Research Topics
Genomes and Genes
| Jacqueline M MatthewsSummaryAffiliation: University of Sydney Country: Australia Publications
| Collaborators
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Detail Information
Publications
Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferationCorrine J Porter
School of Biomedical and Chemical Sciences, University of Western Australia, WA 6009, Australia
BMC Struct Biol 7:58. 2007..Recently, an inhibitory peptide (G7-18NATE) has been developed which binds specifically to the Grb7 SH2 domain and is able to attenuate cancer cell proliferation and migration in various cancer cell lines...
It takes two to tango: the structure and function of LIM, RING, PHD and MYND domainsJ M Matthews
School of Molecular and Microbial Biosciences, University of Sydney, Sydney NSW 2006, Australia
Curr Pharm Des 15:3681-96. 2009..Here we review the structure-function relationships for these domains and discuss strategies to modulate their activity...- LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteinsJacqueline M Matthews
School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia
EMBO Rep 4:1132-7. 2003.... - Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complexJanet E Deane
School of Molecular and Microbial Biosciences, University of Sydney, Australia
EMBO J 23:3589-98. 2004..These combined properties provide a mechanism for the binding of Ldb1 to numerous LMO and LIM-HD proteins. Furthermore, the modular extended interface may form a general mode of binding to tandem LIM domains... - Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interactionChu Kong Liew
School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
Proc Natl Acad Sci U S A 102:583-8. 2005..Details of the architecture of the contact domains and their physical properties provide a molecular explanation for how the GATA-1 mutations contribute to distinct but related genetic diseases... - Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingersBelinda J Westman
School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
Biochemistry 43:13318-27. 2004..These studies provide the first structural insights into how EosC mediates protein-protein interactions and contributes to our understanding of why it does not exhibit high-affinity DNA binding... - Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motifManu J Dubin
School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia
J Biol Chem 279:26932-8. 2004..These results suggest a specific model for CtIP homodimerization via its N terminus and contribute to an improved understanding of how this protein might assemble other factors required for its role as a transcriptional corepressor... - CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactionsRaina J Y Simpson
School of Molecular and Microbial Biosciences, G08, University of Sydney, New South Wales 2006, Australia
J Biol Chem 278:28011-8. 2003.... - Stabilization of a binary protein complex by intein-mediated cyclizationCy M Jeffries
School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia
Protein Sci 15:2612-8. 2006..Thus, the restriction of the more stable component of a complex may enhance stability to a greater extent than restraining less stable components... - Identification of the key LMO2-binding determinants on Ldb1Daniel P Ryan
School of Molecular and Microbial Biosciences, University of Sydney, NSW, Australia
J Mol Biol 359:66-75. 2006..The delineation of this region reveals some specific differences when compared to the equivalent LMO4:Ldb1 interaction that hold promise for the development of reagents to specifically bind LMO2 in the treatment of leukemia... - Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein graftingBelinda K Sharpe
School of Molecular and Microbial Biosciences, University of Sydney, Sydney NSW 2006, Australia
Structure 13:257-66. 2005..These results both highlight the robust nature of small zinc binding domains and underscore the complexity of designing functional proteins, even using such small, highly ordered scaffolds as templates... - Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexesMugdha Bhati
School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales, Australia
EMBO J 27:2018-29. 2008..The resulting alternate protein complexes can target different genes to regulate key biological events... - A classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3Raina J Y Simpson
School of Molecular and Microbial Biosciences, G08, University of Sydney, NSW 2006, Australia
J Biol Chem 279:39789-97. 2004..Our data demonstrate the versatility of cZFs and have implications for the analysis of many as yet uncharacterized cZF proteins... - Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specificationMorgan S Gadd
School of Molecular Bioscience, The University of Sydney, New South Wales 2006, Australia
J Biol Chem 286:42971-80. 2011..The formation of weaker Lhx·Isl complexes would likely be masked by the availability of the other Lhx·Isl complexes in postmitotic motor neurons... - Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12Daniel P Ryan
School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
Proteins 70:1461-74. 2008..Our data provide biophysical evidence for a mechanism, by which LMO2 and TAL1 both regulate transcription in normal blood cell development, and synergistically disrupt E2A function in T-cells to promote the onset of leukaemia... - Dimerization of CtIP may stabilize in vivo interactions with the Retinoblastoma-pocket domainPhilippa H Stokes
School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
Biochem Biophys Res Commun 354:197-202. 2007..Thus dimerization may increase the apparent stability of the proteins and/or the lifetime of the complexes... - A complex mechanism determines polarity of DNA replication fork arrest by the replication terminator complex of Bacillus subtilisIain G Duggin
School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales 2006 and Research School of Chemistry, Australian National University, Australian Capital Territory 0200, Australia
J Biol Chem 280:13105-13. 2005..Furthermore, efficient fork arrest relies on features in addition to the tight binding of RTP to terminator DNA... - Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4Janet E Deane
School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
EMBO J 22:2224-33. 2003..These findings constitute the first molecular definition of LIM-mediated protein-protein interactions and suggest a mechanism by which ldb1 can bind a variety of LIM domains that share low sequence homology... 
