E J Mackie

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi Endochondral ossification: how cartilage is converted into bone in the developing skeleton
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    Int J Biochem Cell Biol 40:46-62. 2008
  2. ncbi The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    J Endocrinol 211:109-21. 2011
  3. ncbi Osteoblasts: novel roles in orchestration of skeletal architecture
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    Int J Biochem Cell Biol 35:1301-5. 2003
  4. ncbi Protease-activated receptors: a means of converting extracellular proteolysis into intracellular signals
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    IUBMB Life 53:277-81. 2002
  5. ncbi Protease-activated receptors in the musculoskeletal system
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, VIC 3010, Australia
    Int J Biochem Cell Biol 40:1169-84. 2008
  6. ncbi Dissection of protease-activated receptor-1-dependent and -independent responses to thrombin in skeletal myoblasts
    M R de Niese
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia
    Exp Cell Res 274:149-56. 2002
  7. ncbi Hypertrophy and physiological death of equine chondrocytes in vitro
    Y A Ahmed
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    Equine Vet J 39:546-52. 2007
  8. ncbi Protease-activated receptor-2 mediates proliferative responses in skeletal myoblasts
    C Chinni
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    J Cell Sci 113:4427-33. 2000
  9. ncbi The gingipains from Porphyromonas gingivalis do not directly induce osteoclast differentiation in primary mouse bone marrow cultures
    R E Fitzpatrick
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Periodontal Res 44:565-7. 2009
  10. ncbi Proteinase-activated receptor-2 is required for normal osteoblast and osteoclast differentiation during skeletal growth and repair
    S R Georgy
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    Bone 50:704-12. 2012

