Helen E MacLean

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi Novel androgen receptor gene mutations in Australian patients with complete androgen insensitivity syndrome
    Helen E MacLean
    Department of Medicine AH NH, University of Melbourne, Austin Health, Heidelberg, VIC 3084, Australia
    Hum Mutat 23:287. 2004
  2. doi Increased adiposity in DNA binding-dependent androgen receptor knockout male mice associated with decreased voluntary activity and not insulin resistance
    Kesha Rana
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    Am J Physiol Endocrinol Metab 301:E767-78. 2011
  3. doi A floxed allele of the androgen receptor gene causes hyperandrogenization in male mice
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    Physiol Genomics 33:133-7. 2008
  4. doi Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    FASEB J 22:2676-89. 2008
  5. ncbi Double-strand DNA break repair with replication slippage on two strands: a novel mechanism of deletion formation
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Australia
    Hum Mutat 27:483-9. 2006
  6. ncbi Age-dependent differences in androgen binding affinity in a family with spinal and bulbar muscular atrophy
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
    Neurol Res 27:548-51. 2005
  7. ncbi Increased frequency of long androgen receptor CAG repeats in male breast cancers
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Vic, 3084, Australia
    Breast Cancer Res Treat 88:239-46. 2004
  8. ncbi DNA-binding-dependent androgen receptor signaling contributes to gender differences and has physiological actions in males and females
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    J Endocrinol 206:93-103. 2010
  9. doi A physiological role for androgen actions in the absence of androgen receptor DNA binding activity
    Tammy P S Pang
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC 3084, Australia
    Mol Cell Endocrinol 348:189-97. 2012
  10. ncbi Continuous testosterone administration prevents skeletal muscle atrophy and enhances resistance to fatigue in orchidectomized male mice
    Anna Maree Axell
    Dept of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
    Am J Physiol Endocrinol Metab 291:E506-16. 2006

