R J MacIsaac

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint The epidemiology of hemoglobin levels in patients with type 2 diabetes
    Merlin C Thomas
    Danielle Alberti Memorial Centre for Diabetes Complications, Baker Heart Research Institute, Melbourne, Vic, Australia
    Am J Kidney Dis 48:537-45. 2006
  2. doi request reprint Markers of and risk factors for the development and progression of diabetic kidney disease
    Richard J MacIsaac
    Department of Endocrinology and Diabetes, St Vincent s Hospital Melbourne, Victoria, Australia University of Melbourne, Victoria, Australia Electronic address
    Am J Kidney Dis 63:S39-62. 2014
  3. pmc The CTGF gene -945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes
    Sheila K Patel
    Department of Medicine, Austin Health, University of Melbourne, Level 7, Lance Townsend Building, 145 Studley Road, Melbourne, VIC 3084, Australia
    Cardiovasc Diabetol 11:42. 2012
  4. pmc Study Protocol--accurate assessment of kidney function in Indigenous Australians: aims and methods of the eGFR study
    Louise J Maple-Brown
    Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Darwin, Australia
    BMC Public Health 10:80. 2010
  5. doi request reprint Intensive glucose control and cardiovascular outcomes in type 2 diabetes
    Richard J MacIsaac
    Department of Endocrinology and Diabetes, St Vincent s Hospital and University of Melbourne, Fitzroy, Victoria, 3065
    Heart Lung Circ 20:647-54. 2011
  6. ncbi request reprint Estimating glomerular filtration rate in diabetes: a comparison of cystatin-C- and creatinine-based methods
    R J MacIsaac
    Endocrine Centre and the Department of Medicine, Austin Health and University of Melbourne, Heidelberg Repatriation Hospital, Level 2, Centaur Building, Heidelberg West, Vic, 3081, Australia
    Diabetologia 49:1686-9. 2006
  7. ncbi request reprint Type 2 diabetes - controlling hyperglycaemia with early insulin use
    Richard MacIsaac
    University of Melbourne, Victoria
    Aust Fam Physician 39:565-9. 2010
  8. ncbi request reprint Is nonalbuminuric renal insufficiency in type 2 diabetes related to an increase in intrarenal vascular disease?
    Richard J MacIsaac
    Endocrine Centre and Department of Medicine, Austin Health, Heidelberg Repatriation Hospital, Waterdale Road, Heidelberg West, Victoria 3081, Australia
    Diabetes Care 29:1560-6. 2006
  9. pmc Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes
    Richard J MacIsaac
    Endocrine Centre, Austin Health and University of Melbourne, Melbourne, Australia
    Cardiovasc Diabetol 7:15. 2008
  10. doi request reprint Diabetic kidney disease with and without albuminuria
    Richard J MacIsaac
    Endocrine Centre, Austin Health and University of Melbourne, Heidelberg West, Victoria, Australia
    Curr Opin Nephrol Hypertens 20:246-57. 2011

Collaborators

Detail Information

Publications46

  1. ncbi request reprint The epidemiology of hemoglobin levels in patients with type 2 diabetes
    Merlin C Thomas
    Danielle Alberti Memorial Centre for Diabetes Complications, Baker Heart Research Institute, Melbourne, Vic, Australia
    Am J Kidney Dis 48:537-45. 2006
    ..The aim of this study is to clarify the natural history of anemia in patients with type 2 diabetes and describe factors that predict a decrease in hemoglobin (Hb) levels...
  2. doi request reprint Markers of and risk factors for the development and progression of diabetic kidney disease
    Richard J MacIsaac
    Department of Endocrinology and Diabetes, St Vincent s Hospital Melbourne, Victoria, Australia University of Melbourne, Victoria, Australia Electronic address
    Am J Kidney Dis 63:S39-62. 2014
    ..Until these or other novel markers become available for clinical use, predictive accuracy often may be increased with greater attention to established markers. ..
  3. pmc The CTGF gene -945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes
    Sheila K Patel
    Department of Medicine, Austin Health, University of Melbourne, Level 7, Lance Townsend Building, 145 Studley Road, Melbourne, VIC 3084, Australia
    Cardiovasc Diabetol 11:42. 2012
    ..This study investigated the association of the CTGF -945 G/C promoter variant with cardiac complications (left ventricular (LV) hypertrophy (LVH), diastolic and systolic dysfunction) and chronic kidney disease (CKD) in type 2 diabetes...