Competition between LIM-binding domainsJacqueline M Matthews
School of Molecular and Microbial Biosciences, The University of Sydney, NSW, Australia
Biochem Soc Trans 36:1393-7. 2008..Through our and other studies, it is emerging that the multiple layers of competitive binding involving LMO and LIM-HD proteins and their partner proteins contribute significantly to cell fate specification and development...- Crystallization of FLINC4, an intramolecular LMO4-ldb1 complexJanet E Deane
School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
Acta Crystallogr D Biol Crystallogr 59:1484-6. 2003..3 and 1.7 A resolution, respectively. Anomalous Patterson maps calculated with data collected at the peak wavelength show strong peaks sufficient to determine the positions of four Zn atoms per asymmetric unit... - Structural analysis of MED-1 reveals unexpected diversity in the mechanism of DNA recognition by GATA-type zinc finger domainsJason A Lowry
School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia
J Biol Chem 284:5827-35. 2009..Our data expand the versatility of DNA recognition by GATA-type zinc fingers and perhaps shed new light on the DNA-binding properties of mammalian GATA factors... - Engineering a protein scaffold from a PHD fingerAnn H Y Kwan
School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006 Australia
Structure 11:803-13. 2003..These results represent a step toward designing new regulatory proteins for modulating aberrant gene expression in vivo... - Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1Roland Gamsjaeger
School of Molecular and Microbial Biosciences, University of Sydney, Building G08, New South Wales, Sydney 2006, Australia
J Biol Chem 283:5158-67. 2008..Our data indicate that MyT1 ZnFs recognize the major groove of DNA in a way that appears to differ from other known zinc binding domains... - Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1Lorna Wilkinson-White
School of Molecular Bioscience, University of Sydney, New South Wales, 2006 Sydney, Australia
Proc Natl Acad Sci U S A 108:14443-8. 2011.... - Characterization of the conserved interaction between GATA and FOG family proteinsKasper Kowalski
School of Molecular and Microbial Biosciences, University of Sydney, Sydney New South Wales 2006, Australia
J Biol Chem 277:35720-9. 2002..Taken together, these results suggest that the CCHC zinc binding topology is required for the integrity of GATA-FOG interactions and that weak interactions can play important roles in vivo... - Dimers, oligomers, everywhereJacqueline M Matthews
School of Molecular Bioscience, University of Sydney, Sydney, Australia
Adv Exp Med Biol 747:1-18. 2012.... - Crystallization and diffraction of an Lhx4-Isl2 complexMorgan S Gadd
School of Molecular and Microbial Biosciences, University of Sydney, Australia
Acta Crystallogr Sect F Struct Biol Cryst Commun 65:151-3. 2009..The monoclinic crystals belonged to space group P2(1), with unit-cell parameters a = 46.8, b = 88.7, c = 49.9 A, beta = 111.9 degrees, and diffracted to 2.16 A resolution... - Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactionsMugdha Bhati
School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia
PLoS ONE 7:e40719. 2012..Thus the mutation would affect the formation of Lhx3-containing transcription factor complexes, particularly in the pituitary gland where these complexes are required for the production of multiple pituitary cell types and hormones... - Zinc fingers--folds for many occasionsJacqueline M Matthews
School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
IUBMB Life 54:351-5. 2002..We review the similarities and differences in structure and functions of different ZnF classes and highlight the versatility of this fold... - Solution structure of a tethered Lmo2(LIM2) /Ldb1(LID) complexSiavoush Dastmalchi
School of Molecular Bioscience, University of Sydney, Sydney, New South Wales 2006, Australia
Protein Sci 21:1768-74. 2012.... - ¹H, ¹⁵N and ¹³C assignments of an intramolecular LMO4-LIM1/CtIP complexChu Wai Liew
School of Molecular Bioscience, University of Sydney, Building G08, Sydney, NSW 2006, Australia
Biomol NMR Assign 6:31-4. 2012..Here we report backbone and side chain NMR assignments for an engineered intramolecular complex of the N-terminal LIM domain from LMO4 tethered to residues 641-685 of C-terminal binding protein interacting protein (CtIP/RBBP8)... - TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancerMargaret Sunde
