edward J Gane
    Auckland City Hospital, Auckland, New Zealand
    Gastroenterology 132:931-7. 2007
    ..We report on long-term safety and efficacy of an alternative strategy of very low doses (400-800 IU/month) of intramuscular (IM) HBIG plus lamivudine...
  20. ncbi request reprint Vitamin D replacement for cirrhosis-related bone disease
    Bronwyn A Crawford
    Royal Prince Alfred Hospital and Concord General Repatriation Hospital, and a Senior Clinical Lecturer in the Faculty of Medicine at the University of Sydney, Australia
    Nat Clin Pract Gastroenterol Hepatol 3:689-99. 2006
    ....
  21. ncbi request reprint Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis
    Alessandra Warren
    Centre for Education and Research on Ageing and the ANZAC Research Institute, Concord RG Hospital and University of Sydney, Sydney, Australia
    J Hepatol 46:239-46. 2007
    ..The liver sinusoidal endothelial cell (LSEC) is increasingly recognized as having an important role in hepatic immunity. However, the responses of LSECs and the hepatic sinusoid in immune-mediated hepatitis are poorly described...
  22. ncbi request reprint T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells
    Alessandra Warren
    Centre for Education and Research on Ageing CERA and the ANZAC Research Institute, Concord RG Hospital and University of Sydney, Sydney, Australia
    Hepatology 44:1182-90. 2006
    ..These results hold implications for the pathogenesis of viral hepatitis in which hepatocytes may represent the main antigen-presenting cell, and for the development of immune tolerance as lymphocytes pass through the liver...
  23. ncbi request reprint Long-term lamivudine monotherapy prevents development of hepatitis B virus infection in hepatitis B surface-antigen negative liver transplant recipients from hepatitis B core-antibody-positive donors
    Emilia Prakoso
    AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, Australia
    Clin Transplant 20:369-73. 2006
    ..The aim of this study is to assess the efficacy of long-term lamivudine monotherapy to prevent development of HBV infection in HBsAg-negative recipients of liver allografts from HBcAb-positive donors...
  24. ncbi request reprint Zoledronic acid prevents bone loss after liver transplantation: a randomized, double-blind, placebo-controlled trial
    Bronwyn A L Crawford
    Royal Prince Alfred Hospital, University of New South Wales, NHMRC Clinical Trials Centre, and University of Sydney, New South Wales, Australia
    Ann Intern Med 144:239-48. 2006
    ..Clinically important rapid bone loss occurs within 3 to 6 months after liver transplantation and may be associated with osteoporotic fractures...
  25. ncbi request reprint The liver: a special case in transplantation tolerance
    Volker Benseler
    Centenary Institute and AW Morrow Gastroenterology and Liver Centre, Sydney, NSW, Australia
    Semin Liver Dis 27:194-213. 2007
    ..Thus, the major challenge in liver transplantation will be to favor these tolerogenic processes while developing strategies that specifically inhibit alloreactive memory T cells...
  26. ncbi request reprint Insulin resistance and liver injury in hepatitis C is not associated with virus-specific changes in adipocytokines
    Ian Homer Y Cua
    Storr Liver Unit, Westmead Millennium Institute and Department of Gastroenterology and Hepatology, University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia
    Hepatology 46:66-73. 2007
    ..HCV-associated IR is most likely an adipocytokine-independent effect of the virus to modulate insulin sensitivity...
  27. ncbi request reprint Liver fibrosis: a balance of ACEs?
    Fiona J Warner
    A W Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Clin Sci (Lond) 113:109-18. 2007
    ..This review focuses on the potential roles of the RAS, angiotensin II and ACE2 in chronic liver injury and fibrogenesis...
  28. doi request reprint A randomized study of adefovir dipivoxil in place of HBIG in combination with lamivudine as post-liver transplantation hepatitis B prophylaxis
    Peter W Angus
    Victorian Liver Transplant Unit, Austin Health, Victoria, Australia
    Hepatology 48:1460-6. 2008
    ..Yearly cost of combination adefovir/lamivudine prophylaxis was $8,290 versus $13,718 IM HBIG/lamivudine...
  29. pmc Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death
    Lauren E Holz
    Centenary Institute, AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital and Faculty of Medicine, University of Sydney, Camperdown, New South Wales, Australia
    Gastroenterology 135:989-97. 2008
    ..However, the molecular mechanism by which intrahepatically activated T cells become tolerant is unknown. Here, we investigated the phenotype and fate of naïve CD8 T cells activated by hepatocytes in vivo...
