F L Mastaglia

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. pmc Plasticity in neurological disorders and challenges for noninvasive brain stimulation (NBS)
    Gary W Thickbroom
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Western Australia, Australia
    J Neuroeng Rehabil 6:4. 2009
  2. ncbi request reprint Distal myopathies
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Western Australia, Australia
    Curr Opin Neurol 18:504-10. 2005
  3. pmc Sporadic inclusion body myositis: variability in prevalence and phenotype and influence of the MHC
    F L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia
    Acta Myol 28:66-71. 2009
  4. ncbi request reprint Prevalence of stroke in Parkinson's disease: a postmortem study
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, Perth, Australia
    Mov Disord 17:772-4. 2002
  5. ncbi request reprint Inflammatory myopathies: how to treat the difficult cases
    F L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, and Department of Medicine, University of Western Australia, Nedlands, WA, Australia
    J Clin Neurosci 10:99-101. 2003
  6. ncbi request reprint Idiopathic inflammatory myopathies: epidemiology, classification, and diagnostic criteria
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, QEII Medical Centre, Department of Medicine, University of Western Australia
    Rheum Dis Clin North Am 28:723-41. 2002
  7. ncbi request reprint Prevalence of amyloid-beta deposition in the cerebral cortex in Parkinson's disease
    Frank L Mastaglia
    Australian Neuromuscular Research Institute, Department of Medicine, University of Western Australia, Perth, Australia
    Mov Disord 18:81-6. 2003
  8. ncbi request reprint Prevalence of cerebral vascular amyloid-beta deposition and stroke in an aging Australian population: a postmortem study
    F L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, QEII Medical Centre, Nedlands, WA 6009, Australia
    J Clin Neurosci 10:186-9. 2003
  9. ncbi request reprint Inflammatory myopathies: clinical, diagnostic and therapeutic aspects
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Australia
    Muscle Nerve 27:407-25. 2003
  10. doi request reprint Sporadic inclusion body myositis: HLA-DRB1 allele interactions influence disease risk and clinical phenotype
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australian Neuromuscular Research Institute ANRI, Queen Elizabeth II Medical Centre, Nedlands, Perth, WA 6009, Australia
    Neuromuscul Disord 19:763-5. 2009

Detail Information

Publications103 found, 100 shown here

  1. pmc Plasticity in neurological disorders and challenges for noninvasive brain stimulation (NBS)
    Gary W Thickbroom
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Western Australia, Australia
    J Neuroeng Rehabil 6:4. 2009
    ....
  2. ncbi request reprint Distal myopathies
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Western Australia, Australia
    Curr Opin Neurol 18:504-10. 2005
    ..This article summarizes the findings of recent clinical, genetic and molecular studies and the current diagnostic approach to this group of patients...
  3. pmc Sporadic inclusion body myositis: variability in prevalence and phenotype and influence of the MHC
    F L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia
    Acta Myol 28:66-71. 2009
    ..The significance of these findings for the pathogenesis of the disease is discussed...
  4. ncbi request reprint Prevalence of stroke in Parkinson's disease: a postmortem study
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, Perth, Australia
    Mov Disord 17:772-4. 2002
    ..Our findings do not indicate either a protective effect against stroke, or a greater susceptibility to death from stroke, in the population studied...
  5. ncbi request reprint Inflammatory myopathies: how to treat the difficult cases
    F L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, and Department of Medicine, University of Western Australia, Nedlands, WA, Australia
    J Clin Neurosci 10:99-101. 2003
    ..The treatment of inclusion body myositis remains unsatisfactory but a trial of prednisolone and methotrexate is warranted in selected patients...
  6. ncbi request reprint Idiopathic inflammatory myopathies: epidemiology, classification, and diagnostic criteria
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, QEII Medical Centre, Department of Medicine, University of Western Australia
    Rheum Dis Clin North Am 28:723-41. 2002
    ....
  7. ncbi request reprint Prevalence of amyloid-beta deposition in the cerebral cortex in Parkinson's disease
    Frank L Mastaglia
    Australian Neuromuscular Research Institute, Department of Medicine, University of Western Australia, Perth, Australia
    Mov Disord 18:81-6. 2003
    ..However, vascular and parenchymal Abeta deposition could still contribute to dementia and cognitive decline when combined with other changes such as alpha-synuclein deposition in the cerebral cortex and cortical Lewy bodies...
  8. ncbi request reprint Prevalence of cerebral vascular amyloid-beta deposition and stroke in an aging Australian population: a postmortem study
    F L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, QEII Medical Centre, Nedlands, WA 6009, Australia
    J Clin Neurosci 10:186-9. 2003
    ..The lack of association between vascular Abeta and cerebral haemorrhage or infarction indicates that, in the present population, CAA was usually asymptomatic...
  9. ncbi request reprint Inflammatory myopathies: clinical, diagnostic and therapeutic aspects
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Australia
    Muscle Nerve 27:407-25. 2003
    ..Improved understanding of the molecular mechanisms of muscle injury in the inflammatory myopathies should lead to the development of more specific forms of immunotherapy for these conditions...