School of Molecular and Microbial Biosciences and Discipline of Medicine, University of Sydney, Australia
Cancer Res 64:2766-73. 2004..These results suggest that overexpression of TC-1 may be important in thyroid carcinogenesis... - The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2Jeremy Turner
School of Molecular and Microbial Biosciences, G08, University of Sydney, New South Wales 2006, Australia
J Biol Chem 278:12786-95. 2003..However, we find FHL3 can repress transcription. We suggest that LIM proteins like FHL3 are important in assembling specific repression or activation complexes, depending on conditions such as cofactor availability and promoter context... - Protein-protein interactions in human diseaseDaniel P Ryan
School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
Curr Opin Struct Biol 15:441-6. 2005..A range of approaches are being developed to generate inhibitors of protein-protein interactions that may form useful therapeutics for human disease... - ATP binding equilibria of the Na(+),K(+)-ATPaseAnne Pilotelle-Bunner
School of Chemistry, University of Sydney, Sydney NSW 2006, Australia
Biochemistry 47:13103-14. 2008.... - Designed metal-binding sites in biomolecular and bioinorganic interactionsJacqueline M Matthews
School of Molecular and Microbial Biosciences, The University of Sydney, NSW 2006, Australia
Curr Opin Struct Biol 18:484-90. 2008.... - The power of two: protein dimerization in biologyNeelan J Marianayagam
School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia
Trends Biochem Sci 29:618-25. 2004..Specific protein dimerization is integral to biological function, structure and control, and must be under substantial selection pressure to be maintained with such frequency throughout biology... - 1H, 15N and 13C assignments of an intramolecular Lmo2-LIM2/Ldb1-LID complexLorna E Wilkinson-White
School of Molecular Bioscience, Building G08, University of Sydney, Sydney, NSW, 2006, Australia
Biomol NMR Assign 4:203-6. 2010..Here we report backbone and side chain NMR assignments for an engineered intramolecular complex of the C-terminal LIM domain from Lmo2 tethered to the LIM interaction domain (LID) from LIM domain binding protein 1 (Ldb1)... - Protein-protein interactions: analysis of a false positive GST pulldown resultSandra Wissmueller
School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales 2006, Australia
Proteins 79:2365-71. 2011..This study emphasizes the need for caution in relying on GST-pulldown results and related methods, without convincing confirmation from different approaches... - Crystallization and diffraction of an Isl1-Ldb1 complexMorgan S Gadd
School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia
Acta Crystallogr Sect F Struct Biol Cryst Commun 68:1398-401. 2012..The orthorhombic crystals belonged to space group P222(1), with unit-cell parameters a=57.2, b=56.7, c=179.8 Å, and diffracted to 3.10 Å resolution... - A new zinc binding fold underlines the versatility of zinc binding modules in protein evolutionBelinda K Sharpe
Department of Biochemistry, University of Sydney, New South Wales 2006, Australia
Structure 10:639-48. 2002..Our data support the idea that zinc binding domains may arise frequently. Additionally, such structures may prove useful as scaffolds for protein design, given their stability and robustness... - 1H, 15N and 13C assignments of an intramolecular Lhx3:ldb1 complexChristopher Lee
J Biomol NMR 33:198. 2005 - Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activityGillian E Begg
Molecular Cardiology Program, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia
J Biol Chem 281:12603-9. 2006.... - Mechanism of allosteric regulation of transglutaminase 2 by GTPGillian E Begg
Victor Chang Cardiac Research Institute, University of New South Wales, 384 Victoria Street, Darlinghurst NSW 2010, Australia
Proc Natl Acad Sci U S A 103:19683-8. 2006..Although not essential for GTP-mediated inhibition of cross-linking, this H bond enhances the rate of formation of the inactive conformer... - Protein interactions: is seeing believing?Joel P Mackay
Trends Biochem Sci 32:530-1. 2007 - Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restrictionLauren K Ely
Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Proc Natl Acad Sci U S A 103:6641-6. 2006....