  30. doi request reprint Blocking indoleamine dioxygenase activity early after rat liver transplantation prevents long-term survival but does not cause acute rejection
    Jerome M Laurence
    Collaborative Transplantation Research Group, Bosch Institute, Royal Prince Alfred Hospital, University of Sydney, Australia
    Transplantation 85:1357-61. 2008
    ..In conclusion, the differential IDO expression by B lymphocytes in the spleen of TOL recipients is not critical for preventing acute rejection...
  31. ncbi request reprint Liver tolerance and the manipulation of immune outcomes
    Lauren E Holz
    AW Morrow Gastroenterology and Liver Centre, Centenary Institute, Locked Bag No 6, Newtown, NSW 2042, Australia
    Inflamm Allergy Drug Targets 7:6-18. 2008
    ....
  32. doi request reprint Heart allograft acceptance induced by anti-CD3 antibody in high-responder rats: effect on foxp3 and cytokine expression and graft infiltration
    Vincent W T Lam
    Collaborative Transplant Research Laboratory, Department of Surgery, University of Sydney and Royal Prince Alfred Hospital, Sydney, Australia
    Transpl Immunol 19:20-4. 2008
    ..18 treatment led to long-term heart transplant survival associated with marked inhibition of early inflammation. Failure to develop tolerance was associated with a lack of early accumulation of Foxp3 cells in the graft or spleen...
  33. doi request reprint Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease
    Devanshi Seth
    Drug Health Services, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia
    J Hepatol 48:614-27. 2008
    ..Aim of our study was to study the direct effect of alcohol on fibrinolysis and plasmin activity in hepatic cell lines and in vivo...
  34. ncbi request reprint Inflammation and repair in viral hepatitis C
    Manuela G Neuman
    In Vitro Drug Safety and Biotechnology, Department of Pharmacology, Biophysics and Global Health, Institute of Drug Research, University of Toronto, Toronto, ON, Canada
    Dig Dis Sci 53:1468-87. 2008
    ..This review will also aim to describe the importance of IFN-alpha-based therapies in HCV infection, ways of monitoring them, and associated complications...
  35. ncbi request reprint Intrahepatic interferon-stimulated gene responses: can they predict treatment responses in chronic hepatitis C infection?
    Nicholas A Shackel
    Hepatology 46:1326-8. 2007
  36. ncbi request reprint Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis
    Xiao X Huang
    A W Morrow Gastroenterology and Liver Centre at Royal Prince Alfred Hospital, NSW, Australia
    Liver Int 27:960-8. 2007
    ..Cirrhosis can lead to hepatocellular carcinoma (HCC). Non-diseased liver and hepatitis C virus (HCV)-associated cirrhosis with or without HCC were compared...
  37. ncbi request reprint Predictors of relapse to harmful alcohol after orthotopic liver transplantation
    Maria Kelly
    Alcohol Problems Service, Royal Edinburgh Hospital, Scotland
    Alcohol Alcohol 41:278-83. 2006
    ..End-stage alcoholic liver disease (ALD) is a common indication for liver transplantation. Outcomes may be limited by return to harmful drinking. Previous studies have identified few predictors of drinking relapse...
  38. ncbi request reprint Early intrahepatic antigen-specific retention of naïve CD8+ T cells is predominantly ICAM-1/LFA-1 dependent in mice
    Patrick Bertolino
    AW Morrow Gastroenterology and Liver Centre and Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, University of Sydney, Newtown, NSW, Australia
    Hepatology 42:1063-71. 2005
    ..In conclusion, LFA-1-dependent intrahepatic T cell retention and activation are linked events that may play a crucial role in the establishment of liver-induced antigen-specific tolerance...
  39. ncbi request reprint Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells
    Marc H Dahlke
    Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, Sydney, Australia
    J Hepatol 44:334-41. 2006
    ..The role of adult bone marrow-derived cells (BMC) in hepatic regeneration is controversial. Both transdifferentiation of BMC as well as fusion with hepatocytes have been suggested in toxin-based and genetic selection models...
  40. ncbi request reprint A prospective cross-over study comparing the effect of mycophenolate versus azathioprine on allograft function and viral load in liver transplant recipients with recurrent chronic HCV infection
    Amany Zekry
    AW Morrow Gastroenterology and Liver Centre, University of Sydney, Camperdown, Australia
    Liver Transpl 10:52-7. 2004
    ..In a cohort of 13 HCV liver transplant recipients with recurrent chronic HCV infection, substitution of azathioprine with MMF did not lead to a decrease in viral load...