  4. pmc Study Protocol--accurate assessment of kidney function in Indigenous Australians: aims and methods of the eGFR study
    Louise J Maple-Brown
    Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Darwin, Australia
    BMC Public Health 10:80. 2010
    ....
  5. doi request reprint Intensive glucose control and cardiovascular outcomes in type 2 diabetes
    Richard J MacIsaac
    Department of Endocrinology and Diabetes, St Vincent s Hospital and University of Melbourne, Fitzroy, Victoria, 3065
    Heart Lung Circ 20:647-54. 2011
    ..Whether this also applies to newer glucose-lowering agents that target the incretin system will depend on CV outcomes of long-term studies which are in progress...
  6. ncbi request reprint Estimating glomerular filtration rate in diabetes: a comparison of cystatin-C- and creatinine-based methods
    R J MacIsaac
    Endocrine Centre and the Department of Medicine, Austin Health and University of Melbourne, Heidelberg Repatriation Hospital, Level 2, Centaur Building, Heidelberg West, Vic, 3081, Australia
    Diabetologia 49:1686-9. 2006
    ..We compared the predictive performance of a GFR based on serum cystatin C levels with commonly used creatinine-based methods in subjects with diabetes...
  7. ncbi request reprint Type 2 diabetes - controlling hyperglycaemia with early insulin use
    Richard MacIsaac
    University of Melbourne, Victoria
    Aust Fam Physician 39:565-9. 2010
    ..Many patients with type 2 diabetes need to progress to insulin use when oral glucose lowering therapies fail to maintain adequate glycaemic control...
  8. ncbi request reprint Is nonalbuminuric renal insufficiency in type 2 diabetes related to an increase in intrarenal vascular disease?
    Richard J MacIsaac
    Endocrine Centre and Department of Medicine, Austin Health, Heidelberg Repatriation Hospital, Waterdale Road, Heidelberg West, Victoria 3081, Australia
    Diabetes Care 29:1560-6. 2006
    ..To investigate the role of intrarenal vascular disease in the pathogenesis of nonalbuminuric renal insufficiency in type 2 diabetes...
  9. pmc Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes
    Richard J MacIsaac
    Endocrine Centre, Austin Health and University of Melbourne, Melbourne, Australia
    Cardiovasc Diabetol 7:15. 2008
    ....
  10. doi request reprint Diabetic kidney disease with and without albuminuria
    Richard J MacIsaac
    Endocrine Centre, Austin Health and University of Melbourne, Heidelberg West, Victoria, Australia
    Curr Opin Nephrol Hypertens 20:246-57. 2011
    ..We review recent findings that suggest that in some people with diabetic CKD there is an uncoupling of progressive increases in AER and declining GFR...
  11. ncbi request reprint The accuracy of cystatin C and commonly used creatinine-based methods for detecting moderate and mild chronic kidney disease in diabetes
    R J MacIsaac
    Endocrine Centre and Department of Medicine, University of Melbourne and Austin Health, Heidelberg West, Victoria, Australia
    Diabet Med 24:443-8. 2007
    ..The accuracy of measuring serum cystatin C levels for detecting various stages of chronic kidney disease (CKD) in diabetes is still unclear...
  12. doi request reprint Patterns of glycaemic control in Australian primary care (NEFRON 8)
    R J MacIsaac
    Endocrine Centre and Department of Medicine, Austin Health and University of Melbourne, Melbourne, Victoria, Australia
    Intern Med J 39:512-8. 2009
    ..The aim of the study was to describe patterns of glycaemic control in subjects participating in the National Evaluation of the Frequency of Renal Impairment co-existing with Non-Insulin Dependent Diabetes Mellitus study...
  13. pmc Failure of functional imaging with gallium-68-DOTA-D-Phe1-Tyr3-octreotide positron emission tomography to localize the site of ectopic adrenocorticotropic hormone secretion: a case report
    Linsey U Gani
    Endocrine Centre and Department of Medicine, Austin Health and University of Melbourne, PO Box 5444, Heidelberg West 3081, Victoria, Australia
    J Med Case Reports 5:405. 2011
    ..abstract:..