  10. doi request reprint Sporadic inclusion body myositis: HLA-DRB1 allele interactions influence disease risk and clinical phenotype
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australian Neuromuscular Research Institute ANRI, Queen Elizabeth II Medical Centre, Nedlands, Perth, WA 6009, Australia
    Neuromuscul Disord 19:763-5. 2009
    ..The findings indicate that interactions between the HLA-DRB1*03 allele and other alleles at the DRB1 locus can influence disease susceptibility and the clinical phenotype in sIBM...
  11. ncbi request reprint Inflammatory muscle diseases
    F L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands 6009, Australia
    Neurol India 56:263-70. 2008
    ..However, experience with these therapies is still limited and there is a need for randomized trials to test their efficacy and establish guidelines for their use in clinical practice...
  12. doi request reprint When the treatment does not work: polymyositis
    F L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, 6009, Australia
    Pract Neurol 8:170-4. 2008
  13. ncbi request reprint Neuromuscular disorders: molecular and therapeutic insights
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Western Australia, Australia
    Lancet Neurol 4:6-7. 2005
  14. ncbi request reprint Familial inclusion body myositis in a mother and son with different ancestral MHC haplotypes
    Frank Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, 4th Floor, A Block, Queen Elizabeth II Medical Centre, Nedlands WA 6009, Australia
    Neuromuscul Disord 16:754-8. 2006
    ..The findings indicate that in this family either the 8.1AH or 52.1AH may carry susceptibility for IBM and that the 52.1AH is associated with a more severe and treatment-resistant form of the disease...
  15. doi request reprint Iatrogenic myopathies
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, Australia
    Curr Opin Neurol 23:445-9. 2010
    ..This review summarizes the recent progress in understanding of myopathies induced by therapeutic agents, the underlying pathogenetic mechanisms and the management of iatrogenic muscle disorders, focussing on statin-associated myopathies...
  16. pmc Novel mutation in the myelin protein zero gene in a family with intermediate hereditary motor and sensory neuropathy
    F L Mastaglia
    Australian Neuromuscular Research Institute, Departments of Medicine, University of Western Australia, Department of Medicine, 6009, Australia
    J Neurol Neurosurg Psychiatry 67:174-9. 1999
    ..The gene defects in families with intermediate HMSN are not known, but it has been suggested that most have X linked HMSN...
  17. ncbi request reprint Can abnormal evoked potentials predict future clinical disability in patients with multiple sclerosis?
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australia
    Nat Clin Pract Neurol 2:304-5. 2006
  18. ncbi request reprint Tibial nerve entrapment in the popliteal fossa
    F L Mastaglia
    Department of Neurology, Sir Charles Gairdner Hospital and Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, Perth, Australia
    Muscle Nerve 23:1883-6. 2000
    ....
  19. doi request reprint Update on toxic myopathies
    F L Mastaglia
    Centre for Neurological and Neuromuscular Disorders, University of Western Australia, Australian Neuromuscular Research Institute, QEII Medical Centre, 4th Floor A Block, Verdun Street, Nedlands, WA, 6009, Australia
    Curr Neurol Neurosci Rep 12:54-61. 2012
    ..Mitochondrial myopathies associated with antiretroviral agents and the pyrimidine nucleoside analogue clevudine, and recent reports of myopathies caused by ingestion of red yeast rice and toxic species of mushrooms are also discussed...
  20. doi request reprint Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases
    M Needham
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australian Neuromuscular Research Institute ANRI, Queen Elizabeth II Medical Centre, Nedlands, Perth 6009, WA, Australia
    J Neurol Neurosurg Psychiatry 79:1056-60. 2008
    ..We studied a large cohort of patients with sIBM in order to determine the degree of phenotypic variability and different modes of presentation, as well as the influence of HLA haplotypes...
  21. doi request reprint Post-exercise depression in corticomotor excitability after dynamic movement: a general property of fatiguing and non-fatiguing exercise
    W P Teo
    Australian Neuro Muscular Research Institute, Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, Nedlands, WA 6009, Australia
    Exp Brain Res 216:41-9. 2012
    ..However, these changes also occur with and are greater with slower rates of movement and are not specific for motor demand, but may be indicative of adaptive changes in the central motor pathway after a period of repetitive movement...
  22. ncbi request reprint Isometric force-related activity in sensorimotor cortex measured with functional MRI
    G W Thickbroom
    Australian Neuromuscular Research Institute, Queen Elizabeth II Medical Centre, Nedlands, WA
    Exp Brain Res 121:59-64. 1998
    ....
  23. doi request reprint The association of sporadic inclusion body myositis and Sjögren's syndrome in carriers of HLA-DR3 and the 8.1 MHC ancestral haplotype
    A Rojana-udomsart
    Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Perth, Western Australia, Australia
    Clin Neurol Neurosurg 113:559-63. 2011
    ..The association of sIBM and Sjögren's syndrome is likely to be due to a common genetic predisposition linked to the MHC and supports the notion that sIBM has an autoimmune basis...