  41. ncbi request reprint Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected]
    Jason M Hui
    Storr Liver Unit, Westmead Millennium Insitute, and Department of Gastroenterology and Hepatology, University of Sydney at Westmead Hospital, New South Wales, Australia
    Gastroenterology 125:1695-704. 2003
    ..Chronic hepatitis C virus infection is associated with an increased prevalence of type 2 diabetes. We hypothesized that virus-induced insulin resistance may be a mechanism for fibrogenesis in chronic hepatitis C virus infection...
  42. pmc Gene expression profiling of alcoholic liver disease in the baboon (Papio hamadryas) and human liver
    Devanshi Seth
    Drug Health Services, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Am J Pathol 163:2303-17. 2003
    ..The gene expression profile of ALD is dominated by alcohol metabolism and inflammation and differs from other liver diseases. Annexins may play a role in the progression of fibrosis in ALD...
  43. ncbi request reprint Impact of immunosuppression on immunopathogenesis of liver damage in hepatitis C virus-infected recipients following liver transplantation
    Geoffrey W McCaughan
    A W Morrow Gastroenterology and Liver Centre, Centenary Research Institute for Cancer Research and Cell Biology, Royal Prince Alfred Hospital, University of Sydney, Australia
    Liver Transpl 9:S21-7. 2003
    ..5. Changes to definitions of types of HCV disease recurrence, disease severity, and acute allograft rejection in the presence of HCV infection are required to improve understanding of the pathogenesis...
  44. ncbi request reprint Hepatitis C virus quasispecies: misunderstood and mistreated?
    Geoffrey W McCaughan
    Liver Transpl 9:1048-52. 2003
  45. ncbi request reprint Intrahepatic expression of collagen and fibroblast activation protein (FAP) in hepatitis C virus infection
    Mark D Gorrell
    A W Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Centenary Institute of Cancer Medicine and Cell Biology and The University of Sydney, Newtown, NSW, Australia
    Adv Exp Med Biol 524:235-43. 2003
  46. ncbi request reprint SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates
    Devanshi Seth
    Drug Health Services and A W Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital and Centenary Institute of Cancer Medicine and Cell Biology, Camperdown, NSW 2050, Australia
    J Biochem Biophys Methods 55:53-66. 2003
    ....
  47. ncbi request reprint Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8 T-cell activation by bone marrow-derived cells
    David G Bowen
    A W Morrow Gastroenterology and Liver Centre and Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia
    Gastroenterology 123:1252-64. 2002
    ..Mouse transgenic models were therefore developed to investigate whether bystander damage to non-antigen-bearing hepatocytes occurs in vivo...
  48. ncbi request reprint Postoperative administration of donor B cells induces rat kidney allograft acceptance: lack of association with Th2 cytokine expression in long-term accepted grafts
    Yiqun Yan
    AW Morrow Liver Immunobiology Laboratory, Centenary Institute, and Department of Pathology, Royal Prince Alfred Hospital, New South Wales 2050, Australia
    Transplantation 73:1123-30. 2002
    ..This study aims to identify the leukocyte subset that is most active in prolonging kidney allograft survival and examine the cytokine expression in long-term acceptance...
  49. ncbi request reprint Intrahepatic cytokine profiles associated with posttransplantation hepatitis C virus-related liver injury
    Amany Zekry
    AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney University, Camperdown, New South Wales, Australia
    Liver Transpl 8:292-301. 2002
    ..In this setting, the TH2 immune response may favor viral replication and graft damage...
  50. ncbi request reprint Role of primary intrahepatic T-cell activation in the 'liver tolerance effect'
    Patrick Bertolino
    Liver Immunobiology Laboratory, TheCentenary Institute Of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Immunol Cell Biol 80:84-92. 2002
    ..Here, we examine the capability of each cell type to act as APC for naive CD4+ or CD8+ T cells and to induce tolerance...
  51. pmc Insights into the pathobiology of hepatitis C virus-associated cirrhosis: analysis of intrahepatic differential gene expression
    Nicholas A Shackel
    A W Morrow Gastroenterology and Liver Centre, Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Sydney, Australia
    Am J Pathol 160:641-54. 2002
    ..In conclusion, HCV-associated cirrhosis was characterized by a proinflammatory, profibrotic, and proapoptotic gene expression profile...
