N A McBrien

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi Scleral remodeling during the development of and recovery from axial myopia in the tree shrew
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 41:3713-9. 2000
  2. ncbi Role of the sclera in the development and pathological complications of myopia
    Neville A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria 3010, Australia
    Prog Retin Eye Res 22:307-38. 2003
  3. ncbi Structural and ultrastructural changes to the sclera in a mammalian model of high myopia
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 42:2179-87. 2001
  4. ncbi The role of visual information in the control of scleral matrix biology in myopia
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Curr Eye Res 23:313-9. 2001
  5. ncbi Retinal acetylcholine content in normal and myopic eyes: a role in ocular growth control?
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Vis Neurosci 18:571-80. 2001
  6. ncbi Diisopropylfluorophosphate alters retinal neurotransmitter levels and reduces experimentally-induced myopia
    C L Cottriall
    Department of Optometry and Vision Sciences, University of Melbourne, Victoria, Australia
    Naunyn Schmiedebergs Arch Pharmacol 364:372-82. 2001
  7. ncbi Expression of muscarinic receptor subtypes in tree shrew ocular tissues and their regulation during the development of myopia
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Mol Vis 15:464-75. 2009
  8. ncbi Inhibition of myopia development in chicks using himbacine: a role for M(4) receptors?
    C L Cottriall
    Department of Optometry and Vision Sciences, University of Melbourne, Victoria 3010, Australia
    Neuroreport 12:2453-6. 2001
  9. ncbi Glycosaminoglycan synthesis in the separate layers of the chick sclera during myopic eye growth: comparison with mammals
    A Gentle
    Department of Optometry and Vision Sciences, University of Melbourne, Victoria, Australia
    Curr Eye Res 23:179-84. 2001
  10. ncbi High-resolution semi-quantitative real-time PCR without the use of a standard curve
    A Gentle
    The University of Melbourne, Victoria, Australia
    Biotechniques 31:502, 504-6, 508. 2001

Collaborators

  • J R Phillips
  • Alex Gentle
  • C L Cottriall
  • A Gentle
  • Andrew I Jobling
  • Sangeetha Metlapally
  • Ravikanth Metlapally
  • Alexandra Jaworski
  • George C Yin
  • Megan S Kenning
  • Hue-Trung Truong
  • Kirstan A Vessey
  • Charles L Cottriall
  • H T Truong
  • Andrew J Zele
  • Algis J Vingrys
  • Martin Nguyen
  • Yanyan Liu
  • Giada L Conti
  • Jennifer E Martin
  • F Anastasopoulos
  • K A Vessey
  • J Brew

