Research Topics
Genomes and Genes
| Fabienne MackaySummaryAffiliation: University of New South Wales Country: Australia Publications
| Collaborators
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Detail Information
Publications
BAFF AND APRIL: a tutorial on B cell survivalFabienne Mackay
Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, Australia
Annu Rev Immunol 21:231-64. 2003..The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells...- The TNF family members BAFF and APRIL: the growing complexityFabienne Mackay
Department of Arthritis and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2030, Australia
Cytokine Growth Factor Rev 14:311-24. 2003..Elevated expression of APRIL has been found in some tumor cell lines and in tumor tissue libraries. Therapies designed to inhibit the BAFF and APRIL pathways holds great promise for the future... - TNF ligands and receptors in autoimmunity: an updateFabienne Mackay
Department of Arthritis and Inflammation, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Curr Opin Immunol 14:783-90. 2002..These new findings revealed exciting innovative strategies for the treatment of autoimmune diseases... - BAFF: a fundamental survival factor for B cellsFabienne Mackay
Garvan Institute of Medical Research, Department of Arthritis and Inflammation, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Nat Rev Immunol 2:465-75. 2002..The elucidation of the role of BAFF has set the stage for a new approach to the treatment of autoimmune disease... 
CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cellsEliana Marino
Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Diabetes 58:1568-77. 2009..We examined the effect of blocking BAFF and APRIL on the development of autoimmune diabetes...
TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptorSandra Gardam
Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst NSW 2010, Australia
Immunity 28:391-401. 2008..This process was TRAF2 dependent, revealing dual roles for TRAF2 in regulating B cell homeostasis...- Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responsesStacey Walters
Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
J Immunol 182:793-801. 2009..Thus, under certain conditions, BAFF can play a surprising anti-inflammatory role in T cell biology by promoting the expansion of Treg cells... - BAFF and MyD88 signals promote a lupuslike disease independent of T cellsJoanna R Groom
Autoimmunity Research Unit, The Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
J Exp Med 204:1959-71. 2007..Therefore, autoimmunity in BAFF Tg mice results from altered B cell tolerance, but requires TLR signaling and is independent of T cell help. It is possible that SLE patients with elevated levels of BAFF show a similar basis for disease... - BAFF augments certain Th1-associated inflammatory responsesAndrew P R Sutherland
Arthritis and Asthma Research Program, Garvan Institute of Medical Research, Sydney, Australia
J Immunol 174:5537-44. 2005..Results in BAFF Tg mice may reflect the situation in certain autoimmune patients or virally infected individuals, because BAFF levels in blood are comparable... - Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndromeJoanna Groom
The Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, NSW, Australia
J Clin Invest 109:59-68. 2002..We conclude that altered B cell differentiation and tolerance induced by excess BAFF may be central to SS pathogenesis... - Development of autoimmune nephritis in genetically asplenic and splenectomized BAFF transgenic miceCarrie A Fletcher
Autoimmunity Research Unit, Immunology and Inflammation Research Program, The Garvan Institute of Medical Research, Sydney, NSW, Australia
J Autoimmun 36:125-34. 2011..Identifying similar innate B cells in humans may offer the possibility of more targeted B cell therapies... - B cells flying soloJoanna Groom
The Autoimmunity Research Unit, The Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
Immunol Cell Biol 86:40-6. 2008..In conclusion, dysregulated innate activation of B cells alone can drive disease independently of T cells, and as such this aspect represents a new pathogenic mechanism in autoimmunity... - The role of the BAFF/APRIL system on T cell functionFabienne Mackay
Department of Immunology and Inflammation, The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Semin Immunol 18:284-9. 2006..Therefore, direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation... - TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphomaMarcel Batten
Department of Arthritis and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
J Immunol 172:812-22. 2004.... - The BAFF/APRIL system: an important player in systemic rheumatic diseasesFabienne Mackay
The Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, Australia
Curr Dir Autoimmun 8:243-65. 2005.... - Neuropeptide Y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesityLaurence Macia
Neuroscience Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
Diabetes 61:3228-38. 2012..Thus, Y1 signaling in hematopoietic-derived cells such as macrophages is critical for the control of inflammation and insulin resistance in obesity... - Marginal-zone B-cells of nonobese diabetic mice expand with diabetes onset, invade the pancreatic lymph nodes, and present autoantigen to diabetogenic T-cellsEliana Marino