  24. ncbi request reprint Short-interval cortical inhibition and corticomotor excitability with fatiguing hand exercise: a central adaptation to fatigue?
    Nicola M Benwell
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, WA, 6009, Australia
    Exp Brain Res 170:191-8. 2006
    ....
  25. doi request reprint Comparing kinematic changes between a finger-tapping task and unconstrained finger flexion-extension task in patients with Parkinson's disease
    W P Teo
    Australian Neuromuscular Research Institute, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elisabeth II Medical Centre, Nedlands, WA 6009, Australia
    Exp Brain Res 227:323-31. 2013
    ..Both movement rate and amplitude improved with levodopa; however, movement rate was more levodopa responsive than amplitude...
  26. doi request reprint Breakdown in central motor control can be attenuated by motor practice and neuro-modulation of the primary motor cortex
    W P Teo
    Australian Neuro Muscular Research Institute, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Western Australia, Australia
    Neuroscience 220:11-8. 2012
    ..The results implicate central motor processes in the performance and sustainability of the MVR task, and indicate that MVR kinematics can improve with short-term training and with non-invasive neuro-modulation...
  27. doi request reprint Changes in corticomotor excitability and inhibition after exercise are influenced by hand dominance and motor demand
    W P Teo
    Australian Neuro Muscular Research Institute, Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, Nedlands, WA 6009, Australia
    Neuroscience 210:110-7. 2012
    ..The findings provide additional evidence for differences in neuronal processing between the dominant and nondominant hemispheres in motor control...
  28. pmc Laing early onset distal myopathy: slow myosin defect with variable abnormalities on muscle biopsy
    P J Lamont
    Neurogenetic Unit, Department of Neurology, Royal Perth Hospital, Box X2213 GPO, Perth, Western Australia 6847
    J Neurol Neurosurg Psychiatry 77:208-15. 2006
    ..It is allelic with myosin storage myopathy, with the commonest form of familial hypertrophic cardiomyopathy, and with one form of dilated cardiomyopathy. However, the clinical picture of MPD1 is distinct from these three conditions...
  29. doi request reprint Low level of systemic autoimmunity in Western Australian multiple sclerosis patients
    - Wei Qiu
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Department of Neurology, Sir Charles Gairdner Hospital, Queen Elizabeth Medical Centre, Perth, Australia
    Mult Scler 16:351-4. 2010
    ..There was no correlation between AAbs and HLA-DRB1 alleles. In conclusion, this study failed to confirm previous reports of increased AAbs in MS or to show an association between HLA-DRB1 genotype and the presence of AAbs...
  30. doi request reprint HLA-DRB1 allele heterogeneity influences multiple sclerosis severity as well as risk in Western Australia
    Jing Shan Wu
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia
    J Neuroimmunol 219:109-13. 2010
    ..51 per DRB11501 allele. We also found evidence that the HLA-DRB11201 allele is associated with less severe disease...
  31. ncbi request reprint Patterns of muscle involvement in inclusion body myositis: clinical and magnetic resonance imaging study
    B A Phillips
    Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, Perth, Western Australia, Australia
    Muscle Nerve 24:1526-34. 2001
    ..Involvement of flexor digitorum profundus on MRI was found in only one third of patients. The results emphasize the variability in the clinical phenotype and differential susceptibility of muscles to the disease process in sIBM...
  32. ncbi request reprint Long-term changes in motor cortical organisation after recovery from subcortical stroke
    M L Byrnes
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australian Neuromuscular Research Institute, Western Australian Institute for Medical Research, Nedlands, Australia
    Brain Res 889:278-87. 2001
    ....
  33. ncbi request reprint Differences in functional magnetic resonance imaging of sensorimotor cortex during static and dynamic finger flexion
    G W Thickbroom
    Australian Neuromuscular Research Institute, Queen Elizabeth II Medical Centre, Nedlands, WA
    Exp Brain Res 126:431-8. 1999
    ....
  34. ncbi request reprint Sporadic inclusion body myositis: a continuing puzzle
    M Needham
    Centre for Neuromuscular and Neurological Disorders, Level 4, A Block, Australian Neuromuscular Research Institute, Queen Elizabeth II Medical Centre, University of Western Australia, Perth, WA 6009, Australia
    Neuromuscul Disord 18:6-16. 2008
    ....
  35. ncbi request reprint Corticomotor excitability and perception of effort during sustained exercise in the chronic fatigue syndrome
    P Sacco
    Australian Neuromuscular Research Institute, QE II Medical Centre, Nedlands, WA, Australia
    Clin Neurophysiol 110:1883-91. 1999
    ..We have investigated the possibility of a central basis for the complaints of fatigue and poor exercise tolerance in subjects with chronic fatigue syndrome (CFS)...
  36. ncbi request reprint Changes in corticomotor excitability after fatiguing muscle contractions
    P Sacco
    Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Western Australia 6009, Australia
    Muscle Nerve 23:1840-6. 2000
    ....