  14. ncbi request reprint Albuminuric and non-albuminuric pathways to renal impairment in diabetes
    R J MacIsaac
    Department of Medicine, University of Melbourne, Austin Health, Melbourne, Australia
    Minerva Endocrinol 30:161-77. 2005
    ..This will allow the detection of subjects following either an albuminuric or non-albuminuric pathway to renal impairment...
  15. ncbi request reprint Renal hyperfiltration in type 2 diabetes: effect of age-related decline in glomerular filtration rate
    E Premaratne
    Endocrinology Unit, Department of Medicine, University of Melbourne, Austin Health, Melbourne, Vic, Australia
    Diabetologia 48:2486-93. 2005
    ..We sought to characterise the effect of the age-related decline of GFR on hyperfiltration in type 2 diabetes and to identify clinical characteristics associated with hyperfiltration...
  16. doi request reprint New and old markers of progression of diabetic nephropathy
    G Jerums
    Endocrine Centre of Excellence, Austin Health and University of Melbourne, Heidelberg Repatriation Hospital, Level 2 Centaur Building, 300 Waterdale Road, Heidelberg West 3081, Victoria, Australia
    Diabetes Res Clin Pract 82:S30-7. 2008
    ..However, improved formulas for estimating GFR based on using creatinine or other markers are still required, because this may still provide the most cost effective approach applicable to existing clinical practice...
  17. ncbi request reprint Unrecognized anemia in patients with diabetes: a cross-sectional survey
    Merlin C Thomas
    Department of Medicine, Austin and Repatriation Medical Center, Heidelberg, Victoria, Australia
    Diabetes Care 26:1164-9. 2003
    ..This study aims to establish the prevalence and independent predictors of anemia in a cross-sectional survey of 820 patients with diabetes in long-term follow-up in a single clinic...
  18. ncbi request reprint Elevated iron indices in patients with diabetes
    M C Thomas
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Center, Heidelberg, Victoria, Australia
    Diabet Med 21:798-802. 2004
    ....
  19. doi request reprint High sodium and low potassium intake in patients with Type 2 diabetes
    E I Ekinci
    Endocrine Centre, Austin Health and University of Melbourne, Heidelberg Repatriation Hospital, Heidelberg West, Victoria 3081, Australia
    Diabet Med 27:1401-8. 2010
    ..To document dietary sodium and potassium intake and adherence to the Australian National Heart Foundation (NHF) guidelines in patients with Type 2 diabetes mellitus attending an Australian tertiary referral and university teaching hospital...
  20. pmc Nonalbuminuric renal impairment in type 2 diabetic patients and in the general population (national evaluation of the frequency of renal impairment cO-existing with NIDDM [NEFRON] 11)
    Merlin C Thomas
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes Care 32:1497-502. 2009
    ..However, its impact may be more significant. New studies are required to address the pathogenesis, prevention, and treatment of nonalbuminuric renal disease...
  21. doi request reprint New approaches for the evaluation of renal vascular function in diabetes
    G Jerums
    Endocrine Centre, Austin Health and University of Melbourne, Heidelberg Repatriation Hospital, Heidelberg West, PO Box 5444, VIC 3081, Australia
    Diabetologia 54:2223-5. 2011
    ....
  22. doi request reprint The clinical significance of hyperfiltration in diabetes
    G Jerums
    Endocrine Centre, Austin Health, Heidelberg Repatriation Hospital, Level 2, Centaur Building, 300 Waterdale Road, PO Box 5444, Heidelberg West, Victoria 3081, Australia
    Diabetologia 53:2093-104. 2010
    ..Future studies will therefore need to address the independent role of hyperfiltration, not only in the evolution of albuminuria, but also in the subsequent decline of GFR...
  23. pmc Effects of salt supplementation on the albuminuric response to telmisartan with or without hydrochlorothiazide therapy in hypertensive patients with type 2 diabetes are modulated by habitual dietary salt intake
    Elif I Ekinci
    Endocrine Centre, Austin Health and University of Melbourne, Heidelberg Repatriation Hospital, Heidelberg West, Victoria, Australia
    Diabetes Care 32:1398-403. 2009
    ..By contrast, when there is already a suppressed renin angiotensin aldosterone system under habitual high dietary salt intake, the additional NaCl does not alter the AER response...