Collaborators

Detail Information

Publications24

  1. ncbi Novel androgen receptor gene mutations in Australian patients with complete androgen insensitivity syndrome
    Helen E MacLean
    Department of Medicine AH NH, University of Melbourne, Austin Health, Heidelberg, VIC 3084, Australia
    Hum Mutat 23:287. 2004
    ..The p.Arg779Trp mutation is associated with the detection of a truncated AR protein in this patient's fibroblasts, suggesting the mutation renders the receptor susceptible to proteolysis...
  2. doi Increased adiposity in DNA binding-dependent androgen receptor knockout male mice associated with decreased voluntary activity and not insulin resistance
    Kesha Rana
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    Am J Physiol Endocrinol Metab 301:E767-78. 2011
    ....
  3. doi A floxed allele of the androgen receptor gene causes hyperandrogenization in male mice
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    Physiol Genomics 33:133-7. 2008
    ..In addition, this androgen hypersensitivity model may be useful to further investigate the effects of subtle perturbations of androgen action in a range of androgen-responsive systems in the male...
  4. doi Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    FASEB J 22:2676-89. 2008
    ..In conclusion, androgens are not required for peak muscle mass in females. In males, androgens act through the AR to regulate multiple gene pathways that control muscle mass, strength, and fatigue resistance...
  5. ncbi Double-strand DNA break repair with replication slippage on two strands: a novel mechanism of deletion formation
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Australia
    Hum Mutat 27:483-9. 2006
    ....
  6. ncbi Age-dependent differences in androgen binding affinity in a family with spinal and bulbar muscular atrophy
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
    Neurol Res 27:548-51. 2005
    ..To investigate androgen receptor (AR) function in spinal and bulbar muscular atrophy (SBMA)...
  7. ncbi Increased frequency of long androgen receptor CAG repeats in male breast cancers
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Vic, 3084, Australia
    Breast Cancer Res Treat 88:239-46. 2004
    ..In conclusion, longer AR CAG repeats are more common in men with breast cancer than in the control male population. Androgen hyposensitivity, caused by long AR CAG repeats, may increase the risk of breast cancer in men...
  8. ncbi DNA-binding-dependent androgen receptor signaling contributes to gender differences and has physiological actions in males and females
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    J Endocrinol 206:93-103. 2010
    ....
  9. doi A physiological role for androgen actions in the absence of androgen receptor DNA binding activity
    Tammy P S Pang
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC 3084, Australia
    Mol Cell Endocrinol 348:189-97. 2012
    ..In conclusion, these data suggest that non-DNA binding dependent AR actions suppress cortical bone growth, which may provide a mechanism to fine-tune the response to androgens in bone...
  10. ncbi Continuous testosterone administration prevents skeletal muscle atrophy and enhances resistance to fatigue in orchidectomized male mice
    Anna Maree Axell
    Dept of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
    Am J Physiol Endocrinol Metab 291:E506-16. 2006
    ..In addition, we showed that testosterone treatment increases resistance to fatigue of slow- but not fast-twitch muscle...
  11. pmc Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice
    Rachel A Davey
    Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia
    J Bone Miner Res 23:1182-93. 2008
    ..These data provide strong evidence for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress...
  12. doi Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferation
    Nicole K L Lee
    Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia
    Am J Physiol Endocrinol Metab 301:E172-9. 2011
    ..In conclusion, androgens act via the AR to upregulate Odc1 in skeletal muscle myoblasts, and Odc1 promotes myoblast proliferation and delays differentiation...
  13. ncbi Androgen regulation of satellite cell function
    Yue Chen
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
    J Endocrinol 186:21-31. 2005
    ..In summary, this review focuses on exploring potential mechanisms through which androgens regulate satellite cells, by analyzing developments from research in this area...
  14. ncbi Genetically modified animal models as tools for studying bone and mineral metabolism
    Rachel A Davey
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    J Bone Miner Res 19:882-92. 2004
    ..This technology provides a unique and powerful way to probe the function of genes and is already revolutionizing our approach to understanding the physiology of bone development and metabolism...
  15. ncbi Application of differential display in the identification of androgen-regulated genes
    Karen J Greenland
    Centre for Hormone Research, Murdoch Children s Research Institute, University of Melbourne, Royal Children s Hospital, Victoria, Australia
    Endocr Res 30:69-82. 2004
    ..While this putatively regulated gene remains to be fully characterized, future studies of may provide insights into the molecular mechanisms governing androgen action in neural cells...
  16. doi Intermittent Fugu parathyroid hormone 1 (1-34) is an anabolic bone agent in young male rats and osteopenic ovariectomized rats
    Julie F McManus
    Department of Medicine, University of Melbourne, Austin Health, Studley Road, Heidelberg, Vic, Australia
    Bone 42:1164-74. 2008
    ..fPth1 was similarly effective in SHAM rats. Notwithstanding the low amino acid sequence homology with hPTH (1-34), we have clearly established the efficacy of fPth1 (1-34) as an anabolic bone agent...
  17. ncbi Normal phenotype in conditional androgen receptor (AR) exon 3-floxed neomycin-negative male mice
    Kesha Rana
    Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Vic, Australia
    Endocr Res 39:130-5. 2014
    ..This study demonstrates the importance of removing the selection cassette, which can potentially alter the phenotype of floxed mouse lines even in the absence of detectable effects on target gene expression. ..
  18. ncbi Current and future approaches using genetically modified mice in endocrine research
    Rachel A Davey
    Dept of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC 3084, Australia
    Am J Physiol Endocrinol Metab 291:E429-38. 2006
    ..These approaches are a powerful means by which to dissect the function of genes and are revolutionizing our understanding of endocrine physiology and metabolism...
  19. doi Polyamines, androgens, and skeletal muscle hypertrophy
    Nicole K L Lee
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    J Cell Physiol 226:1453-60. 2011
    ..This review outlines the role of polyamines in proliferation and hypertrophy, and explores their possible actions in mediating the anabolic actions of androgens in muscle...
  20. ncbi Localization of Indian hedgehog and PTH/PTHrP receptor expression in relation to chondrocyte proliferation during mouse bone development
    Helen E MacLean
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Dev Growth Differ 47:59-63. 2005
    ..This study provides further evidence that in the developing growth plate, cell cycle exit and upregulation of Ihh and PPR mRNA expression are coupled...
  21. pmc The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes
    Helen E MacLean
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 113:1334-43. 2004
    ..These studies suggest that the effects of PTHrP on both the rate and extent of chondrocyte proliferation are mediated, at least in part, through suppression of p57 expression...
  22. ncbi Expression of Stra13 during mouse endochondral bone development
    Helen E MacLean
    Endocrine Unit, WEL501, Massachusetts General Hospital, 50 Blossom St, Boston, MA 02114, USA
    Gene Expr Patterns 4:633-6. 2004
    ..Thus, there was a large degree of overlap in the expression patterns of Stra13 and VEGF in chondrocytes during embryonic development...
  23. ncbi Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development
    Helen E MacLean
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Dev Biol 262:51-63. 2003
    ..5 in the c-maf-null. MMP-13 is known to be regulated by AP-1 and may also be a target of c-Maf. Thus, cartilage is a novel system in which c-Maf acts during development, where c-Maf is required for normal chondrocyte differentiation...
  24. ncbi p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development
    Ferdinand Rossi
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, 10032, USA
    Dev Biol 247:271-85. 2002
    ..The results suggest that Cbfa1 links a p107- and p130-mediated cell cycle arrest to chondrocyte terminal differentiation...