  37. ncbi request reprint Early onset chromosome 14-linked distal myopathy (Laing)
    F L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australian Neuromuscular Research Institute, Nedlands, Australia
    Neuromuscul Disord 12:350-7. 2002
    ..2-q13. The linkage region has been refined to a 24 cM region between D14S283 and D14S49 and mutations have been excluded in the PABP2 gene for oculopharyngeal muscular dystrophy which lies within this region...
  38. doi request reprint Clinical profile and HLA-DRB1 genotype of late onset multiple sclerosis in Western Australia
    Wei Qiu
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Nedlands, Western Australia, Australia
    J Clin Neurosci 17:1009-13. 2010
    ..We concluded that patients with LOMS have a different clinical profile when compared to those with EOMS. Carriers of HLA-DRB1 *0801 may be more prone to develop MS at a later age...
  39. ncbi request reprint Changes in the functional MR signal in motor and non-motor areas during intermittent fatiguing hand exercise
    Nicola M Benwell
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, WA 6009, Australia
    Exp Brain Res 182:93-7. 2007
    ..The results are in keeping with the notion of an increase in sensory processing and corticomotor drive during fatiguing exercise to maintain task performance as fatigue develops...
  40. doi request reprint Influence of HLA-DRB1 allele heterogeneity on disease risk and clinical course in a West Australian MS cohort: a high-resolution genotyping study
    Jing Shan Wu
    Centre of Neuromuscular and Neurological Disorders, University of Western Australia, and Department of Neurology, Sir Charles Gairdner Hospital, Queen Elizabeth Medical Centre, Perth, Western Australia, Australia
    Mult Scler 16:526-32. 2010
    ..Previous studies on the influence of HLA-DRB1 alleles on multiple sclerosis (MS) susceptibility and clinical course have mostly employed the 2-point genotyping method...
  41. doi request reprint Evidence for high-fidelity timing-dependent synaptic plasticity of human motor cortex
    R F H Cash
    Australian Neuro muscular Research Institute and Centre for Neuromuscular and Neurological disorders, University of Western Australia, Nedlands, Australia
    J Neurophysiol 109:106-12. 2013
    ..The results are consistent with timing-dependent synaptic LTP/D-like effects and suggest that there are plasticity mechanisms operating in the human motor cortex with a temporal resolution of the order of a few hundreds of microseconds...
  42. ncbi request reprint Transcranial magnetic stimulation of the human frontal eye field
    G W Thickbroom
    Australian Neuromuscular Research Institute, Queen Elizabeth II Medical Centre, Nedlands, Australia
    J Neurol Sci 144:114-8. 1996
    ....
  43. ncbi request reprint Differential changes in long-interval intracortical inhibition and silent period duration during fatiguing hand exercise
    Nicola M Benwell
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, WA, 6009, Australia
    Exp Brain Res 179:255-62. 2007
    ....
  44. doi request reprint Association of cardiovascular factors and Alzheimer's disease plasma amyloid-beta protein in subjective memory complainers
    Kristyn A Bates
    School of Exercise Biomedical and Health Science, Edith Cowan University, Joondalup, WA, Australia
    J Alzheimers Dis 17:305-18. 2009
    ..The relationship between HDL and Abeta and the potential significance of such an association needs to be validated in a larger longitudinal study...
  45. ncbi request reprint Primary sensorimotor cortex activation with task-performance after fatiguing hand exercise
    Nicola M Benwell
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, WA, 6009, Australia
    Exp Brain Res 167:160-4. 2005
    ..0 +/- 0.5 pre-exercise vs 7.3 +/- 0.6 post-exercise; P<0.01). Reduced functional activation in SM1 may reflect increased variability in the activation rather than a reduction in activation of cortical motor networks after fatigue...
  46. pmc Autosomal dominant distal myopathy: linkage to chromosome 14
    N G Laing
    Australian Neuromuscular Research Institute, Perth
    Am J Hum Genet 56:422-7. 1995
    ....
  47. ncbi request reprint Characterization of the alternate allelic forms of human PAX7
    M R Ziman
    Department of Pathology, University of Western Australia, Nedlands, Australia
    Mamm Genome 11:332-7. 2000
    ..Recognition of genetic polymorphism of PAX7 allows new approaches to understanding the role of PAX7 in myogenesis, neurogenesis, and neuromuscular disorders...
  48. ncbi request reprint Magnetic stimulation mapping of motor cortex: factors contributing to map area
    G W Thickbroom
    Australian Neuromuscular Research Institute, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Australia
    Electroencephalogr Clin Neurophysiol 109:79-84. 1998
    ....
  49. ncbi request reprint A model of the effect of MEP amplitude variation on the accuracy of TMS mapping
    G W Thickbroom
    Australian Neuromuscular Research Institute, Queen Elizabeth II Medical Centre, Western Australia
    Clin Neurophysiol 110:941-3. 1999
    ..The results indicate that reliable and accurate mapping studies can be carried out in the presence of an intrinsic variability in MEP amplitude measurements...