  24. ncbi request reprint Diastolic dysfunction is associated with anaemia in patients with Type II diabetes
    Piyush M Srivastava
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria 3084, Australia
    Clin Sci (Lond) 110:109-16. 2006
    ..Notably, the predictive utility of these markers was eliminated after adjusting for Hb. Consequently, the inexpensive measurement of Hb may be a useful tool to identify diabetic patients at increased risk of cardiac dysfunction...
  25. ncbi request reprint Thiazolidinediones and congestive heart failure--exacerbation or new onset of left ventricular dysfunction?
    P M Srivastava
    Department of Medicine, University of Melbourne, Victoria, Australia
    Diabet Med 21:945-50. 2004
    ..Peripheral oedema and weight gain have been reported in 4.8% of subjects on TZDs alone, with a higher incidence noted in those receiving combination insulin therapy (up to 15%), but there is limited data on the occurrence of CHF...
  26. doi request reprint Salt supplementation blunts the blood pressure response to telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes
    E I Ekinci
    Department of Endocrinology, Austin Health and the University of Melbourne, Level 2 Centaur Building, Repatriation Campus, Austin Health, Heidelberg West, Melbourne, Vic, 3081, Australia
    Diabetologia 53:1295-303. 2010
    ....
  27. ncbi request reprint Nonalbuminuric renal insufficiency in type 2 diabetes
    Richard J MacIsaac
    Endocrinology Unit, Austin Health, Heidelberg, Victoria, Australia
    Diabetes Care 27:195-200. 2004
    ..To determine the prevalence and characteristics of patients with type 2 diabetes who have impaired renal function, defined as a glomerular filtration rate (GFR) <60 ml. min(-1). 1.73 m(-2), and normoalbuminuria...
  28. pmc Dietary salt intake and mortality in patients with type 2 diabetes
    Elif I Ekinci
    Endocrine Centre, Austin Health and the University of Melbourne, Victoria, Australia
    Diabetes Care 34:703-9. 2011
    ..However, the precise relationship between dietary salt intake and mortality in patients with type 2 diabetes has not been previously explored...
  29. doi request reprint Integrating albuminuria and GFR in the assessment of diabetic nephropathy
    George Jerums
    Endocrine Center, Austin Health, Victoria, Australia
    Nat Rev Nephrol 5:397-406. 2009
    ..The successful integration of AER categories with the recently defined stages of GFR represents a new challenge in the management of diabetic nephropathy...
  30. doi request reprint Low testosterone and anaemia in men with type 2 diabetes
    Mathis Grossmann
    Department of Endocrinology and Medicine, University of Melbourne, Austin Health, Australia
    Clin Endocrinol (Oxf) 70:547-53. 2009
    ..Low testosterone levels are also common in men with type 2 diabetes. We hypothesized that low testosterone levels are also associated with anaemia in men with type 2 diabetes, over the effects of chronic kidney disease...
  31. ncbi request reprint Outcomes for general medical inpatients with diabetes mellitus and new hyperglycaemia
    Scott T Baker
    Austin Health and University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 188:340-3. 2008
    ..To investigate the relationship between admission glycaemic status and inpatient mortality in patients with and without pre-existing diabetes...
  32. ncbi request reprint Microalbuminuria and diabetic cardiovascular disease
    Richard J MacIsaac
    Endocrinology Unit and Department of Medicine, University of Melbourne, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia
    Curr Atheroscler Rep 5:350-7. 2003
  33. ncbi request reprint Treatment of microalbuminuria in patients with type 2 diabetes mellitus
    George Jerums
    Endocrinology Unit, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Treat Endocrinol 1:163-73. 2002
    ..Antihypertensive therapy in patients with microalbuminuria and type 2 diabetes mellitus should be initiated with angiotensin converting enzyme (ACE) inhibitors or angiotensin-II type 1 receptor antagonists...