Detail Information

Publications22

  1. ncbi Scleral remodeling during the development of and recovery from axial myopia in the tree shrew
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 41:3713-9. 2000
    ..Scleral glycosaminoglycan (GAG) synthesis and content as well as scleral dry weight changes were monitored as indicators of remodeling in myopic and recovering tree shrew sclerae...
  2. ncbi Role of the sclera in the development and pathological complications of myopia
    Neville A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria 3010, Australia
    Prog Retin Eye Res 22:307-38. 2003
    ..This review aims to build on existing models to illustrate that the prevention of aberrant scleral remodelling must be the goal of any long-term therapy for the amelioration of the permanent vision loss associated with high myopia...
  3. ncbi Structural and ultrastructural changes to the sclera in a mammalian model of high myopia
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 42:2179-87. 2001
    ....
  4. ncbi The role of visual information in the control of scleral matrix biology in myopia
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Curr Eye Res 23:313-9. 2001
    ..These visually-driven changes in scleral biochemistry are placed in the context of both the emmetropisation process and the abnormal enlargement of the eye that is characteristic of human high myopia...
  5. ncbi Retinal acetylcholine content in normal and myopic eyes: a role in ocular growth control?
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Vis Neurosci 18:571-80. 2001
    ..5%) and chicks (dopamine -12.3% and DOPAC -28.2%). These findings demonstrate that, contrary to dopamine and DOPAC content, steady-state retinal acetylcholine and choline content is not significantly altered during myopia development...
  6. ncbi Diisopropylfluorophosphate alters retinal neurotransmitter levels and reduces experimentally-induced myopia
    C L Cottriall
    Department of Optometry and Vision Sciences, University of Melbourne, Victoria, Australia
    Naunyn Schmiedebergs Arch Pharmacol 364:372-82. 2001
    ..Findings argue against a direct cholinergic 'stop-go' pathway controlling ocular growth. Instead the reduction of induced myopia could be related to the action of DFP (directly or indirectly) on dopamine levels in the retina...
  7. ncbi Expression of muscarinic receptor subtypes in tree shrew ocular tissues and their regulation during the development of myopia
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Mol Vis 15:464-75. 2009
    ..However, their site of action is unknown. This study details ocular muscarinic subtype expression within a well documented model of eye growth and investigates their expression during early stages of myopia induction...
  8. ncbi Inhibition of myopia development in chicks using himbacine: a role for M(4) receptors?
    C L Cottriall
    Department of Optometry and Vision Sciences, University of Melbourne, Victoria 3010, Australia
    Neuroreport 12:2453-6. 2001
    ..4 +/- 2.0, p < 0.01). Findings demonstrate himbacine is effective at preventing the development of myopia in chick and implicates a role for the M4 receptor...
  9. ncbi Glycosaminoglycan synthesis in the separate layers of the chick sclera during myopic eye growth: comparison with mammals
    A Gentle
    Department of Optometry and Vision Sciences, University of Melbourne, Victoria, Australia
    Curr Eye Res 23:179-84. 2001
    ....
  10. ncbi High-resolution semi-quantitative real-time PCR without the use of a standard curve
    A Gentle
    The University of Melbourne, Victoria, Australia
    Biotechniques 31:502, 504-6, 508. 2001
    ..The assay was found to be linear over at least four orders of magnitude...
  11. ncbi Pirenzepine affects scleral metabolic changes in myopia through a non-toxic mechanism
    Hue-Trung Truong
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, 3010, Australia
    Exp Eye Res 74:103-11. 2002
    ..Consequently, the prevention of myopia development in chicks, with either pirenzepine or brief periods of unoccluded vision, is associated with the transient modulation of scleral glycosaminoglycan synthesis in the cartilaginous sclera...
  12. ncbi The effect of positive lens defocus on ocular growth and emmetropization in the tree shrew
    Sangeetha Metlapally
    Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia
    J Vis 8:1.1-12. 2008
    ..The threshold for consistent responses to positive lens defocus in tree shrew was between +4 and +6 D. The results will enable targeted investigation of the efficacy of positive lens defocus in inhibiting myopic ocular growth...
  13. ncbi Expression of collagen-binding integrin receptors in the mammalian sclera and their regulation during the development of myopia
    Neville A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, Australia 3010
    Invest Ophthalmol Vis Sci 47:4674-82. 2006
    ..This study identified the major collagen-binding integrin receptors in the mammalian sclera and investigated their mRNA expression during the development of and recovery from experimental myopia...
  14. ncbi Characterization of the integrin receptor subunit profile in the mammalian sclera
    Ravikanth Metlapally
    Department of Optometry and Vision Sciences, University of Melbourne, Carlton, Victoria, Australia
    Mol Vis 12:725-34. 2006
    ....
  15. ncbi Expression and cDNA sequence of matrix metalloproteinase-2 (MMP-2) in a mammalian model of human disease processes: Tupaia belangeri
    Megan S Kenning
    Department of Optometry and Vision Sciences, University of Melbourne, Australia
    DNA Seq 15:332-7. 2004
    ..The tree shrew is a species close to the primate line and is an emerging animal model for a variety of human diseases, including hepatitis and myopia that feature MMP-2 mediated remodelling of the extracellular matrix...
  16. ncbi Pressure-induced changes in axial eye length of chick and tree shrew: significance of myofibroblasts in the sclera
    John R Phillips
    Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia
    Invest Ophthalmol Vis Sci 45:758-63. 2004
    ..To investigate the change in axial eye dimensions resulting from stretching the sclera by acute elevation of intraocular pressure (IOP)...
  17. ncbi Isoform-specific changes in scleral transforming growth factor-beta expression and the regulation of collagen synthesis during myopia progression
    Andrew I Jobling
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 279:18121-6. 2004
    ..In addition, the early alterations in TGF-beta expression levels may reflect a role for these cytokines in mediating the retinoscleral signal that controls myopic eye growth...
  18. ncbi Retinoscleral control of scleral remodelling in refractive development: a role for endogenous FGF-2?
    Alex Gentle
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria 3010, Australia
    Cytokine 18:344-8. 2002
    ..The present study sought to determine whether endogenous FGF-2 was associated with retinoscleral signalling or scleral remodelling during changes in refractive error in a mammalian model of myopia...
  19. ncbi Collagen gene expression and the altered accumulation of scleral collagen during the development of high myopia
    Alex Gentle
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 278:16587-94. 2003
    ....
  20. ncbi Muscarinic antagonist control of myopia: a molecular search for the M1 receptor in chick
    George C Yin
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Mol Vis 10:787-93. 2004
    ..Alternative mechanisms of action are discussed...
  21. ncbi Altered visual sensitivity in axial high myopia: a local postreceptoral phenomenon?
    Alexandra Jaworski
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 47:3695-702. 2006
    ..The present study investigated retinal integrity in high myopia using spatial psychophysical tasks...
  22. ncbi Muscarinic receptor protein expression in the ocular tissues of the chick during normal and myopic eye development
    Kirstan A Vessey
    Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, Vic. 3010, Australia
    Brain Res Dev Brain Res 135:79-86. 2002
    ..However, myopic eye enlargement was not associated with changes in muscarinic receptor protein expression in the chick retina and choroid...