  50. ncbi request reprint Inherited skeletal muscle disorders
    N G Laing
    University of Western Australia, QEII Medical Centre, Nedlands, Australia
    Ann Hum Biol 26:507-25. 1999
    ..The major challenges for the future are to understand the pathophysiology of the diseases, now that the genes are being identified, and then to develop successful therapies...
  51. ncbi request reprint The role of the supplementary motor area in externally timed movement: the influence of predictability of movement timing
    G W Thickbroom
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australian Neuromuscular Research Institute, Nedlands, Australia
    Brain Res 874:233-41. 2000
    ....
  52. ncbi request reprint Temporal aspects of passive movement-related corticomotor inhibition
    Dylan J Edwards
    Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, The University of Western Australia, 4th Floor, A Block, Nedlands, WA 6009, Australia
    Hum Mov Sci 23:379-87. 2004
    ....
  53. doi request reprint Presence of CSF oligoclonal bands (OCB) is associated with the HLA-DRB1 genotype in a West Australian multiple sclerosis cohort
    Jing Shan Wu
    Australian Neuromuscular Research Institute, Sir Charles Gairdner Hospital, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, 6009, Perth, WA, Australia
    J Neurol Sci 288:63-7. 2010
    ..Our study is the first to show that HLA-DRB1 allele interactions and dose-effects influence the frequency of OCB...
  54. doi request reprint Modifying effects of HLA-DRB1 allele interactions on age at onset of multiple sclerosis in Western Australia
    Jing Shan Wu
    Centre of Neuromuscular and Neurological Disorders, University of Western Australia, Department of Neurology, Sir Charles Gairdner Hospital, Queen Elizabeth Medical Centre, Perth, Western Australia
    Mult Scler 16:15-20. 2010
    ..These findings indicate that epistatic interactions at the HLA-DRB1 locus have significant modifying effects on age at onset of multiple sclerosis and demonstrate the value of high-resolution genotyping in detecting such associations...
  55. doi request reprint Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms
    F L Mastaglia
    Australian Neuro Muscular Research Institute, Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Western Australia, Australia Institute for Immunology and Infectious Diseases, Murdoch University, Western Australia, Australia Electronic address
    Neuromuscul Disord 23:969-74. 2013
    ..However, further studies in other s-IBM populations are needed to confirm these findings, as well as expression studies of different TOMM40 alleles in muscle tissue...
  56. doi request reprint Co-regulation of survival of motor neuron and Bcl-xL expression: implications for neuroprotection in spinal muscular atrophy
    R S Anderton
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australian Neuromuscular Research Institute, Western Australia, Australia
    Neuroscience 220:228-36. 2012
    ..Our findings implicate Bcl-xL as another potential target in SMA therapeutics, and indicate that therapeutic increases in SMN may arise from modest increases in total SMN...
  57. ncbi request reprint Genetics of inclusion-body myositis
    M Needham
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Level 4, A Block, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia
    Muscle Nerve 35:549-61. 2007
    ..This review summarizes current understanding of the contribution of genetic susceptibility factors to the development of sIBM...
  58. ncbi request reprint Supraspinal inputs reduce corticomotor excitability during passive movement: evidence from a pure sensory stroke
    D J Edwards
    Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Australia
    Restor Neurol Neurosci 25:527-33. 2007
    ..2+/-0.3 mV vs. 6.6+/-0.1 mV; p=0.0224). These observations provide evidence that supraspinal sensory pathways are involved in reducing corticomotor excitability during rhythmic passive movement...
  59. doi request reprint Modulation of corticomotor excitability by an I-wave intervention delivered during low-level voluntary contraction
    B I Silbert
    Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, Nedlands, WA 6009, Australia
    Exp Brain Res 208:229-35. 2011
    ....
  60. ncbi request reprint Globus pallidus stimulation in advanced Parkinson's disease
    J P Rodrigues
    Movement Disorders Clinic, Australian Neuromuscular Research Institute, Perth, Western Australia, Australia
    J Clin Neurosci 14:208-15. 2007
    ..Beneficial effects on off-period motor symptoms are greater with bilateral stimulation; however, with maintenance of dopaminergic medication, unilateral procedures can also provide important and sustained benefits...
  61. ncbi request reprint Dual representation of the hand in the cerebellum: activation with voluntary and passive finger movement
    Gary W Thickbroom
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, QEII Medical Centre, Nedlands, WA 6009, Australia
    Neuroimage 18:670-4. 2003
    ....
  62. ncbi request reprint Motor outcome after subcortical stroke: MEPs correlate with hand strength but not dexterity
    Gary W Thickbroom
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, QEII Medical Centre, Nedlands, Australia
    Clin Neurophysiol 113:2025-9. 2002
    ..The aim of this study in patients with subcortical stroke was to determine whether there is a correlation between MEP amplitude and threshold and the degree of recovery of strength and dexterity in the affected hand...