  34. ncbi request reprint Diabetic muscle infarction
    Richard J MacIsaac
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Vic, Australia
    Med J Aust 177:323-4. 2002
  35. ncbi request reprint Prevalence and predictors of cardiac hypertrophy and dysfunction in patients with Type 2 diabetes
    Piyush M Srivastava
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3081, Australia
    Clin Sci (Lond) 114:313-20. 2008
    ....
  36. doi request reprint Lowering of proteinuria in response to antihypertensive therapy predicts improved renal function in late but not in early diabetic nephropathy: a pooled analysis
    George Jerums
    Endocrine Centre, Austin Health and University of Melbourne, Heidelberg, Vic, Australia
    Am J Nephrol 28:614-27. 2008
    ..It follows that assessment of renoprotection during antihypertensive therapy in early nephropathy should be based not only on albuminuria but also on the GFR response...
  37. doi request reprint Low testosterone levels are common and associated with insulin resistance in men with diabetes
    Mathis Grossmann
    Department of Endocrinology and Medicine, University of Melbourne, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia
    J Clin Endocrinol Metab 93:1834-40. 2008
    ..Low testosterone levels are common in men with type 2 diabetes and may be associated with insulin resistance...
  38. doi request reprint Serial measurements of cystatin C are more accurate than creatinine-based methods in detecting declining renal function in type 1 diabetes
    Erosha Premaratne
    Endocrine Centre, Austin Health, University of Melbourne, Melbourne, Australia
    Diabetes Care 31:971-3. 2008
    ..Cystatin C-and creatinine-based methods were compared with (99m)-technetium-diethylene-triamine-penta-acetic acid ((99m)Tc-DTPA) plasma clearance (isotopic glomerular filtration rate [iGFR]) for detecting declining renal function...
  39. ncbi request reprint New insights into the significance of microalbuminuria
    Richard J MacIsaac
    Endocrinology Unit, Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
    Curr Opin Nephrol Hypertens 13:83-91. 2004
    ..This review summarizes recent work that has explored the association between microalbuminuria and adverse clinical outcomes in the presence and absence of diabetes...
  40. ncbi request reprint Earlier detection of microalbuminuria in diabetic patients using a new urinary albumin assay
    Wayne D Comper
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Kidney Int 65:1850-5. 2004
    ....
  41. ncbi request reprint The burden of anaemia in type 2 diabetes and the role of nephropathy: a cross-sectional audit
    Merlin C Thomas
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    Nephrol Dial Transplant 19:1792-7. 2004
    ..This study examines the prevalence and predictors of anaemia in long-term outpatients with type 2 diabetes from three large clinical centres...
  42. ncbi request reprint Anemia in patients with type 1 diabetes
    Merlin C Thomas
    Baker Medical Research Institute, P O Box 6492, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 89:4359-63. 2004
    ..Patients at greatest risk can be identified by the presence of renal disease, in the form of albuminuria and/or renal impairment...
  43. ncbi request reprint Influence of age on the presentation and outcome of acidotic and hyperosmolar diabetic emergencies
    R J MacIsaac
    Austin and Repatriation Medical Centre, Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
    Intern Med J 32:379-85. 2002
    ..Traditionally, DKA and HHS have been classified as distinct entities but there is evidence to suggest that patients can present with elements of both conditions...
  44. ncbi request reprint Diabetic ketoacidosis secondary to dento-alveolar infection
    A Chandu
    Oral and Maxillofacial Surgery, University of Melbourne, Austin, Victoria, Australia
    Int J Oral Maxillofac Surg 31:57-9. 2002
    ..We report two cases of dentoalveolar infections in patients with type I diabetes mellitus who presented with DKA. The management of such cases requires both specialist surgical and medical intervention...
  45. ncbi request reprint A case of mucormycosis limited to the parotid gland
    Arun Chandu
    Department of ENT Head and Neck Surgery, Austin Health, Studley Rd, Heidelberg 3084, Victoria, Australia
    Head Neck 27:1108-11. 2005
    ..Common predisposing factors include diabetes and immunosuppression. To date, only one case of mucormycosis involving the parotid gland has been reported, and this infection was associated with a fatal outcome...
  46. ncbi request reprint High prevalence of immunounreactive albumin in urine from diabetic patients with a low glomerular filtration rate and normoalbuminuria
    Tanya M Osicka
    Diabetes Care 27:1515. 2004