Fabienne Mackay

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint BAFF AND APRIL: a tutorial on B cell survival
    Fabienne Mackay
    Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, Australia
    Annu Rev Immunol 21:231-64. 2003
  2. pmc BAFF and MyD88 signals promote a lupuslike disease independent of T cells
    Joanna R Groom
    Autoimmunity Research Unit, The Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    J Exp Med 204:1959-71. 2007
  3. ncbi request reprint The TNF family members BAFF and APRIL: the growing complexity
    Fabienne Mackay
    Department of Arthritis and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2030, Australia
    Cytokine Growth Factor Rev 14:311-24. 2003
  4. ncbi request reprint TNF ligands and receptors in autoimmunity: an update
    Fabienne Mackay
    Department of Arthritis and Inflammation, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Curr Opin Immunol 14:783-90. 2002
  5. ncbi request reprint BAFF: a fundamental survival factor for B cells
    Fabienne Mackay
    Garvan Institute of Medical Research, Department of Arthritis and Inflammation, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Nat Rev Immunol 2:465-75. 2002
  6. pmc CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells
    Eliana Marino
    Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Diabetes 58:1568-77. 2009
  7. doi request reprint TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor
    Sandra Gardam
    Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst NSW 2010, Australia
    Immunity 28:391-401. 2008
  8. ncbi request reprint Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses
    Stacey Walters
    Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    J Immunol 182:793-801. 2009
  9. ncbi request reprint BAFF augments certain Th1-associated inflammatory responses
    Andrew P R Sutherland
    Arthritis and Asthma Research Program, Garvan Institute of Medical Research, Sydney, Australia
    J Immunol 174:5537-44. 2005
  10. pmc Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome
    Joanna Groom
    The Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, NSW, Australia
    J Clin Invest 109:59-68. 2002

Collaborators

Detail Information

Publications47

  1. ncbi request reprint BAFF AND APRIL: a tutorial on B cell survival
    Fabienne Mackay
    Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, Australia
    Annu Rev Immunol 21:231-64. 2003
    ..The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells...
  2. pmc BAFF and MyD88 signals promote a lupuslike disease independent of T cells
    Joanna R Groom
    Autoimmunity Research Unit, The Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    J Exp Med 204:1959-71. 2007
    ..Therefore, autoimmunity in BAFF Tg mice results from altered B cell tolerance, but requires TLR signaling and is independent of T cell help. It is possible that SLE patients with elevated levels of BAFF show a similar basis for disease...
  3. ncbi request reprint The TNF family members BAFF and APRIL: the growing complexity
    Fabienne Mackay
    Department of Arthritis and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2030, Australia
    Cytokine Growth Factor Rev 14:311-24. 2003
    ..Elevated expression of APRIL has been found in some tumor cell lines and in tumor tissue libraries. Therapies designed to inhibit the BAFF and APRIL pathways holds great promise for the future...
  4. ncbi request reprint TNF ligands and receptors in autoimmunity: an update
    Fabienne Mackay
    Department of Arthritis and Inflammation, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Curr Opin Immunol 14:783-90. 2002
    ..These new findings revealed exciting innovative strategies for the treatment of autoimmune diseases...
  5. ncbi request reprint BAFF: a fundamental survival factor for B cells
    Fabienne Mackay
    Garvan Institute of Medical Research, Department of Arthritis and Inflammation, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Nat Rev Immunol 2:465-75. 2002
    ..The elucidation of the role of BAFF has set the stage for a new approach to the treatment of autoimmune disease...
  6. pmc CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells
    Eliana Marino
    Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Diabetes 58:1568-77. 2009
    ..We examined the effect of blocking BAFF and APRIL on the development of autoimmune diabetes...
  7. doi request reprint TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor
    Sandra Gardam
    Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst NSW 2010, Australia
    Immunity 28:391-401. 2008
    ..This process was TRAF2 dependent, revealing dual roles for TRAF2 in regulating B cell homeostasis...
  8. ncbi request reprint Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses
    Stacey Walters
    Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    J Immunol 182:793-801. 2009
    ..Thus, under certain conditions, BAFF can play a surprising anti-inflammatory role in T cell biology by promoting the expansion of Treg cells...