  63. ncbi request reprint A functional MRI protocol for localizing language comprehension in the human brain
    Gary W Thickbroom
    Brain Research Laboratory, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, WA 6009, Australia
    Brain Res Brain Res Protoc 10:175-80. 2003
    ..As well, the method has potential for the study of cortical processing of auditory speech and written language in healthy subjects and in subjects suffering from language disorders...
  64. pmc Therapeutic applications of hypothermia in cerebral ischaemia
    Bruno P Meloni
    Australian Neuromuscular Research Institute A Block, 1st Floor QEII Medical Centre Nedlands, Western Australia, Australia 6009
    Ther Adv Neurol Disord 1:12-35. 2008
    ..Based upon a review of the experimental studies we discuss the clinical implications for the use of hypothermia as an adjunctive therapy in global cerebral ischaemia and stroke and make some suggestions for its use in these situations...
  65. doi request reprint Rapid slowing of maximal finger movement rate: fatigue of central motor control?
    Julian P Rodrigues
    Centre for Neuromuscular and Neurological Disorders, Level 4 A Block, QEII Medical Centre, University of Western Australia, Nedlands, WA, 6009, Australia
    Exp Brain Res 196:557-63. 2009
    ..Overall, these findings suggest a breakdown of motor control rather than failure of muscle force generation during an MVR task, and therefore that the mechanisms underlying the early decline in movement rate are central in origin...
  66. doi request reprint AP-1 inhibitory peptides are neuroprotective following acute glutamate excitotoxicity in primary cortical neuronal cultures
    Amanda J Meade
    Centre for Neuromuscular and Neurological Disorders, The University of Western Australia and Australian Neuromuscular Research Institute, QEII Medical Centre, Nedlands, WA, Australia
    J Neurochem 112:258-70. 2010
    ..Thus, these peptides have potential application as therapeutics directly or for the rational design of small molecule inhibitors in both apoptotic and necrotic neuronal death associated with AP-1 activation...
  67. doi request reprint Improvement in aerobic capacity after an exercise program in sporadic inclusion body myositis
    Liam G Johnson
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Western Australia
    J Clin Neuromuscul Dis 10:178-84. 2009
    ..The study aimed to investigate the effects of a combined functional and aerobic exercise program on aerobic capacity, muscle strength, and functional mobility in a group of patients with sporadic inclusion body myositis (IBM)...
  68. ncbi request reprint Motor outcome after subcortical stroke correlates with the degree of cortical reorganization
    Gary W Thickbroom
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, WA 6009, Australia
    Clin Neurophysiol 115:2144-50. 2004
    ..The purpose of the study was to investigate the relationship between changes in motor cortex organization, and the degree of motor function after a subcortical stroke...
  69. ncbi request reprint Functional MRI near vascular anomalies: comparison of cavernoma and arteriovenous malformation
    Gary W Thickbroom
    Brain Research Laboratory, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australia
    J Clin Neurosci 11:845-8. 2004
    ..Vascular anomalies could influence the BOLD signal via their effects on both blood flow and susceptibility...
  70. doi request reprint Spike-timing-related plasticity is preserved in Parkinson's disease and is enhanced by dopamine: evidence from transcranial magnetic stimulation
    Julian P Rodrigues
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australia
    Neurosci Lett 448:29-32. 2008
    ..The results support the important role of dopamine in regulating synaptic plasticity and justify a larger crossover study to assess the therapeutic effects of iTMS in PD...
  71. doi request reprint Inclusion body myositis: new insights into pathogenesis
    Michael J Garlepp
    School of Pharmacy, Curtin University of Technology, Australia
    Curr Opin Rheumatol 20:662-8. 2008
    ..The pathogenesis of sporadic inclusion body myositis is complex and the disease has a relentless course. Recent observations regarding possible mechanisms of disease may provide targets for therapy...
  72. ncbi request reprint Corticomotor organisation and motor function in multiple sclerosis
    Gary W Thickbroom
    Centre for Neuromuscular and Neurological Disorders M518, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, WA 6009, Australia
    J Neurol 252:765-71. 2005
    ..An understanding of motor function in MS should incorporate models of both axonal demyelination and conduction deficits as well as neural plasticity...
  73. ncbi request reprint Progressive myopathy with up-regulation of MHC-I associated with statin therapy
    Merrilee Needham
    Centre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, University of Western Australia, Australia
    Neuromuscul Disord 17:194-200. 2007
    ..The mechanism of this myopathy is uncertain but may involve the induction by statins of an endoplasmic reticulum stress response with associated up-regulation of MHC-I expression and antigen presentation by muscle fibres...
  74. ncbi request reprint Blinded placebo crossover study of gabapentin in primary orthostatic tremor
    Julian P Rodrigues
    Movement Disorders Clinic, Australian Neuromuscular Research Institute, Western Australia, Australia
    Mov Disord 21:900-5. 2006
    ..The findings confirm that gabapentin is an effective treatment for OT, reducing both tremor and postural instability and improving quality of life, and support its use as add-on or first-line therapy for OT...