Senior Research Fellow, Gene Therapy and Autoimmunity Group, Arthritis and Inflammation Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, N5W 2010, Australia
Diabetes 57:395-404. 2008..However, beyond this, the contribution of different B-cell subsets to diabetes pathogenesis is poorly understood... - Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotypeAlexander Viardot
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney Darlinghurst, New South Wales 2010, Australia
Endocrinology 148:346-53. 2007..This effect of insulin in changing T cell polarization may contribute to its antiinflammatory role not only in sepsis, but also in chronic inflammation associated with obesity and type 2 diabetes... - Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodiesHyun Lee
Immunology and Inflammation Department, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Nat Biotechnol 24:1279-84. 2006..This strategy should be applicable to other important mAb therapeutics... - Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43Kendle M Maslowski
Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Nature 461:1282-6. 2009..GPR43 binding of SCFAs potentially provides a molecular link between diet, gastrointestinal bacterial metabolism, and immune and inflammatory responses... - Targeting BAFF: immunomodulation for autoimmune diseases and lymphomasAndrew P R Sutherland
The Immunology and Inflammation Research Program, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Pharmacol Ther 112:774-86. 2006.... - Y1 signalling has a critical role in allergic airway inflammationLaurence Macia
The Neurobiology Research Program, The Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
Immunol Cell Biol 89:882-8. 2011..Taken together this study demonstrates that signalling through Y1-receptors emerges as a critical pathway for the development of airway inflammation and as such potentially opens novel avenues for therapeutic intervention in asthma... - NPY and receptors in immune and inflammatory diseasesJulie Wheway
Autoimmune Research Unit, Neuroscience Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW, 2010, Australia
Curr Top Med Chem 7:1743-52. 2007.... - The role of the BAFF/APRIL system in B cell homeostasis and lymphoid cancersFabienne Mackay
The Garvan Institute of Medical Research, Department of Arthritis and Inflammation, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Curr Opin Pharmacol 4:347-54. 2004..The strong dependence of certain lymphoid cancer cells on BAFF might be a point of vulnerability, which offers exciting new therapeutic possibilities... - Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7Frederic Sierro
Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
Proc Natl Acad Sci U S A 104:14759-64. 2007..Our results reveal a specialized role for CXCR7 in endothelial biology and valve development and highlight the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CXCR4... - An important role for B-cell activation factor and B cells in the pathogenesis of Sjögren's syndromeFabienne Mackay
The Autoimmunity Research Unit, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Curr Opin Rheumatol 19:406-13. 2007..This review provides an update on the specific, strong association between dysregulated production of the cytokine B-cell activation factor and Sjögren's syndrome, and offers new perspectives on potential pathogenic mechanisms... - B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signalingFabienne Mackay
The Autoimmunity Research Unit, The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Curr Opin Immunol 19:327-36. 2007..In recent years, our understanding of cell signaling and autoimmune mechanisms in this system have seen major advances, refining new possibilities for therapeutic intervention... - TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological propertiesFabienne Mackay
Autoimmunity Research Unit, The Garvan Institute of Medical Research, 384, Victoria Street, Darlinghurst, NSW 2010, Australia
Cytokine Growth Factor Rev 19:263-76. 2008..TACI is emerging as an unusual TNF receptor-like molecule with a sophisticated mode of action... - Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1Kate L Jeffrey
Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
Nat Immunol 7:274-83. 2006..Thus, PAC-1 is a key positive regulator of inflammatory cell signaling and effector functions, mediated through Jnk and Erk mitogen-activated protein kinase crosstalk... - The Y1 receptor for NPY: a key modulator of the adaptive immune systemJulie Wheway
Autoimmune Research Unit, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
Peptides 28:453-8. 2007.... - The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFFAubry Tardivel
Department of Biochemistry, BIL Biomedical Research Center, University of Lausanne, Epalinges, Switzerland
Eur J Immunol 34:509-18. 2004..These results suggest that BAFF is required not only to inhibit apoptosis of maturating B cells, but also to promote differentiation events, in particular those leading to the generation of marginal zone B cells... - The role of BAFF in B-cell maturation, T-cell activation and autoimmunityFabienne Mackay
Trends Immunol 23:113-5. 2002 - BAFF selectively enhances the survival of plasmablasts generated from human memory B cellsDanielle T Avery