  9. ncbi request reprint BAFF augments certain Th1-associated inflammatory responses
    Andrew P R Sutherland
    Arthritis and Asthma Research Program, Garvan Institute of Medical Research, Sydney, Australia
    J Immunol 174:5537-44. 2005
    ..Results in BAFF Tg mice may reflect the situation in certain autoimmune patients or virally infected individuals, because BAFF levels in blood are comparable...
  10. pmc Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome
    Joanna Groom
    The Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, NSW, Australia
    J Clin Invest 109:59-68. 2002
    ..We conclude that altered B cell differentiation and tolerance induced by excess BAFF may be central to SS pathogenesis...
  11. doi request reprint Development of autoimmune nephritis in genetically asplenic and splenectomized BAFF transgenic mice
    Carrie A Fletcher
    Autoimmunity Research Unit, Immunology and Inflammation Research Program, The Garvan Institute of Medical Research, Sydney, NSW, Australia
    J Autoimmun 36:125-34. 2011
    ..Identifying similar innate B cells in humans may offer the possibility of more targeted B cell therapies...
  12. doi request reprint B cells flying solo
    Joanna Groom
    The Autoimmunity Research Unit, The Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    Immunol Cell Biol 86:40-6. 2008
    ..In conclusion, dysregulated innate activation of B cells alone can drive disease independently of T cells, and as such this aspect represents a new pathogenic mechanism in autoimmunity...
  13. ncbi request reprint The role of the BAFF/APRIL system on T cell function
    Fabienne Mackay
    Department of Immunology and Inflammation, The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Semin Immunol 18:284-9. 2006
    ..Therefore, direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation...
  14. ncbi request reprint TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma
    Marcel Batten
    Department of Arthritis and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    J Immunol 172:812-22. 2004
    ....
  15. ncbi request reprint The BAFF/APRIL system: an important player in systemic rheumatic diseases
    Fabienne Mackay
    The Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, Australia
    Curr Dir Autoimmun 8:243-65. 2005
    ....
  16. pmc Neuropeptide Y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity
    Laurence Macia
    Neuroscience Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    Diabetes 61:3228-38. 2012
    ..Thus, Y1 signaling in hematopoietic-derived cells such as macrophages is critical for the control of inflammation and insulin resistance in obesity...
  17. ncbi request reprint Marginal-zone B-cells of nonobese diabetic mice expand with diabetes onset, invade the pancreatic lymph nodes, and present autoantigen to diabetogenic T-cells
    Eliana Marino
    Senior Research Fellow, Gene Therapy and Autoimmunity Group, Arthritis and Inflammation Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, N5W 2010, Australia
    Diabetes 57:395-404. 2008
    ..However, beyond this, the contribution of different B-cell subsets to diabetes pathogenesis is poorly understood...
  18. ncbi request reprint Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype
    Alexander Viardot
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney Darlinghurst, New South Wales 2010, Australia
    Endocrinology 148:346-53. 2007
    ..This effect of insulin in changing T cell polarization may contribute to its antiinflammatory role not only in sepsis, but also in chronic inflammation associated with obesity and type 2 diabetes...
  19. ncbi request reprint Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies
    Hyun Lee
    Immunology and Inflammation Department, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Nat Biotechnol 24:1279-84. 2006
    ..This strategy should be applicable to other important mAb therapeutics...
  20. pmc Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
    Kendle M Maslowski
    Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Nature 461:1282-6. 2009
    ..GPR43 binding of SCFAs potentially provides a molecular link between diet, gastrointestinal bacterial metabolism, and immune and inflammatory responses...
  21. ncbi request reprint Targeting BAFF: immunomodulation for autoimmune diseases and lymphomas
    Andrew P R Sutherland
    The Immunology and Inflammation Research Program, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Pharmacol Ther 112:774-86. 2006
    ....