  75. ncbi request reprint Globus pallidus stimulation improves both motor and nonmotor aspects of quality of life in advanced Parkinson's disease
    Julian P Rodrigues
    Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute, University of Western Australia, Nedlands, Western Australia, Australia
    Mov Disord 22:1866-70. 2007
    ..The impacts are broad and improve QoL domains not directly affected by the motor symptoms of the disease. Reduced dyskinesia plays a major role in the improvement of QoL in GPi-DBS treated patients...
  76. ncbi request reprint Reduced functional activation after fatiguing exercise is not confined to primary motor areas
    Nicola M Benwell
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, WA 6009, Australia
    Exp Brain Res 175:575-83. 2006
    ....
  77. ncbi request reprint Apolipoprotein epsilon alleles in sporadic inclusion body myositis: a reappraisal
    Merrilee Needham
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Australia
    Neuromuscul Disord 18:150-2. 2008
    ..Our findings argue against a specific role for any APOE alleles in conferring susceptibility to sIBM but have demonstrated a non-significant trend towards an earlier age-of-onset in patients with the epsilon2 allele...
  78. ncbi request reprint Gabapentin can improve postural stability and quality of life in primary orthostatic tremor
    Julian P Rodrigues
    Australian Neuromuscular Research Institute, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, WA, Australia
    Mov Disord 20:865-70. 2005
    ..Further work is required to establish the optimal dosage and to validate the methods used to quantify the response to treatment...
  79. ncbi request reprint Repetitive paired-pulse TMS at I-wave periodicity markedly increases corticospinal excitability: a new technique for modulating synaptic plasticity
    Gary W Thickbroom
    Centre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, University of Western Australia, Perth, Nedlands, WA 6009, Australia
    Clin Neurophysiol 117:61-6. 2006
    ..Our objective was to determine whether prolonged iTMS can increase corticospinal excitability, and whether this form of stimulation can have lasting aftereffects...
  80. ncbi request reprint Central motor drive and perception of effort during fatigue in multiple sclerosis
    Gary W Thickbroom
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia Queen Elizabeth II Medical Centre, 6009 Perth, WA, Australia
    J Neurol 253:1048-53. 2006
    ....
  81. ncbi request reprint Reversible reorganisation of the motor cortical representation of the hand in cervical dystonia
    Gary W Thickbroom
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Nedlands WA, Australia
    Mov Disord 18:395-402. 2003
    ..The findings also support the notion that head turning is chiefly mediated by the hemisphere ipsilateral to the direction of the head rotation by means of a corticomotor projection to the contralateral SCM...
  82. doi request reprint Prevalence of sporadic inclusion body myositis and factors contributing to delayed diagnosis
    Merrilee Needham
    Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute ANRI, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Perth 6009, Australia
    J Clin Neurosci 15:1350-3. 2008
    ..2 years, which suggests that even the latest prevalence figure may be an underestimate, and emphasising the need to increase the level of awareness of the condition among the medical community...
  83. doi request reprint Enhanced corticomotor excitability with dynamic fatiguing exercise of the lower limb in multiple sclerosis
    Gary W Thickbroom
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Western Australia WA 6009
    J Neurol 255:1001-5. 2008
    ....
  84. ncbi request reprint Paired-pulse rTMS at trans-synaptic intervals increases corticomotor excitability and reduces the rate of force loss during a fatiguing exercise of the hand
    Nicola M Benwell
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, WA 6009, Australia
    Exp Brain Res 175:626-32. 2006
    ..The results indicate that by increasing corticomotor excitability using paired-pulse rTMS at trans-synaptic intervals, maximum voluntary force can be sustained at a higher level during a brief fatiguing maximal voluntary contraction...
  85. ncbi request reprint Motor cortex reorganisation in Parkinson's disease
    Gary W Thickbroom
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Brain Research Laboratory, Queen Elizabeth II Medical Center, Nedlands, WA 6009, Australia
    J Clin Neurosci 13:639-42. 2006
    ....
  86. doi request reprint Neuromodulation by paired-pulse TMS at an I-wave interval facilitates multiple I-waves
    R F H Cash
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Crawley, WA, Australia
    Exp Brain Res 193:1-7. 2009
    ..The findings are consistent with existing models of I-wave generation and suggest that the intervention increases the efficacy of synaptic events associated with the generation of descending I-wave volleys...
  87. ncbi request reprint Differential activation of frontal lobe areas by lexical and semantic language tasks: a functional magnetic resonance imaging study
    David Blacker
    Brain Research Laboratory, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, WA 6009, Australia
    J Clin Neurosci 13:91-5. 2006
    ..We conclude that Broca's area is more active during tasks that have a semantic content, whereas areas involved in preparatory processing (SMA) and memory retrieval (DLPFC) are engaged equally during both types of task...