Centenary Institute of Cancer Medicine and Cell Biology, Newton, Australia
J Clin Invest 112:286-97. 2003..These findings have wide-ranging implications for the treatment of human immunodeficiencies as well as autoimmune diseases... - Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone nichesMarilyn Thien
Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag Number 6, Newtown, New South Wales 2042, Australia
Immunity 20:785-98. 2004..This partial subversion of B cell self tolerance is likely to underlie the autoimmunity associated with BAFF overexpression... - BAFF costimulation of Toll-like receptor-activated B-1 cellsLai Guan Ng
Laboratory of Immunology, Center for Molecular Medicine and Institute of Molecular and Cell Biology, Singapore
Eur J Immunol 36:1837-46. 2006..Thus, as TLR are innate immune receptors and B-1 cells are "innate-like" lymphocytes, our data provide evidence that BAFF plays a role in innate immunity... - TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablastsClaudia Bossen
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Blood 111:1004-12. 2008..TACI supported survival of activated B cells and plasmablasts in vitro, providing a rational basis to explain the immunoglobulin deficiency reported in TACI-deficient persons... - Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signallingIngrid Mecklenbrauker
Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, New York 10021, USA
Nature 431:456-61. 2004..Our data suggest the existence of a previously unknown BAFF-induced and PKCdelta-mediated nuclear signalling pathway which regulates B-cell survival... - The BAFF/APRIL system: life beyond B lymphocytesLai Guan Ng
Arthritis and Asthma Research Program, The Garvan Institute of Medical Reseach, 384 Victoria St, Sydney, NSW 2010, Australia
Mol Immunol 42:763-72. 2005..Therefore, targeting the BAFF/APRIL system may protect against autoimmunity and lymphoid cancers through the inhibition of pathogenic B and T cell functions... - B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cellsLai Guan Ng
Arthritis and Asthma Research Program, The Garvan Institute of Medical Research, Sydney, New South Wales, Australia
J Immunol 173:807-17. 2004..Thus, BAFF-R is important not only for splenic B cell maturation, but is the major mediator of BAFF-dependent costimulatory responses in peripheral B and T cells... - Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cellsCarrie A Fletcher
Immunology and Inflammation Research Program, The Garvan Institute of Medical Research, Sydney, Australia
Eur J Immunol 36:2504-14. 2006..However, in contrast to old BAFF Tg mice, aging LTbetaDelta-BTg mice no longer developed sialadenitis. Thus, autoimmune disorders in BAFF Tg mice are possibly events coordinated by MZ and B-1 B cells at separate anatomical sites... - B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formationSvetlana Shulga-Morskaya
Biogen Idec, Cambridge, MA 02142, USA
J Immunol 173:2331-41. 2004..These studies clearly demonstrate that BAFF regulates Ab responses in vivo through receptors in addition to BAFF-R... - BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosusWilliam Stohl
Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
Arthritis Rheum 52:2080-91. 2005..To determine whether overexpression of BAFF can accelerate the development of systemic lupus erythematosus-associated end-organ disease in hosts with an underlying autoimmune diathesis... - Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineageDanielle T Avery
Centenary Institute of Cancer Medicine and Cell Biology, New South Wales, Australia
J Immunol 174:4034-42. 2005..We propose that the differentiation of memory B cells into PC involves a transitional stage characterized by a CD27(high)CD38(-) phenotype with the acquired ability to secrete high levels of Ig... - Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathwayJennifer L Gommerman
Department of Exploratory Sciences, Biogen Inc, Cambridge, Massachusetts 02142, USA
J Clin Invest 110:1359-69. 2002..Manipulation of these microenvironments may represent a novel approach to modulating immune function in human disease... - A fundamental bimodal role for neuropeptide Y1 receptor in the immune systemJulie Wheway
The Arthritis and Inflammation Research Program, The Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia
J Exp Med 202:1527-38. 2005..Our findings uncover a sophisticated molecular mechanism regulating immune cell functions that can lead to stress-induced immunosuppression... - NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cellsYoshiteru Sasaki
Immune Disease Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:10883-8. 2008..This mechanism keeps NIK protein levels below detection even when they cause B cell hyperplasia, so that contributions of NIK to B cell pathologies can easily be overlooked... - Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexesMelissa W Boulé
Renal Section, Department of Medicine, Boston University School of Medicine, EBRC 5th Floor, 650 Albany Street, Boston, MA 02118, USA
J Exp Med 199:1631-40. 2004..The data establish a critical role for self-antigen in DC activation and explain how the innate immune system might drive the adaptive immune response in SLE...