  52. ncbi request reprint Increased mononuclear cell activation and apoptosis early after human liver transplantation is associated with a reduced frequency of acute rejection
    Julie R Jonsson
    University of Queensland School of Medicine, Southern Division, Brisbane, Australia
    Liver Transpl 10:397-403. 2004
    ....
  53. pmc Parenchymal expression of CD86/B7.2 contributes to hepatitis C virus-related liver injury
    Jiaren Sun
    Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1019, USA
    J Virol 79:10730-9. 2005
    ..This study provides an additional rationale for exploring immunomodulation-based therapies that could reduce disease progression in individuals with chronic HCV infection...
  54. ncbi request reprint Posttransplant interleukin-4 treatment converts rat liver allograft tolerance to rejection
    Chuanmin Wang
    Liver Laboratory, Centenary Institute, Sydney University, Camperdown, NSW, Australia
    Transplantation 79:1116-20. 2005
    ..The aim of this study was to investigate whether IL-4 treatment converts PVG-->DA liver transplant tolerance to rejection...
  55. ncbi request reprint Development and resolution of experimental colitis in mice with targeted deletion of dipeptidyl peptidase IV
    Mark S Geier
    Child Health Research Institute and Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Cell Physiol 204:687-92. 2005
    ..We conclude that loss of DPIV activity does not increase resistance to experimental colitis and hypothesize that other DPIV family members may also be involved in the cleavage of GLP-2...
  56. ncbi request reprint Liver transplantation for viral hepatitis
    Geoffrey W McCaughan
    AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
    Hosp Med 66:8-12. 2005
    ..This review briefly discusses liver transplantation for fulminant hepatitis but focuses on transplantation for hepatitis B- and hepatitis C-associated cirrhosis...
  57. ncbi request reprint Hepascore: an accurate validated predictor of liver fibrosis in chronic hepatitis C infection
    Leon A Adams
    Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Perth, Australia
    Clin Chem 51:1867-73. 2005
    ..We sought to create an algorithm of serum markers that accurately and reliably predict liver fibrosis stage among hepatitis C patients...
  58. ncbi request reprint Intrahepatic immunity: a tale of two sites?
    David G Bowen
    Center for Vaccines and Immunity, Columbus Children s Research Institute, 700 Childrens Drive, Columbus, OH 43205, USA
    Trends Immunol 26:512-7. 2005
    ..These findings support a novel model of hepatic-immune interactions, with implications for our understanding of the paradoxical nature of liver immunobiology...
  59. ncbi request reprint Combined donor leucocyte administration and immunosuppressive drug treatment for survival of rat heart allografts
    Marcel den Dulk
    AW Morrow Liver Immunobiology Laboratory, Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Locked Bag 6, Newtown, Sydney NSW 2042, Australia
    Transpl Immunol 13:177-84. 2004
    ..They appear to induce early activation, altered patterns of infiltration and death of recipient alloreactive T cells. The ability of immunosuppressive drugs to combine with DL administration was examined in a rat heart transplant model...
  60. pmc The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity
    David G Bowen
    A W Morrow Gastroenterology and Liver Centre, Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales, Australia
    J Clin Invest 114:701-12. 2004
    ..The implications of these novel findings may pertain not only to the normal maintenance of peripheral tolerance, but also to hepatic allograft tolerance and the immunopathogenesis of chronic viral hepatitis...
  61. ncbi request reprint Patient and graft survival after liver transplantation for hereditary hemochromatosis: Implications for pathogenesis
    Darrell H G Crawford
    Queensland Liver Transplant Service and The University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Hepatology 39:1655-62. 2004
    ..Our data suggest that iron excess in HH does not wholly depend on intestinal iron absorption but is also influenced by liver factors that moderate iron metabolism...
  62. ncbi request reprint Expression of growth arrest-specific gene 6 and its receptors in a rat model of chronic renal transplant rejection
    Jian L Yin
    Department of Renal Medicine, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Transplantation 73:657-60. 2002
    ..The proliferation of these cells is a feature of chronic rejection (CR) after kidney transplantation. Therefore, we examined the gene expression of Gas6 and its receptors Rse, Axl, and Mer in a rat model of CR...
  63. ncbi request reprint Hereditary lysozyme amyloidosis: spontaneous hepatic rupture (15 years apart) in mother and daughter. role of emergency liver transplantation
    Martin Loss
    Department of Transplant Surgery, Royal Prince Alfred Hospital, Camperdown, Australia
    Liver Transpl 12:1152-5. 2006
    ..The mother of this patient had presented in an identical fashion 15 years earlier in the pretransplant era and died very rapidly...