  88. ncbi request reprint Seasonal occurrence of relapses in inflammatory myopathies: a preliminary study
    Beverley A Phillips
    Centre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, Nedlands WA, Australia
    J Neurol 249:441-4. 2002
    ..Further prospective studies are needed to assess the role of environmental factors in the initiation and reactivation of the inflammatory myopathies...
  89. ncbi request reprint Primary writing tremor: motor cortex reorganisation and disinhibition
    Michelle L Byrnes
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Nedlands, Australia
    J Clin Neurosci 12:102-4. 2005
    ..In writer's cramp there is evidence of changes in intracortical inhibition (ICI), as well as cortical motor reorganisation...
  90. doi request reprint Longitudinally extensive myelopathy in Caucasians: a West Australian study of 26 cases from the Perth Demyelinating Diseases Database
    W Qiu
    Australian Neuromuscular Research Institute, Sir Charles Gairdner Hospital, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, 6009, Perth, WA, Australia
    J Neurol Neurosurg Psychiatry 81:209-12. 2010
    ..To characterise West Australian cases of longitudinally extensive myelopathy (LEM)...
  91. ncbi request reprint Differences in sensory and motor cortical organization following brain injury early in life
    G W Thickbroom
    Center for Neuromuscular and Neurological Disorders, University of Western Australia, Australian Neuromuscular Research Institute, Nedlands
    Ann Neurol 49:320-7. 2001
    ....
  92. doi request reprint Wedge-shaped medullary lesions in multiple sclerosis
    Wei Qiu
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australia
    J Neurol Sci 290:190-3. 2010
    ....
  93. pmc Mutations in the slow skeletal muscle fiber myosin heavy chain gene (MYH7) cause laing early-onset distal myopathy (MPD1)
    Christopher Meredith
    Centre for Human Genetics, Edith Cowan University, Perth, Australia
    Am J Hum Genet 75:703-8. 2004
    ..These findings demonstrate that heterozygous mutations toward the 3' end of MYH7 cause Laing-type early-onset distal myopathy. MYH7 is the fourth distal-myopathy gene to have been identified...
  94. doi request reprint Paraspinal and scapular myopathy associated with scleroderma
    Arada Rojana-udomsart
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Nedlands, Western Australia
    J Clin Neuromuscul Dis 11:213-22. 2010
    ..To describe a form of inflammatory myopathy with prominent involvement of the paraspinal and scapular muscles in patients with scleroderma...
  95. doi request reprint Two Australian families with inclusion-body myopathy, Paget's disease of bone and frontotemporal dementia: novel clinical and genetic findings
    Kishore R Kumar
    Department of Neurology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Neuromuscul Disord 20:330-4. 2010
    ..Leu198Trp). Our findings broaden the phenotypic spectrum of IBMPFD and further emphasise the resemblance to amyotrophic lateral sclerosis in some cases...
  96. doi request reprint Statin myotoxicity: A review of genetic susceptibility factors
    M Needham
    Australian Neuromuscular Research Institute, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australia Electronic address
    Neuromuscul Disord 24:4-15. 2014
    ..The aim of this review is to summarize studies investigating genetic factors predisposing to statin myopathy and myalgia, as the first step towards pharmacogenomic screening to identify at risk individuals. ..
  97. doi request reprint Survival of motor neuron protein over-expression prevents calpain-mediated cleavage and activation of procaspase-3 in differentiated human SH-SY5Y cells
    R S Anderton
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, WA, Australia
    Neuroscience 181:226-33. 2011
    ..Finally, the cell death model described herein will allow the assessment of future therapeutic agents or strategies aimed at increasing SMN protein levels...
  98. ncbi request reprint Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex
    C C Kok
    Australian Neuromuscular Research Institute, Queen Elizabeth II Medical Centre, Nedlands, Western Australia
    Immunogenetics 49:508-16. 1999
    ..Using the HSP70 and TNF markers and HLA-DR, -B, and C4 typing of our patients with IBM, we defined a potential site for the MHC-associated susceptibility gene(s) in the region between HLA-DR and C4...
  99. ncbi request reprint Perception of comfort during transcranial DC stimulation: effect of NaCl solution concentration applied to sponge electrodes
    J E Dundas
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australia
    Clin Neurophysiol 118:1166-70. 2007
    ..To investigate the relationship between perception of comfort and electrolyte concentration and applied voltage during transcranial direct current stimulation (tDCS)...
  100. ncbi request reprint Inclusion body myositis: current pathogenetic concepts and diagnostic and therapeutic approaches
    Merrilee Needham
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Australia
    Lancet Neurol 6:620-31. 2007
    ..This review covers the clinical presentation, diagnosis, treatment, and the latest information on genetic susceptibility and pathogenesis of sporadic inclusion body myositis...
  101. doi request reprint Wallenberg syndrome caused by multiple sclerosis mimicking stroke
    Wei Qiu
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Nedlands, Western Australia, Australia
    J Clin Neurosci 16:1700-2. 2009
    ..Our report aims to highlight the importance of awareness of MS as a cause of WS, as well as the potential misdiagnosis of MS as stroke...