  22. doi request reprint Y1 signalling has a critical role in allergic airway inflammation
    Laurence Macia
    The Neurobiology Research Program, The Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    Immunol Cell Biol 89:882-8. 2011
    ..Taken together this study demonstrates that signalling through Y1-receptors emerges as a critical pathway for the development of airway inflammation and as such potentially opens novel avenues for therapeutic intervention in asthma...
  23. ncbi request reprint NPY and receptors in immune and inflammatory diseases
    Julie Wheway
    Autoimmune Research Unit, Neuroscience Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW, 2010, Australia
    Curr Top Med Chem 7:1743-52. 2007
    ....
  24. ncbi request reprint The role of the BAFF/APRIL system in B cell homeostasis and lymphoid cancers
    Fabienne Mackay
    The Garvan Institute of Medical Research, Department of Arthritis and Inflammation, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Curr Opin Pharmacol 4:347-54. 2004
    ..The strong dependence of certain lymphoid cancer cells on BAFF might be a point of vulnerability, which offers exciting new therapeutic possibilities...
  25. pmc Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
    Frederic Sierro
    Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 104:14759-64. 2007
    ..Our results reveal a specialized role for CXCR7 in endothelial biology and valve development and highlight the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CXCR4...
  26. ncbi request reprint An important role for B-cell activation factor and B cells in the pathogenesis of Sjögren's syndrome
    Fabienne Mackay
    The Autoimmunity Research Unit, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Curr Opin Rheumatol 19:406-13. 2007
    ..This review provides an update on the specific, strong association between dysregulated production of the cytokine B-cell activation factor and Sjögren's syndrome, and offers new perspectives on potential pathogenic mechanisms...
  27. ncbi request reprint B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling
    Fabienne Mackay
    The Autoimmunity Research Unit, The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Curr Opin Immunol 19:327-36. 2007
    ..In recent years, our understanding of cell signaling and autoimmune mechanisms in this system have seen major advances, refining new possibilities for therapeutic intervention...
  28. doi request reprint TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties
    Fabienne Mackay
    Autoimmunity Research Unit, The Garvan Institute of Medical Research, 384, Victoria Street, Darlinghurst, NSW 2010, Australia
    Cytokine Growth Factor Rev 19:263-76. 2008
    ..TACI is emerging as an unusual TNF receptor-like molecule with a sophisticated mode of action...
  29. ncbi request reprint Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1
    Kate L Jeffrey
    Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Nat Immunol 7:274-83. 2006
    ..Thus, PAC-1 is a key positive regulator of inflammatory cell signaling and effector functions, mediated through Jnk and Erk mitogen-activated protein kinase crosstalk...
  30. ncbi request reprint The Y1 receptor for NPY: a key modulator of the adaptive immune system
    Julie Wheway
    Autoimmune Research Unit, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    Peptides 28:453-8. 2007
    ....
  31. ncbi request reprint The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF
    Aubry Tardivel
    Department of Biochemistry, BIL Biomedical Research Center, University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 34:509-18. 2004
    ..These results suggest that BAFF is required not only to inhibit apoptosis of maturating B cells, but also to promote differentiation events, in particular those leading to the generation of marginal zone B cells...
  32. ncbi request reprint The role of BAFF in B-cell maturation, T-cell activation and autoimmunity
    Fabienne Mackay
    Trends Immunol 23:113-5. 2002
  33. pmc BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
    Danielle T Avery
    Centenary Institute of Cancer Medicine and Cell Biology, Newton, Australia
    J Clin Invest 112:286-97. 2003
    ..These findings have wide-ranging implications for the treatment of human immunodeficiencies as well as autoimmune diseases...
  34. ncbi request reprint Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches
    Marilyn Thien
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag Number 6, Newtown, New South Wales 2042, Australia
    Immunity 20:785-98. 2004
    ..This partial subversion of B cell self tolerance is likely to underlie the autoimmunity associated with BAFF overexpression...
  35. ncbi request reprint BAFF costimulation of Toll-like receptor-activated B-1 cells
    Lai Guan Ng
    Laboratory of Immunology, Center for Molecular Medicine and Institute of Molecular and Cell Biology, Singapore
    Eur J Immunol 36:1837-46. 2006
    ..Thus, as TLR are innate immune receptors and B-1 cells are "innate-like" lymphocytes, our data provide evidence that BAFF plays a role in innate immunity...