Collaborators

Detail Information

Publications20

  1. ncbi Endochondral ossification: how cartilage is converted into bone in the developing skeleton
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    Int J Biochem Cell Biol 40:46-62. 2008
    ..This review, which places an emphasis on recent advances and current areas of debate, discusses the complex interactions between cell types and signalling pathways that govern endochondral ossification...
  2. ncbi The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    J Endocrinol 211:109-21. 2011
    ..This review discusses how the growth plate chondrocyte contributes to endochondral ossification, with some emphasis on recent advances...
  3. ncbi Osteoblasts: novel roles in orchestration of skeletal architecture
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    Int J Biochem Cell Biol 35:1301-5. 2003
    ..Osteoblasts indirectly control levels of bone resorption. Osteoblasts play a key role in the pathophysiology of osteoporosis and the resulting fractures, which constitute a major public health burden in developed countries...
  4. ncbi Protease-activated receptors: a means of converting extracellular proteolysis into intracellular signals
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    IUBMB Life 53:277-81. 2002
    ....
  5. ncbi Protease-activated receptors in the musculoskeletal system
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, VIC 3010, Australia
    Int J Biochem Cell Biol 40:1169-84. 2008
    ..Expression patterns of PARs, the circumstances in which PAR activators are likely to be present, functional responses of PAR activation, and responses to thrombin for which receptors have not yet been identified are considered...
  6. ncbi Dissection of protease-activated receptor-1-dependent and -independent responses to thrombin in skeletal myoblasts
    M R de Niese
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia
    Exp Cell Res 274:149-56. 2002
    ....
  7. ncbi Hypertrophy and physiological death of equine chondrocytes in vitro
    Y A Ahmed
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    Equine Vet J 39:546-52. 2007
    ..Endochondral ossification involves chondrocyte proliferation, hypertrophy and death. Until recently no culture system was available to study these processes in equine chondrocytes...
  8. ncbi Protease-activated receptor-2 mediates proliferative responses in skeletal myoblasts
    C Chinni
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    J Cell Sci 113:4427-33. 2000
    ..The PAR-2-activating peptide did, however, stimulate proliferation of serum-deprived myoblasts. These results demonstrate that skeletal muscle cells express PAR-2, activation of which leads to stimulation of myoblast proliferation...
  9. ncbi The gingipains from Porphyromonas gingivalis do not directly induce osteoclast differentiation in primary mouse bone marrow cultures
    R E Fitzpatrick
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Periodontal Res 44:565-7. 2009
    ..The effects of the gingipains from P. gingivalis on osteoclast differentiation were investigated here to determine whether the enzymes directly contribute to osteoclastogenesis and thus to bone resorption...
  10. ncbi Proteinase-activated receptor-2 is required for normal osteoblast and osteoclast differentiation during skeletal growth and repair
    S R Georgy
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    Bone 50:704-12. 2012
    ..These results suggest that PAR(2) activation contributes to determination of cells of both osteoblast and osteoclast lineages within bone marrow, and thereby participates in the regulation of skeletal growth and bone repair...
  11. ncbi Identification of light and dark hypertrophic chondrocytes in mouse and rat chondrocyte pellet cultures
    K S Chen
    School of Veterinary Science, University of Melbourne, Corner of Flemington Road and Park Drive, Parkville, Victoria 3010, Australia
    Tissue Cell 42:121-8. 2010
    ..This rodent culture system allows the differentiation of light and dark chondrocytes under various conditions in vitro and will be useful for future studies on tissue engineering and mechanisms of chondrocyte hypertrophy...
  12. ncbi Regulation of tenascin-C expression in bone cells by transforming growth factor-beta
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    Bone 22:301-7. 1998
    ..These results indicate that TGF-beta stimulates osteoblastic tenascin-C expression and suggest that tenascin-C may act as a mediator of TGF-beta-induced new bone formation...
  13. ncbi Studies on the receptors mediating responses of osteoblasts to thrombin
    S J Song
    School of Veterinary Science, University of Melbourne, Parkville, Vic. 3010, Australia
    Int J Biochem Cell Biol 37:206-13. 2005
    ..The results demonstrate that thrombin stimulates proliferation and inhibits differentiation of osteoblasts through activation of PAR-1. No other thrombin receptor appears to be involved in these effects...
  14. ncbi Physiological death of hypertrophic chondrocytes
    Y A Ahmed
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    Osteoarthritis Cartilage 15:575-86. 2007
    ..The aims of the current study were to document the ultrastructural appearance of dying hypertrophic chondrocytes, and to establish a culture system in which the mechanism of their death can be examined...
  15. ncbi Expression of protease-activated receptor-2 during embryonic development
    A L Jenkins
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Dev Dyn 218:465-71. 2000
    ..The pattern of PAR-2 expression observed during embryonic development and the association of expression with differentiation in certain tissues suggest compelling physiological roles for this novel receptor...
  16. ncbi Expression of protease-activated receptor-2 by osteoblasts
    L A Abraham
    School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    Bone 26:7-14. 2000
    ....
  17. ncbi The role of tenascin-C and related glycoproteins in early chondrogenesis
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    Microsc Res Tech 43:102-10. 1998
    ..Members of the thrombospondin gene family are expressed in chondrogenic tissues at different stages, suggesting that they each play a unique role in cartilage development...
  18. ncbi The tenascin-C knockout revisited
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    J Cell Sci 112:3847-53. 1999
    ..When examined together, these studies provide evidence for precise functions for tenascin-C, as well as an explanation for why the sequence of tenascin-C is so highly phylogenetically conserved...
  19. ncbi Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion
    A Lourbakos
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Infect Immun 69:5121-30. 2001
    ..gingivalis might mediate inflammatory events associated with periodontal disease on first contact with a primary barrier of cells...
  20. ncbi Thrombin is a pro-fibrotic factor for rat renal fibroblasts in vitro
    T D Hewitson
    Department of Nephrology, The Royal Melbourne Hospital, Melbourne, Australia
    Nephron Exp Nephrol 101:e42-9. 2005
    ..This study examines whether thrombin may potentially exacerbate fibrosis by upregulating the function of interstitial fibroblasts in vitro...