  64. ncbi request reprint Dietary protein intakes in patients with hepatic encephalopathy and cirrhosis: current practice in NSW and ACT
    Joanne K Heyman
    A W Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia joanne heymanATcs nsw gov au
    Med J Aust 185:542-3. 2006
    ....
  65. ncbi request reprint Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line
    Xin Maggie Wang
    A W Morrow Gastroenterology and Liver Centre at Royal Prince Alfred Hospital, Centenary Institute of Cancer Medicine and Cell Biology and The Discipline of Medicine, University of Sydney, Sydney, Australia
    Hepatology 42:935-45. 2005
    ....
  66. ncbi request reprint Combination adefovir-lamivudine prevents emergence of adefovir resistance in lamivudine-resistant hepatitis B
    David Van der Poorten
    Department of Gastroenterology and Hepatology, Concord Hospital, Sydney, New South Wales, Australia
    J Gastroenterol Hepatol 22:1500-5. 2007
    ..This study aims to characterize the virological and biochemical response and to determine factors that may influence the development of resistance to adefovir...
  67. ncbi request reprint Gene array analysis and the liver
    Nicholas A Shackel
    A W Morrow Gastroenterology and Liver Centre, Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital and the University of Sydney, Sydney, Australia
    Hepatology 36:1313-25. 2002
    ..Finally, the importance of a coordinate experimental approach examining both liver protein and mRNA expression is presented...
  68. ncbi request reprint Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization
    Nicholas A Shackel
    A W Morrow Gastroenterology and Liver Centre, Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Sydney, Australia
    Hepatology 38:577-88. 2003
    ..In particular, further studies of the RERE gene and its products in HCV associated liver disease are warranted...
  69. ncbi request reprint Simultaneous vascularized bone marrow transplantation to promote acceptance of hind limb allografts and its effects on central and peripheral chimerism
    Alexander Kubitskiy
    Microsearch Foundation of Australia, The University of Sydney, Sydney, Australia
    Transplantation 83:1273-6. 2007
    ..Few donor cells were observed in thymus. Simultaneous VBM transplantation showed a trend for improved survival of HLTX however the VBM failed to provide a sustained increase in chimerism...
  70. ncbi request reprint Pathogenesis and management of alcoholic hepatitis
    Paul S Haber
    Drug Health Services and AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, and Department of Medicine, University of Sydney, Sydney, Australia
    J Gastroenterol Hepatol 18:1332-44. 2003
    ....
  71. ncbi request reprint Fibroblast activation protein and chronic liver disease
    Xin Maggie Wang
    Centenary Institute, Faculty of Medicine, The University of Sydney, Syndney, Australia
    Front Biosci 13:3168-80. 2008
    ..FAP peptide substrates include denatured collagen and alpha2-antiplasmin. The functional roles of FAP in tumors and fibrotic tissue are not fully understood. This review places FAP in the context of chronic liver injury pathogenesis...
  72. ncbi request reprint Effect of ascites on bone density measurement in cirrhosis
    Eternity D Labio
    NHMRC Center of Clinical Research Excellence to Improve Outcome in Chronic Liver Disease, AW Morrow Gastroenterology and Liver Center, University of Sydney, Camperdown, New South Wales, Australia
    J Clin Densitom 10:391-4. 2007
    ..These results suggest that ascites cause a fluid artifact in the soft tissue and bone interface that can falsely lower BMD measurements, particularly in the spine...
  73. ncbi request reprint Improved prediction of fibrosis in chronic hepatitis C using measures of insulin resistance in a probability index
    Archana Sud
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia
    Hepatology 39:1239-47. 2004
    ..Such an index should prove useful to guide decision making regarding the need for liver biopsy, and potentially for avoiding or deferring biopsy in a large proportion of patients with mild liver disease...
  74. ncbi request reprint Outcome of patients with hepatocellular carcinoma referred to a tertiary centre with availability of multiple treatment options including cadaveric liver transplantation
    John F Perry
    AW Morrow Gastroenterology and Liver Centre, Australian National Liver Transplant Unit, NHMRC Centre for Clinical Research Excellence to Improve Outcomes in Liver Disease, Royal Prince Alfred Hospital and University of Sydney, Sydney, NSW, Australia
    Liver Int 27:1240-8. 2007
    ..Conclusion: In conclusion, both surgical resection and liver transplantation significantly improve the survival of patients with HCC, but improvements need to be made to the delivery of loco-regional therapy to enhance its effectiveness...