  36. ncbi request reprint TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts
    Claudia Bossen
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Blood 111:1004-12. 2008
    ..TACI supported survival of activated B cells and plasmablasts in vitro, providing a rational basis to explain the immunoglobulin deficiency reported in TACI-deficient persons...
  37. ncbi request reprint Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling
    Ingrid Mecklenbrauker
    Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, New York 10021, USA
    Nature 431:456-61. 2004
    ..Our data suggest the existence of a previously unknown BAFF-induced and PKCdelta-mediated nuclear signalling pathway which regulates B-cell survival...
  38. ncbi request reprint The BAFF/APRIL system: life beyond B lymphocytes
    Lai Guan Ng
    Arthritis and Asthma Research Program, The Garvan Institute of Medical Reseach, 384 Victoria St, Sydney, NSW 2010, Australia
    Mol Immunol 42:763-72. 2005
    ..Therefore, targeting the BAFF/APRIL system may protect against autoimmunity and lymphoid cancers through the inhibition of pathogenic B and T cell functions...
  39. ncbi request reprint B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells
    Lai Guan Ng
    Arthritis and Asthma Research Program, The Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    J Immunol 173:807-17. 2004
    ..Thus, BAFF-R is important not only for splenic B cell maturation, but is the major mediator of BAFF-dependent costimulatory responses in peripheral B and T cells...
  40. ncbi request reprint Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cells
    Carrie A Fletcher
    Immunology and Inflammation Research Program, The Garvan Institute of Medical Research, Sydney, Australia
    Eur J Immunol 36:2504-14. 2006
    ..However, in contrast to old BAFF Tg mice, aging LTbetaDelta-BTg mice no longer developed sialadenitis. Thus, autoimmune disorders in BAFF Tg mice are possibly events coordinated by MZ and B-1 B cells at separate anatomical sites...
  41. ncbi request reprint B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation
    Svetlana Shulga-Morskaya
    Biogen Idec, Cambridge, MA 02142, USA
    J Immunol 173:2331-41. 2004
    ..These studies clearly demonstrate that BAFF regulates Ab responses in vivo through receptors in addition to BAFF-R...
  42. ncbi request reprint BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus
    William Stohl
    Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    Arthritis Rheum 52:2080-91. 2005
    ..To determine whether overexpression of BAFF can accelerate the development of systemic lupus erythematosus-associated end-organ disease in hosts with an underlying autoimmune diathesis...
  43. ncbi request reprint Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage
    Danielle T Avery
    Centenary Institute of Cancer Medicine and Cell Biology, New South Wales, Australia
    J Immunol 174:4034-42. 2005
    ..We propose that the differentiation of memory B cells into PC involves a transitional stage characterized by a CD27(high)CD38(-) phenotype with the acquired ability to secrete high levels of Ig...
  44. pmc Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway
    Jennifer L Gommerman
    Department of Exploratory Sciences, Biogen Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 110:1359-69. 2002
    ..Manipulation of these microenvironments may represent a novel approach to modulating immune function in human disease...
  45. pmc A fundamental bimodal role for neuropeptide Y1 receptor in the immune system
    Julie Wheway
    The Arthritis and Inflammation Research Program, The Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia
    J Exp Med 202:1527-38. 2005
    ..Our findings uncover a sophisticated molecular mechanism regulating immune cell functions that can lead to stress-induced immunosuppression...
  46. pmc NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells
    Yoshiteru Sasaki
    Immune Disease Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:10883-8. 2008
    ..This mechanism keeps NIK protein levels below detection even when they cause B cell hyperplasia, so that contributions of NIK to B cell pathologies can easily be overlooked...
  47. pmc Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
    Melissa W Boulé
    Renal Section, Department of Medicine, Boston University School of Medicine, EBRC 5th Floor, 650 Albany Street, Boston, MA 02118, USA
    J Exp Med 199:1631-40. 2004
    ..The data establish a critical role for self-antigen in DC activation and explain how the innate immune system might drive the adaptive immune response in SLE...